CN107296874A - A kind of pharmaceutical composition of anti-inflammation and preparation method thereof - Google Patents
A kind of pharmaceutical composition of anti-inflammation and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention proposes a kind of pharmaceutical composition of anti-inflammation and preparation method thereof, and it consists of the following parts by weight：The parts by weight of polygonum perfoliatum 50 60, the parts by weight of purslane 20 30, the parts by weight of dandelion 5 15, flea stop 5 15 parts by weight, the parts by weight of oriental wormwood 5 15, the parts by weight of frankincense 5 15, the parts by weight of cordate houttuynia 15 25, the parts by weight of myrrh 5 15 and the parts by weight of folium isatidis 5 15, present component is scientific and reasonable, cheap, preparation method is easy, therapeutic effect is good, toxic side effect is small, suitable for clinical practice.
Description
Technical field
The invention belongs to antiphlogistic technical field, pharmaceutical composition and its preparation side of a kind of anti-inflammation are particularly related to
Method.
Background technology
It is reported that, China is in the world its harm to children and old man using one of maximum country of antibiotic excess
It is even more serious, have many on antibiotic is lethal, the important case such as disable is complained and exposes, state food drug surveilance every year
Management board's limit of also ordering is sold, and natural Chinese medicinal herb existing deep cultural and historical in terms of anti-inflammation, Chinese medicine antibacterial has successfully
Experience and unique advantage, with anti-inflammation, improve body's immunity, reduce toxic and side effects of chemoradiotherapy, and regulation body is cloudy
The outstanding roles such as rising tone weighing apparatus.However, existing antibacterial Chinese medicine therapeutic effect is not good.
The content of the invention
The present invention proposes a kind of pharmaceutical composition of anti-inflammation and preparation method thereof, solves antibiotic in the prior art
There is the defect of larger toxic side effect.
The technical proposal of the invention is realized in this way：
A kind of pharmaceutical composition of anti-inflammation, it consists of the following parts by weight：Polygonum perfoliatum 50-60 parts by weight, purslane
20-30 parts by weight, dandelion 5-15 parts by weight, flea stop 5-15 parts by weight, oriental wormwood 5-15 parts by weight, frankincense 5-15 parts by weight, fish
Raw meat grass 15-25 parts by weight, myrrh 5-15 parts by weight and folium isatidis 5-15 parts by weight.
Further, a kind of pharmaceutical composition of anti-inflammation, it consists of the following parts by weight：The parts by weight of polygonum perfoliatum 52,
The parts by weight of purslane 26, the parts by weight of dandelion 8, flea stop 9 parts by weight, the parts by weight of oriental wormwood 8, the parts by weight of frankincense 10, the weight of cordate houttuynia 13
Measure part, the parts by weight of myrrh 12 and the parts by weight of folium isatidis 12.
Further, a kind of pharmaceutical composition of anti-inflammation, it consists of the following parts by weight：The parts by weight of polygonum perfoliatum 58,
The parts by weight of purslane 28, the parts by weight of dandelion 12, flea stop 13 parts by weight, the parts by weight of oriental wormwood 12, the parts by weight of frankincense 15, cordate houttuynia 20
Parts by weight, the parts by weight of myrrh 12 and the parts by weight of folium isatidis 13.
A kind of pharmaceutical composition of anti-inflammation and preparation method thereof, the preparation method step is as follows：
(1) take the polygonum perfoliatums of the parts by weight, purslane, dandelion, flea to stop, oriental wormwood, frankincense, cordate houttuynia, myrrh and
Folium isatidis medicinal material, removes weeds, cleans, and cuts up with a hay cutter broken, adds water, and with frequency 20KHZ, power 14.5KW ultrasonic wave extraction, extracts temperature
Degree control extracts 30-40min at 30-50 DEG C, and extract solution is filtered through fiber cloth, collects filtrate, and the dregs of a decoction add water, again ultrasonic wave
25-30min is extracted, filter and remove residue merges filtrate twice, bulky grain debris are pre-processed through 20 μm of film centrifugations, then it is micro- by 2.2 μm
Pore membrane filtering purification, filtered driving force pressure differential is 102-103Kpa, and 2nm micro-pore-film filtrations, filter pressure difference is 103-
104Kpa, is made filtrate；
(2) clear cream that relative density is 1.12-1.16 is concentrated the filtrate to；
(3) clear cream adds 5-10 times to measure water, stands 12-24 hours, and filtering, filtrate is concentrated to dryness；
(4) obtained solids is milled into fine powder after drying, that is, obtains pharmaceutical composition active component of the present invention.
