HK1245132A1 - 改善細胞治療的方法 - Google Patents

改善細胞治療的方法

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Publication number
HK1245132A1
HK1245132A1 HK18104812.8A HK18104812A HK1245132A1 HK 1245132 A1 HK1245132 A1 HK 1245132A1 HK 18104812 A HK18104812 A HK 18104812A HK 1245132 A1 HK1245132 A1 HK 1245132A1
Authority
HK
Hong Kong
Prior art keywords
methods
cell therapy
improve cell
improve
therapy
Prior art date
Application number
HK18104812.8A
Other languages
English (en)
Inventor
R‧薩克斯滕
Original Assignee
布裏格海姆婦女醫院公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 布裏格海姆婦女醫院公司 filed Critical 布裏格海姆婦女醫院公司
Publication of HK1245132A1 publication Critical patent/HK1245132A1/zh

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HK18104812.8A 2014-12-30 2018-04-12 改善細胞治療的方法 HK1245132A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098048P 2014-12-30 2014-12-30
US201562101863P 2015-01-09 2015-01-09
PCT/US2015/067873 WO2016109543A1 (en) 2014-12-30 2015-12-29 Methods to improve cell therapy

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HK1245132A1 true HK1245132A1 (zh) 2018-08-24

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US (3) US10471103B2 (zh)
EP (2) EP4012024A1 (zh)
JP (3) JP6963500B2 (zh)
KR (2) KR20230127358A (zh)
CN (2) CN116327805A (zh)
AU (2) AU2015374198B2 (zh)
BR (1) BR112017014361B1 (zh)
CA (2) CA3202385A1 (zh)
HK (1) HK1245132A1 (zh)
SG (2) SG10202013095YA (zh)
WO (1) WO2016109543A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190201444A1 (en) * 2016-05-20 2019-07-04 Robert Sackstein Glycoengineering of e-selectin ligands
EP3595683A1 (en) 2017-03-15 2020-01-22 Orca Biosystems, Inc. Compositions and methods for hematopoietic stem cell transplants
US20210023137A1 (en) * 2018-03-27 2021-01-28 Smith Therapeutics Inc. Car-treg-based therapies for treating neurodegenerative diseases
EP3787646A4 (en) * 2018-05-04 2021-12-15 Spinalcyte, LLC INTRADISCAL ADMINISTRATION OF T REGULATORY CELLS FOR THE TREATMENT OF DEGENERATIVE DISCOPATHY
CN112280734A (zh) * 2018-05-17 2021-01-29 广东芙金干细胞再生医学有限公司 一种外泌体的制备方法及含有外泌体的干细胞增殖试剂
WO2019245904A1 (en) * 2018-06-18 2019-12-26 The Brigham And Women's Hospital Compositions and methods for production of exofucosylated cells for clinical applications
MX2021006773A (es) * 2018-12-14 2021-09-21 Promethera Therapeutics Sa Composicion celular que comprende celulas progenitoras del higado que expresan hla-e.
WO2020224450A1 (en) * 2019-05-03 2020-11-12 The University Of Hong Kong Method for peritoneal metastatic cell detection and isolation thereof
EP4153616A4 (en) * 2020-05-18 2024-08-21 Robert Sackstein COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS
TW202421097A (zh) * 2022-09-30 2024-06-01 中國醫藥大學 細胞植體與類膠原蛋白之多功能胜肽組合物及其應用
WO2024152043A1 (en) * 2023-01-13 2024-07-18 The Brigham And Women's Hospital Compositions and methods for identifying and isolating human hematopoietic stem and progenitor cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60140903D1 (de) 2000-10-18 2010-02-04 Brigham & Womens Hospital E-selectin/l-selectin-liganden-polypeptide hämatopoetischer zellen und verfahren zu deren verwendung
WO2006068720A2 (en) * 2004-11-12 2006-06-29 The Brigham And Women's Hospital, Inc. Hematopoietic cell selectin ligand polypeptides and methods of use thereof
US20070003528A1 (en) * 2005-06-29 2007-01-04 Paul Consigny Intracoronary device and method of use thereof
CA2650638A1 (en) * 2006-04-28 2007-11-08 Tulane University Health Sciences Center Methods for treating diabetes
AU2007254777B2 (en) 2006-06-02 2014-02-20 Robert Sackstein Compositions and methods for modifying cell surface glycans
WO2008011094A2 (en) * 2006-07-18 2008-01-24 Robert Sackstein Cytokine induction of selectin ligands on cells
JP2011518888A (ja) 2008-04-29 2011-06-30 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド 細胞膜改変
US20140161782A1 (en) * 2008-06-09 2014-06-12 Targazyme, Inc. Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase
US20130040837A1 (en) 2009-12-01 2013-02-14 Brigham And Women's Hospital, Inc. Aptamer cell compositions
US20170121673A1 (en) * 2014-07-07 2017-05-04 Targazyme, Inc. Manufacture and Cryopreservation of Fucosylated Cells for Therapeutic Use

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AU2015374198A1 (en) 2017-07-27
US10471103B2 (en) 2019-11-12
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US20200281985A1 (en) 2020-09-10
WO2016109543A1 (en) 2016-07-07
KR20230127358A (ko) 2023-08-31
JP2022003094A (ja) 2022-01-11
EP3240893B1 (en) 2021-09-01
US20160184367A1 (en) 2016-06-30
AU2022201482A1 (en) 2022-03-24
CN116327805A (zh) 2023-06-27
US20230138484A1 (en) 2023-05-04
BR112017014361A2 (pt) 2018-01-02
KR102569540B1 (ko) 2023-08-22
SG11201705401YA (en) 2017-08-30
CA2972899A1 (en) 2016-07-07
CA3202385A1 (en) 2016-07-07
CN107249601A (zh) 2017-10-13
JP7339990B2 (ja) 2023-09-06
US12090173B2 (en) 2024-09-17
BR112017014361B1 (pt) 2023-10-31
JP2023156522A (ja) 2023-10-24
CA2972899C (en) 2023-08-08
JP2018502117A (ja) 2018-01-25
AU2015374198B2 (en) 2021-12-23
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