CN103371185A - Synergistic antibacterial composition containing pyrimidine nucleoside antibiotics - Google Patents
Synergistic antibacterial composition containing pyrimidine nucleoside antibiotics Download PDFInfo
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- CN103371185A CN103371185A CN2012101057953A CN201210105795A CN103371185A CN 103371185 A CN103371185 A CN 103371185A CN 2012101057953 A CN2012101057953 A CN 2012101057953A CN 201210105795 A CN201210105795 A CN 201210105795A CN 103371185 A CN103371185 A CN 103371185A
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- Prior art keywords
- pyrimidine nucleoside
- antibiotic
- nucleoside class
- iprovalicarb
- weight ratio
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- 239000003242 anti bacterial agent Substances 0.000 title abstract description 4
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- 239000005797 Iprovalicarb Substances 0.000 claims abstract description 42
- NWUWYYSKZYIQAE-ZBFHGGJFSA-N L-(R)-iprovalicarb Chemical compound CC(C)OC(=O)N[C@@H](C(C)C)C(=O)N[C@H](C)C1=CC=C(C)C=C1 NWUWYYSKZYIQAE-ZBFHGGJFSA-N 0.000 claims abstract description 42
- 239000005764 Dithianon Substances 0.000 claims abstract description 39
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Abstract
The invention discloses a synergistic antibacterial composition containing pyrimidine nucleoside antibiotics. The antibacterial composition contains active ingredient A and active ingredient B. The active ingredient A is selected from pyrimidine nucleoside antibiotics, the active ingredient B is selected from anyone of the following compositions: cymoxanil, dithianon, iprovalicarb and chlorothalonil, and the weight ratio of the active ingredient A to the active ingredient B is1:80-60:1. The composition can be used to control rust disease, powdery mildew, eqpidemic disease, alternaria leaf spot, anthracnose, venturia inaequalis, brown spot, black spot, anthracnose of grape, blight, banded sclerotial blight, leaf spot disease, downy mildew, gray mold, rice blast, leaf mold, white rot, scab, bacterial angular leaf spot and litchi downy blight of multiple crops. The composition has advantages of broad antibacterial spectrum, less dosage, rainwater washing resistance and obvious synergism.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of Synergistic bactericidal composition on crop pest that contains antibiotic in pyrimidine nucleoside class.
Technical background
Antibiotic in pyrimidine nucleoside class (agricultural antiobiotic 120) another name: pesticide corrosion 120; Antimycoin 120; 120 agricultural antibiotics.Antibiotic in pyrimidine nucleoside class is a kind of efficient, broad spectrum biological disinfection agent, has prevention protection and interior suction treatment double effects; The protection composition of this product can at the polymer protective film of plant and the densification of fruit surface formation one deck, have strong inhibition and inhibition to multiple pathogen; It is inner that therapeutic component can arrive fruit by the limb conduction, directly hinders the synthetic of cause of disease protein, causes its death.This product protection is fine and close, and interior absorption is strong, uses continuously to be difficult for developing immunity to drugs, even use in rainy season, still can keep stronger interior suction drug effect.
Frost urea cyanogen (cymoxanil) chemical name: 2-cyano group-N-[(ethylamino-) carbonyl]-2-(methoxyl group imido grpup) acetamide, molecular formula: C
7H
10N
4O
3, white urea cyanogen has contact and local systemic action, can suppress spore germination, and is effective to downy mildew of garpe, epidemic disease etc., uses with to prolong the lasting period with protective fungicide.
Dithianon (dithianon) chemical name: 2,3-dinitrile-Isosorbide-5-Nitrae-anthraquinone dithio, molecular formula: C
14H
4N
2O
2S
2, this medicine is the protective fungicide that is mainly used in multiple leaf diseases, control Chinese cabbage downy mildew is to Chinese cabbage safety.The alkali decomposition is met in this agent, can not use with the mineral oil spray.
