CN107307231A - It is a kind of to prevent Chinese herbal feed additive of golden trout stigmatosis and application thereof - Google Patents
It is a kind of to prevent Chinese herbal feed additive of golden trout stigmatosis and application thereof Download PDFInfo
- Publication number
- CN107307231A CN107307231A CN201710595420.2A CN201710595420A CN107307231A CN 107307231 A CN107307231 A CN 107307231A CN 201710595420 A CN201710595420 A CN 201710595420A CN 107307231 A CN107307231 A CN 107307231A
- Authority
- CN
- China
- Prior art keywords
- parts
- stigmatosis
- chinese herbal
- golden trout
- feed additive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001327684 Oncorhynchus mykiss aguabonita Species 0.000 title claims abstract description 70
- 239000003674 animal food additive Substances 0.000 title claims abstract description 39
- 230000002265 prevention Effects 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 239000000654 additive Substances 0.000 claims abstract description 9
- 230000000996 additive effect Effects 0.000 claims abstract description 9
- 240000004980 Rheum officinale Species 0.000 claims abstract description 7
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 7
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 6
- 241001016310 Epimedium grandiflorum Species 0.000 claims abstract description 6
- 235000013717 Houttuynia Nutrition 0.000 claims abstract description 6
- 240000000691 Houttuynia cordata Species 0.000 claims abstract description 6
- 239000009636 Huang Qi Substances 0.000 claims abstract description 6
- 244000234609 Portulaca oleracea Species 0.000 claims abstract description 6
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 6
- 240000004064 Poterium sanguisorba Species 0.000 claims abstract description 6
- 235000008291 Poterium sanguisorba Nutrition 0.000 claims abstract description 6
- 235000008282 Sanguisorba officinalis Nutrition 0.000 claims abstract description 6
- 235000018905 epimedium Nutrition 0.000 claims abstract description 6
- 241000830536 Tripterygium wilfordii Species 0.000 claims abstract description 5
- 235000015398 thunder god vine Nutrition 0.000 claims abstract description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 19
- 238000000227 grinding Methods 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000008187 granular material Substances 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 5
- 239000008361 herbal raw material Substances 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 3
- 241000411851 herbal medicine Species 0.000 abstract description 19
- 201000010099 disease Diseases 0.000 abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 6
- 230000001954 sterilising effect Effects 0.000 abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 5
- 230000007123 defense Effects 0.000 abstract description 3
- 244000005700 microbiome Species 0.000 abstract description 3
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 239000003053 toxin Substances 0.000 abstract description 3
- 231100000765 toxin Toxicity 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 21
- 210000000170 cell membrane Anatomy 0.000 description 10
- 229940079593 drug Drugs 0.000 description 8
- 230000003834 intracellular effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 241001502129 Mullus Species 0.000 description 4
- 210000002421 cell wall Anatomy 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 241000251468 Actinopterygii Species 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 102000004310 Ion Channels Human genes 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 235000019621 digestibility Nutrition 0.000 description 3
- 235000019688 fish Nutrition 0.000 description 3
- 244000045947 parasite Species 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 241000972773 Aulopiformes Species 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000019515 salmon Nutrition 0.000 description 2
- XAGIMRPOEJSYER-CIUDSAMLSA-N Ala-Cys-Lys Chemical compound C[C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O)N XAGIMRPOEJSYER-CIUDSAMLSA-N 0.000 description 1
- 241000345998 Calamus manan Species 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- ZHCCYSDALWJITB-SRVKXCTJSA-N Cys-Phe-Cys Chemical compound N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(O)=O ZHCCYSDALWJITB-SRVKXCTJSA-N 0.000 description 1
