CN103371185B - Synergistic antibacterial composition containing pyrimidine nucleoside antibiotics - Google Patents
Synergistic antibacterial composition containing pyrimidine nucleoside antibiotics Download PDFInfo
- Publication number
- CN103371185B CN103371185B CN201210105795.3A CN201210105795A CN103371185B CN 103371185 B CN103371185 B CN 103371185B CN 201210105795 A CN201210105795 A CN 201210105795A CN 103371185 B CN103371185 B CN 103371185B
- Authority
- CN
- China
- Prior art keywords
- pyrimidine nucleoside
- nucleoside class
- antibiotic
- cymoxanil
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002718 pyrimidine nucleoside Substances 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 22
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 15
- 229940088710 antibiotic agent Drugs 0.000 title claims abstract description 15
- 230000002195 synergetic effect Effects 0.000 title claims abstract description 15
- 239000005756 Cymoxanil Substances 0.000 claims abstract description 41
- XERJKGMBORTKEO-VZUCSPMQSA-N (1e)-2-(ethylcarbamoylamino)-n-methoxy-2-oxoethanimidoyl cyanide Chemical compound CCNC(=O)NC(=O)C(\C#N)=N\OC XERJKGMBORTKEO-VZUCSPMQSA-N 0.000 claims abstract description 40
- 201000010099 disease Diseases 0.000 claims abstract description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 29
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims abstract description 19
- 241000233679 Peronosporaceae Species 0.000 claims abstract description 18
- 241000221785 Erysiphales Species 0.000 claims abstract description 13
- 206010039509 Scab Diseases 0.000 claims abstract description 13
- 241001530056 Athelia rolfsii Species 0.000 claims abstract description 9
- 240000007594 Oryza sativa Species 0.000 claims abstract description 9
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 9
- 235000009754 Vitis X bourquina Nutrition 0.000 claims abstract description 9
- 235000012333 Vitis X labruscana Nutrition 0.000 claims abstract description 9
- 240000006365 Vitis vinifera Species 0.000 claims abstract description 9
- 235000014787 Vitis vinifera Nutrition 0.000 claims abstract description 9
- 235000009566 rice Nutrition 0.000 claims abstract description 9
- 230000001580 bacterial effect Effects 0.000 claims abstract description 8
- 230000003115 biocidal effect Effects 0.000 claims description 64
- 239000000375 suspending agent Substances 0.000 claims description 24
- 239000003094 microcapsule Substances 0.000 claims description 16
- 239000004563 wettable powder Substances 0.000 claims description 15
- 239000000839 emulsion Substances 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 13
- 241000193738 Bacillus anthracis Species 0.000 claims description 12
- 239000004562 water dispersible granule Substances 0.000 claims description 11
- 241000582441 Peronospora tabacina Species 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- 206010008570 Chloasma Diseases 0.000 claims description 7
- 208000003351 Melanosis Diseases 0.000 claims description 7
- 239000004530 micro-emulsion Substances 0.000 claims description 7
- 229930182470 glycoside Natural products 0.000 claims description 3
- 150000002338 glycosides Chemical class 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 239000005797 Iprovalicarb Substances 0.000 abstract description 38
- NWUWYYSKZYIQAE-ZBFHGGJFSA-N L-(R)-iprovalicarb Chemical compound CC(C)OC(=O)N[C@@H](C(C)C)C(=O)N[C@H](C)C1=CC=C(C)C=C1 NWUWYYSKZYIQAE-ZBFHGGJFSA-N 0.000 abstract description 37
- 239000005764 Dithianon Substances 0.000 abstract description 31
- PYZSVQVRHDXQSL-UHFFFAOYSA-N dithianon Chemical compound S1C(C#N)=C(C#N)SC2=C1C(=O)C1=CC=CC=C1C2=O PYZSVQVRHDXQSL-UHFFFAOYSA-N 0.000 abstract description 31
- 239000005747 Chlorothalonil Substances 0.000 abstract description 13
- CRQQGFGUEAVUIL-UHFFFAOYSA-N chlorothalonil Chemical compound ClC1=C(Cl)C(C#N)=C(Cl)C(C#N)=C1Cl CRQQGFGUEAVUIL-UHFFFAOYSA-N 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 6
- 241000223600 Alternaria Species 0.000 abstract 1
- 206010027146 Melanoderma Diseases 0.000 abstract 1
- 244000183278 Nephelium litchi Species 0.000 abstract 1
- 241000228452 Venturia inaequalis Species 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 29
- 238000012360 testing method Methods 0.000 description 29
- -1 ethylamino- Chemical class 0.000 description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- 239000003795 chemical substances by application Substances 0.000 description 15
- 239000002270 dispersing agent Substances 0.000 description 12
- 239000013530 defoamer Substances 0.000 description 11
- 239000008367 deionised water Substances 0.000 description 10
- 229910021641 deionized water Inorganic materials 0.000 description 10
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000002777 nucleoside Substances 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- 230000003449 preventive effect Effects 0.000 description 10
- 239000002562 thickening agent Substances 0.000 description 10
- 230000002528 anti-freeze Effects 0.000 description 9
- 239000000470 constituent Substances 0.000 description 9
- 239000000575 pesticide Substances 0.000 description 9
- 239000012071 phase Substances 0.000 description 9
- 230000010165 autogamy Effects 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 231100000820 toxicity test Toxicity 0.000 description 8
- 239000000080 wetting agent Substances 0.000 description 8
- 238000009472 formulation Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 244000141359 Malus pumila Species 0.000 description 6
- 235000011430 Malus pumila Nutrition 0.000 description 6
