CN107249601A - 改善细胞治疗的方法 - Google Patents

改善细胞治疗的方法 Download PDF

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Publication number
CN107249601A
CN107249601A CN201580076144.8A CN201580076144A CN107249601A CN 107249601 A CN107249601 A CN 107249601A CN 201580076144 A CN201580076144 A CN 201580076144A CN 107249601 A CN107249601 A CN 107249601A
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cells
population
selectin
tissue
cell
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Chinese (zh)
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R·萨克斯滕
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The Brigham and Women's Hospital Inc
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The Brigham and Women's Hospital Inc
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Priority to CN202310228900.0A priority Critical patent/CN116327805A/zh
Publication of CN107249601A publication Critical patent/CN107249601A/zh
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CN201580076144.8A 2014-12-30 2015-12-29 改善细胞治疗的方法 Pending CN107249601A (zh)

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CN202310228900.0A CN116327805A (zh) 2014-12-30 2015-12-29 改善细胞治疗的方法

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US201462098048P 2014-12-30 2014-12-30
US62/098,048 2014-12-30
US201562101863P 2015-01-09 2015-01-09
US62/101,863 2015-01-09
PCT/US2015/067873 WO2016109543A1 (en) 2014-12-30 2015-12-29 Methods to improve cell therapy

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CN (2) CN107249601A (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113316633A (zh) * 2018-12-14 2021-08-27 普罗米瑟拉疗法公司 包含表达hla-e的肝祖细胞的细胞组合物
CN114158275A (zh) * 2019-05-03 2022-03-08 香港大学 腹膜转移细胞的检测和分离方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3024869A1 (en) * 2016-05-20 2017-11-23 Robert Sackstein Glycoengineering of e-selectin ligands
AU2017281631B2 (en) * 2016-06-23 2023-06-15 Tithon Biotech, Inc. Cells expressing parathyroid hormone 1 receptor and uses thereof
CN118662615A (zh) 2017-03-15 2024-09-20 浩康生物系统公司 用于造血干细胞移植的组合物和方法
EP3773629A4 (en) * 2018-03-27 2022-01-19 AZTherapies, Inc. CAR-TREG-BASED THERAPIES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
WO2019213495A1 (en) * 2018-05-04 2019-11-07 Spinalcyte, Llc Intradiscal t-regulatory cell administration for treatment of disc degenerative disease
CN112280734A (zh) * 2018-05-17 2021-01-29 广东芙金干细胞再生医学有限公司 一种外泌体的制备方法及含有外泌体的干细胞增殖试剂
WO2019245904A1 (en) * 2018-06-18 2019-12-26 The Brigham And Women's Hospital Compositions and methods for production of exofucosylated cells for clinical applications
AU2021276312A1 (en) * 2020-05-18 2022-12-22 Robert Sackstein Compositions and methods for treatment of inflammatory disorders
TWI883563B (zh) * 2022-09-30 2025-05-11 中國醫藥大學 細胞植體與類膠原蛋白之多功能胜肽組合物及其應用
IL322061A (en) * 2023-01-13 2025-09-01 The Brigham And Womens Hospital Compositions and methods for identifying and isolating human hematopoietic stem and progenitor cells
WO2026010977A1 (en) * 2024-07-01 2026-01-08 Robert Sackstein Compositions and methods for treatment of human diseases with glycocalyx-modified mesenchymal stem cells

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006068720A2 (en) * 2004-11-12 2006-06-29 The Brigham And Women's Hospital, Inc. Hematopoietic cell selectin ligand polypeptides and methods of use thereof
WO2007005180A2 (en) * 2005-06-29 2007-01-11 Advanced Cardiovascular Systems, Inc. Method for enhancing engraftment of therapeutic cells at a target site
WO2007143204A2 (en) * 2006-06-02 2007-12-13 Sacktein Robert Compositions and methods for modifying cell surface glycans
WO2008011094A2 (en) * 2006-07-18 2008-01-24 Robert Sackstein Cytokine induction of selectin ligands on cells
US20140161782A1 (en) * 2008-06-09 2014-06-12 Targazyme, Inc. Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU782952C (en) * 1999-08-25 2006-09-07 Altarex Medical Corp. Therapeutic immune condition compositions and methods
ES2338757T3 (es) 2000-10-18 2010-05-12 The Brigham And Women's Hospital, Inc. Polipeptidos ligandos para selectina-e/selectina-l de la celula hematopoyetica y metodos de utilizacion de los mismos.
WO2006015209A2 (en) * 2004-07-29 2006-02-09 Stem Cell Innovations, Inc. Differentiation of stem cells
WO2007127408A2 (en) * 2006-04-28 2007-11-08 Tulane University Health Sciences Center Methods for treating diabetes
WO2009134866A2 (en) 2008-04-29 2009-11-05 The Brigham And Women's Hospital, Inc. Cell membrane engineering
WO2011068909A2 (en) 2009-12-01 2011-06-09 Brigham And Women's Hospital, Inc. Aptamer cell compositions
CN114540266A (zh) * 2014-07-07 2022-05-27 塔尔加泽梅股份有限公司 用于治疗用途的岩藻糖基化细胞的制备和冷冻干燥

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006068720A2 (en) * 2004-11-12 2006-06-29 The Brigham And Women's Hospital, Inc. Hematopoietic cell selectin ligand polypeptides and methods of use thereof
WO2007005180A2 (en) * 2005-06-29 2007-01-11 Advanced Cardiovascular Systems, Inc. Method for enhancing engraftment of therapeutic cells at a target site
WO2007143204A2 (en) * 2006-06-02 2007-12-13 Sacktein Robert Compositions and methods for modifying cell surface glycans
WO2008011094A2 (en) * 2006-07-18 2008-01-24 Robert Sackstein Cytokine induction of selectin ligands on cells
US20140161782A1 (en) * 2008-06-09 2014-06-12 Targazyme, Inc. Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113316633A (zh) * 2018-12-14 2021-08-27 普罗米瑟拉疗法公司 包含表达hla-e的肝祖细胞的细胞组合物
CN114158275A (zh) * 2019-05-03 2022-03-08 香港大学 腹膜转移细胞的检测和分离方法

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