CN107184913A - Treat Chinese medicine composition of rheumatoid arthritis and preparation method thereof - Google Patents
Treat Chinese medicine composition of rheumatoid arthritis and preparation method thereof Download PDFInfo
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- CN107184913A CN107184913A CN201710501949.3A CN201710501949A CN107184913A CN 107184913 A CN107184913 A CN 107184913A CN 201710501949 A CN201710501949 A CN 201710501949A CN 107184913 A CN107184913 A CN 107184913A
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Abstract
The invention provides a kind of Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：10 ~ 30 parts of cassia twig, 10 ~ 30 parts of the root of herbaceous peony, 5 ~ 20 parts of west safflower, 5 ~ 20 parts of dragon's blood, 5 ~ 20 parts of folium artemisiae argyi, 3 ~ 15 parts of swordleaf cymbidium leaf, 3 ~ 15 parts of certain herbaceous plants with big flowers of match, 3 ~ 15 parts of pine mushroom, 3 ~ 15 parts of turmeric, 1 ~ 10 part of myrrh, 1 ~ 10 part of the root bark of shaggy-fruited dittany.The present invention is cooperateed with using theory of traditional Chinese medical science as guidance by medicine, realizes the neutralizing of the stagnant state of the joint stasis of blood, improves blood vessel and muscular states, dredges plan and control, and damp dispelling and pain relieving realizes the purpose for the treatment of rheumatoid arthritis, is made joint recovery " cleaning " state, is improved joint circulation.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to a kind of Chinese medicine composition for treating rheumatoid arthritis and
Its preparation method.
Background technology
Rheumatoid arthritis (rheumatoidarthritis, RA) is a kind of chronic, inflammatory, systemic autoimmune
Disease, shows as joint continuation and the synovitis of progressive, then causes cartilage destruction and bone erosion, cause joint deformity,
Deformity, the final disability of severe patient or even self care ability.The disease is apt to occur in the Minor articulus such as hand, wrist, foot, sends out repeatedly
Make, be symmetric.There are joint red and swollen heat pain and dysfunction early stage, and advanced joint may occur in which different degrees of stiff deformity,
And with Bones and joints narrow gaps or fusion and the atrophy of skeletal muscle, easily disable, life and the health care belt to patient come serious
Harm, therefore to effectively treat measure particularly significant for selection.
Rheumatoid arthritis belongs to the category such as its " stupid numbness ", " severe and migratory arthralgia " in traditional Chinese medicine numbness disease.More because battalion defends imbalance, evil visitor's warp
The stasis of blood is made in arteries and veins, QI and blood being obstructed, stasis, and deep volt bone joint is deadlocked not understand, inducing muscle, muscles and bones, joint Fa Sheng Acid pains, it is numb, weigh,
Joint stuffiness, scorching hot stiff, tetanic, the lopsided and limitation of activity of arthrocele.Modern pathology think that rheumatoid arthritis is
One kind mainly involves synovium of joint (can feed through to articular cartilage, bone tissue, articular ligament and tendon forceps later), next serous coat, the heart,
The popularity diseases associated with inflammation of the connective tissue such as lung and eye.The systemic manifestation of rheumatoid arthritis is in addition to arthropathy, also
There are heating, fatigue and weak, subcutaneous nodule, pleurisy, arteritis, peripheral neuropathy etc..The rheumatoid arthritis of broad sense is removed
Outside the inflammatory disorderses of joint part, include the popularity lesion of whole body.Do not have still to rheumatoid arthritis clinically at present
The measure cured completely.
Publication No. CN105641295A patent provides a kind of pharmaceutical composition and in rheumatic arthritis treatment
Application, pharmaceutical composition is made up of the bulk drug of following masses part：10-70 parts of cassia twig, 10-50 parts of Ligusticum wallichii, dragon's blood 10-50
Part, 10-50 parts of the root of herbaceous peony, 10-50 parts of chrysanthemum, 10-50 parts of notopterygium root, 10-40 parts of the root of kudzu vine, 10-50 parts of grass-leaved sweetflag, Radix Angelicae Sinensis tail 5-30
Part, any conventional internal dosage form can be made into.The technical scheme of the invention is used to treat rheumatic arthritis, with promoting blood circulation
Stagnation resolvation, dispelling wind and removing obstruction in the meridians, the efficiency of swelling and pain relieving, have no toxic side effect, can long-term taking.The invention is to caused by rheumatic arthritis
Complication is without alleviation or therapeutic action.
