CN115088712B - Medicament for preventing and treating rust disease of radix puerariae lobatae - Google Patents
Medicament for preventing and treating rust disease of radix puerariae lobatae Download PDFInfo
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- CN115088712B CN115088712B CN202210716152.6A CN202210716152A CN115088712B CN 115088712 B CN115088712 B CN 115088712B CN 202210716152 A CN202210716152 A CN 202210716152A CN 115088712 B CN115088712 B CN 115088712B
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- carvacrol
- tebuconazole
- flusilazole
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- 239000003814 drug Substances 0.000 title claims abstract description 24
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 201000010099 disease Diseases 0.000 title claims abstract description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 21
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims abstract description 54
- 235000007746 carvacrol Nutrition 0.000 claims abstract description 54
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims abstract description 54
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000000203 mixture Substances 0.000 claims abstract description 24
- FQKUGOMFVDPBIZ-UHFFFAOYSA-N flusilazole Chemical compound C=1C=C(F)C=CC=1[Si](C=1C=CC(F)=CC=1)(C)CN1C=NC=N1 FQKUGOMFVDPBIZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims description 11
- 235000010804 Maranta arundinacea Nutrition 0.000 claims description 6
- 235000012419 Thalia geniculata Nutrition 0.000 claims description 6
- 239000012752 auxiliary agent Substances 0.000 claims description 3
- 244000145580 Thalia geniculata Species 0.000 claims 1
- 239000005839 Tebuconazole Substances 0.000 abstract description 27
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 abstract description 26
- 244000052616 bacterial pathogen Species 0.000 abstract description 7
- 241000731396 Pueraria montana var. thomsonii Species 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 235000010575 Pueraria lobata Nutrition 0.000 abstract description 4
- 241000219781 Pueraria montana var. lobata Species 0.000 abstract description 4
- 239000000575 pesticide Substances 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 description 10
- 241001560086 Pachyrhizus Species 0.000 description 6
- 244000151018 Maranta arundinacea Species 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 230000035784 germination Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000004763 spore germination Effects 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- GOFJDXZZHFNFLV-UHFFFAOYSA-N 5-fluoro-1,3-dimethyl-N-[2-(4-methylpentan-2-yl)phenyl]pyrazole-4-carboxamide Chemical compound CC(C)CC(C)C1=CC=CC=C1NC(=O)C1=C(F)N(C)N=C1C GOFJDXZZHFNFLV-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 241000221785 Erysiphales Species 0.000 description 2
- 239000005815 Penflufen Substances 0.000 description 2
- 241000682645 Phakopsora pachyrhizi Species 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- -1 flusilazole triazole Chemical class 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- WURBVZBTWMNKQT-UHFFFAOYSA-N 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one Chemical compound C1=NC=NN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 WURBVZBTWMNKQT-UHFFFAOYSA-N 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- TWFZGCMQGLPBSX-UHFFFAOYSA-N Carbendazim Natural products C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000221300 Puccinia Species 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 239000005842 Thiophanate-methyl Substances 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000006013 carbendazim Substances 0.000 description 1
- JNPZQRQPIHJYNM-UHFFFAOYSA-N carbendazim Chemical compound C1=C[CH]C2=NC(NC(=O)OC)=NC2=C1 JNPZQRQPIHJYNM-UHFFFAOYSA-N 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical group COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000005068 transpiration Effects 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the technical field of pesticides, in particular to a medicament for preventing and treating rust disease of radix puerariae. The medicine for preventing and treating rust of kudzu vine is compounded with carvacrol and flusilazole or tebuconazole as effective components; wherein the mass ratio of the carvacrol to the flusilazole is 1-20:60-1; the mass ratio of the carvacrol to the tebuconazole is 1-40:20-1. The carvacrol and flusilazole or tebuconazole in the effective components of the composition have good synergistic effect after being compounded, and particularly when the mass ratio of the carvacrol to the flusilazole is 1:8, and the mass ratio of carvacrol to tebuconazole is 5:1, the synergy is particularly obvious. Compared with single active ingredient, the composition can effectively inhibit pathogenic bacteria of Pueraria thomsonii, improve the control effect on Pueraria thomsonii, reduce the dosage and reduce the control cost.
Description
Technical Field
The invention relates to the technical field of pesticides, in particular to a medicament for preventing and treating rust disease of radix puerariae.