- JRZMCSIUYGSJKP-ZKWXMUAHSA-N Cys-Val-Asn Chemical compound SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O JRZMCSIUYGSJKP-ZKWXMUAHSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- DGLAHESNTJWGDO-SRVKXCTJSA-N His-Ser-His Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CN=CN2)C(=O)O)N DGLAHESNTJWGDO-SRVKXCTJSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- WCTCIIAGNMFYAO-DCAQKATOSA-N Leu-Cys-Val Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(O)=O WCTCIIAGNMFYAO-DCAQKATOSA-N 0.000 description 1
- 244000179560 Prunella vulgaris Species 0.000 description 1
- 241000277331 Salmonidae Species 0.000 description 1
- 241000304432 Sedum sarmentosum Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 108010004073 cysteinylcysteine Proteins 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 108010040030 histidinoalanine Proteins 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000008113 selfheal Nutrition 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
- A01K61/10—Culture of aquatic animals of fish
- A01K61/13—Prevention or treatment of fish diseases
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Marine Sciences & Fisheries (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Environmental Sciences (AREA)
- Physiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Insects & Arthropods (AREA)
- Health & Medical Sciences (AREA)
- Birds (AREA)
- Biodiversity & Conservation Biology (AREA)
- Fodder In General (AREA)
Abstract
The invention discloses a kind of Chinese herbal feed additive of prevention golden trout stigmatosis and application thereof, the composition and its parts by weight of additive are:15 20 parts of purslane, 22 25 parts of honeysuckle, 18 22 parts of rheum officinale, 11 15 parts of tripterygium wilfordii, 18 22 parts of cordate houttuynia, 10 15 parts of the Radix Astragali, 25 parts of radix glycyrrhizae, 47 parts of rhizoma atractylodis, 23 parts of barrenwort, 47 parts of garden burnet.Have the beneficial effect that:The raw material of the feed addictive of the present invention is Chinese herbal medicine, can be degradable, it is pollution-free to fishpond, effect with clearing heat and detoxicating sterilization antibacterial, infringement that can be with microorganism outside defense cell and its toxin to body can prevent the disease hair of golden trout stigmatosis, stigmatosis can be treated, therapeutic effect is good, and can improve the immunity of golden trout, and promotes the generation of stigmatosis antibody.
Description
Technical field
The present invention relates to aquaculture feeds additive processing technique field, more particularly to a kind of prevention golden trout stigmatosis
Chinese herbal feed additive and application thereof.
Background technology
Golden trout, salmon shape mesh salmonidae Pacific Ocean salmon category belongs to cold water fishes, and meat flavour is delicious, nutritious, and the few meat of thorn is more, food
It is high with value, it is to integrate view and admire, swim fishing, the improved seeds of cuisines.A kind of fish occur in golden trout breeding process
Common disease --- stigmatosis.Stigmatosis is that cause of disease scale in the body surface of dorsal fin has subcircular erythema, focus comes off, and is eventually formed
Ulcer even exposes bone or internal organ.Lift golden trout immunity therefore, it is necessary to provide a kind of can improve, prevent stigmatosis
Feed addictive, so as to avoid the economic loss caused in golden trout breeding process due to stigmatosis.Chinese herbal medicine conduct
A kind of natural Substitutes For Antibiotic increasingly attracts attention, and fish production practice also demonstrates that Chinese herbal medicine is used as mixed feeding agent
It is simultaneous or feed addictive can fully ensure that the health of human body while aquatic livestock production performance and feed efficiency is improved again
There is the double action of the property of medicine and trophism, be that traditional chemical synthesis feed addictive is incomparable, be particularly suitable for use in current
The need for the intensive of culture fishery, large-scale production.Therefore, with the additive of Chinese herbal medicine substitute antibiotics will increasingly by
To the concern of people, its application prospect also can be more extensive.But the research level of current Chinese herbal feed additive is relatively low, makes
Technique simple coarse, the technological element of a product is relatively low, and quality is not sufficiently stable, and such problem seriously governs Chinese medicine fodder addition
Popularization and application.At present, do not disclose also both at home and abroad any on the Chinese herbal medicine for improving golden trout immunity, preventing stigmatosis
Feed addictive and its relevant report of application.