- 235000015103 Malus silvestris Nutrition 0.000 description 6
- 230000035613 defoliation Effects 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 241001672694 Citrus reticulata Species 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- 238000013329 compounding Methods 0.000 description 5
- 230000000857 drug effect Effects 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 206010011732 Cyst Diseases 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- 206010067482 No adverse event Diseases 0.000 description 4
- 241000220324 Pyrus Species 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 208000031513 cyst Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000013401 experimental design Methods 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 125000003835 nucleoside group Chemical group 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- LDFKFZLKFVECOU-UHFFFAOYSA-N 5,10-dioxobenzo[g][1,4]benzodithiine-2,3-dicarbonitrile hydrate Chemical compound O.O=c1c2ccccc2c(=O)c2sc(C#N)c(sc12)C#N LDFKFZLKFVECOU-UHFFFAOYSA-N 0.000 description 3
- 240000008067 Cucumis sativus Species 0.000 description 3
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 3
- 235000014443 Pyrus communis Nutrition 0.000 description 3
- 241000209140 Triticum Species 0.000 description 3
- 235000021307 Triticum Nutrition 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 2
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 description 2
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- IHYVOJBVNJQSAY-UHFFFAOYSA-N anthracene-9,10-dione oxalonitrile Chemical class C1=CC=CC=2C(C3=CC=CC=C3C(C12)=O)=O.N#CC#N IHYVOJBVNJQSAY-UHFFFAOYSA-N 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- JHXVRRJXCDAINK-UHFFFAOYSA-N NC(=O)N.N#CC#N Chemical compound NC(=O)N.N#CC#N JHXVRRJXCDAINK-UHFFFAOYSA-N 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 241000233614 Phytophthora Species 0.000 description 1
- KWYHKXQDUHJSGC-UHFFFAOYSA-N S1C(C#N)=C(C#N)SC2=C1C(=O)C1=CC=CC=C1C2=O.S1C(C#N)=C(C#N)SC2=C1C(=O)C1=CC=CC=C1C2=O Chemical compound S1C(C#N)=C(C#N)SC2=C1C(=O)C1=CC=CC=C1C2=O.S1C(C#N)=C(C#N)SC2=C1C(=O)C1=CC=CC=C1C2=O KWYHKXQDUHJSGC-UHFFFAOYSA-N 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- RGHILYZRVFRRNK-UHFFFAOYSA-N anthracene-1,2-dione Chemical compound C1=CC=C2C=C(C(C(=O)C=C3)=O)C3=CC2=C1 RGHILYZRVFRRNK-UHFFFAOYSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003592 biomimetic effect Effects 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000001965 increasing effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 230000004763 spore germination Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
Abstract
The invention discloses a synergistic antibacterial composition containing pyrimidine nucleoside antibiotics. The antibacterial composition contains active ingredient A and active ingredient B. The active ingredient A is selected from pyrimidine nucleoside antibiotics, the active ingredient B is selected from anyone of the following compositions: cymoxanil, dithianon, iprovalicarb and chlorothalonil, and the weight ratio of the active ingredient A to the active ingredient B is1:80-60:1. The composition can be used to control rust disease, powdery mildew, eqpidemic disease, alternaria leaf spot, anthracnose, venturia inaequalis, brown spot, black spot, anthracnose of grape, blight, banded sclerotial blight, leaf spot disease, downy mildew, gray mold, rice blast, leaf mold, white rot, scab, bacterial angular leaf spot and litchi downy blight of multiple crops. The composition has advantages of broad antibacterial spectrum, less dosage, rainwater washing resistance and obvious synergism.
Description
Technical field
The invention belongs to technical field of pesticide, it is related to a kind of Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class and is making
Application in thing disease.
Technical background
Antibiotic in pyrimidine nucleoside class (agricultural antiobiotic 120) is called：Pesticide corrosion 120；Antimycoin
120；120 agricultural antibiotics.Antibiotic in pyrimidine nucleoside class be a kind of efficiently, broad spectrum biological disinfection agent, there is prevention ＆ protection and interior
Inhale treatment double effects；The protective ingredient of this product can form one layer of fine and close polymer protective film on plant and fruit surface,
There are strong suppression and inhibition to multiple pathogen；Therapeutic component can be conducted by branch and reach inside fruit, directly hinder
Hinder the synthesis of pathogenic proteins matter, lead to it dead.This product protection is fine and close, and absorbability is strong, and continuous use is not likely to produce Drug resistance, that is,
Make to use in rainy season, still can keep stronger interior suction drug effect.
Cymoxanil (cymoxanil) chemical name：2- cyano group-N- [(ethylamino-) carbonyl] -2- (methoxyl group imido grpup) second
Amide, molecular formula：C7H10N4O3, cymoxanil have contact and local systemic action, spore germination can be suppressed, to downy mildew of garpe,
Epidemic disease etc. effectively, mixed with protective fungicide to extend the lasting period.
Dithianon (dithianon) chemical name：2,3- dinitriles-Isosorbide-5-Nitrae-anthraquinone dithio, molecular formula：
C14H4N2O2S2, this medicine is the protective fungicide being mainly used in multiple leaf diseases, prevents and treats Chinese cabbage downy mildew, to Chinese cabbage
Safety.This agent meets caustic digestion it is impossible to mixed with mineral oil spray.