Iprovalicarb (iprovalicarb) chemical name: [2-methyl isophthalic acid-[1-(4-aminomethyl phenyl)-ethylamino formoxyl]-propyl group]-carbamyl isopropyl ester, molecular formula: C
18H
28N
2O
3, iprovalicarb is the amino-acid ester analog derivative, has unique brand-new biomimetic features and makes its mechanism of action be different from the bactericide that other prevent and treat Oomycete.Its mechanism of action is act on fungal cell wall and protein synthetic, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, causes its distortion, death.Have good treatment and eradicant action for Peronosporaceae and the fungus-caused disease of Phytophthora.
Tpn (chlorothalonil) chemical name: daconil M (2,4,5,6-tetrachloro-1,3-benzene dicarbonitrile), molecular formula: C
8C
14N
2, can with the fungal cell in glyceraldehyde 3-phosphate dehydro-genase in the combined with protein of cysteine, destroy the metabolism of cell and loss of life power.Its Main Function is the prevention fungal infection, does not have interior suction conduction, but at plant surface good adhesivity is arranged, and is not subject to rain drop erosion, and the long drug effect phase is arranged.
Summary of the invention
Antibiotic in pyrimidine nucleoside class, white urea cyanogen, dithianon, iprovalicarb, the long-term use of tpn single dose may bring degradation problem under resistance generation, the drug effect, the bactericidal composition that the present invention proposes contains active components A, active component B, and an amount of surfactant and carrier.
A kind of Synergistic bactericidal composition that contains antibiotic in pyrimidine nucleoside class, contain active components A and active component B, it is characterized in that: active components A and active component B weight ratio are 1: 80～60: 1, described active components A is selected from antibiotic in pyrimidine nucleoside class, active component B is selected from a kind of in white urea cyanogen, dithianon, iprovalicarb, the tpn, and active components A and the preferred weight ratio of active component B are 1: 40～30: 1; More preferably the weight ratio of antibiotic in pyrimidine nucleoside class and white urea cyanogen is 1: 20～10: 1, the weight ratio of antibiotic in pyrimidine nucleoside class and dithianon is 1: 20～10: 1, antibiotic in pyrimidine nucleoside class and iprovalicarb weight ratio are 1: 30～20: 1, and the weight ratio of antibiotic in pyrimidine nucleoside class and tpn is 1: 20～2: 1.
The described Synergistic bactericidal composition that contains antibiotic in pyrimidine nucleoside class is used for the purposes of disease on control control cereal crop, fruit tree, vegetables, the ornamental plants; Described disease comprises: rust, powdery mildew, epidemic disease, spot defoliation, anthracnose, scab, rust, black spot, anthrachose of grape, fusarium wilt, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, bacterial angular leaf spot, peronospora tabacina.
The weight ratio of active components A and active component B is 1: 80～60: 1.Usually the weight percentage of active component is 0.5%～90% of gross weight in the composition, and better is 5%～80%.According to different preparation types, the active component content scope is different.Usually, liquid preparation contains by weight 0.5%～70% active substance, preferably is 5%～50%; Solid pharmaceutical preparation contains by weight 5%～80% active substance, preferably is 10%～80%.
At least contain a kind of surfactant in the Synergistic bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of Synergistic bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, binding agent or the defoamer.According to different dosage form, can also contain disintegrant known in those skilled in the art, antifreeze etc. in the preparation.
Synergistic bactericidal composition of the present invention can be by the user before use through dilution or directly use.Its preparation can be by common processing method preparation known in those skilled in the art, after being about to active substance and liquid flux or solid carrier mixing, add again one or more in surfactant such as dispersant, stabilizing agent, wetting agent, binding agent, the defoamer etc.
Synergistic bactericidal composition of the present invention, can be processed on demand acceptable formulation on any agricultural chemicals, wherein more excellent formulation is: wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsules suspension-suspending agent.
When making wetting powder, composition comprises following constituent content: active components A 1%～70%, active component B 1%～70%, dispersant 2%～10%, wetting agent 2%～10%, filler surplus.