The property of medicine of Chinese medicine used of the invention is as follows：
Polygonum perfoliatum：It is clearing heat and detoxicating, inducing diuresis to remove edema, for the infection of the upper respiratory tract, tracheitis, pertussis, acute tonsillitis,
Enteritis, dysentery, nephritic dropsy；Herpes zoster, eczema, carbuncle furuncle poison, snake bite are controlled in external application.It is to staphylococcus aureus, second
Type streptococcus, bacillus anthracis, corynebacterium diphtheriae, hay bacillus, typhoid bacillus, Pseudomonas aeruginosa and haemophilus influenzae etc. also have stronger
Antibacterial action.
Purslane：It is cold in nature, sweet, acid；Enter the heart, liver, spleen, large intestine channel.Hygroscopic is antipruritic, clearing heat for detumescence, clearing heat and detoxicating, Li Shui
Dry, dissipate blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, blood-stanching and blood-cooling.Modern medicine study confirms that purslane is to shigella dysenteriae, wound
Cold bacillus and Escherichia coli have stronger inhibitory action, available for the auxiliary treatment of various inflammation, have " natural antibiotics " it
Claim.
Dandelion：Sweet, slight bitter, it is cold in nature.It is clearing heat and detoxicating, dispersing swelling and dissipating binds.Available for temperature disease, removing heat from the liver, treatment liver heat
Red eye, swell pain, and multi-infection, purulent disease.Modern medicine study confirms that dandelion is to staphylococcus aureus resistance
Bacterial strain, hemolytic streptococcus have stronger bactericidal action, to Diplococcus pneumopniae, meningococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa,
Proteus, shigella dysenteriae, typhoid bacillus etc. and micrococcus catarrhalis also have certain bactericidal action.
Flea stops：《Detailed outline》：The poison of snakeworm, obtain that this controls stops, therefore has flea to stop, stings not all names, Chong Tai, three layers, Yin Qiye
Shape, RHIZOMA PARIDIS, because its is flower-shaped, the root of gansui, because of its root shape, dried human placenta, because of its function, Paris polyphylla gold thread, there is it everywhere,
The dark and damp ground in remote mountains is born in, on a stem is only, stem works as the leaf heart, leaf green, like Chinese herbaceous peony, all two, three layers, each leaf of layer seven, stem head summer
Month bloom, one spends seven valves, there is a spun gold stamen, long by three, four cun, Wangwu Shan Mountain production person to five, seven layers, root such as Podophyllum emodi var chinense, rhizoma atractylodis shape, in outer purple
In vain, there are viscous glutinous two kinds, be used as medicine to wash and cut roasting use.
Oriental wormwood：Gas is fragrant, pungent cool, clearing heat and promoting diuresis；Removing jaundice, is cured mainly：Jaundice, difficult urination, wet sore itch, infectiousness are yellow
Subcutaneous ulcer type hepatitis.There is cholagogic Deng pharmaceutical researches, liver function protecting is antipyretic, anti-inflammatory, reducing blood lipid, be depressured, the effect such as coronary dilatation is right
Combined hepatitis A and B vaccine, icteric hepatitis have significant curative effect.
Frankincense：Pungent, hardship, slightly warm in nature.Enter the heart, liver, the spleen channel.Regulating qi and activating blood, analgesic therapy is chased after poison.Cure mainly qi and blood stagnation, trusted subordinate
Pain, ulcerative carbuncle pyogenic infections, traumatic injury, dysmenorrhoea, hemostasis shouting pain.《Detailed outline》Carry：" all poison of the ulcer that disappears, Tuoli shield heart, analgesic therapy of invigorating blood circulation,
Stretch muscle." modern medicine study confirms that Olibanum volatile oil has analgesic activity, polynuclear leucocyte can be promoted to increase, and swallows dead blood
Ball and cell, improve metabolism, there is anti-inflammatory antisepsis.
Myrrh；Property is bitter, pungent, flat.Enter Liver Channel.Dissipate blood and relieving pain, detumescence and promoting granulation；Cure mainly：Ulcer sore pain, trusted subordinate, all pains of muscles and bones,
Blood is damaged, external application can expelling pus and promoting granulation.
Cordate houttuynia：It is pungent, cold, return lung warp；Can clearing heat and detoxicating, detumescence treatment sore, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach invigorating
Help digestion, be lung carbuncle, sore swollen toxin, hemorrhoidal hemorrhage, the retention of heat in the spleen and stomach etc. suffered from real heat, heat toxin, damp evil, disease heat is controlled；Modern pharmacology
Experiment shows that this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Cordate houttuynia is to Staphylococcus aureus
Bacterium, Bacillus influenzae, tubercle bacillus, Diplococcus pneumopniae, micrococcus catarrhalis, corynebacterium diphtheriae, bacillus enteritidis, interests bacillus, proteus
Etc. there is inhibitory action.