Prior art such as Authorization Notice No. is the B of CN 103892051 Chinese invention patent, discloses a kind of preventing and treating mullet
The Chinese herbal feed additive of hemorrhage, raw material includes golden cypress, rheum officinale, radix glycyrrhizae, chrysanthemum, selfheal, stringy stonecrop, preparation method
It is:Said components are put into mixer, after being sufficiently mixed, is crushed in micronizer, the material after crushing is sieved
Net, is made the Chinese herb feed additive of preventing and treating mullet hemorrhage.The morbidity of mullet hemorrhage can be reduced after this feed addictive
Rate, the immune and oxidation resistance for improving mullet, enhancing resistance against diseases, but the Ultramicro-powder that the feed addictive is used in preparing
Broken method is unreasonable, and sporoderm-broken rate is low, causes Chinese herbal medicine utilization rate low.
The content of the invention
It is extensive, green, environmentally friendly it is an object of the invention to provide a kind of raw material sources, the bacillary gill of golden trout can be prevented
Inflammation, improves absorbing for golden trout, effect of drugs significantly prevents Chinese herbal feed additive of golden trout stigmatosis and application thereof.
The present invention is directed to the problem of being mentioned in above-mentioned technology, and the technical scheme taken is:A kind of prevention golden trout stigmatosis
Chinese herbal feed additive, composition and its parts by weight are:15-20 parts of purslane, 22-25 parts of honeysuckle, 18-22 parts of rheum officinale, thunder
Public rattan 11-15 parts, 18-22 parts of cordate houttuynia, 10-15 parts of the Radix Astragali, 2-5 parts of radix glycyrrhizae, 4-7 parts of rhizoma atractylodis, 2-3 parts of barrenwort, garden burnet 4-7
Part.The raw material of above-mentioned additive is Chinese herbal medicine, can be degradable, pollution-free to fishpond, with clearing heat and detoxicating, sterilization antibacterial
Effect, infringement that can be with microorganism outside defense cell and its toxin to body can prevent the disease hair of golden trout stigmatosis, can treat
Stigmatosis, therapeutic effect is good, and can improve the immunity of golden trout, and promotes the generation of stigmatosis antibody.
A kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis, specifically includes following steps:
Herbal raw material is distinguished into size-reduced machine to crush, crosses 100-120 mesh sieves and obtains coarse granule, thick of each raw material is measured by formula
Grain, is well mixed, and adds mixture into water and active peptide, and the addition of water is 2-3 times of compound, and the addition of active peptide is
The 0.003-0.004% of compound weight, is put into micronizer and crushes 30-40min, and it is 15-25 to control ultramicro grinding temperature
DEG C, spray drying produces Chinese herbal feed additive after crushing terminates, and the amino acid sequence of active peptides is
HSHACKLCVCVNCFCCGAAKCYLCRVLCSK, the active peptides may act on the coarse grained cell membrane of Chinese herbal medicine, on film
The ion channel of cross-film is formed, the integrality of cell membrane is destroyed, comes out intracellular active drug composition quick release, greatly
It is big to improve the sporoderm-broken rate of ultramicro grinding, and the activity of active ingredient is not influenceed;Ultramicro grinding can destroy Chinese herbal medicine in the step
Cell membrane, cell-wall breaking ratio is not less than 95%, intracellular effective drug ingedient is fully exposed, improves the life of medicine
Thing utilization rate, the consumption for reducing Chinese medicine, medium-height grass the effective elements of the medicine can effectively discharge rapidly in golden trout enteron aisle, golden trout stomach
Enteron aisle can be absorbed effectively, improve drug effect, and improve the uniformity of particle to a certain extent, raise Chinese herbal medicine
Feed additives are easier to be dispersed in feed.
A kind of purposes of the Chinese herbal feed additive of prevention golden trout stigmatosis:Chinese herbal feed addition is carried out in feed
Feed, addition is the 0.05-0.09% of golden trout feed relative, on the one hand the feed has the work of clearing heat and detoxicating sterilization antibacterial
With can eliminate into the pathogen in golden trout body and parasite, reach the purpose of prevention golden trout stigmatosis, on the other hand add
The addition of agent can be effectively facilitated digestibility and utilization of the feed nutrition material in golden trout enteron aisle, improve the immunocompetence of golden trout itself
And resistance against diseases, the cultivation survival rate of golden trout is improved, increases the income of raiser.