When making water dispersible granules, composition comprises following constituent content: active components A 1%～70%, active component B1%～70%, dispersant 3%～12%, wetting agent 1%～8%, disintegrant 1%～10%, binding agent 0～4%, filler surplus.
Comprise following constituent content when composition is made suspending agent: active components A 0.5%～50%, active component B 0.5%～50%, dispersant 2%～10%, wetting agent 2%～10%, defoamer 0.01%～2%, thickener 0.05%～2%, antifreeze 0～8%, deionized water add to 100%.
Comprise following constituent content when composition is made suspension emulsion: active components A 0.5%～50%, active component B 0.5%～50%, dispersant 2%～10%, defoamer 0.01%～2%, solvent 0%～15%, thickener 0.05%～2%, emulsifier 2%～12%, antifreeze 0～8%, stabilizing agent 0～3%, deionized water add to 100%.
Comprise following constituent content when composition is made aqueous emulsion: active components A 0.5%～50%, active component B 0.5%～50%, solvent 0～30%, emulsifier 1%～15%, antifreeze 0～8%, thickener 0.05%～2%, defoamer 0.01%～2%, deionized water are supplied surplus.
Comprise following constituent content when composition is made microemulsion: active components A 0.5%～50%, active component B 0.5%～50%, solvent 0～30%, emulsifier 3%～20%, antifreeze 0～8%, thickener 0.05%～2%, defoamer 0.01%～2%, stabilizing agent 0～4%, deionized water is supplied surplus.
Comprise following constituent content when composition is made microcapsule suspending agent: active components A 0.5%～50%, active component B 0.5%～50%, macromolecule cyst material 2%～10%, dispersant 1%～10%, organic solvent 0～10%, emulsifier 1%～7%, pH adjusting agent 0.1%～5%, deionized water add to 100%.
Composition comprises following constituent content when making microcapsule suspension-suspending agent: active components A 0.5%～50%, active component B 0.5%～50%, macromolecule cyst material 2%～12%, surfactant 3%～15%, organic solvent 1%～15%, emulsifier 1%～6%, defoamer 0.01%～2%, thickener 0.05%～2%, pH adjusting agent 0.1%～5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension of the present invention-suspending agent the key technical indexes:
The invention has the advantages that:
(1) behind antibiotic in pyrimidine nucleoside class, white urea cyanogen, dithianon, iprovalicarb, the chlorothalonil compound, has obvious synergy and lasting effect; (2) rust on cereal crop, fruit tree, vegetables, the ornamental plants, powdery mildew, epidemic disease, spot defoliation, anthracnose, scab, rust, black spot, anthrachose of grape, fusarium wilt, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, bacterial angular leaf spot, peronospora tabacina etc. all there is special efficacy; (3) reduce the agricultural chemicals dosage, reduced the residual quantity of agricultural chemicals on crop, alleviated environmental pollution; (4) to the person poultry safety, Environmental compatibility is good; And the preparation adhesion strength strengthens, resistance of rainwater washing against.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
Application Example one
Example 1～10 wetting powder
Antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, filler are mixed in mixed cylinder, after airslide disintegrating mill is pulverized, mix again, can make wetting powder product of the present invention, specifically see Table 1.
Table 1 embodiment 1～10 each component and weight portion
White urea cyanogen, dithianon, iprovalicarb, tpn exchange in will showing, and can make novel formulation.
Example 11～20 water dispersible granules
Antibiotic in pyrimidine nucleoside class, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through air-flow crushing together, add again other auxiliary agents such as binding agent, obtain the materials of granulating.With item quantitatively send in the fluidized bed granulation dryer through granulation and drying after, can make water dispersible granules product of the present invention, specifically see Table 2.
Table 2 embodiment 11～20 each component and weight portions
White urea cyanogen, dithianon, iprovalicarb, tpn exchange in will showing, and can make novel formulation.