Publication No. CN106798906A patent provides a kind of tincture dose medicament for treating rheumatoid arthritis, the medicine
Each component and its mass parts ratio of thing are as follows：3 ~ 12g of radix aconiti sinensis, 3 ~ 12g of RADIX ACONITI KUSNEZIFFII, 3 ~ 12g of the tuber of pinellia, 3 ~ 12g of cassia twig, Tian Nan
3 ~ 12g of star, 6 ~ 12g of the wind-weed, 3 ~ 10g of vomiting nut, 5 ~ 12g of the root of herbaceous peony, 3 ~ 10g of datura flower, windproof 8 ~ 16g, 3 ~ 10g of pseudo-ginseng, dragon's blood 3
~ 8g, 15 ~ 25g of reticulate millettia, 3 ~ 10g of Ligusticum wallichii, 3 ~ 10g of turmeric, 5 ~ 15g of safflower, 8 ~ 20g of corydalis tuber, 4 ~ 15g of the radix paeoniae rubrathe, vinegar pangolin
5 ~ 10g, 3 ~ 15g of the root of Dahurain angelica, 5 ~ 16g of frankincense, 6 ~ 10g of rhizoma alismatis, 5 ~ 20g of myrrh, 1 ~ 10g of camphor, 1.5 ~ 3g of MEIHUA BINGPIAN, ginger 3 ~
10g；The medicine that the invention is provided is a Chinese prescription treated both principal and secondary aspect of disease.Invention formula medicinal material species used is more, pharmacology
Not clear, a variety of medicinal materials have toxicity, and security is not high, and single tincture external application is for treatment moderate or severe rheumatoid
For arthritic, curative effect is poor.
The content of the invention
In view of this, the technical problems to be solved by the invention are to provide a kind of Chinese traditional medicine composition for treating rheumatoid arthritis
Thing, formula safety is evident in efficacy, has no toxic side effect, and have active prevention effect to pulmonary complication.
To achieve the above object, the technical solution adopted in the present invention is：
A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：10 ~ 30 parts of cassia twig, the root of herbaceous peony
10 ~ 30 parts, 5 ~ 20 parts of west safflower, 5 ~ 20 parts of dragon's blood, 5 ~ 20 parts of folium artemisiae argyi, 3 ~ 15 parts of swordleaf cymbidium leaf, match 3 ~ 15 parts of certain herbaceous plants with big flowers, pine mushroom 3 ~ 15
Part, 3 ~ 15 parts of turmeric, 1 ~ 10 part of myrrh, 1 ~ 10 part of the root bark of shaggy-fruited dittany.
Preferably, the Chinese medicine composition of the treatment rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig 15
~ 25 parts, 15 ~ 25 parts of the root of herbaceous peony, 10 ~ 15 parts of west safflower, 10 ~ 15 parts of dragon's blood, 10 ~ 15 parts of folium artemisiae argyi, 6 ~ 12 parts of swordleaf cymbidium leaf, match certain herbaceous plants with big flowers 6 ~ 12
Part, 6 ~ 12 parts of pine mushroom, 6 ~ 12 parts of turmeric, 4 ~ 8 parts of myrrh, 4 ~ 8 parts of the root bark of shaggy-fruited dittany.
Preferably, the Chinese medicine composition of the treatment rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig 20
Part, 20 parts of the root of herbaceous peony, 12 parts of west safflower, 12 parts of dragon's blood, 12 parts of folium artemisiae argyi, 9 parts of swordleaf cymbidium leaf, 9 parts of certain herbaceous plants with big flowers of match, 9 parts of pine mushroom, 9 parts of turmeric, do not have
6 parts of medicine, 6 parts of the root bark of shaggy-fruited dittany.
The preparation method of the Chinese medicine composition of above-mentioned treatment rheumatoid arthritis, comprises the following steps：
Step S1：Dry cassia twig, the root of herbaceous peony, west safflower, dragon's blood, folium artemisiae argyi, swordleaf cymbidium leaf and match certain herbaceous plants with big flowers are weighed respectively, are crushed, mixing, plus
Enter the water of 4 ~ 6 times of weight, microwave treatment 30 ~ 40 minutes is filtrated to get filtrate I and filter residue；4 ~ 6 times of its weight is added in filter residue
Edible alcohol, be heated to reflux 2 ~ 3 times, 30 ~ 40 minutes every time, filter respectively, each filtrate merges to obtain filtrate II, by the filter
Liquid II is mixed with the filtrate I, and lotion I is condensed into after reclaiming edible alcohol；
Step S2：Dry pine mushroom, turmeric, myrrh and the root bark of shaggy-fruited dittany are weighed, crushes, adds water, the water and the raw material after crushing
Weight ratio is 6 ~ 8:1, decoct 45 ~ 60 minutes, filter to obtain decoction liquor, the decoction liquor is condensed into lotion II；
Step S3：The lotion I and lotion II are merged, dried, ultramicro grinding obtains Ultramicro-powder.
Preferably, the step S3 also includes：The auxiliary material relative to its quality 2 ~ 5% is added in the Ultramicro-powder, is mixed
Close, pelletize, dry, obtain granule.
Preferably, the frequency of the microwave treatment is 25 ~ 30kHz, and power is 700 ~ 800W, and temperature is 50 ~ 60 DEG C.
Preferably, the volume fraction of ethanol is 95% in the edible alcohol.
Preferably, the lotion I and lotion II are 1.20 ~ 1.26 in 75 DEG C of relative density.
Preferably, the auxiliary material is using weight ratio as 1 by microcrystalline cellulose and magnesium stearate：The mixture of 0.4 ~ 1 composition.
A kind of Chinese medicine preparation for treating rheumatoid arthritis, Chinese medicine composition using above-mentioned treatment rheumatoid arthritis is has
Composition is imitated, oral formulations are made.
