CN107320529A - It is a kind of that there is feed addictive of preventing and treating fresh-water fishes furunculosis effect and application thereof - Google Patents
It is a kind of that there is feed addictive of preventing and treating fresh-water fishes furunculosis effect and application thereof Download PDFInfo
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- CN107320529A CN107320529A CN201710595387.3A CN201710595387A CN107320529A CN 107320529 A CN107320529 A CN 107320529A CN 201710595387 A CN201710595387 A CN 201710595387A CN 107320529 A CN107320529 A CN 107320529A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention discloses a kind of feed addictive for having and preventing and treating fresh-water fishes furunculosis effect and application thereof, the composition and its parts by weight of the feed addictive are：20 30 parts of mountain spill, 20 25 parts of the root of fangji, 13 17 parts of Chinese gall, 15 20 parts of cassia twig, 8 13 parts of Semen Ricini, 7 11 parts of caulis lonicerae, 0.4 0.7 parts of orfloxacin, 0.1 0.2 parts of sulfamethoxazole.Have the beneficial effect that：Rationally, Chinese and Western medicine is combined compatibility, with significant cooperative synergism effect between each composition of additive of the present invention, and the function of each component, the overall therapeutic effect to fresh-water fishes furunculosis of lifting medicine can be played to greatest extent；There is significant bactericidal to act on the pathogen of furunculosis, the purpose of preventing and treating and prevention fresh-water fishes furunculosis can be reached, while the generation of furunculosis antibody can be promoted, improve the immunity and resistance of fresh-water fishes.
Description
Technical field
It is more particularly to a kind of that there is preventing and treating fresh-water fishes furunculosis work(the present invention relates to aquaculture feeds processing technique field
Feed addictive of effect and application thereof.
Background technology
Furunculosis is a kind of fresh-water fishes common bacterial disease as caused by furuncle sore type Aeromonas punctata, main harm grass
The fish such as fish, black carp, carp, megalobrama amblycephala, silver carp, flathead.This several fish is all the main kind of China's freshwater aquiculture, and yield is every kind of
Up to millions of tons.Once infecing furunculosis, immeasurable loss is brought to raiser.Lesion often occurs in back flesh
Meat, back protuberance, with hand flicking bump pad, muscle follows the string, quality is softer, affected area bleeding inflammation when serious, festers.Lead
The reason for causing fresh-water fishes infection furunculosis mainly has a lot：Cultivation density is excessive, breeding water body water quality is excessively poor, feed nutrition is uneven
Weighing apparatus, protein content are low.These reasons all may result in fresh-water fishes and suffer from furunculosis.Therefore, it is necessary to provide a kind of with anti-
Furunculosis effect fresh water fish feed additive is controlled, during improving the immunity and survival rate of fresh-water fishes, prevention freshwater fish culturing
Suffer from the economic loss that furunculosis is caused.Chinese herbal medicine has increasingly attracted attention as a kind of natural Substitutes For Antibiotic, fishing
Industry production practices also demonstrate that Chinese herbal medicine is improving aquatic livestock production performance and feed efficiency as mixed feeding agent or feed addictive
While, the health of human body is can fully ensure that again, the double action of the property of medicine and trophism is had concurrently, is traditional chemical synthesis feed
Additive is incomparable, the need for be particularly suitable for use in the intensive of current culture fishery, large-scale production.Therefore, in
The additive of herbal medicine substitute antibiotics increasingly will be paid close attention to by people, and its purposes prospect also can be more extensive.But it is current
The research level of Chinese herbal feed additive is relatively low, and manufacture craft simple coarse, the technological element of a product is relatively low, and quality is not sufficiently stable,
Such problem seriously governs the popularization and application of Chinese medicine fodder addition.