Iprovalicarb (iprovalicarb) chemical name：[2- methyl isophthalic acid-[1- (4- aminomethyl phenyl)-ethylcarbamoyl
Base]-propyl group]-carbamyl isopropyl ester, molecular formula：C18H28N2O3, iprovalicarb is amino-acid ester analog derivative, has uniqueness
Brand-new biomimetic features make its mechanism of action be different from the antibacterial that other prevent and treat Oomycete.Its mechanism of action is thin for acting on funguses
Cell wall and the synthesis of protein, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, lead to its deformation,
Dead.For Peronosporaceae and the fungus-caused disease of Phytophthora, there is good treatment and eradicant action.
Bravo (chlorothalonil) chemical name：Daconil M (2,4,5,6- tetra- chloro- 1,3- benzene diformazans
Nitrile), molecular formula：C8C14N2, can be combined with the protein of the cysteine in the glyceraldehyde 3-phosphate dehydro-genase in fungal cell,
Destroy the metabolism of cell and loss of life power.Its Main Function is prevention fungal infection, does not have Uptake and translocation effect, but
Plant surface has good cohesiveness, is difficult by rain drop erosion, has the longer drug effect phase.
Content of the invention
Antibiotic in pyrimidine nucleoside class, cymoxanil, dithianon, iprovalicarb, Bravo single dose life-time service may bring anti-
Property occur, drug effect is the problems such as decline, bactericidal composition proposed by the present invention contains active components A, active component B, and in right amount
Surfactant and carrier.
A kind of Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class, containing active components A and active component B, it is special
Levy and be：Active components A and active component B weight are than for 1: 80～60: 1, described active components A is selected from pyridimine nucleosides and resists
Rhzomorph, active component B is selected from one of cymoxanil, dithianon, iprovalicarb, Bravo kind, active components A and active component B
Preferably weight is than for 1: 40～30: 1；The weight ratio of more preferably antibiotic in pyrimidine nucleoside class and cymoxanil is for 1: 20～10:
1, the weight of antibiotic in pyrimidine nucleoside class and dithianon is than for 1: 20～10: 1, antibiotic in pyrimidine nucleoside class and iprovalicarb weight
Than for 1: 30～20: 1, the weight of antibiotic in pyrimidine nucleoside class and Bravo is than for 1: 20～2: 1.
The described Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class be used for preventing and treating preventing and treating cereal crop, fruit tree,
The purposes of disease on vegetable, ornamental plant；Described disease includes：Rust, powdery mildew, epidemic disease, spot defoliation, anthrax,
Scab, rust, melasma, anthrachose of grape, droop, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold,
White rot, shot hole, bacterial angular leaf spot, peronospora tabacina.
The weight of active components A and active component B is than for 1: 80～60: 1.The weight hundred of active component generally in compositionss
Divide content for the 0.5%～90% of gross weight, preferably 5%～80%.According to different preparation types, active component content
Scope is different.Generally, liquid preparation contains by weight 0.5%～70% active substance, preferably 5%～
50%；Solid preparation contains by weight 5%～80% active substance, and preferably 10%～80%.
At least contain a kind of surfactant in the Synergistic bactericidal composition of the present invention, be beneficial to active component during administration and exist
Dispersion in water.Surface-active contents are the 5%～30% of total formulation weight, balance of solid or liquid diluent.
Surfactant selected by the Synergistic bactericidal composition of the present invention is known in those skilled in the art：Permissible
Selected from one or more of dispersant, wetting agent, binding agent or defoamer.According to different dosage form, can also contain in preparation
Disintegrating agent known in those skilled in the art, antifreeze etc..
The Synergistic bactericidal composition of the present invention can be by user before use through dilution or directly use.It is prepared can be by
Common processing method preparation known in those skilled in the art, will active substance be mixed with liquid flux or solid carrier
Afterwards, surfactant such as one or more of dispersant, stabilizer, wetting agent, binding agent, defoamer etc. are added.
The Synergistic bactericidal composition of the present invention, can be processed into acceptable dosage form on any pesticide, wherein relatively on demand
Excellent dosage form is：Wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule
Suspension-suspending agent.
Compositionss are made and are comprised following constituent content during wettable powder：Active components A 1%～70%, active component B
1%～70%, dispersant 2%～10%, wetting agent 2%～10%, filler surplus.
Compositionss are made and are included following constituent content during water dispersible granules：Active components A 1%～70%, active component
More than B1%～70%, dispersant 3%～12%, wetting agent 1%～8%, disintegrating agent 1%～10%, binding agent 0～4%, filler
Amount.
Compositionss are made and are included following constituent content during suspending agent：Active components A 0.5%～50%, active component B
0.5%～50%, dispersant 2%～10%, wetting agent 2%～10%, defoamer 0.01%～2%, thickening agent 0.05%～
2%th, antifreeze 0～8%, deionized water add to 100%.
Compositionss are made and are included following constituent content during suspension emulsion：Active components A 0.5%～50%, active component B
0.5%～50%, dispersant 2%～10%, defoamer 0.01%～2%, solvent 0%～15%, thickening agent 0.05%～
2%th, emulsifying agent 2%～12%, antifreeze 0～8%, stabilizer 0～3%, deionized water add to 100%.
Compositionss are made and are comprised following constituent content during aqueous emulsion：Active components A 0.5%～50%, active component B
0.5%～50%, solvent 0～30%, emulsifying agent 1%～15%, antifreeze 0～8%, thickening agent 0.05%～2%, defoamer
0.01%～2%, deionized water supplies surplus.
Compositionss are made and are comprised following constituent content during microemulsion：Active components A 0.5%～50%, active component B
0.5%～50%, solvent 0～30%, emulsifying agent 3%～20%, antifreeze 0～8%, thickening agent 0.05%～2%, defoamer
0.01%～2%, stabilizer 0～4%, deionized water supplies surplus.