Compared with prior art, beneficial effects of the present invention are as follows：
1）The present invention has activating muscle and blood, promoting blood circulation and removing blood stasis, damp dispelling and pain relieving concurrently using harmonizing yingfen and weifen, strengthening vital QI to eliminate pathogenic factors as main principle of reatment
The effect of, cure mainly muscle caused by rheumatoid arthritis, muscles and bones, joint Fa Sheng Acid pains, it is numb, weigh, joint stuffiness, joint
The symptoms such as scorching hot stiff, tetanic, the lopsided and limitation of activity of enlargement, and the pulmonary complication that thus prevention and treatment trigger, example
Such as：The infection of the upper respiratory tract, pulmonary infection, interstitial pneumonia and pulmonary fibrosis, improve microcirculation, adjust in immunity, the present invention
The pharmacology of each raw medicinal material is as follows：
Cassia twig：For the dry twig of canella Chinese cassia tree.Spring, the harvesting of season in summer two, except defoliation, are dried, or section is dried.Nature and flavor
Acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.Major function sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, flat gas that spins.《This warp is dredged
Card》Record：" all medicines must study carefully its body use, and cassia twig can sharp joint, warming meridians and promoting circulation of qi, this its body.”；
The root of herbaceous peony：For the dry root of ranunculaceae plant Chinese herbaceous peony.Summer, the excavation of season in autumn two, clean, remove end to end and radicula, put in boiling water
Boil, dry again after crust or peeling are removed after boiling.Bitter in taste, acid, is slightly cold.Return liver, the spleen channel.Major function smooth liver and relieve pain, blood-nourishing
Menstruation regulating, astringing YIN to stop sweating；
West safflower, is Iridaceae crocus plant safron CrocussativusL. drying column cap.Nature and flavor are sweet, put down, nothing
Poison.The thoughts of returning home, Liver Channel.Major function is promoting blood circulation and removing blood stasis, removing pattogenic heat from the blood and toxic material from the body, resolving stagnation for tranquilization；
Dragon's blood：Also known as sargentodoxa cuneata, it is the stem of plants of Lardizabalaceae sargentodoxa cuneata.Cure mainly invigorate blood circulation, dispelling wind and eliminating dampness.According to《Chinese book on Chinese herbal medicine》
Record, dragon's blood contains rheum emodin, Physcion, cupreol, Daucosterol, stearic acid, salidroside, dextrorotation syringaresinol two
The compositions such as glycoside, have a certain impact to angiocarpy tool；
Folium artemisiae argyi：The dried leaf ended for feverfew.Nature and flavor toil, temperature is nontoxic.Enter spleen, liver and kidney channel.Rationale blood, by cold-dampness；Temperature
Through hemostasis is antiabortive.Control under trusted subordinate's crymodynia, diarrhea convulsion, protracted dysentery, hematemesis, lower blood, irregular menstruation, uterine bleeding, band, fetal irritability,
Large carbuncle, mange；
Swordleaf cymbidium leaf, is the blade of orchid sword-leaved cymbidium.Whole year can adopt, and using fresh herb or dry use.It is pungent, put down, it is nontoxic.Enter the heart, spleen, lung
Three warps.Heat-clearing, cool blood, qi-regulating, dampness removing.《Detailed outline is picked up any lost article from the road》Record：Logical easypro channels and collaterals, lead ailment said due to cold or exposure off；
Match certain herbaceous plants with big flowers：The herb of certain herbaceous plants with big flowers is matched for malvaceae plant.Nature and flavor micro-sweet；It is cool；It is nontoxic.Channel tropism lung；Liver；Large intestine channel.Major function is clear
Hot dampness removing；Removing toxicity for detumescence.《Guangxi Chinese herbal medicine》：" clearing heat and promoting diuresis, stasis eliminatings detumescence.Control jaundice, dysentery, malaria, children's food stagnation, lung
Heat cough, laryngitis, boil, treating swelling and pain by traumatic injury.”；
Pine mushroom, is the fructification of Tricholomataceae fungi Trichotoma matsutake.Nature and flavor are sweet, flat, nontoxic；Major function is stimulated the circulation of the blood and cause the muscles and joints to relax；Regulating qi-flowing for eliminating phlegm；
Dampness removing is not turbid.Main lumbocrural pain；It is numb in every limb；Grain does not relax；Abundant expectoration shortness of breath；Urine stranguria with turbid discharge；
Turmeric：For the rhizome of zingiberaceous plant turmeric.Section is dried when winter or the early spring take rhizome, cleans, is cooked, drying or be fresh
It is standby.Its shape is in irregular oval or spindle, and 1 ~ 3cm of diameter, surface buff has wrinkle and obvious link, and matter is hard
It is not easily broken in fact, section is pale brown to golden yellow.Pungent, hardship, it is nontoxic, it is warm-natured, enter spleen Liver Channel, it is inducing meastruation to relieve menalgia with blood-activating and qi-promoting
Work(.For caused by energy stagnation and blood stasis chest side of body shouting pain, amenorrhoea, the brachialgia of rheumatism shoulder, tumbling and swelling etc.；
Myrrh：For olive subject plant Chinese violet tree or Ha Didingshu dry resin, pungent, hardship is nontoxic, mild-natured；The thoughts of returning home, liver, spleen
Through；With scattered stasis pain, the effect of detumescence and promoting granulation.It is usually used in chest impediment and cardialgia, gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis , Disorder lumps in the abdomen
Stomachache, arthralgia pain due to rheumatism, traumatic injury, the treatment of the illness such as carbuncle swells sore；
The root bark of shaggy-fruited dittany：For the dry root skin of rutaceae shaggy-fruited dittany.Bitter；It is salty；It is cold；It is nontoxic.Cure mainly heat-clearing and damp-drying drug；Dispelling wind and arresting itching；
Removing toxic substances.Rubella caused by main wind-heat wet poison；Eczema；Mange；Jaundice；Damp-heat arthralgia.
