CN107184725A - 一种治疗糖尿病的中药及其制备方法 - Google Patents
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Abstract
本发明公开了一种治疗糖尿病的中药,属于医药技术领域。该中药组合物由以下重量份的原料制成:黄芪5‑10份、茯苓4‑12份、夜交藤3‑12份、熟地黄3‑8份、五味子2‑8份、夏枯草3‑8份、白术2‑8份、蝉蜕2‑8份、甘草3‑10份、栀子3‑8份、纤冠藤1‑5份、蒲公英3‑8份、佛手2‑5份,猫爪草3‑6份,墨旱莲2‑6份、婆婆针3‑8份。本发明的治疗糖尿病的中药配伍合理,标本兼治,维持身体代谢平衡,疗效显著,无毒副作用,治愈后不易复发,具有广阔的应用前景。
Description
技术领域
本发明涉及医药技术领域,具体涉及一种治疗糖尿病的中药及其制备方法。
背景技术
糖尿病是一组以高血糖为特征的代谢性疾病。高血糖则是由于胰岛素分泌缺陷或其生物作用受损,或两者兼有引起。糖尿病时长期存在的高血糖,导致各种组织,特别是眼、肾、心脏、血管、神经的慢性损害、功能障碍。近年来,糖尿病的发病率呈逐年上升趋势。现有技术中,治疗糖尿病的西药存在着明显的副作用,而中药虽然可以减轻副作用,但是对糖尿病治疗的效果不显著,多数还容易反弹。
因此设计一种无毒副作用、疗效显著的治疗糖尿病的中药具有很大的实用价值。
发明内容
本发明提供一种治疗糖尿病的中药,可以解决现有技术中的上述问题。
本发明提供了一种治疗糖尿病的中药,由以下重量份的原料制成:黄芪5-10份、茯苓4-12份、夜交藤3-12份、熟地黄3-8份、五味子2-8份、夏枯草3-8份、白术2-8份、蝉蜕2-8份、甘草3-10份、栀子3-8份、纤冠藤1-5份、蒲公英3-8份、佛手2-5份,猫爪草3-6份,墨旱莲2-6份、婆婆针3-8份。
较佳地,由以下重量份的原料制成:黄芪8份、茯苓10份、夜交藤6份、熟地黄5份、五味子5份、夏枯草6份、白术3份、蝉蜕3份、甘草5份、栀子5份、纤冠藤3份、蒲公英5份、佛手3份,猫爪草4份,墨旱莲4份、婆婆针6份。
较佳地,由以下重量份的原料制成:黄芪7份、茯苓8份、夜交藤10份、熟地黄6份、五味子6份、夏枯草5份、白术5份、蝉蜕5份、甘草8份、栀子7份、纤冠藤4份、蒲公英6份、佛手4份,猫爪草5份,墨旱莲5份、婆婆针4份。
较佳地,黄芪6份、茯苓8份、夜交藤8份、熟地黄5份、五味子4份、夏枯草4份、白术6份、蝉蜕6份、甘草6份、栀子6份、纤冠藤5份、蒲公英5份、佛手5份,猫爪草4份,墨旱莲4份、婆婆针5份。
本发明还提供了上述治疗糖尿病的中药的制备方法,包括以下步骤:
步骤1:将各个所述原料干燥、粉碎至80-120目粉末备用;
步骤2:按重量份称取各个所述原料的粉末,混匀,然后加入总粉末重量的8-10倍的水,浸泡2-3小时,加热至沸腾,保温0.5-2小时,过滤得滤液,分离出滤渣;
步骤3:将步骤2收集的滤渣,再加入总粉末重量的0.5~4倍水,煎煮0.5~2h,过滤,得到滤液,合并两次滤液,将滤液浓缩为之前体积的30-80%,待滤液降温至50-65℃,再加入占浓缩后的滤液体积40~60%的乙醇,进行醇沉,静置48h后减压回收乙醇;
步骤4:将步骤3醇沉之后的滤液浓缩至相对密度为1.08-1.18,得到提取液。
本发明中的各个原料的药理如下:
黄芪:味苦、性寒,归心、肺、胃、胆、大肠经,具有补气升阳,益卫固表,托毒生肌,利水消肿的功效,主治湿热所致之腹泻、痢疾、黄疸、热淋;肺热咳嗽,口渴咽痛,还可用于胎热不安,热毒火邪侵淫皮肤之疮痈毒肿之证,黄芪功。它对机体非特异性及特异性细胞免疫都有增强作用,可提高T细胞增殖能力,促进巨噬细胞活化,黄芪可以止盗汗、加速病灶吸收和空洞愈合、提高痰菌阴转率,并对抗结核药物的毒副作用有明显的对抗作用。
