CN109892338A - Composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole - Google Patents
Composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole Download PDFInfo
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- CN109892338A CN109892338A CN201910259486.3A CN201910259486A CN109892338A CN 109892338 A CN109892338 A CN 109892338A CN 201910259486 A CN201910259486 A CN 201910259486A CN 109892338 A CN109892338 A CN 109892338A
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- probenazole
- pyrimidine nucleoside
- antibiotic
- composition
- nucleoside class
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Abstract
The invention discloses a kind of composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole, composition effective active composition is made of antibiotic in pyrimidine nucleoside class and probenazole, the weight ratio of antibiotic in pyrimidine nucleoside class and probenazole in the composition is 20:1~1:20, and the weight percent of antibiotic in pyrimidine nucleoside class and probenazole weight summation in the composition is 0.1%~85%；Disease excellent on composition pesticide prevention and treatment crops of the present invention, the lasting period is long, to Crop securify；Obvious synergy after antibiotic in pyrimidine nucleoside class and probenazole combination, can reduce Pesticide use amount, reduce use cost, mitigate the pollution to environment, delay the generation of pathogen drug resistance, increase the Pesticide use service life.
Description
Technical field
The present invention relates to composition pesticide and its application fields, specifically using effective component as pyridimine nucleosides antibacterial
Element, probenazole binary composition, the prevention and treatment applied to disease on crops.
Background technique
The long-time of pesticide single variety is used continuously, and is easy to produce resistance risk and dosage increases risk, and then increase
Use cost and carrying capacity of environment.And being applied in combination by different pesticide species, filter out the pesticide with synergistic function
Composition not only can be reduced Pesticide use amount, reduce use cost, reduce resistance risk, moreover it is possible to potential environmental risk is reduced,
Increase the Pesticide use service life.
Different pesticide species combinations are presented with synergistic effect, summation action and antagonism to target collaboration virulence.
The present inventor is during studying antibiotic in pyrimidine nucleoside class and probenazole combination formula, surprisingly
Antibiotic in pyrimidine nucleoside class and probenazole are combined, in a certain proportion to citrus resin germ, cotton wilt
There is the germs such as bacterium significant synergistic function to complete the present invention after further study.
Summary of the invention
The purpose of the present invention is to provide a kind of component is reasonable, obvious synergy, bactericidal effect is outstanding, the lasting period
Long, drug cost is low, pathogen can be delayed to develop drug resistance, and contain antibiotic in pyrimidine nucleoside class to one kind of Crop securify
With probenazole composition and preparation method thereof.
Technical solution of the present invention: to achieve the above object, the present invention provide it is a kind of containing antibiotic in pyrimidine nucleoside class and
The composition pesticide of probenazole, effective active composition are made of antibiotic in pyrimidine nucleoside class and probenazole, pyridimine nucleosides antibacterial
Element and the weight ratio of probenazole in the composition are 20:1~1:20, and antibiotic in pyrimidine nucleoside class and probenazole weight summation are in group
Close object in weight percent be 0.1%~85%, remaining be can agriculturally receive and allow using pesticidal preparations assist at
Point.
Further, the preferred weight ratio of antibiotic in pyrimidine nucleoside class and probenazole in the composition is 5:1~1:5；Pyrimidine
The preferred weight percent of nucleosides antibiotics and probenazole weight summation in the composition is 5%~70%.
Composition pesticide of the present invention can be prepared into a variety of dosage forms used in suitable agricultural production, and relatively good dosage form has
Suspending agent, water dispersible granules, wettable powder.
It further include pesticide other than effective active composition in the various application forms that composition pesticide of the present invention is prepared into
In allow using with the various auxiliary elements of acceptable.The auxiliary element includes but is not limited to emulsifier, wetting agent, divides
Powder, stabilizer, antifreezing agent, thickener, binder, disintegrating agent, defoaming agent, bleeding agent, synergist, preservative, film forming agent and
Filler etc. is all ingredient commonly used or allowed to use in pesticidal preparations, is not particularly limited that specific ingredient and dosage are according to formula
It is required that being determined by test.
The production technology of the various application forms of the composition pesticide belongs to existing known technology, no longer superfluous herein
It states.
Compared with the prior art, the advantages of the present invention are as follows:
1, antibiotic in pyrimidine nucleoside class and probenazole combination, have significant synergistic function, are used alone compared with single dose bright
The aobvious control efficiency improved to disease on crops.