2）A variety of known drawbacks such as the no thoroughness of the invention based on existing western medical treatment, and the course for the treatment of of Chinese traditional treatment are long,
Dose is big, the problems such as slowly effect, it is proposed that one kind formula safety, evident in efficacy, has no toxic side effect, and have to pulmonary complication
There is the Chinese medicine composition of the treatment rheumatoid arthritis of active prevention effect, and there is provided the preparation side of the Chinese medicine composition
Method.The present invention is cooperateed with using theory of traditional Chinese medical science as guidance by medicine, realizes the neutralizing of the stagnant state of the joint stasis of blood, improves blood vessel and muscle
State, dredges plan and control, damp dispelling and pain relieving realizes the purpose for the treatment of rheumatoid arthritis, joint is recovered " cleaning " state, improves and closes
Section circulation.
Embodiment
For a better understanding of the present invention, present disclosure, but this hair are further fairly set out with reference to embodiment
Bright protection content is not limited solely to the following examples.In the following description, give a large amount of concrete details so as to
More thorough understanding of the invention is provided.It will be apparent, however, to one skilled in the art that the present invention can be with
It is carried out without one or more of these details.
Embodiment 1：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig
20 parts, 20 parts of the root of herbaceous peony, 12 parts of west safflower, 12 parts of dragon's blood, 12 parts of folium artemisiae argyi, 9 parts of swordleaf cymbidium leaf, match 9 parts of certain herbaceous plants with big flowers, 9 parts of pine mushroom, 9 parts of turmeric,
6 parts of myrrh, 6 parts of the root bark of shaggy-fruited dittany.
Embodiment 2：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig
15 parts, 15 parts of the root of herbaceous peony, 10 parts of west safflower, 10 parts of dragon's blood, 10 parts of folium artemisiae argyi, 6 parts of swordleaf cymbidium leaf, match certain herbaceous plants with big flowers 6,8 parts of pine mushroom, 8 parts of turmeric, do not have
4 parts of medicine, 4 parts of the root bark of shaggy-fruited dittany.
Embodiment 3：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig
25 parts, 25 parts of the root of herbaceous peony, 15 parts of west safflower, 15 parts of dragon's blood, 15 parts of folium artemisiae argyi, 12 parts of swordleaf cymbidium leaf, match 12 parts of certain herbaceous plants with big flowers, 10 parts of pine mushroom, turmeric
10 parts, 8 parts of myrrh, 8 parts of the root bark of shaggy-fruited dittany.
Embodiment 4：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig
18 parts, 18 parts of the root of herbaceous peony, 12 parts of west safflower, 12 parts of dragon's blood, 12 parts of folium artemisiae argyi, 8 parts of swordleaf cymbidium leaf, match 8 parts of certain herbaceous plants with big flowers, 6 parts of pine mushroom, 6 parts of turmeric,
5 parts of myrrh, 5 parts of the root bark of shaggy-fruited dittany.
Embodiment 5：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig
10 parts, 12 parts of the root of herbaceous peony, 5 parts of west safflower, 5 parts of dragon's blood, 6 parts of folium artemisiae argyi, 3 parts of swordleaf cymbidium leaf, 3 parts of certain herbaceous plants with big flowers of match, 3 parts of pine mushroom, 5 parts of turmeric, do not have
1 part of medicine, 3 parts of the root bark of shaggy-fruited dittany.
Embodiment 6：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig
12 parts, 10 parts of the root of herbaceous peony, 8 parts of west safflower, 8 parts of dragon's blood, 5 parts of folium artemisiae argyi, 5 parts of swordleaf cymbidium leaf, 5 parts of certain herbaceous plants with big flowers of match, 5 parts of pine mushroom, 3 parts of turmeric, do not have
3 parts of medicine, 1 part of the root bark of shaggy-fruited dittany.
Embodiment 7：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig
30 parts, 30 parts of the root of herbaceous peony, 18 parts of west safflower, 20 parts of dragon's blood, 20 parts of folium artemisiae argyi, 15 parts of swordleaf cymbidium leaf, match 15 parts of certain herbaceous plants with big flowers, 14 parts of pine mushroom, turmeric
14 parts, 10 parts of myrrh, 10 parts of the root bark of shaggy-fruited dittany.