Compared with prior art, the advantage of the invention is that:The raw material of additive is Chinese herbal medicine, can be degradable, right
Fishpond is pollution-free, the effect with clearing heat and detoxicating sterilization antibacterial, body can be invaded with microorganism outside defense cell and its toxin
Evil, can prevent the disease hair of golden trout stigmatosis, can treat stigmatosis, therapeutic effect is good, and can improve the immunity of golden trout, and promotees
Enter the generation of stigmatosis antibody;The mode that the present invention is combined using active peptides and ultramicro grinding, can destroy Chinese herbal medicine thin
Cell wall and cell membrane, make intracellular effective drug ingedient fully be exposed, improve medicine bioavailability, reduce in
The consumption of medicine, while improving performance and the value of Chinese herbal medicine drug effect;Chinese herbal feed additive of the present invention is added in feed, makes
Obtaining feed has the effect of prevention golden trout stigmatosis, and can be effectively facilitated digestion profit of the feed nutrition material in golden trout enteron aisle
With the immunocompetence and resistance against diseases of raising golden trout itself improve the cultivation survival rate of golden trout.
Specific embodiment
The present invention program is described further below by embodiment:
Embodiment 1:
A kind of Chinese herbal feed additive of prevention golden trout stigmatosis, composition and its parts by weight are:18 parts of purslane, honeysuckle 23
Part, 20 parts of rheum officinale, 13 parts of tripterygium wilfordii, 20 parts of cordate houttuynia, 13 parts of the Radix Astragali, 3 parts of radix glycyrrhizae, 6 parts of rhizoma atractylodis, 2.5 parts of barrenwort, garden burnet 6
Part.
A kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis, is concretely comprised the following steps:
Herbal raw material is distinguished into size-reduced machine to crush, crosses 120 mesh sieves and obtains coarse granule, each raw material coarse granule is measured by formula, mix
Close uniform, add mixture into water and active peptide, the addition of water is 2.5 times of compound, the addition of active peptide is mixing
Expect the 0.0035% of weight, be put into micronizer and crush 35min, it is 15-25 DEG C to control ultramicro grinding temperature, and crushing terminates
Spray drying produces Chinese herbal feed additive afterwards, and the amino acid sequence of active peptides is
HSHACKLCVCVNCFCCGAAKCYLCRVLCSK, the active peptides may act on the coarse grained cell membrane of Chinese herbal medicine, on film
The ion channel of cross-film is formed, the integrality of cell membrane is destroyed, comes out intracellular active drug composition quick release, greatly
It is big to improve the sporoderm-broken rate of ultramicro grinding, and the activity of active ingredient is not influenceed;Ultramicro grinding can destroy Chinese herbal medicine in the step
Cell membrane, cell-wall breaking ratio is not less than 95%, intracellular effective drug ingedient is fully exposed, improves the life of medicine
Thing utilization rate, the consumption for reducing Chinese medicine, medium-height grass the effective elements of the medicine can effectively discharge rapidly in golden trout enteron aisle, golden trout stomach
Enteron aisle can be absorbed effectively, improve drug effect, and improve the uniformity of particle to a certain extent, raise Chinese herbal medicine
Feed additives are easier to be dispersed in feed.
A kind of purposes of the Chinese herbal feed additive of prevention golden trout stigmatosis:Chinese herbal feed addition is carried out in feed
Feed, addition is the 0.07% of golden trout feed relative, on the one hand the feed has the effect of clearing heat and detoxicating sterilization antibacterial, can
Eliminate enter golden trout body in pathogen and parasite, reach prevention golden trout stigmatosis purpose, another aspect additive plus
Enter the digestibility and utilization that can be effectively facilitated feed nutrition material in golden trout enteron aisle, improve the immunocompetence of golden trout itself and disease-resistant
Ability, improves the cultivation survival rate of golden trout, increases the income of raiser.
