CN106550942A - A kind of bactericidal composition containing 1,8 cineoles - Google Patents
A kind of bactericidal composition containing 1,8 cineoles Download PDFInfo
- Publication number
- CN106550942A CN106550942A CN201610903499.6A CN201610903499A CN106550942A CN 106550942 A CN106550942 A CN 106550942A CN 201610903499 A CN201610903499 A CN 201610903499A CN 106550942 A CN106550942 A CN 106550942A
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- Prior art keywords
- cineole
- acid
- weight
- echinocystic acid
- composition containing
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing 1,8 cineoles, 1,8 cineole and echinocystic acid, 1,8 cineole with the ratio of the parts by weight of echinocystic acid is, 9:1‑10:1.By finding the effect of leaf spot is prevented and treated with collaboration well by 1,8 cineole and echinocystic acid compatibility under specific ratio, particularly 1,8 cineoles are 9 with the ratio of the parts by weight of echinocystic acid to the present invention:1‑10:Between 1, its synergy is apparent.
Description
Technical field
The present invention relates to a kind of medicament, specifically a kind of bactericidal composition containing 1, 8-Cineole, belong to agricultural technology neck
Domain.
Background technology
1, 8-Cineole (CAS 470-82-6) is colorless oil transparency liquid.There are Camphora breath and refrigerant medical herbs taste
Road, with certain pest-resistant effect of sterilization.
Echinocystic acid (CAS 510-30-5) source is leguminous plant Mengzi Herba Albiziae Albizzia julibrissin
Durazz. the actual pesticide of inflorescence experience have shown that, repeat and a kind of reactive compound of single-minded administration is harmful true to prevent and treat
Bacterium will cause the fast selective of fungal bacterial strain under many circumstances, be that reduction refractory fungal bacterial strain is selectively dangerous, mesh
Before the mixture of different activities compound is usually used to prevent and treat harmful fungoid.By the activation that will there are the different mechanisms of action
Compound is combined, can delaying drug resistance produce, reduce amount of application, reduce cost accounting, it is found by the applicant that 1, 8-Cineole and thorn
Capsule acid coordinates for the effect for preventing leaf spot to have potentiation under certain proportion.
The content of the invention
For the problem that above-mentioned prior art is present, it is an object of the invention to provide the sterilization group containing 1, 8-Cineole
Compound, it is to compound the sterilization component of two kinds of different structures, the different mechanisms of action, is expanding prevention spectrum and raising drug effect
Effective way, it is often more important that avoid or delay generation of the disease to new composition resistance.To realize the purpose of the present invention, invention
1, 8-Cineole is compounded by people with echinocystic acid, for preventing and treating the disease of crop.
To achieve these goals, the technical solution used in the present invention is：It is a kind of to include two kinds of principle active components：1,8-
Cineole and echinocystic acid.
Described 1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 1:1-20:1.
The weight sum of described 1, 8-Cineole and echinocystic acid accounts for the 1-80% of medicament gross weight.
Described bactericidal composition, said composition can be made into suspending agent, wettable powder, seed coat agent, aqueous emulsion, microemulsion
Agent, cream, granule, water dispersible granules, and can be needed using corresponding solvent, carrier and auxiliary agent according to exploitation.
Suitable solvent, auxiliary agent include：Toluene, dimethylbenzene, dichloromethane, chloroform, paraffin, kerosene, diesel oil, first
Alcohol, ethanol, propanol, butanol, amylalcohol, Hexalin, benzyl alcohol, Ketohexamethylene, isophorone, ketopyrrolidine, ethyl acetate, acetic acid fourth
One or more combination of ester, ethylene acetate, dimethyl sulfoxide etc..
Carrier include clay, bentonite, attapulgite, calcium sulfate, precipitated calcium carbonate, sucrose, industrial chitin, silica gel,
One or more combination of Pulvis Talci, white carbon, sericite in powder etc.；
Available auxiliary agent includes phosphoric acid salt, hydrochloric acid salt, lignosulphonateses, naphthalenesulfonate, phenolsulfonate
Class, succinic acid Sulfonateses, polystyrene-based phenol polyethenoxy ether sulfate, Pluronic PE 6800, molecular weight are 20000-
30000 macromolecular grafted copolymer, triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether, polystyrene-based phenol polyethenoxy
Ethers, NPE class, polystyrene-based polyethenoxy ether class, alkyl naphthalene sulfonic acid salt, aliphatic alcohol polyethenoxy
Ethers, dialkyl succinylsuccinate Sulfonateses, branched fatty alcohol polyethenoxy ether class, alkyl polyoxyethylene ether class, carboxyl alkyl cellulose
Class, hydroxy alkyl cellulose class, Magnesiumaluminumsilicate, xanthan gum, poly- alkyl silicon ethylene oxide, phosphoric acid, glacial acetic acid, citric acid, suitable fourth
One kind in enedioic acid, dibutyl hydroxy methane, Butylated hydroxyanisole, tert-butylhydroquinone, propylgallate etc. or
Multiple combination.