Prior art such as Authorization Notice No. is the B of CN 101049337 Chinese invention patent, discloses one kind and treats malignant boil furuncle
Medicine of sore carbuncle and preparation method thereof, it is prepared from the following raw materials in parts by weight, Semen Ricini 80-120, cinnabar 20-40, camphor
80-120, myrrh 8-12, frankincense 8-12, borneol 8-12, vermilion 40-80, the medicine to treatment bedsore, ulcer on the shank, furuncle, sore, and carbuncle and
Slight wound superficial wound, which is particularly not convergent not callus mouthful long, special effect；It has poly- purulence draw out pus by applying a plaster to the affected part, detoxify, detoxification, toxin expelling and
The effect of malicious evil diffusion is prevented, rotten skin can be impregnated with, there is anti-inflammation, draw out pus by applying a plaster to the affected part and inhale effect of pus and growing muscle.Its therapeutic action
Rapidly, the course of disease is short, and no scar, thorough treatment has no toxic side effect.But the pharmaceutical composition preparation process is only to crush to decoct
Boil, the effect that medicine effect is played is limited.
The content of the invention
It is an object of the invention to provide a kind of raw material sources extensively, material effective component utilization rate is high, can prevent and
Fresh-water fishes furunculosis is treated, prevention effect is good, preparation method is simple, easy to use having prevents and treats fresh-water fishes furunculosis effect
Feed addictive and application thereof.
The present invention is directed to the problem of being mentioned in above-mentioned technology, and the technical scheme taken is：One kind has preventing and treating fresh-water fishes furuncle
The feed addictive of sore disease effect, composition and its parts by weight are：Spill 20-30 parts of mountain, 20-25 parts of the root of fangji, Chinese gall 13-17
Part, 15-20 parts of cassia twig, 8-13 parts of Semen Ricini, 7-11 parts of caulis lonicerae, 0.4-0.7 parts of orfloxacin, sulfamethoxazole 0.1-
0.2 part.Rationally, Chinese and Western medicine is combined compatibility between above-mentioned each composition of additive, with significant cooperative synergism effect, eliminates medicine
Side effect in thing, the function of each component, the overall treatment to fresh-water fishes furunculosis of lifting medicine can be played to greatest extent
Effect；Infringement that can be with microorganism outside defense cell and its toxin to body, has significant sterilization to the pathogen of furunculosis
Bacteriostasis, can reach the purpose of preventing and treating and prevention fresh-water fishes furunculosis, while can promote the generation of furunculosis antibody, improve light
The immunity and resistance of water fish.
A kind of preparation method of the feed addictive with preventing and treating fresh-water fishes furunculosis effect, specifically includes following steps：
Pretreatment of raw material：Mountain spill, the root of fangji, Chinese gall, cassia twig, Semen Ricini, caulis lonicerae are measured by formula, after low temperature is continuous drying
60-80 mesh just is crushed to, then ultramicro grinding produces medicinal powder to 300-500 mesh, standby, the continuous drying technique of low temperature can drop
The volatility of active ingredient in low Chinese herbal medicine, reduces loss, and the original of certain fineness can be provided for ultramicro grinding by just crushing
Material, makes ultramicro grinding be more prone to progress, improves the operating efficiency of ultramicro grinding, reduces energy consumption, saves energy consumption and cost,
Ultramicro grinding can destroy Chinese herbal medicine cell membrane, intracellular effective drug ingedient is fully exposed, improve medicine
Bioavailability, the consumption for reducing medicine, and the uniformity of particle is improved to a certain extent, feed addictive is more held
Easily it is dispersed in feed；
It is prepared by Aqueous extracts：It is 1 by weight by medicinal powder and water:8-13 is mixed, and adds medicinal powder weight 0.006-0.009% work
Property polypeptide, be put into power be 280-320W ultrasonic wave in handle 15-22min, be then heated to boiling after boil 40-60min,
Decoction liquor as Aqueous extracts are isolated, the amino acid sequence of above-mentioned active peptides is
HSHACKLCVCVNCFCCGARVLHPGKLCVCNCSK, the active peptides can deploy to be arranged in parallel within cell under charge effect
Film surface forms a thing, changes the surface tension of cell membrane using hydrophobic effect and molecular tension effect, forms transmembrane potential
Difference and cause membrane damage, the active drug composition quick release for making medicinal powder intracellular comes out；
It is prepared by additive：Mixed liquor is filtered, formula ratio orfloxacin and sulfamethoxazole are added in filtrate, is then dried,
The feed addictive with preventing and treating fresh-water fishes furunculosis effect is produced, the additive can improve immunity of organisms, improve body resistance to
Hypoxia ability, eliminates free radical, the characteristic with stimulation of host non-specific resistance, immune idiosyncrasy；Can be with defense cell
The infringement of outer microorganism and its toxin to body, there is significant bactericidal to act on the pathogen of furunculosis, reaches preventing and treating
With the purpose of prevention fresh-water fishes furunculosis.