Embodiment 2:
A kind of Chinese herbal feed additive of prevention golden trout stigmatosis, composition and its parts by weight are:16 parts of purslane, honeysuckle 25
Part, 18 parts of rheum officinale, 15 parts of tripterygium wilfordii, 18 parts of cordate houttuynia, 15 parts of the Radix Astragali, 5 parts of radix glycyrrhizae, 4 parts of rhizoma atractylodis, 2.3 parts of barrenwort, garden burnet 7
Part.
A kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis, is concretely comprised the following steps:
Herbal raw material is distinguished into size-reduced machine to crush, crosses 100 mesh sieves and obtains coarse granule, each raw material coarse granule is measured by formula, mix
Close uniform, add mixture into water and active peptide, the addition of water is 2 times of compound, the addition of active peptide is compound
The 0.004% of weight, is put into micronizer and crushes 30min, and it is 15-25 DEG C to control ultramicro grinding temperature, and crushing is sprayed after terminating
Mist is drying to obtain Chinese herbal feed additive, and the amino acid sequence of active peptides is
HSHACKLCVCVNCFCCGAAKCYLCRVLCSK, the active peptides may act on the coarse grained cell membrane of Chinese herbal medicine, on film
The ion channel of cross-film is formed, the integrality of cell membrane is destroyed, comes out intracellular active drug composition quick release, greatly
It is big to improve the sporoderm-broken rate of ultramicro grinding, and the activity of active ingredient is not influenceed;Ultramicro grinding can destroy Chinese herbal medicine in the step
Cell membrane, cell-wall breaking ratio is not less than 95%, intracellular effective drug ingedient is fully exposed, improves the life of medicine
Thing utilization rate, the consumption for reducing Chinese medicine, medium-height grass the effective elements of the medicine can effectively discharge rapidly in golden trout enteron aisle, golden trout stomach
Enteron aisle can be absorbed effectively, improve drug effect, and improve the uniformity of particle to a certain extent, raise Chinese herbal medicine
Feed additives are easier to be dispersed in feed.
A kind of purposes of the Chinese herbal feed additive of prevention golden trout stigmatosis:Chinese herbal feed addition is carried out in feed
Feed, addition is the 0.05% of golden trout feed relative, on the one hand the feed has the effect of clearing heat and detoxicating sterilization antibacterial, can
Eliminate enter golden trout body in pathogen and parasite, reach prevention golden trout stigmatosis purpose, another aspect additive plus
Enter the digestibility and utilization that can be effectively facilitated feed nutrition material in golden trout enteron aisle, improve the immunocompetence of golden trout itself and disease-resistant
Ability, improves the cultivation survival rate of golden trout, increases the income of raiser.
Embodiment 3:
A kind of Chinese herbal feed additive of prevention golden trout stigmatosis, composition and its parts by weight are:20 parts of purslane, honeysuckle 22
Part, 21 parts of rheum officinale, 11 parts of tripterygium wilfordii, 20 parts of cordate houttuynia, 11 parts of the Radix Astragali, 5 parts of radix glycyrrhizae, 4 parts of rhizoma atractylodis, 3 parts of barrenwort, 4 parts of garden burnet.
A kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis, specifically includes following steps:
Herbal raw material is distinguished into size-reduced machine to crush, crosses 120 mesh sieves and obtains coarse granule, each raw material coarse granule is measured by formula, mix
Close uniform, add mixture into water and active peptide, the addition of water is 3 times of compound, the addition of active peptide is compound
The 0.003% of weight, is put into micronizer and crushes 40min, and it is 15-25 DEG C to control ultramicro grinding temperature, and crushing is sprayed after terminating
Mist is drying to obtain Chinese herbal feed additive, and the amino acid sequence of active peptides is
HSHACKLCVCVNCFCCGAAKCYLCRVLCSK。
A kind of purposes of the Chinese herbal feed additive of prevention golden trout stigmatosis:Chinese herbal feed addition is carried out in feed
Feed, addition is the 0.09% of golden trout feed relative.