Embodiment 8：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig
28 parts, 28 parts of the root of herbaceous peony, 20 parts of west safflower, 18 parts of dragon's blood, 18 parts of folium artemisiae argyi, 14 parts of swordleaf cymbidium leaf, match 14 parts of certain herbaceous plants with big flowers, 15 parts of pine mushroom, turmeric
155 parts, 9 parts of myrrh, 9 parts of the root bark of shaggy-fruited dittany.
Illustrate the preparation method of Chinese medicine composition of the present invention by taking the formula of embodiment 1 as an example below.
Embodiment 9：
A kind of preparation method for the Chinese medicine composition for treating rheumatoid arthritis, comprises the following steps：
Step S1：Dry cassia twig, the root of herbaceous peony, west safflower, dragon's blood, folium artemisiae argyi, swordleaf cymbidium leaf and match certain herbaceous plants with big flowers are weighed respectively, are crushed, mixing, plus
Enter the water of 4 times of weight, microwave treatment 30 minutes is filtrated to get filtrate I and filter residue；The edible of 4 times of its weight is added in filter residue
Alcohol, is heated to reflux 2 times, 30 minutes every time, filters respectively, each filtrate merges to obtain filtrate II, by the filtrate II with it is described
Filtrate I mixes, and reclaims the lotion I for being concentrated into that 75 DEG C of relative densities are 1.26 after edible alcohol；
Step S2：Dry pine mushroom, turmeric, myrrh and the root bark of shaggy-fruited dittany are weighed, crushes, adds water, the water and the raw material after crushing
Weight ratio is 6:1, decoct 45 minutes, filter to obtain decoction liquor, the decoction liquor is concentrated into the cream that 75 DEG C of relative densities are 1.26
Body II；
Step S3：The lotion I and lotion II are merged, dried, ultramicro grinding obtains Ultramicro-powder.
In the present embodiment, the frequency of the microwave treatment is 25kHz, and power is 700W, and temperature is 50 DEG C.
The volume fraction of ethanol is 95% in the edible alcohol.
The auxiliary material is microcrystalline cellulose or magnesium stearate.
Gained Ultramicro-powder is as oral formulations, with single dose Vacuum Package, 10 grams every bag.
Embodiment 10：
A kind of preparation method for the Chinese medicine composition for treating rheumatoid arthritis, comprises the following steps：
Step S1：Dry cassia twig, the root of herbaceous peony, west safflower, dragon's blood, folium artemisiae argyi, swordleaf cymbidium leaf and match certain herbaceous plants with big flowers are weighed respectively, are crushed, mixing, plus
Enter the water of 5 times of weight, microwave treatment 35 minutes is filtrated to get filtrate I and filter residue；The edible of 5 times of its weight is added in filter residue
Alcohol, is heated to reflux 3 times, 35 minutes every time, filters respectively, each filtrate merges to obtain filtrate II, by the filtrate II with it is described
Filtrate I mixes, and reclaims the lotion I for being concentrated into that 75 DEG C of relative densities are 1.23 after edible alcohol；
Step S2：Dry pine mushroom, turmeric, myrrh and the root bark of shaggy-fruited dittany are weighed, crushes, adds water, the water and the raw material after crushing
Weight ratio is 7:1, decoct 50 minutes, filter to obtain decoction liquor, the decoction liquor is concentrated into the cream that 75 DEG C of relative densities are 1.23
Body II；
Step S3：The lotion I and lotion II are merged, dried, ultramicro grinding obtains Ultramicro-powder, is added in the Ultramicro-powder
Relative to the auxiliary material of its quality 3.5%, mix, pelletize, dry, obtain granule.
In the present embodiment, the frequency of the microwave treatment is 28kHz, and power is 750W, and temperature is 55 DEG C.
The volume fraction of ethanol is 95% in the edible alcohol.
The auxiliary material is using weight ratio as 1 by microcrystalline cellulose and magnesium stearate：The mixture of 0.4 composition.
Embodiment 11：
A kind of preparation method for the Chinese medicine composition for treating rheumatoid arthritis, comprises the following steps：
Step S1：Dry cassia twig, the root of herbaceous peony, west safflower, dragon's blood, folium artemisiae argyi, swordleaf cymbidium leaf and match certain herbaceous plants with big flowers are weighed respectively, are crushed, mixing, plus
Enter the water of 6 times of weight, microwave treatment 40 minutes is filtrated to get filtrate I and filter residue；The edible of 6 times of its weight is added in filter residue
Alcohol, is heated to reflux 3 times, 40 minutes every time, filters respectively, each filtrate merges to obtain filtrate II, by the filtrate II with it is described
Filtrate I mixes, and reclaims the lotion I for being concentrated into that 75 DEG C of relative densities are 1.20 after edible alcohol；
Step S2：Dry pine mushroom, turmeric, myrrh and the root bark of shaggy-fruited dittany are weighed, crushes, adds water, the water and the raw material after crushing
Weight ratio is 8:1, decoct 60 minutes, filter to obtain decoction liquor, the decoction liquor is concentrated into the cream that 75 DEG C of relative densities are 1.20
Body II；
Step S3：The lotion I and lotion II are merged, dried, ultramicro grinding obtains Ultramicro-powder, is added in the Ultramicro-powder
Relative to the auxiliary material of its quality 5%, mix, pelletize, dry, obtain granule.