Background
The arrowroot is a leguminous plant, and the root tuber of the arrowroot can be eaten fresh and processed into arrowroot, so that the arrowroot has good nutritional and health-care values. The diseases occurring on the radix Puerariae mainly include rust disease, root rot, anthracnose, wilt, brown spot and empty heart disease. Among them, rust disease of arrowroot occurs mostly in warm and rainy climates, and the damage to the leaves is greatest. The pathogenic bacteria of the pachyrhizus rust disease are pachyrhizus rust bacteria (Phakopsora pachyrhizi Syd.) of basidiomycotina, and at the initial stage of plant disease, tiny faint yellow or light brown disease spots appear on leaves, after a period of time, the disease spots naturally crack, and a small amount of orange yellow powder is visible, and the yellow powder is summer sporum of bacteria. The leaves with serious disease are seen to have a large number of disease spots on the leaf surfaces, yellow to rust powder is mixed in the leaf surfaces, the leaves are twisted and curled, photosynthesis cannot be normally carried out, the water content is reduced due to a large number of transpirations, and finally the leaves are slowly withered, so that the expansion of underground tuberous roots is influenced, and the yield is reduced.
At present, the domestic prevention and treatment of the rust disease of the radix puerariae are mainly carried out by medicaments such as thiophanate methyl, carbendazim, triadimefon and the like, but the medicament is continuously used for many years, so that the drug resistance of pathogenic bacteria is generated, and the prevention and treatment effect on the rust disease of the radix puerariae is continuously reduced. Therefore, there is an urgent need for novel agents capable of effectively controlling Pueraria rust.
The carvacrol is a pure plant source bactericide which is prepared by extracting and processing yellow flower buds, has a strong antibacterial effect, and can effectively inhibit the growth of pathogenic bacteria spores and hyphae. CN201510084511.0 discloses a bactericidal composition containing penflufen and carvacrol and application thereof, and particularly discloses a bactericidal composition which has good prevention and treatment effects on powdery mildew or rust diseases of wheat, fruit trees, flowers, vegetables and the like after the penflufen and the carvacrol are compounded.
The flusilazole triazole bactericide mainly damages the biosynthesis of ergosterol which is an important component of cell membranes of tissue pathogenic bacteria, so that the cell membranes cannot be formed, and the bacteria die. Flusilazole is effective against pathogens of basidiomycetes and fungi imperfecti.
The tebuconazole is broad-spectrum triazole bactericide, is a sterol demethylation inhibitor, has strong systemic property, and can prevent and treat various diseases in various crops, such as brown spot, powdery mildew, rust and fusarium wilt.
At present, no report on the compounding of carvacrol and flusilazole or tebuconazole is yet known.
Disclosure of Invention
The invention aims to provide a medicament for preventing and treating rust disease of radix puerariae.
In order to achieve the above purpose, the present invention provides the following technical solutions:
The first aim of the invention is to provide a composition for preventing and treating pachyrhizua rust, the active ingredients of the composition are compounded by carvacrol and flusilazole or tebuconazole; wherein the mass ratio of the carvacrol to the flusilazole is 1-20:60-1; the mass ratio of the carvacrol to the tebuconazole is 1-40:9-1.
Preferably, the mass ratio of the carvacrol to the flusilazole is 1:8.
Preferably, the mass ratio of carvacrol to tebuconazole is 5:1.
The second object of the invention is to provide a medicament for preventing and treating rust disease of radix puerariae, which consists of active ingredients of the composition and an auxiliary agent acceptable in agriculture and pharmacy, wherein the auxiliary agent acceptable in agriculture and pharmacy consists of one or more of a filler, a wetting agent, an emulsifying agent, a binding agent, a disintegrating agent, a dispersing agent, a thickening agent, a preservative, an antifoaming agent, an antifreezing agent, a solvent and a stabilizing agent for a person skilled in the technical field.
Preferably, the mass of the active ingredients of the composition accounts for 1.5-65% of the total mass of the medicament.
Compared with the prior art, the invention has the following beneficial effects:
The carvacrol and flusilazole or tebuconazole in the effective components of the composition have good synergistic effect after being compounded, and particularly when the mass ratio of the carvacrol to the flusilazole is 1:8, and the mass ratio of carvacrol to tebuconazole is 5:1, the synergy is particularly obvious. Compared with single active ingredient, the composition can effectively inhibit pathogenic bacteria of Pueraria thomsonii, improve the control effect on Pueraria thomsonii, reduce the dosage and reduce the control cost.
Detailed Description
The following description of the embodiments of the present invention will be apparent from the description of the embodiments of the present invention, which is provided in part, but not in whole. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, are intended to fall within the scope of the present invention.
Examples: indoor biological activity test of carvacrol compound
1. Test strain: pachyrhizus (Phakopsora pachyrhizi Syd.)
2. Test agent
98% Carvacrol stock (Shanghai Yuan Ye Biotechnology Co., ltd.)
95% Fluorosilicone azole (Jiangsu Zhongqi scientific and technological Co., ltd.)
97% Tebuconazole original drug (Shenyang scientific chemical Co., ltd.)