2, antibiotic in pyrimidine nucleoside class and the combination of probenazole two kinds of active components, reduce Pesticide use amount, reducing makes
With cost, the pollution to environment is alleviated.
3, antibiotic in pyrimidine nucleoside class and the combination of probenazole two kinds of active components, the mechanism of action is different, action site
Increase, has delayed the generation of pathogen drug resistance, increased the service life of pesticide.
Specific embodiment
To better understand the essence of the present invention, below with reference to embodiment, the content of the present invention will be further explained,
But limitation of the present invention cannot be considered as, the following description is only for the purpose of explaining the present invention, for without departing from spirit of that invention and principle
Modification, replacement or the improvement made, fall within the scope of the claimed invention.
Embodiment one: antibiotic in pyrimidine nucleoside class and probenazole compounding try the indoor toxicity test of cotton-wilt fusarium
It tests
The co-toxicity coefficient (CTC value) of mixture is calculated according to Sun Yunpei's Method, co-toxicity coefficient (CTC) >=120 shows as synergistic work
With；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 < co-toxicity coefficient (CTC) < 120 show as summation action.
1 antibiotic in pyrimidine nucleoside class of table and probenazole compound the The Toxicity Determination result to cotton-wilt fusarium
As it can be seen from table 1 antibiotic in pyrimidine nucleoside class and probenazole 20:1~1:20(by weight) in the range of compound when,
Co-toxicity coefficient (CTC) is all larger than 120, illustrates to show synergistic function to cotton-wilt fusarium；Antibiotic in pyrimidine nucleoside class
With probenazole 5:1~1:5(by weight) in the range of combine, synergistic function is more significant, and co-toxicity coefficient (CTC) exists
150 or more；Antibiotic in pyrimidine nucleoside class and probenazole with 1:2(by weight) compounding, synergistic function is the most significant, altogether poison system
Number (CTC) reaches maximum, is 170.14.
Two: 30% antibiotic in pyrimidine nucleoside class probenazole suspending agent of embodiment
Following substance is weight percentage: antibiotic in pyrimidine nucleoside class 10%, probenazole 20%, fatty acid ethylene oxide addition
Object sulfonate 8%, xanthan gum 2%, propylene glycol 1%, C8-C10Fatty alcohol 0.2%, citric acid 0.1%, Kathon CG Kathon 0.3%, deionization
Water supplies 100%.Above-mentioned material is mixed in proportion, after being uniformly dispersed through high speed shear, being sanded in sand mill, 30% pyrimidine is made
Nucleosides antibiotics probenazole suspending agent.
Embodiment prevention and treatment cotton wilt: 30% antibiotic in pyrimidine nucleoside class probenazole suspending agent dosage 90g a.i./
Ha carries out first time application in cotton wilt early stage, and second is carried out after 7d and is administered, preventive effect 93.30%；Comparison medicine
30% antibiotic in pyrimidine nucleoside class suspending agent dosage 90g a.i./ha preventive effect of agent is 84.09%；30% probenazole suspending agent dosage 90g
A.i./ha preventive effect is 87.94.As it can be seen that obvious synergy after antibiotic in pyrimidine nucleoside class and probenazole compounding, hence it is evident that good
It is used alone in each single dose.
Three: 40% antibiotic in pyrimidine nucleoside class probenazole wettable powder of embodiment
Following substance is weight percentage: antibiotic in pyrimidine nucleoside class 20%, probenazole 20%, K-12 4%, NNO 4%,
Antioxidant 0.7%, polycarboxylate 2%, kaolin are mended to 100%.Material is added in cone-type mixer together and is uniformly mixed,
It is crushed by airslide disintegrating mill, 40% antibiotic in pyrimidine nucleoside class probenazole wettable powder of corresponding weight percent is made.
The embodiment prevents and treats strawberry wilt disease: 40% antibiotic in pyrimidine nucleoside class probenazole wettable powder dilution agent 3000
Times liquid drenches root, carries out first time application in cotton wilt early stage, second is carried out after 710 and is administered, preventive effect is
91.82%；40% 3000 times of preventive effects of antibiotic in pyrimidine nucleoside class suspension dilution agent of comparison medicament are 82.69%；40% probenazole is wettable
Property 3000 times of preventive effects of Dilution for powder be 85.05%.As it can be seen that synergistic function after antibiotic in pyrimidine nucleoside class and probenazole compounding
Significantly, hence it is evident that be better than each single dose and be used alone.