Compositionss are made and are included following constituent content during microcapsule suspending agent：Active components A 0.5%～50%, active component B
0.5%～50%, macromolecule cyst material 2%～10%, dispersant 1%～10%, organic solvent 0～10%, emulsifying agent 1%
～7%, pH adjusting agent 0.1%～5%, deionized water add to 100%.
Compositionss are made and are included following constituent content during microcapsule suspension-suspendinagent agent：Active components A 0.5%～50%, activity
Composition B 0.5%～50%, macromolecule cyst material 2%～12%, surfactant 3%～15%, organic solvent 1%～
15%th, emulsifying agent 1%～6%, defoamer 0.01%～2%, thickening agent 0.05%～2%, pH adjusting agent 0.1%～5%, go
Ionized water adds to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
It is an advantage of the current invention that：
(1) antibiotic in pyrimidine nucleoside class, cymoxanil, dithianon, iprovalicarb, after chlorothalonil compound, there is obvious increasing
Effect and lasting effect；(2) to the rust on cereal crop, fruit tree, vegetable, ornamental plant, powdery mildew, epidemic disease, speckle fallen leaves
Disease, anthrax, scab, rust, melasma, anthrachose of grape, droop, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast
Disease, leaf mold, white rot, shot hole, bacterial angular leaf spot, peronospora tabacina etc. all have specially good effect；(3) decrease pesticide usage amount,
Reduce residual quantity on crop for the pesticide, alleviate environmental pollution；(4) to person poultry safety, Environmental compatibility is good；And preparation
Adhesion strength strengthens, resistance of rainwater washing against.
Specific embodiment
With reference to embodiment to further instruction of the present invention, the percentage ratio in embodiment is all weight percentage, but
The invention is not limited in this.
Application Example one
Example 1～10 wettable powder
By antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, filler mix homogeneously in mixed cylinder, warp
Jet mill remixes after pulverizing uniformly, you can of the present invention wettable powder product is obtained, is specifically shown in Table 1.
The each component of table 1 embodiment 1～10 and weight portion
Cymoxanil, dithianon, iprovalicarb, Bravo in table are exchanged, novel formulation can be obtained.
Example 11～20 water dispersible granules
By antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, disintegrating agent, filler etc. together through air-flow powder
The broken particle diameter obtaining needs, adds other auxiliary agent such as binding agent, obtains granulation materials.Item is quantitatively sent into fluidized bed granulation
In drying machine after granulation and drying, you can of the present invention water dispersible granules product is obtained, is specifically shown in Table 2.
The each component of table 2 embodiment 11～20 and weight portion
Cymoxanil, dithianon, iprovalicarb, Bravo in table are exchanged, novel formulation can be obtained.
Example 21～28 suspending agent
By dispersant, wetting agent, defoamer, thickening agent, antifreeze, through high speed shear mix homogeneously, add pyrimidine core
Glycoside antibiotics, active component B, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μm, surplus spends
Ionized water is supplied, you can of the present invention suspending agent product is obtained, is specifically shown in Table 3.
The each component of table 3 embodiment 21～28 and weight portion
Cymoxanil, dithianon, iprovalicarb, Bravo in table are exchanged, novel formulation can be obtained.
Example 29～32 suspension emulsion
By dispersant, defoamer, solvent, thickening agent, antifreeze, stabilizer through high speed shear mix homogeneously, add phonetic
Pyridine nucleoside antibiotics, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μm, prepared pyridimine nucleosides
Antibiotics suspending agent, then by active component B, emulsifying agent and various auxiliary agent with the direct emulsifying of high speed agitator in suspending agent,
Surplus deionized water is supplied, and of the present invention suspension emulsion product is obtained, is specifically shown in Table 4.
The each component of table 4 embodiment 29～32 and weight portion
Cymoxanil, dithianon, iprovalicarb, Bravo in table are exchanged, novel formulation can be obtained.
Example 33～36 aqueous emulsion
Antibiotic in pyrimidine nucleoside class, active component B, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；Will
Deionized water, antifreeze, thickening agent, defoamer mix, and become homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil
Phase, surplus deionized water is supplied；Can be prepared by aqueous emulsion product of the present invention, be specifically shown in Table 5.
The each component of table 5 embodiment 33～36 and weight portion
Cymoxanil, dithianon, iprovalicarb, Bravo in table are exchanged, novel formulation can be obtained.
Example 37～40 microemulsion
Antibiotic in pyrimidine nucleoside class, active component B, solvent, emulsifying agent, antifreeze, thickening agent, defoamer are sufficiently mixed
Uniformly transparent oil phase, is slowly added into deionized water under agitation, forms Water in Oil emulsion, more agitated heating, makes
Rapid phase inversion become oil-in-water type, be cooled to room temperature and make up to balance, through filtering, surplus deionized water supplies；Can be prepared by
Microemulsion product of the present invention, is specifically shown in Table 6.
The each component of table 6 embodiment 37～40 and weight portion
Cymoxanil, dithianon, iprovalicarb, Bravo in table are exchanged, novel formulation can be obtained.
Example 41,42 microcapsule suspending agents
By antibiotic in pyrimidine nucleoside class, active component B, macromolecule cyst material, solvent mixing, make dissolving uniformly oily
Phase, in a shear condition, oil phase is added to containing in emulsifying agent, pH adjusting agent, the aqueous phase solution of dispersant, surplus spend from
Sub- water is supplied, and bi-material reacts in oil-water interfaces, forms high score ascus wall, makes the present composition finely disseminated
Microcapsule suspending agent product, is specifically shown in Table 7.