A kind of purposes of the feed addictive with preventing and treating fresh-water fishes furunculosis effect：The feed addictive is directly added
Fed in feed, addition is the 0.2-0.4% of feed relative, the addition of feed addictive causes the feed has clear
Thermal detoxification, the effect for sterilizing antibacterial, can eliminate the pathogen into fresh-water fishes body and parasite, with preventing and treating furunculosis
Effect, and the immunocompetence and resistance against diseases of fresh-water fishes itself can be improved.
Compared with prior art, the advantage of the invention is that：The additive of the present invention can improve immunity of organisms, improve machine
Body hypoxia-bearing capability, eliminates free radical, the characteristic with stimulation of host non-specific resistance, immune idiosyncrasy；It can defend
The infringement of extracellular microorganisms and its toxin to body, there is significant bactericidal to act on the pathogen of furunculosis, reaches
Preventing and treating and the purpose of prevention fresh-water fishes furunculosis；The disease into fresh-water fishes body can be eliminated by adding the feed of the feed addictive
Substance and parasite, the effect with preventing and treating furunculosis, and the immunocompetence and resistance against diseases of fresh-water fishes itself can be improved, carry
The cultivation survival rate of high fresh-water fishes, increase cultivation income.
Specific embodiment
The present invention program is described further below by embodiment：
Embodiment 1：
A kind of to have the feed addictive for preventing and treating fresh-water fishes furunculosis effect, composition and its parts by weight are：25 parts of mountain spill, the root of fangji
22 parts, 15 parts of Chinese gall, 17 parts of cassia twig, 10 parts of Semen Ricini, 9 parts of caulis lonicerae, 0.5 part of orfloxacin, sulfamethoxazole 0.15
Part.Rationally, Chinese and Western medicine is combined compatibility between above-mentioned each composition of additive, with significant cooperative synergism effect, eliminates medicine
In side effect, can play the function of each component to greatest extent, lifting medicine it is overall curative effect is controlled to fresh-water fishes furunculosis
Really；Infringement that can be with microorganism outside defense cell and its toxin to body, there is significant sterilization to press down the pathogen of furunculosis
Bacterium acts on, and can reach the purpose of preventing and treating and prevention fresh-water fishes furunculosis, while can promote the generation of furunculosis antibody, improves fresh water
The immunity and resistance of fish.
