CN1071754C - 嘧啶基吡唑衍生物 - Google Patents

嘧啶基吡唑衍生物 Download PDF

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Publication number
CN1071754C
CN1071754C CN95196449A CN95196449A CN1071754C CN 1071754 C CN1071754 C CN 1071754C CN 95196449 A CN95196449 A CN 95196449A CN 95196449 A CN95196449 A CN 95196449A CN 1071754 C CN1071754 C CN 1071754C
Authority
CN
China
Prior art keywords
group
pyrimidyl
hydrochloride
pyrazolyl
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN95196449A
Other languages
English (en)
Chinese (zh)
Other versions
CN1166833A (zh
Inventor
江岛明男
杉森正道
三井郁雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of CN1166833A publication Critical patent/CN1166833A/zh
Application granted granted Critical
Publication of CN1071754C publication Critical patent/CN1071754C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN95196449A 1994-09-26 1995-09-25 嘧啶基吡唑衍生物 Expired - Fee Related CN1071754C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP22942294 1994-09-26
JP229422/1994 1994-09-26
JP229422/94 1994-09-26
JP135010/95 1995-06-01
JP135010/1995 1995-06-01
JP13501095 1995-06-01

Publications (2)

Publication Number Publication Date
CN1166833A CN1166833A (zh) 1997-12-03
CN1071754C true CN1071754C (zh) 2001-09-26

Family

ID=26468965

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95196449A Expired - Fee Related CN1071754C (zh) 1994-09-26 1995-09-25 嘧啶基吡唑衍生物

Country Status (13)

Country Link
US (1) US5852019A (enExample)
EP (1) EP0784055B1 (enExample)
KR (1) KR100388568B1 (enExample)
CN (1) CN1071754C (enExample)
AT (1) ATE232528T1 (enExample)
CA (1) CA2201110A1 (enExample)
DE (2) DE69529619T4 (enExample)
DK (1) DK0784055T3 (enExample)
ES (1) ES2192584T3 (enExample)
FI (1) FI971227L (enExample)
NO (1) NO313196B1 (enExample)
TW (1) TW312694B (enExample)
WO (1) WO1996010024A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169086B1 (en) 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
WO1998032739A1 (en) * 1997-01-27 1998-07-30 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
WO2000005230A1 (en) * 1998-07-24 2000-02-03 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives and salts thereof
AU3078000A (en) * 1999-01-25 2000-08-07 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compounds and antitumor agents containing the same as the active ingredient
US7071189B2 (en) * 2001-04-27 2006-07-04 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent containing the same as active ingredient
WO2003011837A1 (en) * 2001-08-01 2003-02-13 Merck & Co., Inc. Tyrosine kinase inhibitors
US20050130989A1 (en) * 2003-01-28 2005-06-16 Aventis Pharma S. A. N-arylheteroaromatic products compositions containing them and use thereof
FR2850379B1 (fr) * 2003-01-28 2006-11-17 Aventis Pharma Sa Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
JP2006516656A (ja) * 2003-01-28 2006-07-06 アヴェンティス ファーマ エス．エー． Ｎ−アリールヘテロ芳香族物質、それを含む組成物およびその用途
WO2005028467A1 (en) * 2003-09-15 2005-03-31 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds
CA2561406C (en) * 2004-03-31 2012-07-03 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and anti-malignant-tumor agent comprising the same as effective component
AU2006221285B2 (en) * 2005-03-11 2011-03-31 Zenyaku Kogyo Kabushikikaisha Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient
US20070244110A1 (en) * 2006-04-14 2007-10-18 Zenyaku Kogyo Kabushiki Kaisha Treatment of prostate cancer, melanoma or hepatic cancer
CA2675511A1 (en) 2006-10-10 2008-04-17 Amgen Inc. N-aryl pyrazole compounds for use against diabetes
WO2016154081A1 (en) 2015-03-26 2016-09-29 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
DK3356345T3 (da) 2015-09-30 2024-02-12 Max Planck Gesellschaft Heteroaryl-derivater som sepiapterin-reduktase-inhibitorer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102893A (en) * 1986-07-07 1992-04-07 Warner-Lambert Company Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3778433A (en) * 1969-04-18 1973-12-11 Sumitomo Chemical Co Process for producing benzodiazepine derivatives
JPS4842072A (enExample) * 1971-09-29 1973-06-19
JPS61129129A (ja) * 1984-11-28 1986-06-17 Kureha Chem Ind Co Ltd 抗腫瘍剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102893A (en) * 1986-07-07 1992-04-07 Warner-Lambert Company Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis

Also Published As

Publication number Publication date
WO1996010024A1 (fr) 1996-04-04
TW312694B (enExample) 1997-08-11
NO313196B1 (no) 2002-08-26
DE69529619D1 (en) 2003-03-20
FI971227A0 (fi) 1997-03-24
HK1001396A1 (en) 1998-06-19
FI971227A7 (fi) 1997-05-23
KR970706275A (ko) 1997-11-03
FI971227L (fi) 1997-05-23
US5852019A (en) 1998-12-22
EP0784055A1 (en) 1997-07-16
NO971384D0 (no) 1997-03-24
ES2192584T3 (es) 2003-10-16
EP0784055A4 (en) 1998-01-07
EP0784055B1 (en) 2003-02-12
CA2201110A1 (en) 1996-04-04
KR100388568B1 (ko) 2003-10-04
CN1166833A (zh) 1997-12-03
DK0784055T3 (da) 2003-06-02
ATE232528T1 (de) 2003-02-15
DE69529619T2 (de) 2003-12-18
DE69529619T4 (de) 2005-01-27
NO971384L (no) 1997-05-23

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