In the present embodiment, the frequency of the microwave treatment is 30kHz, and power is 800W, and temperature is 60 DEG C.
The volume fraction of ethanol is 95% in the edible alcohol.
The auxiliary material is using weight ratio as 1 by microcrystalline cellulose and magnesium stearate：The mixture of 1 composition.
The present invention using above-mentioned Chinese medicine composition as active ingredient, be prepared into oral formulations, except can be prepared into pulvis and
Outside granula, conventional aqua, paste or tablet can also be prepared into.
Comparative example 1：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig
20 parts, 20 parts of the root of herbaceous peony, 12 parts of west safflower, 12 parts of dragon's blood, 12 parts of folium artemisiae argyi, 9 parts of turmeric, 6 parts of myrrh, 6 parts of the root bark of shaggy-fruited dittany.
The comparative example omits the use of swordleaf cymbidium leaf, match certain herbaceous plants with big flowers and pine mushroom, and preparation method refers to embodiment 1.
Comparative example 2：A kind of Chinese medicine composition for treating rheumatoid arthritis, is made up of the raw material of following parts by weight：Cassia twig 5
Part, 5 parts of the root of herbaceous peony, 12 parts of west safflower, 12 parts of dragon's blood, 12 parts of folium artemisiae argyi, 9 parts of swordleaf cymbidium leaf, 9 parts of certain herbaceous plants with big flowers of match, 9 parts of pine mushroom, 9 parts of turmeric, do not have
6 parts of medicine, 6 parts of the root bark of shaggy-fruited dittany.
The comparative example reduces cassia twig and the consumption of the root of herbaceous peony, adjusts to 5 parts, remaining raw material dosage is constant, preparation method ginseng
Read embodiment 1.
Comparative example 3：A kind of Chinese medicine composition for treating rheumatoid arthritis, formula is same as Example 1, different
It is：The preparation method of the Chinese medicine composition is：
Dry cassia twig, the root of herbaceous peony, west safflower, dragon's blood, folium artemisiae argyi, swordleaf cymbidium leaf, match certain herbaceous plants with big flowers, pine mushroom, turmeric, myrrh and the root bark of shaggy-fruited dittany are weighed,
Crush, add water, the weight ratio of the water and the raw material after crushing is 6:1, decoct 45 minutes, filter to obtain decoction liquor, decocted described
Boil liquid is concentrated into the lotion that 75 DEG C of relative densities are 1.26；The lotion dry, pulverize, cross 300 mesh sieves, obtain pulvis.
Incompatibility is not present in 1 ~ comparative example of comparative example 3, meets the basic principle of Chinese prescription, edible safety.
Observation of curative effect is with evaluating
1.1 general information：Choose the clinical money for 250 rheumatoid arthritis patients accepted for medical treatment in June, 2013 in December, 2016
Material, all patients meet the diagnostic criteria (American society of rheumatism, ACR, 1987) of rheumatoid arthritis.By all patients with
Machine is divided into 5 groups, is respectively：Observation group, 1 group of contrast, 2 groups of contrast, contrast 3 groups and control group, every group of 50 patients.Case is excluded
Standard：1. the patient for the diagnostic criteria for not meeting rheumatoid arthritis is excluded；2. the patient for having serious cardiovascular and cerebrovascular disease is excluded；
3. the patient for having serious hepatic and kidney function obstacle is excluded；4. the patient for having general immunity function disease is excluded.Through statistics, every group of patient
The no difference of science of statistics (P ＞ 0.05) in the general information indexs such as age, sex composition ratio, the course of disease, it is balanced comparable.
The Western medicine diagnostic criteria and its functional classification of 1.2 rheumatoid arthritis
1.2.1 diagnostic criteria：1. morning stiffness time daily ＞ 1h, while the course of disease >=8 week；2. there are the pass of 3 or more than 3
Save swelling time >=8 week；3. the wrist of patient, arthroncus time >=8 week such as refer to；4. the symmetry diarthrodial joint swelling time >=
8 weeks；5. patient's subcutaneous nodule；6. the hand x-ray of patient shows the symptoms such as osteoporosis；7. the rheumatoid factor (RF) of patient
Show the positive.Above-mentioned 7 kinds of indexs, which occupy 4, just can make a definite diagnosis.
1.2.2 functional classification is according to functional classification：The usually life of patient can not be limited, I grade is designated as；Patient's
Daily life, the joint motion for having moderate strength is limited, and is designated as II grade；The daily life of patient is significantly limited,
Many occupations can not be engaged in simultaneously or can not be taken care of number one, and be designated as III grade；Patient's can't take care of oneself, can only lie in bed or
Wheelchair, is designated as IV grade.