A kind of preparation method of the feed addictive with preventing and treating fresh-water fishes furunculosis effect, specifically includes following steps：
1）Pretreatment of raw material：Mountain spill, the root of fangji, Chinese gall, cassia twig, Semen Ricini, caulis lonicerae are measured by formula, low temperature is continuous drying
70 mesh just are crushed to afterwards, then ultramicro grinding produces medicinal powder to 400 mesh, standby, and the continuous drying technique of low temperature can reduce medium-height grass
The volatility of active ingredient in medicine, reduces loss, and the raw material of certain fineness can be provided for ultramicro grinding by just crushing, makes to surpass
Crushing of Ultrafine is more prone to carry out, and improves the operating efficiency of ultramicro grinding, reduces energy consumption, saves energy consumption and cost, Ultramicro-powder
It is broken to destroy Chinese herbal medicine cell membrane, intracellular effective drug ingedient is fully exposed, improve the biology profit of medicine
With rate, the consumption of medicine is reduced, and improves the uniformity of particle to a certain extent, feed addictive is easier uniformly
It is dispersed in feed；
2）It is prepared by Aqueous extracts：It is 1 by weight by medicinal powder and water:10 mixing, add the active peptides of medicinal powder weight 0.008%,
It is put into the ultrasonic wave that power is 300W and handles 19min, boils 50min after being then heated to boiling, isolating decoction liquor is
Aqueous extracts, the amino acid sequence of above-mentioned active peptides is HSHACKLCVCVNCFCCGARVLHPGKLCVCNCSK, the active peptides
Under charge effect, it can deploy to be arranged in parallel within cell membrane surface or form a thing, be acted on using hydrophobic effect and molecular tension
Change the surface tension of cell membrane, form transmembrane potential difference and cause membrane damage, the active drug composition for making medicinal powder intracellular is fast
Quick-release is released；
3）It is prepared by additive：Water extraction is filtered, formula ratio orfloxacin and sulfamethoxazole are added in filtrate, is then dried,
The feed addictive with preventing and treating fresh-water fishes furunculosis effect is produced, the additive can improve immunity of organisms, improve body resistance to
Hypoxia ability, eliminates free radical, the characteristic with stimulation of host non-specific resistance, immune idiosyncrasy；Can be with defense cell
The infringement of outer microorganism and its toxin to body, there is significant bactericidal to act on the pathogen of furunculosis, reaches preventing and treating
With the purpose of prevention fresh-water fishes furunculosis.
A kind of purposes of the feed addictive with preventing and treating fresh-water fishes furunculosis effect：The feed addictive is directly added
Fed in feed, addition is the 0.3% of feed relative, and the addition of feed addictive causes the feed to have heat-clearing solution
The effect of poison, sterilization antibacterial, can eliminate the pathogen into fresh-water fishes body and parasite, the effect with preventing and treating furunculosis
Really, and the immunocompetence and resistance against diseases of fresh-water fishes itself can be improved.
Embodiment 2：
A kind of to have the feed addictive for preventing and treating fresh-water fishes furunculosis effect, composition and its parts by weight are：22 parts of mountain spill, the root of fangji
24 parts, 14 parts of Chinese gall, 18 parts of cassia twig, 8 parts of Semen Ricini, 10 parts of caulis lonicerae, 0.4 part of orfloxacin, sulfamethoxazole 0.2
Part.
A kind of preparation method of the feed addictive with preventing and treating fresh-water fishes furunculosis effect, specifically includes following steps：
1）Mountain spill, the root of fangji, Chinese gall, cassia twig, Semen Ricini, caulis lonicerae are measured by formula, is just crushed to after low temperature is continuous drying
65 mesh, then ultramicro grinding produce medicinal powder to 300 mesh, it is standby, the continuous drying technique of low temperature can reduce in Chinese herbal medicine effectively into
The volatility divided, reduces loss, and the raw material of certain fineness can be provided for ultramicro grinding by just crushing, makes ultramicro grinding more
Easily carry out, improve the operating efficiency of ultramicro grinding, reduce energy consumption, save energy consumption and cost, ultramicro grinding can be destroyed
Chinese herbal medicine cell membrane, makes intracellular effective drug ingedient fully be exposed, and improves the bioavailability of medicine, reduces medicine
The consumption of thing, and the uniformity of particle is improved to a certain extent, make feed addictive be easier to be dispersed in feed
In；
2）It is 1 by weight by medicinal powder and water:12 mixing, add the active peptides of medicinal powder weight 0.009%, being put into power is
17min is handled in 300W ultrasonic wave, 45min is boiled after being then heated to boiling, isolates decoction liquor as Aqueous extracts, it is above-mentioned
The amino acid sequence of active peptides is HSHACKLCVCVNCFCCGARVLHPGKLCVCNCSK, and the active peptides are in charge effect
Under, it can deploy to be arranged in parallel within cell membrane surface or form a thing, cell membrane is changed using hydrophobic effect and molecular tension effect
Surface tension, formed transmembrane potential difference and cause membrane damage, the active drug composition quick release for making medicinal powder intracellular comes out；
3）Aqueous extracts are filtered, formula ratio orfloxacin and sulfamethoxazole are added in filtrate, is then dried, are produced with anti-
The feed addictive of fresh-water fishes furunculosis effect is controlled, the additive can improve immunity of organisms, improve body's hypoxia tolerance, disappear
Except free radical, the characteristic with stimulation of host non-specific resistance, immune idiosyncrasy；Can with microorganism outside defense cell and its
Infringement of the toxin to body, there is significant bactericidal to act on the pathogen of furunculosis, reach preventing and treating and prevention fresh-water fishes
The purpose of furunculosis.