Table 7 embodiment 41,42 each components and weight portion
Example 43,44 microcapsule suspension-suspendinagent agent
By antibiotic in pyrimidine nucleoside class, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase, oil phase is existed
It is added under shearing condition containing in emulsifying agent, the aqueous phase solution of pH adjusting agent, make finely disseminated microcapsule suspending agent.To disappear
Infusion, thickening agent, through high speed shear mix homogeneously, add active component B, ball milling 2～3 hours in ball mill, make microgranule grain
Footpath all below 5 μm, prepared suspending agent, then suspending agent is added in the aqueous phase solution of micro-capsule suspension, deionization
Water supplies surplus, makes the present composition finely disseminated microcapsule suspension-suspendinagent agent product.
Table 8 embodiment 43,44 each components and weight portion
The embodiment of the present invention is the method being combined using Toxicity Determination and field test.The embodiment of the present invention is to adopt
The method being combined with Toxicity Determination and field test.First pass through Toxicity Determination, a definite proportion pressed by clear and definite two kinds of medicaments
Synergy ratio (SR) after example is compounding, SR ＜ 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR ＞ 1.5 is potentiation
Effect, on this basis, then carries out field test.
Antibiotic in pyrimidine nucleoside class is compounded to crop pest Toxicity Determination with active component B.Determine each medicine through prerun
After agent effective inhibition concentration scope, each medicament sets 5 dosage respectively by active constituent content and processes, if clear water comparison.Reference
《Farm-chemical indoor determination test rule antibacterial》Carry out, the poison to crop pathogenic bacteria for the medicament is measured using mycelial growth rate method
Power.Measure colony diameter with crossing method after 72h, calculate each process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) is converted into logarithm value (x), with minimum
Square law tries to achieve virulence regression equation (y=a+bx), and thus calculates the EC of every kind of medicament50Value.Simultaneously according to Wadley method
Calculate two medicaments different ratio synergy ratio (SR), SR ＜ 0.5 is antagonism, 0.5≤SR≤1.5 are summation action,
SR ＞ 1.5 is potentiation.Computing formula is as follows：
Wherein：A, b are respectively active component antibiotic in pyrimidine nucleoside class and active component B (cymoxanil, dithianon, figured silk fabrics
Mould prestige, Bravo) ratio shared in combination；
A is antibiotic in pyrimidine nucleoside class；
B is one of cymoxanil, dithianon, iprovalicarb, Bravo.
Implementation of an application example two：Antibiotic in pyrimidine nucleoside class is compounded to cucumber downy mildew Toxicity Determination with cymoxanil.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Determine that antibiotic in pyrimidine nucleoside class, cymoxanil active compound and the two different ratio mix through pilot study
Effective inhibition concentration scope of agent.
Toxicity test result
Table 9 pyridine nucleoside antibiotics, cymoxanil and its compounding toxicity test analysis of results table to cucumber downy mildew
As shown in Table 9, antibiotic in pyrimidine nucleoside class, the EC to cucumber downy mildew for the cymoxanil50Be respectively 3.67mg/L and
7.21mg/L, and proportioning is when 60: 1 to 1: 80, and synergy ratio SR is all higher than 1.5, and antibiotic in pyrimidine nucleoside class and frost are described
Both urea cyanogen mixture in the range of 60: 1 to 1: 80 all shows potentiation, especially when the proportioning of the two is 1: 20 to 10: 1
When, potentiation becomes apparent from projecting, and synergy ratio is all higher than 2.00, wherein when antibiotic in pyrimidine nucleoside class and cymoxanil weight
More maximum than for synergy ratio SR when 1: 2, potentiation is the most obvious, and test finds, when antibiotic in pyrimidine nucleoside class and cymoxanil
Proportioning 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,
To rust, powdery mildew, epidemic disease, spot defoliation, anthrax, scab, rust, black speck when 1: 9,1: 10,1: 15,1: 20
Disease, anthrachose of grape, droop, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, antibacterial
Property angular leaf spot, peronospora tabacina potentiation substantially, synergy ratio is all higher than 1.5.
Implementation of an application example three：Antibiotic in pyrimidine nucleoside class is compounded to wheat rust Toxicity Determination with dithianon.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Determine antibiotic in pyrimidine nucleoside class, dithianon active compound and the two different ratio through pilot study
Effective inhibition concentration scope of mixture.
Toxicity test result
Table 10 pyridine nucleoside antibiotics, dithianon and its compounding toxicity test analysis of results table to wheat rust
As shown in Table 10, antibiotic in pyrimidine nucleoside class, the EC to wheat rust for the dithianon50Be respectively 3.85mg/L and
7.56mg/L, and proportioning is when 60: 1 to 1: 80, and synergy ratio SR is all higher than 1.5, and antibiotic in pyrimidine nucleoside class and two are described
Both cyanogen anthraquinones mixture in the range of 60: 1 to 1: 80 all shows potentiation, especially when the proportioning of the two is 1: 20 to 10
: when 1, potentiation becomes apparent from projecting, and synergy ratio is all higher than 2.10, wherein when antibiotic in pyrimidine nucleoside class and dithianon
Weight is more maximum than for synergy ratio SR when 1: 2, and potentiation is the most obvious, and test finds, when antibiotic in pyrimidine nucleoside class and two
The proportioning of cyanogen anthraquinone is 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1:
7th, 1: 8,1: 9,1: 10,1: 15,1: 20 when to rust, powdery mildew, epidemic disease, spot defoliation, anthrax, scab, rust,
Melasma, anthrachose of grape, droop, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole,
Substantially, synergy ratio is all higher than 1.5 for bacterial angular leaf spot, peronospora tabacina potentiation.