1.3 treatment method：Control group patient give methotrexate (MTX)（Chinese medicines quasi-word H31020644, specification 2.5mg/ pieces）
7.5mg, 1 times a week.Observation group patient gives the Chinese medicine powder of embodiment 1, hot water is taken after mixing it with water, often on the basis of control group treatment
Bag, which divides 2 times, to be taken, daily 1 dose.1 group of patient is contrasted on the basis of control group treatment, the Chinese medicine powder of comparative example 1, hot water is given
Take after mixing it with water, every bag is taken points for 2 times, daily 1 dose.2 groups of patients are contrasted on the basis of control group treatment, the traditional Chinese medicine powder of comparative example 2 is given
Agent, hot water is taken after mixing it with water, and every bag is taken points for 2 times, daily 1 dose.3 groups of patients are contrasted on the basis of control group treatment, comparative example 3 is given
Chinese medicine powder, hot water is taken after mixing it with water, and every bag is taken points for 2 times, daily 1 dose.
1.4 complication are evaluated：Recorded by experimenter's all-the-way tracking and participate in check and follow-up, five groups of patients of record occur
The infection of the upper respiratory tract, pulmonary infection, interstitial pneumonia and pulmonary fibrosis number, calculate incidence.
1.5 statistical procedures：All datas carry out statistical analysis, meter using the statistics software bags of SPSS 17.0
Number data is expressed as a percentage, χ2Inspection is analyzed.P ＜ 0.05 are that difference is statistically significant.
Functional classification situation before and after 1.6 5 groups of patient's treatments
Before treatment, each group patient case loads at different levels are substantially suitable, no difference of science of statistics.1. after treating, I grade of case of observation group patient
Digital display, which writes, to be increased, and II grade, III grade and IV grade case load is substantially reduced, and I grade of case percentage of patient has before relatively treating
Significant difference.I grade of case load for contrast 1 group, contrasting 2 groups and contrast 3 groups increases before relatively treating, II grade, III grade and IV grade
Case load has different degrees of reduction before also relatively treating.Control group is compared with I grade of case percentage of patient before treatment without significantly
Sex differernce.2. after treating, compared with I grade of percentage 28.0% (14/50) of control group patient：I grade of percentage of observation group patient
70.00% (35/50) has significant difference；Contrast 1 group, there are no significant for I grade of percentage of 3 groups of patients of 2 groups of contrast and contrast
Difference.Compared with control group curative effect, observation group's therapeutic effect is notable.It the results are shown in Table 1.
Classification situation before and after 1 five groups of patient's treatments of table（Example）
1.7 5 groups of complication for patients situations compare
Before treatment, five groups of patient's infection of the upper respiratory tract, pulmonary infection, interstitial pneumonia and pulmonary fibrosis incidence are not present notable
Difference (P ＞ 0.05).After treatment, the clinical scale case load of observation group patient is significantly improved, and patient is total with control group
Complication rate is compared, and difference is statistically significant.Contrast 3 groups of 1 group, 2 groups of contrast and contrast total with control group patient
Complication rate is compared, and difference is not notable.It the results are shown in Table 2.
2 five groups of complication for patients situations [n/%] of table
The studies above result absolutely proves that the present invention has very significant treat using therapy of combing traditional Chinese and Western medicine rheumatoid arthritis
Effect, can obviously improve the clinical scale and related symptoms of patient.Methotrexate used in control group is that clinical treatment rheumatoid is closed
One of scorching maximally efficient ground medicine of section, can obviously relieve the state of an illness of patient, but its onset time is slower, and side effect is more,
Many patients are difficult to be resistant to, therefore its clinical practice receives certain limitation.Remedy measures base of the present invention in regular western medicine
Add on plinth and use oral formulations, all medicines share, rheumatoid arthritis clinical symptoms, active prevention is concurrent with auxiliary treatment
Disease, reduces the occurrence probability of pulmonary complication.In summary, combination of Chinese tradiational and Western medicine method treatment rheumatoid arthritis of the present invention, tool
There is significant curative effect, safe and reliable, clinic promotion and application.
Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, this area is common
Other modifications or equivalent substitution that technical staff is made to technical scheme, without departing from technical solution of the present invention
Spirit and scope, all should cover among scope of the presently claimed invention.
Claims (9)
1. a kind of Chinese medicine composition for treating rheumatoid arthritis, it is characterised in that be made up of the raw material of following parts by weight：Cassia twig
10 ~ 30 parts, 10 ~ 30 parts of the root of herbaceous peony, 5 ~ 20 parts of west safflower, 5 ~ 20 parts of dragon's blood, 5 ~ 20 parts of folium artemisiae argyi, 3 ~ 15 parts of swordleaf cymbidium leaf, match certain herbaceous plants with big flowers 3 ~ 15
Part, 3 ~ 15 parts of pine mushroom, 3 ~ 15 parts of turmeric, 1 ~ 10 part of myrrh, 1 ~ 10 part of the root bark of shaggy-fruited dittany.
2. a kind of Chinese medicine composition for treating rheumatoid arthritis according to claim 1, it is characterised in that：Cassia twig 15 ~
25 parts, 15 ~ 25 parts of the root of herbaceous peony, 10 ~ 15 parts of west safflower, 10 ~ 15 parts of dragon's blood, 10 ~ 15 parts of folium artemisiae argyi, 6 ~ 12 parts of swordleaf cymbidium leaf, match certain herbaceous plants with big flowers 6 ~ 12
Part, 6 ~ 12 parts of pine mushroom, 6 ~ 12 parts of turmeric, 4 ~ 8 parts of myrrh, 4 ~ 8 parts of the root bark of shaggy-fruited dittany.