A kind of purposes of the feed addictive with preventing and treating fresh-water fishes furunculosis effect：The feed addictive is directly added
Fed in feed, addition is the 0.2% of feed relative, and the addition of feed addictive causes the feed to have heat-clearing solution
The effect of poison, sterilization antibacterial, can eliminate the pathogen into fresh-water fishes body and parasite, the effect with preventing and treating furunculosis
Really, and the immunocompetence and resistance against diseases of fresh-water fishes itself can be improved.
Embodiment 3：
A kind of to have the feed addictive for preventing and treating fresh-water fishes furunculosis effect, composition and its parts by weight are：29 parts of mountain spill, the root of fangji
21 parts, 17 parts of Chinese gall, 15 parts of cassia twig, 13 parts of Semen Ricini, 7 parts of caulis lonicerae, 0.7 part of orfloxacin, sulfamethoxazole 0.17
Part.
It is a kind of there is preventing and treating fresh-water fishes furunculosis effect the preparation method of feed addictive be：Mountain is measured by formula to twist with the fingers
Son, the root of fangji, Chinese gall, cassia twig, Semen Ricini, caulis lonicerae, just 80 mesh are crushed to after low temperature is continuous drying, and then ultramicro grinding is extremely
500 mesh, are 1 by weight by gained medicinal powder and water:9 mixing, add the active peptides of medicinal powder weight 0.009%, are put into power
To handle 16min in 280W ultrasonic wave, 55min is boiled after being then heated to boiling, decoction liquor as Aqueous extracts, mistake are isolated
Formula ratio orfloxacin and sulfamethoxazole are added in filter, filtrate, is then dried, is produced with preventing and treating fresh-water fishes furunculosis work(
The feed addictive of effect.
A kind of purposes of the feed addictive with preventing and treating fresh-water fishes furunculosis effect：The feed addictive is directly added
Fed in feed, addition is the 0.4% of feed relative.
Routine operation in the operating procedure of the present invention is well known to those skilled in the art, herein without repeating.
Technical scheme is described in detail embodiment described above, it should be understood that it is described above only
For the specific embodiment of the present invention, it is not intended to limit the invention, all any modifications made in the spirit of the present invention,
Supplement or similar fashion replacement etc., should be included in the scope of the protection.
SEQUENCE LISTING
<110>Tonghua Teachers College
<120>It is a kind of that there is feed addictive of preventing and treating fresh-water fishes furunculosis effect and application thereof
<130> 1
<160> 1
<170> PatentIn version 3.5
<210> 1
<211> 33
<212> PRT
<213>It is artificial synthesized go out
<400> 1
His Ser His Ala Cys Lys Leu Cys Val Cys Val Asn Cys Phe Cys Cys
1 5 10 15
Gly Ala Arg Val Leu His Pro Gly Lys Leu Cys Val Cys Asn Cys Ser
20 25 30
Lys
Claims (9)
1. a kind of have the feed addictive for preventing and treating fresh-water fishes furunculosis effect, it is characterised in that：The composition of described additive
And its parts by weight are：Spill 20-30 parts of mountain, 20-25 parts of the root of fangji, 13-17 parts of Chinese gall, 15-20 parts of cassia twig, Semen Ricini 8-13
Part, 7-11 parts of caulis lonicerae, 0.4-0.7 parts of orfloxacin, 0.1-0.2 parts of sulfamethoxazole.