Routine operation in the operating procedure of the present invention is well known to those skilled in the art, herein without repeating.
Technical scheme is described in detail embodiment described above, it should be understood that it is described above only
For the specific embodiment of the present invention, it is not intended to limit the invention, all any modifications made in the spirit of the present invention,
Supplement or similar fashion replacement etc., should be included in the scope of the protection.
SEQUENCE LISTING
<110>Tonghua Teachers College
<120>It is a kind of to prevent Chinese herbal feed additive of golden trout stigmatosis and application thereof
<130> 1
<160> 1
<170> PatentIn version 3.5
<210> 1
<211> 30
<212> PRT
<213>It is artificial synthesized
<400> 1
His Ser His Ala Cys Lys Leu Cys Val Cys Val Asn Cys Phe Cys Cys
1 5 10 15
Gly Ala Ala Lys Cys Tyr Leu Cys Arg Val Leu Cys Ser Lys
20 25 30
Claims (9)
1. a kind of Chinese herbal feed additive of prevention golden trout stigmatosis, it is characterised in that:The composition of described additive and its
Parts by weight are:15-20 parts of purslane, 22-25 parts of honeysuckle, 18-22 parts of rheum officinale, 11-15 parts of tripterygium wilfordii, 18-22 parts of cordate houttuynia,
10-15 parts of the Radix Astragali, 2-5 parts of radix glycyrrhizae, 4-7 parts of rhizoma atractylodis, 2-3 parts of barrenwort, 4-7 parts of garden burnet.
2. a kind of Chinese herbal feed additive of prevention golden trout stigmatosis according to claim 1, it is characterised in that:It is described
The preparation method of additive concretely comprise the following steps:Herbal raw material is distinguished into size-reduced machine to crush, sieve to obtain coarse granule, by with
Side measures each raw material coarse granule, is well mixed, adds mixture into water and active peptide, is put into micronizer and crushes, and crushes
Spray drying produces Chinese herbal feed additive after end.
3. a kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis according to claim 2, it is special
Levy and be:Described coarse granule was 100-120 mesh sieves.
4. a kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis according to claim 2, it is special
Levy and be:The amino acid sequence of described active peptides is HSHACKLCVCVNCFCCGAAKCYLCRVLCSK.
5. a kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis according to claim 2, it is special
Levy and be:The addition of described active peptides is the 0.003-0.004% of compound weight.
6. a kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis according to claim 2, it is special
Levy and be:The addition of described water is 2-3 times of compound.
7. a kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis according to claim 2, it is special
Levy and be:Described ultramicro grinding 30-40min.
8. a kind of preparation method of the Chinese herbal feed additive of prevention golden trout stigmatosis according to claim 2, it is special
Levy and be:Described ultramicro grinding temperature is 15-25 DEG C.
9. a kind of purposes of the Chinese herbal feed additive of prevention golden trout stigmatosis, it is characterised in that:Described Chinese herbal feed
Addition is fed in feed, and addition is the 0.05-0.09% of golden trout feed relative.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710595420.2A CN107307231A (en) | 2017-07-20 | 2017-07-20 | It is a kind of to prevent Chinese herbal feed additive of golden trout stigmatosis and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710595420.2A CN107307231A (en) | 2017-07-20 | 2017-07-20 | It is a kind of to prevent Chinese herbal feed additive of golden trout stigmatosis and application thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107307231A true CN107307231A (en) | 2017-11-03 |
Family
ID=60178075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710595420.2A Pending CN107307231A (en) | 2017-07-20 | 2017-07-20 | It is a kind of to prevent Chinese herbal feed additive of golden trout stigmatosis and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107307231A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108782998A (en) * | 2018-06-04 | 2018-11-13 | 广州市联鲲生物科技有限公司 | A kind of Ba Shayu premixes and its preparation method and application |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101152391A (en) * | 2007-09-30 | 2008-04-02 | 北京凯瑞创新医药科技有限公司 | Pharmaceutical formulations for treating traumatic injury, preparing method and quality control method thereof |