Folium isatidis：Warm disease excess heat polydipsia is controlled in heat-clearing, removing toxic substances, cool blood, hemostasis, influenza, acute infectious hepatitis,
Bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas is spitted blood, bleeding from five sense organs or subcutaneous tissue, jaundice, dysentery, larynx numbness, aphtha, swollen ulcer drug.
Using polygonum perfoliatum as monarch drug in a prescription in prescription, this is enter liver, kidney, lung, small intestinl channel, clearing heat and detoxicating, inducing diuresis to remove edema, decompression, profit
Water, draws out pus by applying a plaster to the affected part, stop dysentery.Purslane stop dysentery is detoxified, and has confirmed that it act as：Antibacterial, diuresis.Active ingredient may be sylvite, be
Ministerial drug, assistant is stopped with dandelion, flea, oriental wormwood, cordate houttuynia are product that hardship lets out removing toxic substances, is on the point of the medicine of lake meaning meridian of Foot-JUE YIN, lid removing summer-heat liver and gall
It is hot and suffocating, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. sending down abnormally ascending, also can detumescence dissolving phlegm, Li Shui dried, and frankincense is applied flexibly in blood stasis pain, takes it to have analgesic activity, is equipped with
Myrrh and folium isatidis promoting blood circulation and stopping pain, detumescence and promoting granulation.
In summary, the advantage of the invention is that：
Pharmaceutical composition of a kind of anti-inflammation of the present invention and preparation method thereof, medicine of the present invention has wind-expelling pain-stopping,
It is clearing heat and detoxicating, effect of antiphlogistic antibacterial, it is adaptable to the bactericidal antiphlogistic that clinical laboratory trauma wounds sample is extracted, it can also be used to skin with
And the sterilization of mucous membrane, skin injury sterilization, treatment colpomycosis, skin fungus infection etc..
Embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common
The every other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.
Embodiment 1
A kind of pharmaceutical composition of anti-inflammation, it consists of the following parts by weight：The parts by weight of polygonum perfoliatum 52, the weight of purslane 26
Amount part, the parts by weight of dandelion 8, flea stop 9 parts by weight, the parts by weight of oriental wormwood 8, the parts by weight of frankincense 10, the parts by weight of cordate houttuynia 13, myrrh 12
Parts by weight and the parts by weight of folium isatidis 12, described pharmaceutical composition preparation method step are as follows：
(1) take the polygonum perfoliatums of the parts by weight, purslane, dandelion, flea to stop, oriental wormwood, frankincense, cordate houttuynia, myrrh and
Folium isatidis medicinal material, removes weeds, cleans, and cuts up with a hay cutter broken, adds water, and with frequency 20KHZ, power 14.5KW ultrasonic wave extraction, extracts temperature
Degree control extracts 30-40min at 30-50 DEG C, and extract solution is filtered through fiber cloth, collects filtrate, and the dregs of a decoction add water, again ultrasonic wave
25-30min is extracted, filter and remove residue merges filtrate twice, bulky grain debris are pre-processed through 20 μm of film centrifugations, then it is micro- by 2.2 μm
Pore membrane filtering purification, filtered driving force pressure differential is 102-103Kpa, and 2nm micro-pore-film filtrations, filter pressure difference is 103-
104Kpa, is made filtrate；
(2) clear cream that relative density is 1.12-1.16 is concentrated the filtrate to；
(3) clear cream adds 5-10 times to measure water, stands 12-24 hours, and filtering, filtrate is concentrated to dryness；
(4) obtained solids is milled into fine powder after drying, that is, obtains pharmaceutical composition active component of the present invention.
Embodiment 2
A kind of pharmaceutical composition of anti-inflammation, it consists of the following parts by weight：Polygonum perfoliatum 50-60 parts by weight, purslane
20-30 parts by weight, dandelion 5-15 parts by weight, flea stop 5-15 parts by weight, oriental wormwood 5-15 parts by weight, frankincense 5-15 parts by weight, fish
Raw meat grass 15-25 parts by weight, myrrh 5-15 parts by weight and folium isatidis 5-15 parts by weight.
A kind of pharmaceutical composition of anti-inflammation and preparation method thereof, the preparation method step is as follows：
(1) take the polygonum perfoliatums of the parts by weight, purslane, dandelion, flea to stop, oriental wormwood, frankincense, cordate houttuynia, myrrh and
Folium isatidis medicinal material, removes weeds, cleans, and cuts up with a hay cutter broken, adds water, and with frequency 20KHZ, power 14.5KW ultrasonic wave extraction, extracts temperature
Degree control extracts 30-40min at 30-50 DEG C, and extract solution is filtered through fiber cloth, collects filtrate, and the dregs of a decoction add water, again ultrasonic wave
25-30min is extracted, filter and remove residue merges filtrate twice, bulky grain debris are pre-processed through 20 μm of film centrifugations, then it is micro- by 2.2 μm
Pore membrane filtering purification, filtered driving force pressure differential is 102-103Kpa, and 2nm micro-pore-film filtrations, filter pressure difference is 103-
104Kpa, is made filtrate；
(2) clear cream that relative density is 1.12-1.16 is concentrated the filtrate to；
(3) clear cream adds 5-10 times to measure water, stands 12-24 hours, and filtering, filtrate is concentrated to dryness；
(4) obtained solids is milled into fine powder after drying, that is, obtains pharmaceutical composition active component of the present invention.