茯苓:性味:甘、淡,平。归心经、肺经、脾经、肾经。宁心安神,败毒抗癌。药性平和,利湿而不伤正气。可治小便不利、水肿胀满、痰饮咳逆、呕逆、恶阻、泄泻、遗精、淋浊、惊悸、健忘等症。
夜交藤:性味归经:甘微苦,平。功效:养心,安神,通络,祛风。治失眠症,劳伤,多汗,血虚身痛,痈疽,瘰疬,风疮疥癣。
熟地黄:味甘;性温。归肝;肾经。补血滋润;益精填髓。用于血虚萎黄;眩晕心悸;月经不调;崩不止;肝肾阴亏;潮热盗汗;遗精阳痿;不育不孕;月经不调;崩漏下血;腰膝酸软;耳鸣耳聋;头目昏花;须发早白;消渴;便秘;肾虚喘促。
五味子:性温,味酸、甘,归肺、心、肾经,具有收敛固涩,益气生津,补肾宁心的功效,主治久嗽虚喘,梦遗滑精,遗尿尿频,久泻不止,自汗,盗汗,津伤口渴,短气脉虚,内热消渴,心悸失眠等症。
夏枯草:性寒,味甘、辛、微苦,具有清泄肝火、散结消肿、清热解毒、祛痰止咳、凉血止血的功效,适用于淋巴结核、甲状腺肿、乳痈、头目眩晕、口眼歪斜、筋骨疼痛、肺结核、血崩、带下、急性传染性黄疸型肝炎及细菌性痢疾等。现代药理研究表明,夏枯草有降低血压的作用,并能扩张血管,其所含芦丁有抗炎作用,并能降低血管通透性,减少脆性,降低肝脂。夏枯草还有抵制癌细胞的作用。
白术:苦、甘,温。归脾、胃经。用于健脾益气、燥湿利水、止汗、安胎,脾虚食少、腹胀泄泻、痰饮眩悸、水肿、自汗、胎动不安。
蝉蜕:味咸、甘、寒、无毒。归肺、肝经。散风除热,利咽,透疹,退翳,解痉。用于风热感冒,咽痛,音哑,麻疹不透,风疹瘙痒,目赤翳障,惊风抽搐,破伤风。
甘草:味甘甜,性平和,入心、脾、肺、胃四经。生用偏凉,可泻火解毒、缓急止痛;炙用偏温,能散表寒、补中益气。此外,甘草还善于调和药性,解百药之毒。
栀子:气味苦、寒、无毒。归心经;肝经;肺经;胃经;三焦经。用于清热泻火、泻火除烦、清热利湿、凉血解毒、凉血止血。主治:热病心烦;肝火目赤;头痛;湿热黄疸;淋证;血痢尿血;口舌生疮;疮疡肿毒;扭伤肿痛。
纤冠藤:性味苦,温。入肝经。祛风活血。可用于治疗腰肌劳损、关节疼痛。
蒲公英:味甘,微苦,性寒。清热解毒,消肿散结。主治:上呼吸道感染,眼结膜炎,流行性腮腺炎,高血糖,乳痈肿痛,胃炎,痢疾,肝炎,胆襄炎,急性阑尾炎,泌尿系感染,盆腔炎,痈疖疔疮,咽炎,治急性乳腺炎,淋巴腺炎,瘰疠,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎、尿路感染。
佛手:性温,味辛、苦、酸。归肝、脾、肺经。具有舒肝理气,和胃止痛的功效。用于肝胃气滞,胸肋胀痛,胃脘痞满,食少呕吐等症。
猫爪草:味甘、辛,性微温,归肝、肺经,具有化痰散结,解毒消肿的功效,主治瘰疬痰核,疔疮,虫蛇咬伤,偏头痛,疟疾,牙痛。肺结核,淋巴结结核,淋巴结炎,咽喉炎等证,猫爪草中含有的小毛莨内酯可增强机体细胞毒性T细胞的杀伤活性,达到抗耐药性结核分支杆菌的目的。
墨旱莲:性味:甘、酸,寒。归经:归肾、肝经。功能主治:滋补肝肾,凉血止血。用于牙齿松动,须发早白,眩晕耳鸣,腰膝酸软,阴虚血热、吐血、衄血、尿血,血痢,崩漏下血,外伤出血。
婆婆针:味苦;性微寒。归肝、肺、大肠经。功能与主治:清热解毒,止血止泻,散瘀消肿。用于阑尾炎,肾炎,胆囊炎,肠炎,细菌性痢疾,肝炎,腹膜炎,上呼吸道感染,扁桃体炎,喉炎,闭经,烫伤,毒蛇咬伤,跌打损伤,皮肤感染,小儿惊风、疳积等症。
与现有技术相比,本发明的有益效果是:本发明的治疗糖尿病的中药配伍合理,标本兼治,维持身体代谢平衡,疗效显著,无毒副作用,治愈后不易复发,具有广阔的应用前景。
具体实施方式
下面对本发明的具体实施方式进行详细描述,但应当理解本发明的保护范围并不受具体实施方式的限制。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所获得的所有其他实施例,都属于本发明保护的范围。