The test agent is dissolved by dimethyl sulfoxide, diluted by 0.1% Tween-80 aqueous solution to prepare single-agent mother solution, a plurality of groups of proportions are arranged, and each single-agent and the proportion mixture are provided with 5 mass concentration gradients according to an equal proportion method for standby.
3. Test method (refer to "NY/T1156.1-2006. Criterion for laboratory biological tests of pesticides section 1: concave slide method for tests for inhibiting spore germination of pathogenic fungi
Fresh summer spores of Pueraria lobata (Pueraria lobata) which are pathogenic bacteria of Pueraria thomsonii are collected in Pueraria lobata test bases of the national institute of agricultural sciences in Guangxi, the spores are resuspended to 1X 10 5 to 1X 10 7 spores per milliliter by deionized water, and 0.5% glucose solution is added. Sequentially sucking 0.5mL of liquid medicine from low concentration to high concentration by a pipette, respectively adding the liquid medicine into small test tubes, and then sucking 0.5mL of prepared spore suspension, so that the liquid medicine and the spore suspension are uniformly mixed in equal quantity. The mixed liquid is sucked by a microsampler and is put on a concave slide, then the concave slide is put in a culture dish with shallow water, and the culture dish is covered and placed in a light incubator at 25 ℃. Each treatment was set up in 3 replicates and a treatment with 0.1% tween-80 in water was set up as a blank. After 24 hours, checking germination conditions of spores of each treatment, randomly observing 3 visual fields each treatment, checking the total number of spores to be not less than 200, and recording the germination number and the total number of spores respectively, wherein the spore dental canal length is larger than the short radius of the spores, and the spores are regarded as germination. Based on the survey data, the relative inhibition of spore germination was calculated for each treatment.
4. Data analysis: and carrying out data statistical analysis by adopting DPS software, carrying out regression analysis according to the concentration log value of each medicament and the probability value of the corresponding spore germination relative inhibition rate, calculating EC 50 of each medicament, and calculating the co-toxicity coefficient (CTC value) of the mixture according to the grand cloud Pei method.
In the above formula: ati—the measured virulence index of the mixture; s- -EC 50 of standard medicament in mg/L; m- -EC 50 of the test mixture in mg/L.
TTI＝TIA×PA+TIB×PB
In the above formula: TTI- -theoretical toxicological index of the mixture; toxicity index of TI A - -A agents; the percentage content of the P A -A medicament in the mixture is expressed as percentage (%); toxicity index of TI B - -B agent; the percentage of the P B -B medicament in the mixture is expressed as percentage (%).
In the above formula: ctc—co-toxicity coefficient; ati—actual measured virulence index of the mixture; tti—the theoretical toxicity index of the mixture.
5. Measurement results
The synergy of the agents was evaluated based on the calculated co-toxicity coefficient (CTC), CTC.ltoreq.80 being antagonism, CTC.ltoreq.120 being additive, CTC.ltoreq.120 being synergy, the results being shown in tables 1-2.
TABLE 1 determination of indoor biological Activity of carvacrol and flusilazole Complex against Puccinia pachyrhizi
| Medicament name and ratio | EC50(mg/L) | ATI | TTI | CTC |
| Carvacrol | 16.54 | 100.00 | -- | -- |
| Fluorosilazole | 30.42 | 54.37 | -- | -- |
| Carvacrol 1: flusilazole 60 | 23.53 | 70.29 | 55.12 | 127.53 |
| Carvacrol 1: flusilazole 40 | 17.73 | 93.29 | 55.48 | 168.13 |
| Carvacrol 1: fluorosilazole 20 | 10.17 | 162.64 | 56.54 | 287.62 |
| Carvacrol 1: fluorosilazole 10 | 6.42 | 257.63 | 58.52 | 440.25 |
| Carvacrol 1: fluorosilazole 8 | 2.54 | 651.18 | 59.44 | 1095.49 |
| Carvacrol 1: fluorosilazole 5 | 9.52 | 173.74 | 61.98 | 280.33 |
| Carvacrol 1: fluorosilazole 2 | 16.69 | 99.10 | 69.58 | 142.42 |
| Carvacrol 1: fluorosilazole 1 | 12.57 | 131.58 | 77.19 | 170.48 |
| Carvacrol 2: fluorosilazole 1 | 8.17 | 202.45 | 84.79 | 238.76 |
| Carvacrol 5: fluorosilazole 1 | 4.98 | 332.13 | 92.40 | 359.46 |
| Carvacrol 8: fluorosilazole 1 | 10.29 | 160.74 | 94.93 | 169.32 |
| Carvacrol 10: fluorosilazole 1 | 5.49 | 301.28 | 95.85 | 314.31 |
| Carvacrol 20: fluorosilazole 1 | 6.93 | 238.67 | 97.83 | 243.97 |
As shown in Table 1, after the active ingredients of carvacrol and flusilazole are compounded, the mass ratio is 1-20: the co-toxicity coefficient of the pachyrhizus in the range of 60-1 is more than 120, and the synergistic effect is shown; especially when the mass ratio is 1:8, the co-toxicity coefficient reaches 1095.49, and the synergy is particularly obvious.
