CN107190034A - 生产蛋白质的方法 - Google Patents

生产蛋白质的方法 Download PDF

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Publication number
CN107190034A
CN107190034A CN201710499437.8A CN201710499437A CN107190034A CN 107190034 A CN107190034 A CN 107190034A CN 201710499437 A CN201710499437 A CN 201710499437A CN 107190034 A CN107190034 A CN 107190034A
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China
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cell
cell culture
culture
suspension
filter assemblies
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CN201710499437.8A
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English (en)
Chinese (zh)
Inventor
J.罗班
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Novo Nordisk AS
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Novo Nordisk AS
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43735957&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN107190034(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CN107190034A publication Critical patent/CN107190034A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201710499437.8A 2010-10-05 2011-10-05 生产蛋白质的方法 Pending CN107190034A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10186545.9 2010-10-05
EP10186545 2010-10-05
US39271310P 2010-10-13 2010-10-13
US61/392713 2010-10-13
CN2011800482244A CN103154233A (zh) 2010-10-05 2011-10-05 生产蛋白质的方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2011800482244A Division CN103154233A (zh) 2010-10-05 2011-10-05 生产蛋白质的方法

Publications (1)

Publication Number Publication Date
CN107190034A true CN107190034A (zh) 2017-09-22

Family

ID=43735957

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201710499437.8A Pending CN107190034A (zh) 2010-10-05 2011-10-05 生产蛋白质的方法
CN2011800482244A Pending CN103154233A (zh) 2010-10-05 2011-10-05 生产蛋白质的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011800482244A Pending CN103154233A (zh) 2010-10-05 2011-10-05 生产蛋白质的方法

Country Status (7)

Country Link
US (1) US10138290B2 (https=)
EP (2) EP2625262B1 (https=)
JP (2) JP6282467B2 (https=)
CN (2) CN107190034A (https=)
ES (1) ES2556454T3 (https=)
PL (1) PL2625262T3 (https=)
WO (1) WO2012045769A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111263631A (zh) * 2017-10-26 2020-06-09 瑞普利金公司 微型交替切向流灌注过滤器、处理容器及其使用方法
WO2021008571A1 (zh) * 2019-07-16 2021-01-21 信达生物制药(苏州)有限公司 高密度连续接种的细胞培养方法及其应用

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* Cited by examiner, † Cited by third party
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CN104583386A (zh) * 2012-08-20 2015-04-29 泰尔茂比司特公司 浓缩穿过细胞生长腔室循环的流体的组分
KR102245547B1 (ko) * 2013-09-30 2021-04-28 얀센 백신스 앤드 프리벤션 비.브이. 고밀도의 미정제 세포 배양 수거물의 정화를 위한 방법
JP6530171B2 (ja) * 2014-09-09 2019-06-12 旭化成メディカル株式会社 培養産生物の回収方法
JP7102391B2 (ja) * 2016-07-25 2022-07-19 レプリゲン・コーポレイション 交互タンジェンシャルフローによる高速収穫
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
CN108504562A (zh) * 2018-06-21 2018-09-07 江苏澳创生物科技有限公司 一种发酵生产l-苏氨酸的系统及其应用

Citations (2)

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CN101490239A (zh) * 2006-07-14 2009-07-22 帝斯曼知识产权资产管理有限公司 改进的细胞培养方法
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DE3785102T2 (de) 1986-01-03 1993-07-22 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
CA1331157C (en) 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
US4956080A (en) * 1987-08-03 1990-09-11 Microlift Systems, Incorporated High pressure oxygen-saturated water treatment apparatus
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111263631A (zh) * 2017-10-26 2020-06-09 瑞普利金公司 微型交替切向流灌注过滤器、处理容器及其使用方法
US11946033B2 (en) 2017-10-26 2024-04-02 Repligen Corporation Micro alternating tangential flow perfusion filter, micro bioreactor, and methods of use thereof
WO2021008571A1 (zh) * 2019-07-16 2021-01-21 信达生物制药(苏州)有限公司 高密度连续接种的细胞培养方法及其应用
CN114127260A (zh) * 2019-07-16 2022-03-01 信达生物制药(苏州)有限公司 高密度连续接种的细胞培养方法及其应用

Also Published As

Publication number Publication date
ES2556454T3 (es) 2016-01-18
EP2625262A1 (en) 2013-08-14
JP6282467B2 (ja) 2018-02-21
US20130244283A1 (en) 2013-09-19
EP2625262B1 (en) 2015-09-23
JP2016187360A (ja) 2016-11-04
WO2012045769A1 (en) 2012-04-12
JP2013538588A (ja) 2013-10-17
PL2625262T3 (pl) 2016-05-31
EP2957628A1 (en) 2015-12-23
US10138290B2 (en) 2018-11-27
CN103154233A (zh) 2013-06-12

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Application publication date: 20170922