Example 21～28 suspending agents
With dispersant, wetting agent, defoamer, thickener, antifreeze, mix through high speed shear, add antibiotic in pyrimidine nucleoside class, active component B, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, surplus is supplied with deionized water, can make suspending agent product of the present invention, specifically sees Table 3.
Table 3 embodiment 21～28 each component and weight portions
White urea cyanogen, dithianon, iprovalicarb, tpn exchange in will showing, and can make novel formulation.
Example 29～32 suspension emulsions
Dispersant, defoamer, solvent, thickener, antifreeze, stabilizing agent are mixed through high speed shear, add antibiotic in pyrimidine nucleoside class, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make the antibiotic in pyrimidine nucleoside class suspending agent, then with active component B, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, surplus is supplied with deionized water, make suspension emulsion product of the present invention, specifically see Table 4.
Table 4 embodiment 29～32 each component and weight portions
White urea cyanogen, dithianon, iprovalicarb, tpn exchange in will showing, and can make novel formulation.
Example 33～36 aqueous emulsions
Antibiotic in pyrimidine nucleoside class, active component B, solvent, emulsifier are added together, make and be dissolved into even oil phase; Deionized water, antifreeze, thickener, defoamer are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, surplus is supplied with deionized water; Can make aqueous emulsion product of the present invention, specifically see Table 5.
Table 5 embodiment 33～36 each component and weight portions
White urea cyanogen, dithianon, iprovalicarb, tpn exchange in will showing, and can make novel formulation.
Example 37～40 microemulsions
Antibiotic in pyrimidine nucleoside class, active component B, solvent, emulsifier, antifreeze, thickener, defoamer fully are mixed into the oil phase of homogeneous transparent, under agitation slowly add deionized water, form WO emulsion, again through agitating heating, make it rapid phase inversion and become oil-in-water type, be chilled to room temperature and make it to reach balance, after filtration, surplus is supplied with deionized water; Can make microemulsion product of the present invention, specifically see Table 6.
Table 6 embodiment 37～40 each component and weight portions
White urea cyanogen, dithianon, iprovalicarb, tpn exchange in will showing, and can make novel formulation.
Example 41,42 microcapsule suspending agents
With antibiotic in pyrimidine nucleoside class, active component B, macromolecule cyst material, solvent, make and be dissolved into even oil phase, under shearing condition, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent, dispersant, surplus is supplied with deionized water, and bi-material reacts at oil-water interfaces, forms the macromolecule cyst wall, make the finely disseminated microcapsule suspending agent product of the present composition, specifically see Table 7.
Table 7 embodiment 41,42 each component and weight portions
Example 43,44 microcapsule suspensions-suspending agent
With antibiotic in pyrimidine nucleoside class, macromolecule cyst material, solvent, make and be dissolved into even oil phase, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent under shearing condition, make finely disseminated microcapsule suspending agent.Defoamer, thickener are mixed through high speed shear, add active component B, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make suspending agent, then suspending agent is joined in the aqueous phase solution of micro-capsule suspension, deionized water is supplied surplus, makes the finely disseminated microcapsule suspension of the present composition-suspending agent product.
Table 8 embodiment 43,44 each component and weight portions
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Antibiotic in pyrimidine nucleoside class and active component B are composite to the crop pest Toxicity Determination.After each medicament establishment concentration range was determined in prerun, each medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of crop germ.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component antibiotic in pyrimidine nucleoside class and active component B (white urea cyanogen, dithianon, iprovalicarb, tpn) shared ratio in combination;
A is antibiotic in pyrimidine nucleoside class;
B is a kind of in white urea cyanogen, dithianon, iprovalicarb, the tpn.