2. a kind of feed addictive with preventing and treating fresh-water fishes furunculosis effect according to claim 1, it is characterised in that：
The preparation process of described additive includes：Prepared by pretreatment of raw material, Aqueous extracts, prepared by additive.
3. a kind of preparation method of feed addictive with preventing and treating fresh-water fishes furunculosis effect according to claim 2,
It is characterized in that：Described Aqueous extracts preparation process is：Medicinal powder is added water and active peptides, is put into ultrasonic wave and handles, then
Boiled after being heated to boiling, isolate decoction liquor as Aqueous extracts.
4. a kind of preparation method of feed addictive with preventing and treating fresh-water fishes furunculosis effect according to claim 3,
It is characterized in that：The addition of active peptides is medicinal powder weight 0.006-0.009%, its ammonia in described Aqueous extracts preparation process
Base acid sequence is HSHACKLCVCVNCFCCGARVLHPGKLCVCNCSK.
5. a kind of preparation method of feed addictive with preventing and treating fresh-water fishes furunculosis effect according to claim 3,
It is characterized in that：The power of ultrasonication is 280-320W in described Aqueous extracts preparation process, and the time is 15-22min.
6. a kind of preparation method of feed addictive with preventing and treating fresh-water fishes furunculosis effect according to claim 3,
It is characterized in that：Described Aqueous extracts preparation process traditional Chinese medicine powder and the weight ratio of water are 1:8-13.
7. a kind of preparation method of feed addictive with preventing and treating fresh-water fishes furunculosis effect according to claim 3,
It is characterized in that：40-60min is boiled after being seethed with excitement in described Aqueous extracts preparation process.
8. a kind of preparation method of feed addictive with preventing and treating fresh-water fishes furunculosis effect according to claim 2,
It is characterized in that：Ultramicro grinding to medicinal powder particle diameter is 300-500 mesh in described feed pretreatment step.
9. a kind of purposes of the feed addictive with preventing and treating fresh-water fishes furunculosis effect, it is characterised in that：Described purposes is：
The feed addictive directly addition is fed in feed, addition is the 0.2-0.4% of feed relative.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710595387.3A CN107320529A (en) | 2017-07-20 | 2017-07-20 | It is a kind of that there is feed addictive of preventing and treating fresh-water fishes furunculosis effect and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710595387.3A CN107320529A (en) | 2017-07-20 | 2017-07-20 | It is a kind of that there is feed addictive of preventing and treating fresh-water fishes furunculosis effect and application thereof |
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| CN107320529A true CN107320529A (en) | 2017-11-07 |
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| CN201710595387.3A Pending CN107320529A (en) | 2017-07-20 | 2017-07-20 | It is a kind of that there is feed addictive of preventing and treating fresh-water fishes furunculosis effect and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108354086A (en) * | 2017-12-29 | 2018-08-03 | 磐安县派普特生物科技有限公司 | Preparation method containing mussel polysaccharide prawn phagostimulant |
| CN108782998A (en) * | 2018-06-04 | 2018-11-13 | 广州市联鲲生物科技有限公司 | A kind of Ba Shayu premixes and its preparation method and application |
-
2017
- 2017-07-20 CN CN201710595387.3A patent/CN107320529A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108354086A (en) * | 2017-12-29 | 2018-08-03 | 磐安县派普特生物科技有限公司 | Preparation method containing mussel polysaccharide prawn phagostimulant |
| CN108782998A (en) * | 2018-06-04 | 2018-11-13 | 广州市联鲲生物科技有限公司 | A kind of Ba Shayu premixes and its preparation method and application |
| CN108782998B (en) * | 2018-06-04 | 2021-11-26 | 广州市联鲲生物科技有限公司 | Premix for basha fish and preparation method and application thereof |
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