本发明提供的一种治疗糖尿病的中药,由以下重量份的原料制成:黄芪5-10份、茯苓4-12份、夜交藤3-12份、熟地黄3-8份、五味子2-8份、夏枯草3-8份、白术2-8份、蝉蜕2-8份、甘草3-10份、栀子3-8份、纤冠藤1-5份、蒲公英3-8份、佛手2-5份,猫爪草3-6份,墨旱莲2-6份、婆婆针3-8份。
实施例1:
一种治疗糖尿病的中药,由以下重量克的原料制成:黄芪8克、茯苓10克、夜交藤6克、熟地黄5克、五味子5克、夏枯草6克、白术3克、蝉蜕3克、甘草5克、栀子5克、纤冠藤3克、蒲公英5克、佛手3克,猫爪草4克,墨旱莲4克、婆婆针6克。
实施例2:
一种治疗糖尿病的中药,由以下重量克的原料制成:黄芪7克、茯苓8克、夜交藤10克、熟地黄6克、五味子6克、夏枯草5克、白术5克、蝉蜕5克、甘草8克、栀子7克、纤冠藤4克、蒲公英6克、佛手4克,猫爪草5克,墨旱莲5克、婆婆针4克。
实施例3:
一种治疗糖尿病的中药,由以下重量克的原料制成:黄芪6克、茯苓8克、夜交藤8克、熟地黄5克、五味子4克、夏枯草4克、白术6克、蝉蜕6克、甘草6克、栀子6克、纤冠藤5克、蒲公英5克、佛手5克,猫爪草4克,墨旱莲4克、婆婆针5克。
另外,上述治疗糖尿病的中药也可以直接把各原料研磨成粉,服用时用开水冲服即可。也根据所需要的剂型,加入常规辅助成分,如淀粉、环糊精或蔗糖等,该工艺及设备均属制药领域常规技术,本发明对此不作限定,故在此不予详述。本发明的中药组合物可制备成口服液、散剂、片剂、胶囊剂等。
实施例4:
上述中药组合物的制备方法如下:
步骤1:将各个所述原料干燥、粉碎至100目粉末备用;
步骤2:按重量份称取各个所述原料的粉末,混匀,然后加入总粉末重量的9倍的水,浸泡2小时,加热至沸腾,保温1小时,过滤得滤液,分离出滤渣;
步骤3:将步骤2收集的滤渣,再加入总粉末重量的2倍水,煎煮1h,过滤,得到滤液,合并两次滤液,将滤液浓缩为之前体积的40%,待滤液降温至55℃,再加入占浓缩后的滤液体积50%的乙醇,进行醇沉,静置48h后减压回收乙醇;
步骤4:将步骤3醇沉之后的滤液浓缩至相对密度为1.15,得到提取液。
对本发明实施例1-3的中药组合物进行以下试验:
1、毒理学试验
对小鼠180只,随机平均分为9个组:3个高剂量组、3个中剂量组和3个低剂量组。高剂量组分别按60mg/kg的剂量给予实施例1-3的中药组合物;中剂量组分别按40mg/kg的剂量给予实施例1-3的中药组合物;3个低剂量组分别按20mg/kg的剂量给予实施例1-3的中药组合物。连续皮下注射30天。每个组每次注射都配合80mg/kg的甘露醇。
试验结果:高剂量组小鼠有明显毒性反应,低剂量组均无因药物毒性引起的明显异常,停药21天后各组小鼠均未见异常。
2、动物安全性试验
2.1.动物对药物的依赖性试验
给小鼠以首日按照400mg/kg的剂量皮下注射实施例1的配方制成针剂,以后以持续递增每日剂量方式连续给药7天,小鼠未见明显依赖性现象。
2.2.药物对动物的刺激性试验
给加入以40mg/kg的剂量在股四头肌部位注射按照实施例1制作的针剂,1mL/只,间隔48小时后处死动物检查,结果注射部位皮下及附近组织未见局部刺激性反应,符合中药注射剂的有关检查标准。
3、临床观察
3.1病例资料
根据我院糖尿病患者300例,随机平均分为三个试验组和一个对照组,每组75例。四组的患者经统计学分析无显著性差异(P>0.05),具有可比性。
3.2治疗方法
试验组分别服用本发明实施例1、2、3采用实施例4制备出的中药,每日两次,每次一剂;
对照组服用市售某降血糖中药,每日两次,每次一剂。
两周为一个疗程,并且不服用其他药物,所有患者服用药物一个疗程后停止服药,再观察30天。
3.3疗效评定标准
在服药一天前、服用药物结束后、停药后第30天,对每位病例进行空腹血糖检测。经统计学分析,P<0.05,具有显著意义。
