CN107257803B - 用于治疗细菌感染的多粘菌素类抗菌剂 - Google Patents

用于治疗细菌感染的多粘菌素类抗菌剂 Download PDF

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Publication number
CN107257803B
CN107257803B CN201580075652.4A CN201580075652A CN107257803B CN 107257803 B CN107257803 B CN 107257803B CN 201580075652 A CN201580075652 A CN 201580075652A CN 107257803 B CN107257803 B CN 107257803B
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alkyl
aryl
atoms
compound
diaryl
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CN107257803A (zh
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M·F·高德福
刘进前
王星海
袁征宇
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Shanghai Mengke Pharmaceutical Co ltd
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Shanghai Mengke Pharmaceutical Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
CN201580075652.4A 2014-12-16 2015-12-16 用于治疗细菌感染的多粘菌素类抗菌剂 Active CN107257803B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462092780P 2014-12-16 2014-12-16
US62/092,780 2014-12-16
PCT/US2015/066210 WO2016100578A2 (en) 2014-12-16 2015-12-16 Antimicrobial polymyxins for treatment of bacterial infections

Publications (2)

Publication Number Publication Date
CN107257803A CN107257803A (zh) 2017-10-17
CN107257803B true CN107257803B (zh) 2021-02-05

Family

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Family Applications (1)

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CN201580075652.4A Active CN107257803B (zh) 2014-12-16 2015-12-16 用于治疗细菌感染的多粘菌素类抗菌剂

Country Status (8)

Country Link
US (1) US9771394B2 (https=)
EP (1) EP3233889B1 (https=)
JP (1) JP6896628B2 (https=)
KR (1) KR102585108B1 (https=)
CN (1) CN107257803B (https=)
CA (1) CA2970546A1 (https=)
ES (1) ES2924058T3 (https=)
WO (1) WO2016100578A2 (https=)

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WO2017189866A1 (en) * 2016-04-27 2017-11-02 Spero Opco Polymyxin analogs useful as antibiotic potentiators
EP3388445A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Peptide macrocycles and use thereof in the treatment of bacterial infections
CN111527100A (zh) 2017-11-02 2020-08-11 昆士兰大学 肽类抗生素
WO2019237186A1 (en) * 2018-06-12 2019-12-19 University Of Manitoba Preparation of dilipid polymyxins and use thereof as antimicrobial adjuvants
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
GB201904534D0 (en) * 2019-04-01 2019-05-15 Centauri Therapeutics Ltd Novel compounds an therapeutic uses thereof
CN112300247B (zh) * 2019-07-24 2022-12-27 广东东阳光药业有限公司 一种Teixobactin类似物及其用途
JP7045520B2 (ja) * 2020-01-02 2022-03-31 上海上薬第一生化薬業有限公司 ポリミキシンｂ成分又はその塩、その製造方法及び使用
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
JP7755347B2 (ja) * 2021-07-21 2025-10-16 シャンハイ ミクウルク ファーマシューティカル シーオー．エルティーディー 腎癌の標的治療のための新規化合物及び組成物
US20250109171A1 (en) * 2021-07-21 2025-04-03 Shanghai MICURX Pharmaceuticals Co., Ltd. Compounds and compositions for targeted therapy of renal diseases

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CN104086633A (zh) * 2008-02-08 2014-10-08 北方抗生素有限公司 短链脂肪酸尾多粘菌素衍生物及其用途

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DE1906699A1 (de) 1968-02-12 1970-02-05 Pfizer Neue Polymyxinderivate und Verfahren zu deren Herstellung
US4091092A (en) 1976-09-20 1978-05-23 E. R. Squibb & Sons, Inc. Polymyxin F and process of producing polymyxin F
JPS5831918B2 (ja) 1976-10-27 1983-07-09 塩野義製薬株式会社 新規抗生物質ポリミキシンｓ↓１
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BRPI0715095B8 (pt) 2006-08-11 2021-05-25 Northern Antibiotics Oy derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i).
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WO2013112548A1 (en) 2012-01-23 2013-08-01 University Of South Florida Gamma-aapeptides with potent and broad-spectrum antimicrobial activity
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JP6334546B2 (ja) 2012-10-18 2018-05-30 ダウ グローバル テクノロジーズ エルエルシー リン含有カルボン酸アルミニウム塩難燃剤
KR20150107793A (ko) 2013-01-11 2015-09-23 셀리아 파마슈티칼즈 에이피에스 폴리믹신, 조성물, 제조 방법 및 사용 방법
CN103923190B (zh) 2013-01-14 2018-04-03 上海医药工业研究院 从多黏菌素b的混合组分中分离纯化多黏菌素b1的方法
KR102354902B1 (ko) * 2013-05-22 2022-01-24 에버레스트 메디신즈 (싱가포르) 피티이. 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
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CN104086633A (zh) * 2008-02-08 2014-10-08 北方抗生素有限公司 短链脂肪酸尾多粘菌素衍生物及其用途
CN103044529A (zh) * 2012-12-06 2013-04-17 山东鲁抗医药股份有限公司 一种在硫酸多粘菌素b中提取b1单组份的方法

Also Published As

Publication number Publication date
JP2018502845A (ja) 2018-02-01
KR20170086671A (ko) 2017-07-26
JP6896628B2 (ja) 2021-06-30
WO2016100578A2 (en) 2016-06-23
KR102585108B1 (ko) 2023-10-05
US20160185823A1 (en) 2016-06-30
EP3233889A2 (en) 2017-10-25
EP3233889B1 (en) 2022-07-06
ES2924058T3 (es) 2022-10-04
WO2016100578A3 (en) 2016-08-11
CN107257803A (zh) 2017-10-17
CA2970546A1 (en) 2016-06-23
US9771394B2 (en) 2017-09-26

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Effective date of registration: 20200811

Address after: 3 / F, building B, 1976 Gaoke Middle Road, Pudong New Area, Shanghai

Applicant after: Shanghai Mengke Pharmaceutical Co.,Ltd.

Address before: Georgetown, Grand Cayman, Cayman Islands

Applicant before: Mercer pharmaceutical technologies (Cayman Islands)

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Address after: Room B301, 3rd floor, building 1, no.1976, Gaoke Middle Road, free trade zone, Pudong New Area, Shanghai 201203

Applicant after: Shanghai mengke Pharmaceutical Co.,Ltd.

Address before: 201203 3rd floor, building B, 1976 Gaoke Middle Road, Pudong New Area, Shanghai

Applicant before: Shanghai Mengke Pharmaceutical Co.,Ltd.

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