Implementation of an application example four：Antibiotic in pyrimidine nucleoside class is compounded to downy mildew of garpe Toxicity Determination with iprovalicarb.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Determine that antibiotic in pyrimidine nucleoside class, iprovalicarb active compound and the two different ratio mix through pilot study
Effective inhibition concentration scope of agent.
Toxicity test result
Table 11 pyridine nucleoside antibiotics, iprovalicarb and its compounding toxicity test analysis of results table to downy mildew of garpe
As shown in Table 11, antibiotic in pyrimidine nucleoside class, the EC to downy mildew of garpe for the iprovalicarb50Be respectively 3.97mg/L and
5.95mg/L, and proportioning is when 60: 1 to 1: 80, and synergy ratio SR is all higher than 1.5, and antibiotic in pyrimidine nucleoside class and figured silk fabrics are described
Both mould prestige mixture in the range of 60: 1 to 1: 80 all shows potentiation, especially when the proportioning of the two is 1: 30 to 20: 1
When, potentiation becomes apparent from projecting, and synergy ratio is all higher than 1.90, wherein when antibiotic in pyrimidine nucleoside class and iprovalicarb weight
More maximum than for synergy ratio SR when 2: 3, potentiation is the most obvious, and test finds, when antibiotic in pyrimidine nucleoside class and iprovalicarb
Proportioning 20: 1,10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1:
7th, 1: 8,1: 9,1: 10,1: 15,1: 20,1: 30 when to rust, powdery mildew, epidemic disease, spot defoliation, anthrax, scab, red
Star disease, melasma, anthrachose of grape, droop, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, skin ulcer
Substantially, synergy ratio is all higher than 1.5 for scall, bacterial angular leaf spot, peronospora tabacina potentiation.
Implementation of an application example five：Antibiotic in pyrimidine nucleoside class is surveyed to apple peels and cores indoor virulence with chlorothalonil compound
Fixed.
Test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN：Determine that antibiotic in pyrimidine nucleoside class, Bravo active compound and the two different ratio mix through pilot study
Effective inhibition concentration scope of agent.
Toxicity test result
Table 12 pyridine nucleoside antibiotics, Bravo and its compounding toxicity test interpretation of result to apple peels and cores
Table
As shown in Table 12, antibiotic in pyrimidine nucleoside class, the EC to apple peels and cores for the Bravo50It is respectively
4.05mg/L and 39.80mg/L, and proportioning is when 60: 1 to 1: 80, and synergy ratio SR is all higher than 1.5, and pyridimine nucleosides are described
Antibiotics and Bravo mixture in the range of 60: 1 to 1: 80 all show potentiation, especially when the proportioning of the two exists
When 1: 20 to 2: 1, potentiation becomes apparent from projecting, and synergy ratio is all higher than 2.00, wherein when antibiotic in pyrimidine nucleoside class with
Bravo weight is more maximum than for synergy ratio SR when 1: 10, and potentiation is the most obvious, and test finds, when pyridimine nucleosides antibacterial
Element and the proportioning of Bravo are when 2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 15,1: 20 pair
Rust, powdery mildew, epidemic disease, spot defoliation, anthrax, scab, rust, melasma, anthrachose of grape, droop, banded sclerotial blight,
Leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, bacterial angular leaf spot, peronospora tabacina potentiation are made
With obvious, synergy ratio is all higher than 1.5.
Application Example Elmidone nucleoside antibiotics and cymoxanil, dithianon, iprovalicarb, chlorothalonil compound preventing and treating pears
The tree scab test of pesticide effectiveness
This experimental establishment is carried by Shaanxi Welch Crop Protection Co., Ltd. in Xianyang, Shanxi province suburban area, test medicine
For comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 8% cymoxanil suspending agent (autogamy), 66% dithianon water
Dispersible granule (commercial), 5.5% iprovalicarb wettable powder (autogamy), 75% Bravo wettable powder (commercial).
The pear scab state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 10 days once, is total to dispenser 2 times before medicine.
7 days after second dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 13 antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, Bravo preventing and treating pear scab drug effect
Test
As can be seen from Table 13, antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, after chlorothalonil compound
Pear scab can effectively be prevented and treated, prevention effect is superior to the preventive effect of single dose, and efficiency time is long；Right in test scope of medication
Target crop has no adverse effects.
Application Example seven antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, chlorothalonil compound preventing and treating Citrus chachiensis Hort.
The tangerine shot hole test of pesticide effectiveness
This experimental establishment is carried by Shaanxi Welch Crop Protection Co., Ltd. in Shaanxi Province Hanzhong suburban area, test medicine
For comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 8% cymoxanil suspending agent (autogamy), 66% dithianon water
Dispersible granule (commercial), 5.5% iprovalicarb wettable powder (autogamy), 75% Bravo wettable powder (commercial).
The mandarin tree shot hole state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 10 days once, is total to dispenser 2 before medicine
Secondary.7 days after second dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 14 antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, Bravo preventing and treating mandarin tree shot hole medicine
Effect test
As can be seen from Table 14, antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, after chlorothalonil compound
Mandarin tree shot hole can effectively be prevented and treated, prevention effect is superior to the preventive effect of single dose, and efficiency time is long；In test scope of medication
Target crop is had no adverse effects.