Table 2 determination of indoor biological Activity of carvacrol and tebuconazole Complex against pachyrhizus
| Medicament name and ratio | EC50(mg/L) | ATI | TTI | CTC |
| Carvacrol | 16.54 | 100.00 | -- | -- |
| Tebuconazole | 9.06 | 182.56 | -- | -- |
| Carvacrol 1: tebuconazole 9 | 5.43 | 304.60 | 174.30 | 174.75 |
| Carvacrol 1: tebuconazole 7 | 3.11 | 531.83 | 172.24 | 308.77 |
| Carvacrol 1: tebuconazole 5 | 1.67 | 990.42 | 168.80 | 586.74 |
| Carvacrol 1: tebuconazole 3 | 4.70 | 351.91 | 161.92 | 217.34 |
| Carvacrol 1: tebuconazole 1 | 8.24 | 200.73 | 141.28 | 142.08 |
| Carvacrol 2: tebuconazole 1 | 7.57 | 218.49 | 127.52 | 171.34 |
| Carvacrol 5: tebuconazole 1 | 2.13 | 776.53 | 113.76 | 682.60 |
| Carvacrol 8: tebuconazole 1 | 4.02 | 411.44 | 109.17 | 376.87 |
| Carvacrol 10: tebuconazole 1 | 3.28 | 504.27 | 107.51 | 469.06 |
| Carvacrol 20: tebuconazole 1 | 11.18 | 147.94 | 103.93 | 142.35 |
| Carvacrol 40: tebuconazole 1 | 9.15 | 180.77 | 102.01 | 177.20 |
As shown in Table 2, after the active ingredients carvacrol and tebuconazole are compounded, the mass ratio is 1-40: the co-toxicity coefficient of the pachyrhizus in the range of 9-1 is more than 120, and the synergistic effect is shown; especially when the mass ratio is 5: in the 1, the co-toxicity coefficient reaches 682.60, and the synergy is particularly obvious.
From the comprehensive tables 1 and 2, the carvacrol and the flusilazole or the tebuconazole have good synergistic effect after being compounded, and the control effect of the pachyrhizua angulatus rust can be improved.
Claims (4)
1. The bactericidal composition is applied to preventing and treating rust disease of radix puerariae, and is characterized in that the effective components of the bactericidal composition are compounded by carvacrol and flusilazole; wherein the mass ratio of the carvacrol to the flusilazole is 1-20:60-1.
2. The use of the bactericidal composition in preventing and treating rust of arrowroot as claimed in claim 1, wherein the mass ratio of carvacrol to flusilazole is 1:8.
3. A medicament for preventing and treating rust disease of radix puerariae, which is characterized by comprising the effective components of the bactericidal composition in any one of claims 1-2 and an auxiliary agent acceptable in agro-pharmacology.
4. A medicament according to claim 3, wherein the mass of the active ingredient of the bactericidal composition is 1.5-65% of the total mass of the medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210716152.6A CN115088712B (en) | 2022-06-23 | 2022-06-23 | Medicament for preventing and treating rust disease of radix puerariae lobatae |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210716152.6A CN115088712B (en) | 2022-06-23 | 2022-06-23 | Medicament for preventing and treating rust disease of radix puerariae lobatae |
Publications (2)
| Publication Number | Publication Date |
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| CN115088712A CN115088712A (en) | 2022-09-23 |
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| CN108651458A (en) * | 2018-06-27 | 2018-10-16 | 广西南宁益土生物科技有限责任公司 | A kind of bactericidal composition containing carvacrol and hexaconazole |
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| CN101632382B (en) * | 2009-07-14 | 2012-07-25 | 广东中迅农科股份有限公司 | Pesticide composition containing flusilazole and tebuconazole and application thereof |
| CN103053529B (en) * | 2012-12-29 | 2014-12-31 | 广东中迅农科股份有限公司 | Carvacrol-fluazinam pesticide composition |
| CN107333761A (en) * | 2016-04-29 | 2017-11-10 | 陕西韦尔奇作物保护有限公司 | A kind of composition pesticide of ester containing chrysanthemin and triazole type |
| CN114097795A (en) * | 2020-08-26 | 2022-03-01 | 山东省联合农药工业有限公司 | Bactericidal composition containing pyrazole amide compounds and triazole bactericide |
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| CN108651458A (en) * | 2018-06-27 | 2018-10-16 | 广西南宁益土生物科技有限责任公司 | A kind of bactericidal composition containing carvacrol and hexaconazole |
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| 小麦锈病防治药剂试验报告;朱一博等;《农民致富之友》(第10期);130 * |
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