3. a kind of Chinese medicine composition for treating rheumatoid arthritis according to claim 2, it is characterised in that：Cassia twig 20
Part, 20 parts of the root of herbaceous peony, 12 parts of west safflower, 12 parts of dragon's blood, 12 parts of folium artemisiae argyi, 9 parts of swordleaf cymbidium leaf, 9 parts of certain herbaceous plants with big flowers of match, 9 parts of pine mushroom, 9 parts of turmeric, do not have
6 parts of medicine, 6 parts of the root bark of shaggy-fruited dittany.
4. the preparation method of the Chinese medicine composition of the treatment rheumatoid arthritis according to any one of claim 1 ~ 3, it is special
Levy and be, comprise the following steps：
Step S1：Dry cassia twig, the root of herbaceous peony, west safflower, dragon's blood, folium artemisiae argyi, swordleaf cymbidium leaf and match certain herbaceous plants with big flowers are weighed respectively, are crushed, mixing, plus
Enter the water of 4 ~ 6 times of weight, microwave treatment 30 ~ 40 minutes is filtrated to get filtrate I and filter residue；4 ~ 6 times of its weight is added in filter residue
Edible alcohol, be heated to reflux 2 ~ 3 times, 30 ~ 40 minutes every time, filter respectively, each filtrate merges to obtain filtrate II, by the filter
Liquid II is mixed with the filtrate I, and lotion I is condensed into after reclaiming edible alcohol；
Step S2：Dry pine mushroom, turmeric, myrrh and the root bark of shaggy-fruited dittany are weighed, crushes, adds water, the water and the raw material after crushing
Weight ratio is 6 ~ 8:1, decoct 45 ~ 60 minutes, filter to obtain decoction liquor, the decoction liquor is condensed into lotion II；
Step S3：The lotion I and lotion II are merged, dried, ultramicro grinding obtains Ultramicro-powder.
5. the preparation method of the Chinese medicine composition for the treatment of rheumatoid arthritis according to claim 4, it is characterised in that：Institute
Stating step S3 also includes：The auxiliary material relative to its quality 2 ~ 5% is added in the Ultramicro-powder, is mixed, is pelletized, dries, obtains particle
Agent.
6. the preparation method of the Chinese medicine composition for the treatment of rheumatoid arthritis according to claim 4, it is characterised in that：Institute
The frequency for stating microwave treatment is 25 ~ 30kHz, and power is 700 ~ 800W, and temperature is 50 ~ 60 DEG C.
7. the preparation method of the Chinese medicine composition for the treatment of rheumatoid arthritis according to claim 4, it is characterised in that：Institute
The volume fraction for stating ethanol in edible alcohol is 95%.
8. the preparation method of the Chinese medicine composition for the treatment of rheumatoid arthritis according to claim 4, it is characterised in that：Institute
The relative density that lotion I and lotion II are stated at 75 DEG C is 1.20 ~ 1.26.
9. the preparation method of the Chinese medicine composition for the treatment of rheumatoid arthritis according to claim 5, it is characterised in that：Institute
It is using weight ratio as 1 by microcrystalline cellulose and magnesium stearate to state auxiliary material：The mixture of 0.4 ~ 1 composition.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110537687A (en) * | 2019-10-10 | 2019-12-06 | 王雅洁 | Composition for dredging channels and collaterals and preparation method thereof |
| CN110548090A (en) * | 2019-09-29 | 2019-12-10 | 中国医学科学院肿瘤医院 | Traditional Chinese medicine composition for treating morning stiffness and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1235840A (en) * | 1998-05-20 | 1999-11-24 | 曹建中 | Chinese medicine powder for curing rheumatoid and rheumatic diseases |
| CN1775256A (en) * | 2004-11-15 | 2006-05-24 | 程升群 | Capsule for treating rheumatalgia |
| CN105641295A (en) * | 2016-04-06 | 2016-06-08 | 华北理工大学 | Traditional Chinese medicine composition and application thereof to treatment of rheumatic arthritis |
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2017
- 2017-06-27 CN CN201710501949.3A patent/CN107184913A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1235840A (en) * | 1998-05-20 | 1999-11-24 | 曹建中 | Chinese medicine powder for curing rheumatoid and rheumatic diseases |
| CN1775256A (en) * | 2004-11-15 | 2006-05-24 | 程升群 | Capsule for treating rheumatalgia |
| CN105641295A (en) * | 2016-04-06 | 2016-06-08 | 华北理工大学 | Traditional Chinese medicine composition and application thereof to treatment of rheumatic arthritis |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110548090A (en) * | 2019-09-29 | 2019-12-10 | 中国医学科学院肿瘤医院 | Traditional Chinese medicine composition for treating morning stiffness and preparation method thereof |
| CN110537687A (en) * | 2019-10-10 | 2019-12-06 | 王雅洁 | Composition for dredging channels and collaterals and preparation method thereof |
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Application publication date: 20170922 |