The present invention is by having found have collaboration well anti-by 1, 8-Cineole and echinocystic acid compatibility under specific ratio
Control the effect of leaf spot, be 9 with the ratio of the parts by weight of echinocystic acid particularly in 1, 8-Cineole:1-10:Between 1, its collaboration
Prevent and treat that leaf spot effect is apparent, toxicity is less.
Specific embodiment
Embodiment 1
1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 15:1,
Described 1, 8-Cineole accounts for the 11% of medicament gross weight with the weight sum of echinocystic acid, methyl naphthalene sulfonic acid sodium formaldehyde
Condensation substance 8%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 8%, remaining water complement to 100%.
Embodiment 2
1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 10:1,
Described 1, 8-Cineole accounts for the 11% of medicament gross weight with the weight sum of echinocystic acid, methyl naphthalene sulfonic acid sodium formaldehyde
Condensation substance 8%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 8%, remaining water complement to 100%
Embodiment 3
1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 9:1,
Described 1, 8-Cineole accounts for the 11% of medicament gross weight with the weight sum of echinocystic acid, methyl naphthalene sulfonic acid sodium formaldehyde
Condensation substance 8%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 8%, remaining water complement to 100%.
Embodiment 4
1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 8:1,
Described 1, 8-Cineole accounts for the 11% of medicament gross weight with the weight sum of echinocystic acid, methyl naphthalene sulfonic acid sodium formaldehyde
Condensation substance 8%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 8%, remaining water complement to 100%.
Embodiment 5
1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 5:1,
The weight sum of described 1, 8-Cineole and echinocystic acid accounts for the 11% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 6
1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 2:1,
The weight sum of described 1, 8-Cineole and echinocystic acid accounts for the 11% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 7
1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 1:1,
Described 1, 8-Cineole accounts for the 11% of medicament gross weight with the weight sum of echinocystic acid, methyl naphthalene sulfonic acid sodium formaldehyde
Condensation substance 8%, sodium lignosulfonate 15%, xanthan gum 3%, silicone oil 5%, glycerol 8%, remaining water complement to 100%.
Embodiment 8
1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 1:2,
The weight sum of described 1, 8-Cineole and echinocystic acid accounts for the 11% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Embodiment 9
1, 8-Cineole with the ratio of the parts by weight of echinocystic acid is, 1:6,
The weight sum of described 1, 8-Cineole and echinocystic acid accounts for the 11% of medicament gross weight, methyl oleate 1%, polyoxy
Ethylene (30) dimerization hydroxy stearic acid fat 1%, balance of pure water.
Laboratory test：
Subjects：Leaf spot pathogenic bacteria
According to the incidence of the whole strain blade of test grade scale investigation Fructus Luffae, disease index and prevention effect are calculated.Will
Prevention effect is converted into niqueMin (y), and medicinal liquid is done height (μ g/ml) and is converted into logarithm value (x), calculates virulence with method of least square
Concentration EC50 in equation and suppression, calculates toxicity index level co-toxicity coefficient (CTC) of medicament according to the abundant methods of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agents EC50) * 100
Percentage composition+B medicament toxicity index * the mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
The percentage composition co-toxicity coefficient (CTC) of middle B=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] *
100CTC≤80, compositionss show as antagonism, 80 ＜ CTC ＜ 120, and compositionss show as summation action, CTC >=120, group
Compound shows as potentiation.
Table 11,8- cineoles：Echinocystic acid and its different ratio are compounded to leaf spot toxicity test interpretation of result.
A is 1, 8-Cineole, and B is echinocystic acid,
| Reagent treatment | ATI | TTI | Co-toxicity coefficient CTC |
| A：B(15:1) | 72.6 | 78.5 | 92.5 |
| A：B(10:1) | 69.4 | 76.4 | 90.8 |
| A：B(9:1) | 182.4 | 74.2 | 245.8 |
| A：B(8:1) | 163.1 | 70.1 | 232.6 |
| A：B(5:1) | 60.3 | 68.1 | 88.5 |
| A：B(3:1) | 62.7 | 64.8 | 96.8 |
| A：B(1:1) | 61.9 | 60.2 | 102.8 |
| A：B(1:6) | 50.6 | 57.3 | 88.3 |
From the measurement result of table 1, work as 1, 8-Cineole：Echinocystic acid proportioning is 9:1-10:When between 1, co-toxicity coefficient
200 are both significantly higher than, with obvious potentiation, and other ratios mix, and co-toxicity coefficient is not obvious.