Implementation of an application example two: antibiotic in pyrimidine nucleoside class and white urea cyanogen are composite to the cucumber downy mildew Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: the establishment concentration range of determining antibiotic in pyrimidine nucleoside class, the former medicine of white urea cyanogen and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 9 pyridine ucleosides antibiotic, white urea cyanogen and composite toxicity test analysis of results table to cucumber downy mildew thereof
As shown in Table 9, antibiotic in pyrimidine nucleoside class, white urea cyanogen are to the EC of cucumber downy mildew
50Be respectively 3.67mg/L and 7.21mg/L, and proportioning was at 60: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrating that antibiotic in pyrimidine nucleoside class and white urea cyanogen were mixed in the scope at 60: 1 to 1: 80 all shows synergistic effect, especially when the two proportioning during at 1: 20 to 10: 1, synergistic effect is more obviously outstanding, synergy ratio is all greater than 2.00, wherein synergy ratio SR is maximum when antibiotic in pyrimidine nucleoside class and white urea cyanogen weight ratio are 1: 2, synergistic effect is the most obvious, test is found, when the proportioning of antibiotic in pyrimidine nucleoside class and white urea cyanogen at 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 15,1: 20 o'clock to rust, powdery mildew, epidemic disease, spot defoliation, anthracnose, scab, rust, black spot, anthrachose of grape, fusarium wilt, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, bacterial angular leaf spot, the peronospora tabacina synergistic effect is obvious, and synergy ratio is all greater than 1.5.
Implementation of an application example three: antibiotic in pyrimidine nucleoside class and dithianon are composite to the wheat rust Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: the establishment concentration range of determining antibiotic in pyrimidine nucleoside class, the former medicine of dithianon and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 10 pyridine ucleosides antibiotic, dithianon and composite toxicity test analysis of results table to wheat rust thereof
As shown in Table 10, antibiotic in pyrimidine nucleoside class, dithianon are to the EC of wheat rust
50Be respectively 3.85mg/L and 7.56mg/L, and proportioning was at 60: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrating that antibiotic in pyrimidine nucleoside class and dithianon were mixed in the scope at 60: 1 to 1: 80 all shows synergistic effect, especially when the two proportioning during at 1: 20 to 10: 1, synergistic effect is more obviously outstanding, synergy ratio is all greater than 2.10, wherein synergy ratio SR is maximum when antibiotic in pyrimidine nucleoside class and dithianon weight ratio are 1: 2, synergistic effect is the most obvious, test is found, when the proportioning of antibiotic in pyrimidine nucleoside class and dithianon at 10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 15,1: 20 o'clock to rust, powdery mildew, epidemic disease, spot defoliation, anthracnose, scab, rust, black spot, anthrachose of grape, fusarium wilt, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, bacterial angular leaf spot, the peronospora tabacina synergistic effect is obvious, and synergy ratio is all greater than 1.5.
Implementation of an application example four: antibiotic in pyrimidine nucleoside class and iprovalicarb are composite to the downy mildew of garpe Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: the establishment concentration range of determining antibiotic in pyrimidine nucleoside class, the former medicine of iprovalicarb and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 11 pyridine ucleosides antibiotic, iprovalicarb and composite toxicity test analysis of results table to downy mildew of garpe thereof
As shown in Table 11, antibiotic in pyrimidine nucleoside class, iprovalicarb are to the EC of downy mildew of garpe
50Be respectively 3.97mg/L and 5.95mg/L, and proportioning was at 60: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrating that antibiotic in pyrimidine nucleoside class and iprovalicarb were mixed in the scope at 60: 1 to 1: 80 all shows synergistic effect, especially when the two proportioning during at 1: 30 to 20: 1, synergistic effect is more obviously outstanding, synergy ratio is all greater than 1.90, wherein synergy ratio SR is maximum when antibiotic in pyrimidine nucleoside class and iprovalicarb weight ratio are 2: 3, synergistic effect is the most obvious, test is found, when the proportioning of antibiotic in pyrimidine nucleoside class and iprovalicarb at 20: 1,10: 1,9: 1,8: 1,7: 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 15,1: 20,1: 30 o'clock to rust, powdery mildew, epidemic disease, spot defoliation, anthracnose, scab, rust, black spot, anthrachose of grape, fusarium wilt, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, bacterial angular leaf spot, the peronospora tabacina synergistic effect is obvious, and synergy ratio is all greater than 1.5.