Application Example eight antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, chlorothalonil compound preventing and treating Herba Marsileae Quadrifoliae
The fruit tree powdery mildew test of pesticide effectiveness
This experimental establishment is carried by Shaanxi Welch Crop Protection Co., Ltd. in Shaanxi Province Weinan suburban area, test medicine
For comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 8% cymoxanil suspending agent (autogamy), 66% dithianon water
Dispersible granule (commercial), 5.5% iprovalicarb wettable powder (autogamy), 75% Bravo wettable powder (commercial).
The apple tree powdery mildew state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 10 days once, is total to dispenser 2 before medicine
Secondary.7 days after second dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 15 antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, Bravo preventing and treating apple tree powdery mildew medicine
Effect test
As can be seen from Table 15, antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, after chlorothalonil compound
Energy effectively preventing and treating apple-tree powdery mildew, prevention effect is superior to the preventive effect of single dose, and efficiency time is long；In test scope of medication
Target crop is had no adverse effects.
Application Example nine antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, chlorothalonil compound preventing and treating flower
The grass anthrax test of pesticide effectiveness
, in Shaanxi Province Weinan City Dengcheng County suburb, test medicine is by the limited public affairs of Shaanxi Wei Erqi crop protection for this experimental establishment
Department provides, comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 8% cymoxanil suspending agent (autogamy), 66% dicyan anthracene
Quinone water dispersible granules (commercial), 5.5% iprovalicarb wettable powder (autogamy), 75% Bravo wettable powder (commercial).
The flowers anthrax state of an illness is investigated, in the first time dispenser of state of an illness initial stage, dispenser in every 10 days once, is total to dispenser 2 times before medicine.
7 days after second dispenser, investigate disease index respectively and calculate preventive effect within 14 days, 30 days.Experimental result is as follows：
Table 16 antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, Bravo preventing and treating flowers anthrax drug effect
Test
As can be seen from Table 16, antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon, iprovalicarb, after chlorothalonil compound
Flowers anthrax can effectively be prevented and treated, prevention effect is superior to the preventive effect of single dose, and efficiency time is long；Right in test scope of medication
Target crop has no adverse effects.
Test through different places throughout the country draws afterwards, antibiotic in pyrimidine nucleoside class and cymoxanil, dithianon,
Iprovalicarb, chlorothalonil compound make wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule hang
After floating agent, microcapsule suspension-suspendinagent agent to the rust of all kinds of crops, powdery mildew, epidemic disease, spot defoliation, anthrax, scab,
Rust, melasma, anthrachose of grape, droop, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot,
The preventive effect of the Common Diseases such as shot hole, bacterial angular leaf spot, peronospora tabacina all more than 95%, better than single dose preventive effect, make by potentiation
With obvious.
Claims (6)
1. a kind of Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class, effective active composition is that active components A is become with activity
Point B it is characterised in that：For 1 80 ~ 60 1, described active components A is pyrimidine core to active components A and active component B weight ratio
Glycoside antibiotics, active component B is cymoxanil.
2. the Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 1 it is characterised in that：Activity becomes
The weight of point A and active component B ratio is for 1 40 ~ 30 1.
3. the Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 2 it is characterised in that：Pyrimidine core
The weight of glycoside antibiotics and cymoxanil is than for 1 20 ~ 10 1.
4. the Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class according to any one of claim 1 to 3, its feature
It is：Compositionss make wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent,
Microcapsule suspension-suspending agent.
5. the Synergistic bactericidal composition containing antibiotic in pyrimidine nucleoside class according to claim 4 is used for preventing and treating disease on crops
The purposes of evil.
6. purposes according to claim 5 it is characterised in that described disease be rust, powdery mildew, epidemic disease, speckle fall
Leaf disease, anthrax, scab, rust, melasma, anthrachose of grape, droop, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice
Pestilence, leaf mold, white rot, shot hole, bacterial angular leaf spot, peronospora tabacina.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210105795.3A CN103371185B (en) | 2012-04-12 | 2012-04-12 | Synergistic antibacterial composition containing pyrimidine nucleoside antibiotics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210105795.3A CN103371185B (en) | 2012-04-12 | 2012-04-12 | Synergistic antibacterial composition containing pyrimidine nucleoside antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103371185A CN103371185A (en) | 2013-10-30 |
| CN103371185B true CN103371185B (en) | 2017-02-15 |
Family
ID=49457506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210105795.3A Expired - Fee Related CN103371185B (en) | 2012-04-12 | 2012-04-12 | Synergistic antibacterial composition containing pyrimidine nucleoside antibiotics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103371185B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104336080B (en) * | 2014-10-30 | 2016-08-24 | 陕西麦可罗生物科技有限公司 | A kind of containing antibiotic in pyrimidine nucleoside class and the bactericidal composition of hymexazol and application |