In conclusion the composition pesticide of the invention containing antibiotic in pyrimidine nucleoside class and probenazole, synergy is made
With significant, preventive effect is improved compared to the exclusive use of each single dose, the disease on crops can be effectively prevented, the lasting period is long, to farming
Object safety is worth promoting and applying in agricultural production.
Claims (8)
1. a kind of composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole, it is characterised in that: effective active composition by
Antibiotic in pyrimidine nucleoside class and probenazole composition, the weight ratio of antibiotic in pyrimidine nucleoside class and probenazole in the composition are 20:1
~1:20, the weight percent of antibiotic in pyrimidine nucleoside class and probenazole weight summation in the composition are 0.1%~85%.
2. a kind of composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole according to claim 1, feature
Be: the weight ratio of antibiotic in pyrimidine nucleoside class and probenazole in the composition is 10:1~1:10.
3. a kind of composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole according to claim 2, feature
Be: the weight ratio of antibiotic in pyrimidine nucleoside class and probenazole in the composition is 5:1~1:5.
4. a kind of composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole according to claim 3, feature
Be: the weight ratio of antibiotic in pyrimidine nucleoside class and probenazole in the composition is 1:2.
5. a kind of composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole according to claim 1, feature
Be: the dosage form of the composition is suspending agent, water dispersible granules, wettable powder.
6. a kind of composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole according to claim 1, feature
It is, when composition is processed as 30% antibiotic in pyrimidine nucleoside class probenazole suspending agent, weight percentage of each component are as follows: phonetic
Pyridine nucleosides antibiotics 10%, probenazole 20%, fatty acid ethylene oxide addition product sulfonate 8%, xanthan gum 2%, propylene glycol 1%,
C8-C10Fatty alcohol 0.2%, citric acid 0.1%, Kathon CG Kathon 0.3%, deionized water supply 100%.
7. a kind of composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole according to claim 1, feature
It is, when composition is processed as 40% antibiotic in pyrimidine nucleoside class probenazole wettable powder, weight percentage of each component
Are as follows: antibiotic in pyrimidine nucleoside class 20%, probenazole 20%, neopelex 4%, dispersing agent NNO 4%, antioxidant
0.7%, polycarboxylate 2%, kaolin is mended to 100%.
8. a kind of composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole according to claim 1 is for preventing
Control the purposes of the microbial corps diseases of cotton wilt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910259486.3A CN109892338A (en) | 2019-04-02 | 2019-04-02 | Composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910259486.3A CN109892338A (en) | 2019-04-02 | 2019-04-02 | Composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole |
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| CN109892338A true CN109892338A (en) | 2019-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910259486.3A Pending CN109892338A (en) | 2019-04-02 | 2019-04-02 | Composition pesticide containing antibiotic in pyrimidine nucleoside class and probenazole |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111109274A (en) * | 2020-01-16 | 2020-05-08 | 陕西麦可罗生物科技有限公司 | Pesticide composition with pyrimidine nucleoside antibiotic and iodopropynyl alcohol butyl carbamate as active components and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103371190A (en) * | 2012-04-17 | 2013-10-30 | 陕西韦尔奇作物保护有限公司 | Pesticide combination containing pyrimidine nucleosides antibiotics |
| CN109303074A (en) * | 2018-11-06 | 2019-02-05 | 于海峰 | The mix preparation of controlling plant diseases and its application |
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2019
- 2019-04-02 CN CN201910259486.3A patent/CN109892338A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103371190A (en) * | 2012-04-17 | 2013-10-30 | 陕西韦尔奇作物保护有限公司 | Pesticide combination containing pyrimidine nucleosides antibiotics |
| CN109303074A (en) * | 2018-11-06 | 2019-02-05 | 于海峰 | The mix preparation of controlling plant diseases and its application |
Non-Patent Citations (2)
| Title |
|---|
| 韩新才 等编: "农抗120与多菌灵混配对棉花枯萎病菌的增效作用研究", 《棉花学报》 * |
| 骆焱平 等编: "《农药制剂加工技术》", 31 August 2015, 化学工业出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111109274A (en) * | 2020-01-16 | 2020-05-08 | 陕西麦可罗生物科技有限公司 | Pesticide composition with pyrimidine nucleoside antibiotic and iodopropynyl alcohol butyl carbamate as active components and application thereof |
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Application publication date: 20190618 |