Field efficacy checking test
Test method：At the initial stage of a disease, first time spraying being carried out immediately, second dispenser being carried out after 7 days, each processes 4
Individual cell, each 20 square meter of cell.10 days investigation statisticses incidences before medicine and after second medicine, 5 points of each cell are random
Sampling, 5 plants of crops of per investigation, investigates the lesion area in whole strain per blade and accounts for the percentage rate of blade area and be classified, calculate
Disease index and prevention effect.
Expected preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single dose preventive effect)
Grade scale：
0 grade：Disease-free spot；
1 grade：Leaf spot lesion is less than 5, and length is less than 1cm；
3 grades：Leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades：Leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-211% of leaf area；
7 grades：Leaf spot lesion more than 26, scab are linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades：Scab is linked to be piece, and lesion area accounts for more than the 50% of leaf area or full leaf is withered.
The field control effectiveness test of embodiment and matched group to leaf spot.
| Process group | Dosage (a.i.g/hm2) | Prevention effect (%) |
| A：B(15:1) | 60 | 57.5 |
| A：B(10:1) | 30 | 89.7 |
| A：B(10:1) | 60 | 94.4 |
| A：B(9:1) | 60 | 91.3 |
| A：B(5:1) | 60 | 50.1 |
| A：B(2:1) | 60 | 48.6 |
| A：B(1:1) | 60 | 44.5 |
| A：B(1:5) | 60 | 43.5 |
| A：B(1:10) | 60 | 41.5 |
| A | 60 | 51.1 |
| B | 60 | 37.5 |
It can be seen that embodiment 1 has significantly prevents and treats leaf spot effect, it is seen that 1, 8-Cineole is with echinocystic acid certain
Under ratio, to prevent and treat leaf spot effect apparent for proportioning collaboration, and single 1, 8-Cineole has certain prevention effect,
But effect is not notable, single echinocystic acid prevention and control capability is also effect on driving birds is not good.The parts by weight of 1, 8-Cineole and echinocystic acid
Ratio be 9:1-10:When 1, synergy is most notable, and effect is not very notable during other proportions.
Claims (4)
1. a kind of bactericidal composition containing 1, 8-Cineole, it is characterised in that comprising two kinds of principle active components：1, 8-Cineole
With echinocystic acid.
2. a kind of bactericidal composition containing 1, 8-Cineole according to claim 1, described 1, 8-Cineole and thorn capsule
The ratio of the parts by weight of acid is 1:1-20:1.
3. a kind of bactericidal composition containing 1, 8-Cineole according to claim 1, it is characterised in that it is characterized in that having
Effect composition accounts for the 1%～90% of gross weight.
4. a kind of bactericidal composition containing 1, 8-Cineole according to claim 1, it is characterised in that said composition can be made
Into suspending agent, wettable powder, seed coat agent, aqueous emulsion, microemulsion, cream, granule, water dispersible granules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610903499.6A CN106550942A (en) | 2016-10-17 | 2016-10-17 | A kind of bactericidal composition containing 1,8 cineoles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610903499.6A CN106550942A (en) | 2016-10-17 | 2016-10-17 | A kind of bactericidal composition containing 1,8 cineoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106550942A true CN106550942A (en) | 2017-04-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610903499.6A Pending CN106550942A (en) | 2016-10-17 | 2016-10-17 | A kind of bactericidal composition containing 1,8 cineoles |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314086A (en) * | 2000-03-16 | 2001-09-26 | 苏胜奎 | 18% Haoan emulsion |
| CN1438237A (en) * | 2003-01-21 | 2003-08-27 | 吉林天药科技股份有限公司 | Echinocystic acid preparation, medicinal preparation and new use as medicine |
| US20070014739A1 (en) * | 2005-07-14 | 2007-01-18 | Eldridge Gary R | Compositions and methods for controlling biofilms and bacterial infections |
-
2016
- 2016-10-17 CN CN201610903499.6A patent/CN106550942A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314086A (en) * | 2000-03-16 | 2001-09-26 | 苏胜奎 | 18% Haoan emulsion |
| CN1438237A (en) * | 2003-01-21 | 2003-08-27 | 吉林天药科技股份有限公司 | Echinocystic acid preparation, medicinal preparation and new use as medicine |
| US20070014739A1 (en) * | 2005-07-14 | 2007-01-18 | Eldridge Gary R | Compositions and methods for controlling biofilms and bacterial infections |
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Application publication date: 20170405 |