CN107257803B - 用于治疗细菌感染的多粘菌素类抗菌剂 - Google Patents

用于治疗细菌感染的多粘菌素类抗菌剂 Download PDF

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Publication number
CN107257803B
CN107257803B CN201580075652.4A CN201580075652A CN107257803B CN 107257803 B CN107257803 B CN 107257803B CN 201580075652 A CN201580075652 A CN 201580075652A CN 107257803 B CN107257803 B CN 107257803B
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alkyl
aryl
atoms
compound
diaryl
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Chinese (zh)
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CN107257803A (zh
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M·F·高德福
刘进前
王星海
袁征宇
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Shanghai Mengke Pharmaceutical Co ltd
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Shanghai Mengke Pharmaceutical Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
CN201580075652.4A 2014-12-16 2015-12-16 用于治疗细菌感染的多粘菌素类抗菌剂 Active CN107257803B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462092780P 2014-12-16 2014-12-16
US62/092,780 2014-12-16
PCT/US2015/066210 WO2016100578A2 (en) 2014-12-16 2015-12-16 Antimicrobial polymyxins for treatment of bacterial infections

Publications (2)

Publication Number Publication Date
CN107257803A CN107257803A (zh) 2017-10-17
CN107257803B true CN107257803B (zh) 2021-02-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580075652.4A Active CN107257803B (zh) 2014-12-16 2015-12-16 用于治疗细菌感染的多粘菌素类抗菌剂

Country Status (8)

Country Link
US (1) US9771394B2 (https=)
EP (1) EP3233889B1 (https=)
JP (1) JP6896628B2 (https=)
KR (1) KR102585108B1 (https=)
CN (1) CN107257803B (https=)
CA (1) CA2970546A1 (https=)
ES (1) ES2924058T3 (https=)
WO (1) WO2016100578A2 (https=)

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WO2017189866A1 (en) * 2016-04-27 2017-11-02 Spero Opco Polymyxin analogs useful as antibiotic potentiators
EP3388445A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Peptide macrocycles and use thereof in the treatment of bacterial infections
AU2018359018B2 (en) 2017-11-02 2022-11-24 The University Of Queensland Peptide antibiotics
US20210261621A1 (en) * 2018-06-12 2021-08-26 University Of Manitoba Preparation of Dilipid Polymixins and Use Thereof as Antimicrobial Adjuvants
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
GB201904534D0 (en) * 2019-04-01 2019-05-15 Centauri Therapeutics Ltd Novel compounds an therapeutic uses thereof
EP4004015A4 (en) 2019-07-24 2023-07-26 Sunshine Lake Pharma Co., Ltd. TEIXOBACTIN ANALOG AND ITS USE
JP7045520B2 (ja) * 2020-01-02 2022-03-31 上海上薬第一生化薬業有限公司 ポリミキシンｂ成分又はその塩、その製造方法及び使用
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
JP7755347B2 (ja) * 2021-07-21 2025-10-16 シャンハイ ミクウルク ファーマシューティカル シーオー．エルティーディー 腎癌の標的治療のための新規化合物及び組成物
EP4373836A4 (en) * 2021-07-21 2025-10-22 Shanghai Micurx Pharmaceutical Co Ltd COMPOUNDS AND COMPOSITIONS FOR TARGETED THERAPY OF KIDNEY DISEASES

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CN101010336A (zh) * 2004-07-01 2007-08-01 生物资源药物股份有限公司 肽类抗生素和制备它们的方法
CN103044529A (zh) * 2012-12-06 2013-04-17 山东鲁抗医药股份有限公司 一种在硫酸多粘菌素b中提取b1单组份的方法
CN104086633A (zh) * 2008-02-08 2014-10-08 北方抗生素有限公司 短链脂肪酸尾多粘菌素衍生物及其用途