Implementation of an application example five: antibiotic in pyrimidine nucleoside class and chlorothalonil compound are to apple tree spot defoliation Toxicity Determination.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
Experimental scheme: the establishment concentration range of determining antibiotic in pyrimidine nucleoside class, the former medicine of tpn and the two different proportioning mixture through preliminary experiment.
Toxicity test result
Table 12 pyridine ucleosides antibiotic, tpn and composite toxicity test analysis of results table to the apple tree spot defoliation thereof
As shown in Table 12, antibiotic in pyrimidine nucleoside class, tpn are to the EC of apple tree spot defoliation
50Be respectively 4.05mg/L and 39.80mg/L, and proportioning was at 60: 1 to 1: 80 o'clock, synergy ratio SR is all greater than 1.5, illustrating that antibiotic in pyrimidine nucleoside class and tpn were mixed in the scope at 60: 1 to 1: 80 all shows synergistic effect, especially when the two proportioning during at 1: 20 to 2: 1, synergistic effect is more obviously outstanding, synergy ratio is all greater than 2.00, wherein synergy ratio SR is maximum when antibiotic in pyrimidine nucleoside class and tpn weight ratio are 1: 10, synergistic effect is the most obvious, test is found, when the proportioning of antibiotic in pyrimidine nucleoside class and tpn at 2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7,1: 8,1: 9,1: 10,1: 15,1: 20 o'clock to rust, powdery mildew, epidemic disease, spot defoliation, anthracnose, scab, rust, black spot, anthrachose of grape, fusarium wilt, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, bacterial angular leaf spot, the peronospora tabacina synergistic effect is obvious, and synergy ratio is all greater than 1.5.
Application Example Elmidone ucleosides antibiotic and white urea cyanogen, dithianon, iprovalicarb, the chlorothalonil compound control pear scab test of pesticide effectiveness
This experimental establishment is at the Xianyang, Shanxi province suburban area; test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 8% white urea cyanogen suspending agent (autogamy), 66% dithianon water-dispersion granule (commercial), 5.5% iprovalicarb wetting powder (autogamy), 75% tpn wetting powder (commercial).
The investigation pear scab state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 10 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 13 antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the tpn control pear scab test of pesticide effectiveness
As can be seen from Table 13, can effectively prevent and treat pear scab behind antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the chlorothalonil compound, control efficiency all is better than the preventive effect of single dose, and efficiency time is long; In the test scope of medication, the target crop is had no adverse effects.
Application Example seven antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the chlorothalonil compound control mandarin tree shot hole test of pesticide effectiveness
This experimental establishment is in Hanzhong City suburb, Shaanxi Province; test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 8% white urea cyanogen suspending agent (autogamy), 66% dithianon water-dispersion granule (commercial), 5.5% iprovalicarb wetting powder (autogamy), 75% tpn wetting powder (commercial).
The investigation mandarin tree shot hole state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 10 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 14 antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the tpn control mandarin tree shot hole test of pesticide effectiveness
As can be seen from Table 14, can effectively prevent and treat the mandarin tree shot hole behind antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the chlorothalonil compound, control efficiency all is better than the preventive effect of single dose, and efficiency time is long; In the test scope of medication, the target crop is had no adverse effects.
Application Example eight antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the chlorothalonil compound control apple tree powdery mildew test of pesticide effectiveness
This experimental establishment is in Weinan City suburb, Shaanxi Province; test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 8% white urea cyanogen suspending agent (autogamy), 66% dithianon water-dispersion granule (commercial), 5.5% iprovalicarb wetting powder (autogamy), 75% tpn wetting powder (commercial).
The investigation apple tree powdery mildew state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 10 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 15 antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the tpn control apple tree powdery mildew test of pesticide effectiveness
As can be seen from Table 15, energy effectively preventing and treating apple-tree powdery mildew behind antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the chlorothalonil compound, control efficiency all is better than the preventive effect of single dose, and efficiency time is long; In the test scope of medication, the target crop is had no adverse effects.