| CN104904734B (en) * | 2015-05-25 | 2018-05-18 | 广东中迅农科股份有限公司 | Composition pesticide containing Zhongshengmycin and cymoxanil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828557A (en) * | 2010-05-27 | 2010-09-15 | 浙江省桐庐汇丰生物化工有限公司 | Pyrimidine nucleoside antibiotic and hexaconazole compound bactericide |
| CN101849543A (en) * | 2010-05-27 | 2010-10-06 | 浙江省桐庐汇丰生物化工有限公司 | Compounded sterilizing agent of pyrimidine nucleoside antibiotics and alkene oxime amine |
| CN101856026A (en) * | 2010-05-27 | 2010-10-13 | 浙江省桐庐汇丰生物化工有限公司 | Pyrimidine nucleotide antibiotic and trifluzamide combined bactericide |
-
2012
- 2012-04-12 CN CN201210105795.3A patent/CN103371185B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828557A (en) * | 2010-05-27 | 2010-09-15 | 浙江省桐庐汇丰生物化工有限公司 | Pyrimidine nucleoside antibiotic and hexaconazole compound bactericide |
| CN101849543A (en) * | 2010-05-27 | 2010-10-06 | 浙江省桐庐汇丰生物化工有限公司 | Compounded sterilizing agent of pyrimidine nucleoside antibiotics and alkene oxime amine |
| CN101856026A (en) * | 2010-05-27 | 2010-10-13 | 浙江省桐庐汇丰生物化工有限公司 | Pyrimidine nucleotide antibiotic and trifluzamide combined bactericide |
Non-Patent Citations (2)
| Title |
|---|
| "农抗120与多菌灵混配与棉花枯萎病的增效作用研究";韩新才等;《棉花学报》;20080915;第20卷(第5期);摘要，表1 * |
| "农抗120和百菌清对辣椒炭疽病菌联合毒力的测定";韩新才等;《华中农业大学学报》;20050430;第24卷(第2期);摘要，表1，第1.6节，第1页左右第2段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103371185A (en) | 2013-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104642360A (en) | Sterilization composition containing fluorothiazole pyriethanone and methoxyl acrylate | |
| CN103371190B (en) | Pesticide combination containing pyrimidine nucleosides antibiotics | |
| CN105309487A (en) | High-effective pesticide composition containing polygonum cuspidatum extract | |
| CN104336033A (en) | A compound sterilization composition containing oxathiapiprolin and thiocarbamate | |
| CN104938488B (en) | High-efficiency bactericidal composition | |
| CN103371185B (en) | Synergistic antibacterial composition containing pyrimidine nucleoside antibiotics | |
| CN103518724B (en) | Bactericidal composition containing fluopyram and methoxyacrylate | |
| CN105851059A (en) | Germicidal composition containing bromothalonil and copper preparation | |
| CN104413019A (en) | Pesticide composition containing fluoride ether bacterium amide | |
| CN104642350A (en) | Compounded bactericidal composition containing zinc thiazole | |
| CN106857582A (en) | A kind of composition pesticide containing tetramycin | |
| CN104285954A (en) | Efficient fungicidal composition | |
| CN103478152B (en) | Fenamidone-containing sterilization composition | |
| CN103828821B (en) | A kind of bactericidal composition containing azoles mepanipyrim and methoxy acrylic | |
| CN103371187B (en) | Bactericidal composition containing antibiotic in pyrimidine nucleoside class | |
| CN103371186B (en) | A kind of bactericidal composition | |
| CN105475356B (en) | A kind of composition pesticide containing Propineb and prochloraz-manganese chloride complex | |
| CN104106582B (en) | A kind of bactericidal composition containing chlorine nalidixic bacterium ester and thiocarbamates | |
| CN104412983A (en) | Efficient bactericidal composition containing fluoride ether bacteria amide | |
| CN105211063B (en) | A kind of bactericidal composition containing dimoxystrobin and antibioticses | |
| CN105284806A (en) | Sterilization composition containing zoxamide and strobilurin | |
| CN104106581B (en) | A kind of bactericidal composition containing chlorine nalidixic bacterium ester and triazole type | |
| CN104814033A (en) | Chesulfamide-containing pesticide composition | |
| CN103355354B (en) | Bacteriocidal composition containing pyrimidine nucleoside antibiotics and triazoles | |
| CN103651450B (en) | Bactericidal composition containing dimoxystrobin and thiocarbamate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Ma Guofeng Inventor before: Zhang Wei |
|
| COR | Change of bibliographic data | ||
| GR01 | Patent grant | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170119 Address after: 19-1 No. 325700 Zhejiang province Wenzhou city Dongtou District North Ao Street Liancheng Road Applicant after: Ma Guofeng Address before: 715500 Shaanxi city of Weinan province Shaanxi Pucheng agricultural base industrial park Applicant before: Shaanxi Welch Crop Protection Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20181207 Address after: Room 1402, Ziyang Building, 99 Mingzhu Road, Huaishang District, Bengbu City, Anhui Province Patentee after: Bengbu HRABERO Intellectual Property Service Co.,Ltd. Address before: 325700 No. 19-1 Liancheng Avenue, Beidan Street, Dongtou District, Wenzhou City, Zhejiang Province Patentee before: Ma Guofeng |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190102 Address after: Room A208, Xuzhou Kechuang Software Park Management Co., Ltd. in Science Park of National University of China Mining University, Jiefangnan Road, Xuzhou City, Jiangsu Province, 221000 Patentee after: Li Yunhao Address before: Room 1402, Ziyang Building, 99 Mingzhu Road, Huaishang District, Bengbu City, Anhui Province Patentee before: Bengbu HRABERO Intellectual Property Service Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191125 Address after: Room 613, building 1, innovation and entrepreneurship Park, Linyi Avenue, bailutang Town, Suxian District, Chenzhou City, Hunan Province Patentee after: Hunan xiangsihai Agricultural Technology Co.,Ltd. Address before: 221000 Jiangsu city in Xuzhou Province, the liberation of South Road, China University of Mining and Technology National University Science and Technology Park Xuzhou Branch Software Park Management Limited A208 room Patentee before: Li Yunhao |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170215 |