Embodiment 3：Animal toxicology is tested
Acute toxicity test
10 body weight 20g ± 2g of male and female half and half experiment mice is taken, experiment medication is powder prepared by the embodiment of the present invention 2
Agent, daily every mouse takes pulvis 0.33g, prepares 1ml decoctions and awards gavage, dosage equivalent to mouse weight 50g/kg,
Equivalent to 1000 times of people's quantity, continuous 7 days, observation mouse is acted normally, and LD50 is not detected, illustrates the medicine of the present invention
Composition is non-toxic, Clinical practice safety.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
God is with principle, and any modification, equivalent substitution and improvements made etc. should be included in the scope of the protection.
Claims (4)
1. a kind of pharmaceutical composition of anti-inflammation, it is characterised in that：It consists of the following parts by weight：Polygonum perfoliatum 50-60 weight
Part, purslane 20-30 parts by weight, dandelion 5-15 parts by weight, flea stop 5-15 parts by weight, oriental wormwood 5-15 parts by weight, frankincense 5-15
Parts by weight, cordate houttuynia 15-25 parts by weight, myrrh 5-15 parts by weight and folium isatidis 5-15 parts by weight.
2. a kind of pharmaceutical composition of anti-inflammation according to claim 1, it is characterised in that：It is by following parts by weight group
Into：The parts by weight of polygonum perfoliatum 52, the parts by weight of purslane 26, the parts by weight of dandelion 8, flea stop 9 parts by weight, the parts by weight of oriental wormwood 8, frankincense 10
Parts by weight, the parts by weight of cordate houttuynia 13, the parts by weight of myrrh 12 and the parts by weight of folium isatidis 12.
3. a kind of pharmaceutical composition of anti-inflammation according to claim 1, it is characterised in that：It is by following parts by weight group
Into：The parts by weight of polygonum perfoliatum 58, the parts by weight of purslane 28, the parts by weight of dandelion 12, flea stop 13 parts by weight, the parts by weight of oriental wormwood 12, breast
Fragrant 15 parts by weight, the parts by weight of cordate houttuynia 20, the parts by weight of myrrh 12 and the parts by weight of folium isatidis 13.
4. a kind of pharmaceutical composition of anti-inflammation and preparation method thereof, the preparation method step is as follows：
(1) take the polygonum perfoliatums of the parts by weight, purslane, dandelion, flea to stop, oriental wormwood, frankincense, cordate houttuynia, myrrh and smalt
Leaf medicinal material, removes weeds, cleans, and cuts up with a hay cutter broken, adds water, with frequency 20KHZ, power 14.5KW ultrasonic wave extraction, Extracting temperature control
System extracts 30-40min at 30-50 DEG C, and extract solution is filtered through fiber cloth, collects filtrate, and the dregs of a decoction add water, again ultrasonic wave extraction
25-30min, filter and remove residue merges filtrate twice, through 20 μm of film centrifugation pretreatment bulky grain debris, then by 2.2 μm of microporous barriers
Filtering purification, filtered driving force pressure differential is 102-103Kpa, and 2nm micro-pore-film filtrations, filter pressure difference is 103-104Kpa, system
Obtain filtrate；
(2) clear cream that relative density is 1.12-1.16 is concentrated the filtrate to；
(3) clear cream adds 5-10 times to measure water, stands 12-24 hours, and filtering, filtrate is concentrated to dryness；
(4) obtained solids is milled into fine powder after drying, that is, obtains pharmaceutical composition active component of the present invention.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108096112A (en) * | 2018-01-12 | 2018-06-01 | 福建师范大学 | A kind of plant composition with preservative efficacy and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861208A (en) * | 2012-09-19 | 2013-01-09 | 王吉坤 | Antibacterial, anti-inflammation and antiviral traditional Chinese medicine compound |
| CN105267396A (en) * | 2015-11-25 | 2016-01-27 | 严瑾 | Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861208A (en) * | 2012-09-19 | 2013-01-09 | 王吉坤 | Antibacterial, anti-inflammation and antiviral traditional Chinese medicine compound |
| CN105267396A (en) * | 2015-11-25 | 2016-01-27 | 严瑾 | Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096112A (en) * | 2018-01-12 | 2018-06-01 | 福建师范大学 | A kind of plant composition with preservative efficacy and preparation method thereof |
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