3.4治疗结果
三个试验组和对照组治疗结果见表1所示。
表1试验组和对照组不同阶段血糖检测结果
4、典型病例
①陈某,女53岁,患糖尿病5年多,近来病情加重,血糖用药无效,胰岛器官失去活性,打胰岛素后,血糖略有降低,但还是很高。来我院诊治,服用本发明实施例1采用实施例4的方法制备出的中药,用药一个疗程后,症状有所缓解,后继续用药半年后,病症基本消除。
②周某,男60岁,自述疲劳乏力,吃饭后不久就感觉饥饿,畏寒,手足心烧热。服用本发明实施例2采用实施例4的方法制备出的中药两个疗程后,病症基本消失,随访一年,无复发。
③高某,男63岁,患糖尿病达10年之久,常年服用降糖西药,疲劳乏力,身体瘙痒,感觉痛苦不堪。来我院服用实施例3采用实施例4的方法制备出的药物四个疗程后,以上症状基本消失血糖控制在正常范围内。
通过以上临床试验及典型病例可见,本发明的治疗糖尿病的中药配伍合理,标本兼治,维持身体代谢平衡,疗效显著,无毒副作用,治愈后不易复发,具有广阔的应用前景。
尽管已描述了本发明的优选实施例,但本领域内的技术人员一旦得知了基本创造性概念,则可对这些实施例作出另外的变更和修改。所以,所附权利要求意欲解释为包括优选实施例以及落入本发明范围的所有变更和修改。
显然,本领域的技术人员可以对本发明进行各种改动和变型而不脱离本发明的精神和范围。这样,倘若本发明的这些修改和变型属于本发明权利要求及其等同技术的范围之内,则本发明也意图包含这些改动和变型在内。
Claims (6)
1.一种治疗糖尿病的中药,其特征在于,由以下重量份的原料制成:黄芪5-10份、茯苓4-12份、夜交藤3-12份、熟地黄3-8份、五味子2-8份、夏枯草3-8份、白术2-8份、蝉蜕2-8份、甘草3-10份、栀子3-8份、纤冠藤1-5份、蒲公英3-8份、佛手2-5份,猫爪草3-6份,墨旱莲2-6份、婆婆针3-8份。
2.如权利要求1所述的治疗糖尿病的中药,其特征在于,由以下重量份的原料制成:黄芪8份、茯苓10份、夜交藤6份、熟地黄5份、五味子5份、夏枯草6份、白术3份、蝉蜕3份、甘草5份、栀子5份、纤冠藤3份、蒲公英5份、佛手3份,猫爪草4份,墨旱莲4份、婆婆针6份。
3.如权利要求1所述的治疗糖尿病的中药,其特征在于,由以下重量份的原料制成:黄芪7份、茯苓8份、夜交藤10份、熟地黄6份、五味子6份、夏枯草5份、白术5份、蝉蜕5份、甘草8份、栀子7份、纤冠藤4份、蒲公英6份、佛手4份,猫爪草5份,墨旱莲5份、婆婆针4份。
4.如权利要求1所述的治疗糖尿病的中药,其特征在于,由以下重量份的原料制成:黄芪6份、茯苓8份、夜交藤8份、熟地黄5份、五味子4份、夏枯草4份、白术6份、蝉蜕6份、甘草6份、栀子6份、纤冠藤5份、蒲公英5份、佛手5份,猫爪草4份,墨旱莲4份、婆婆针5份。
5.如权利要求1-4任一所述的治疗糖尿病的中药的制备方法,其特征在于,包括以下步骤:
步骤1:将各个所述原料干燥、粉碎至80-120目粉末备用;
步骤2:按重量份称取各个所述原料的粉末,混匀,然后加入总粉末重量的8-10倍的水,浸泡2-3小时,加热至沸腾,保温0.5-2小时,过滤得滤液,分离出滤渣;
步骤3:将步骤2收集的滤渣,再加入总粉末重量的0.5~4倍水,煎煮0.5~2h,过滤,得到滤液,合并两次滤液,将滤液浓缩为之前体积的30-80%,待滤液降温至50-65℃,再加入占浓缩后的滤液体积40~60%的乙醇,进行醇沉,静置48h后减压回收乙醇;
步骤4:将步骤3醇沉之后的滤液浓缩至相对密度为1.08-1.18,得到提取液。
6.如权利要求5所述的治疗糖尿病的中药的制备方法,其特征在于,将步骤3醇沉之后的滤液浓缩至相对密度为1.15,得到提取液。
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