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DE1906699A1 (de) 1968-02-12 1970-02-05 Pfizer Neue Polymyxinderivate und Verfahren zu deren Herstellung
US4091092A (en) 1976-09-20 1978-05-23 E. R. Squibb & Sons, Inc. Polymyxin F and process of producing polymyxin F
JPS5831918B2 (ja) 1976-10-27 1983-07-09 塩野義製薬株式会社 新規抗生物質ポリミキシンｓ↓１
US6380356B1 (en) 1999-12-07 2002-04-30 Advanced Medicine, Inc. Multivalent polymyxin antibiotics
WO2006045156A1 (en) 2004-10-29 2006-05-04 Monash University Therapy for multi-drug resistant microorganisms
KR100750658B1 (ko) 2005-12-09 2007-08-20 한국생명공학연구원 폴리믹신 생합성 효소 및 이를 코딩하는 유전자 군
US7807637B2 (en) 2006-08-11 2010-10-05 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
HUE028271T2 (en) 2006-08-11 2016-12-28 Northern Antibiotics Oy Polymixin derivatives and their applications
US8193148B2 (en) 2008-02-08 2012-06-05 Northern Antibiotics Ltd. Short fatty acid tail polymyxin derivatives and uses thereof
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TW201035111A (en) 2008-12-23 2010-10-01 Biosource Pharm Inc Antibiotic compositions for the treatment of gram negative infections
WO2010091294A2 (en) 2009-02-05 2010-08-12 The Regents Of The University Of California New targeted antimicrobial moieties
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WO2013112548A1 (en) 2012-01-23 2013-08-01 University Of South Florida Gamma-aapeptides with potent and broad-spectrum antimicrobial activity
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US9353246B2 (en) 2012-10-18 2016-05-31 Dow Global Technologies Llc Phosphorous-containing aluminum carboxylate salt flame retardants
EP2943503B1 (en) 2013-01-11 2017-08-23 Xellia Pharmaceuticals ApS Polymyxins, compositions, methods of making and methods of use
CN103923190B (zh) 2013-01-14 2018-04-03 上海医药工业研究院 从多黏菌素b的混合组分中分离纯化多黏菌素b1的方法
JP6643758B2 (ja) 2013-05-22 2020-02-12 スペロ・セラピューティクス・インコーポレーテッド 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用
WO2015031602A1 (en) 2013-08-29 2015-03-05 Rhk Technology, Inc. Optical alignment interface
RU2740190C2 (ru) * 2014-03-11 2021-01-12 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
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Patent Citations (3)

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CN101010336A (zh) * 2004-07-01 2007-08-01 生物资源药物股份有限公司 肽类抗生素和制备它们的方法
CN104086633A (zh) * 2008-02-08 2014-10-08 北方抗生素有限公司 短链脂肪酸尾多粘菌素衍生物及其用途
CN103044529A (zh) * 2012-12-06 2013-04-17 山东鲁抗医药股份有限公司 一种在硫酸多粘菌素b中提取b1单组份的方法

Also Published As

Publication number Publication date
EP3233889B1 (en) 2022-07-06
CN107257803A (zh) 2017-10-17
CA2970546A1 (en) 2016-06-23
JP2018502845A (ja) 2018-02-01
US9771394B2 (en) 2017-09-26
ES2924058T3 (es) 2022-10-04
US20160185823A1 (en) 2016-06-30
WO2016100578A2 (en) 2016-06-23
KR20170086671A (ko) 2017-07-26
EP3233889A2 (en) 2017-10-25
JP6896628B2 (ja) 2021-06-30
KR102585108B1 (ko) 2023-10-05
WO2016100578A3 (en) 2016-08-11

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Effective date of registration: 20200811

Address after: 3 / F, building B, 1976 Gaoke Middle Road, Pudong New Area, Shanghai

Applicant after: Shanghai Mengke Pharmaceutical Co.,Ltd.

Address before: Georgetown, Grand Cayman, Cayman Islands

Applicant before: Mercer pharmaceutical technologies (Cayman Islands)

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Address after: Room B301, 3rd floor, building 1, no.1976, Gaoke Middle Road, free trade zone, Pudong New Area, Shanghai 201203

Applicant after: Shanghai mengke Pharmaceutical Co.,Ltd.

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Applicant before: Shanghai Mengke Pharmaceutical Co.,Ltd.

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