CN104872392A (en) * | 2015-05-27 | 2015-09-02 | 石东秀 | Feed for treating rotten-skin disease of cyclemys trifasciata and preparation method of feed |
CN105249003A (en) * | 2015-10-29 | 2016-01-20 | 青岛海之源智能技术有限公司 | Feed additive for preventing stigmatosis of Siamese fighting fish and preparation method thereof |
-
2017
- 2017-07-20 CN CN201710595420.2A patent/CN107307231A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101152391A (en) * | 2007-09-30 | 2008-04-02 | 北京凯瑞创新医药科技有限公司 | Pharmaceutical formulations for treating traumatic injury, preparing method and quality control method thereof |
CN104872392A (en) * | 2015-05-27 | 2015-09-02 | 石东秀 | Feed for treating rotten-skin disease of cyclemys trifasciata and preparation method of feed |
CN105249003A (en) * | 2015-10-29 | 2016-01-20 | 青岛海之源智能技术有限公司 | Feed additive for preventing stigmatosis of Siamese fighting fish and preparation method thereof |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108782998A (en) * | 2018-06-04 | 2018-11-13 | 广州市联鲲生物科技有限公司 | A kind of Ba Shayu premixes and its preparation method and application |
CN108782998B (en) * | 2018-06-04 | 2021-11-26 | 广州市联鲲生物科技有限公司 | Premix for basha fish and preparation method and application thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101129168B (en) | Granulated feed of kirschner crawfish | |
CN106614162B (en) | High-yield river snail breeding method | |
CN114601076B (en) | Compound feed for promoting mandarin fish ingestion and preventing and treating mandarin fish virus diseases and preparation method thereof | |
CN106387511A (en) | Green and high-efficient attractant for freshwater fish and preparation method thereof | |
CN106386732A (en) | A green and efficient attractant for carp and a preparation method therefor | |
CN105766710A (en) | Preventing and treating method for white abdominal shell disease of soft-shelled turtles | |
CN106615612A (en) | Traditional Chinese medicine ferment fish feed employing traditional Chinese medicine residues and fruit and vegetable peels as raw materials | |
KR101070993B1 (en) | A feedstuff using sulfur neutralizing poison and manufacturing method thereof | |
CN105394445A (en) | Snakehead fish fry feed | |
CN107006538A (en) | A kind of plant environment-friendly type bactericide used for aquiculture and preparation method thereof | |
CN107307231A (en) | It is a kind of to prevent Chinese herbal feed additive of golden trout stigmatosis and application thereof | |
CN105010891A (en) | Chicken feed containing Chinese herbal medicine additive | |
CN107410764A (en) | A kind of Chinese herbal feed additive for preventing golden trout ich and application thereof | |
CN104171447A (en) | Pellet feed for eriocheir sinensis | |
CN106614192A (en) | Cultivation method of crayfish | |
CN107320529A (en) | It is a kind of that there is feed addictive of preventing and treating fresh-water fishes furunculosis effect and application thereof | |
CN106106270B (en) | Disease-preventing and yield-increasing cultivation method for freshwater shrimps in summer | |
KR20190091919A (en) | Functional feed additive mainly composed of Houttuynia cordata Thumb | |
CN107691870A (en) | Feed addictive for duck parasitic disease and preparation method thereof | |
CN107027828A (en) | A kind of plant environment-friendly type bactericide used for aquiculture and preparation method thereof | |
CN106386731A (en) | A green and efficient attractant for grass carp and a preparation method therefor | |
CN107319197A (en) | One kind prevention golden trout infectious pancreatic necrosis disease(IPN)Chinese herbal feed additive and application thereof | |
CN106360144A (en) | Green efficient crucian feeding attracting agent and preparation method thereof | |
CN107361244A (en) | It is a kind of to prevent scorching Chinese herbal feed additive of the bacillary gill of golden trout and application thereof | |
CN108669378A (en) | Tilapia feed and preparation method thereof for the egg-laying season |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171103 |
|
RJ01 | Rejection of invention patent application after publication |