Application Example nine antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the chlorothalonil compound control flowers anthracnose test of pesticide effectiveness
This experimental establishment is in suburb, Weinan City Dengcheng County, Shaanxi Province; test medicine is provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 4% antibiotic in pyrimidine nucleoside class aqua (commercial), 8% white urea cyanogen suspending agent (autogamy), 66% dithianon water-dispersion granule (commercial), 5.5% iprovalicarb wetting powder (autogamy), 75% tpn wetting powder (commercial).
The investigation flowers anthracnose state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 10 days once is total to dispenser 2 times.Investigated respectively disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 16 antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the tpn control flowers anthracnose test of pesticide effectiveness
As can be seen from Table 16, can effectively prevent and treat flowers anthracnose behind antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, the chlorothalonil compound, control efficiency all is better than the preventive effect of single dose, and efficiency time is long; In the test scope of medication, the target crop is had no adverse effects.
After draw through different local throughout the country tests, antibiotic in pyrimidine nucleoside class and white urea cyanogen, dithianon, iprovalicarb, chlorothalonil compound is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, behind microcapsule suspension-suspending agent to the rust of all kinds of crops, powdery mildew, epidemic disease, spot defoliation, anthracnose, scab, rust, black spot, anthrachose of grape, fusarium wilt, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, bacterial angular leaf spot, the preventive effect of the Common Diseases such as peronospora tabacina is all more than 95%, be better than the single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. Synergistic bactericidal composition that contains antibiotic in pyrimidine nucleoside class, contain active components A and active component B, it is characterized in that: active components A and active component B weight ratio are 1: 80～60: 1, described active components A is selected from antibiotic in pyrimidine nucleoside class, and active component B is selected from a kind of in white urea cyanogen, dithianon, iprovalicarb, the tpn.
2. the Synergistic bactericidal composition that contains antibiotic in pyrimidine nucleoside class according to claim 1, it is characterized in that: the weight ratio of active components A and active component B is 1: 40～30: 1.
3. the Synergistic bactericidal composition that contains antibiotic in pyrimidine nucleoside class according to claim 2 is characterized in that:
The weight ratio of antibiotic in pyrimidine nucleoside class and white urea cyanogen is 1: 20～10: 1;
The weight ratio of antibiotic in pyrimidine nucleoside class and dithianon is 1: 20～10: 1;
The weight ratio of antibiotic in pyrimidine nucleoside class and iprovalicarb is 1: 30～20: 1;
The weight ratio of antibiotic in pyrimidine nucleoside class and tpn is 1: 20～2: 1.
4. each described Synergistic bactericidal composition that contains antibiotic in pyrimidine nucleoside class in 3 according to claim 1, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsules suspension-suspending agent.
5. the Synergistic bactericidal composition that contains antibiotic in pyrimidine nucleoside class according to claim 4 is used for the purposes of disease on the control crops.
6. purposes according to claim 5, it is characterized in that described disease comprises: rust, powdery mildew, epidemic disease, spot defoliation, anthracnose, scab, rust, black spot, anthrachose of grape, fusarium wilt, banded sclerotial blight, leaf spot, downy mildew, gray mold, rice blast, leaf mold, white rot, shot hole, bacterial angular leaf spot, peronospora tabacina.
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Effective date of registration: 20191125 Address after: Room 613, building 1, innovation and entrepreneurship Park, Linyi Avenue, bailutang Town, Suxian District, Chenzhou City, Hunan Province Patentee after: Hunan xiangsihai Agricultural Technology Co.,Ltd. Address before: 221000 Jiangsu city in Xuzhou Province, the liberation of South Road, China University of Mining and Technology National University Science and Technology Park Xuzhou Branch Software Park Management Limited A208 room Patentee before: Li Yunhao |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170215 |