CN107115247A - A kind of Chinese medicine bath cream of inflammation-resisting itch-stopping - Google Patents
A kind of Chinese medicine bath cream of inflammation-resisting itch-stopping Download PDFInfo
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- CN107115247A CN107115247A CN201710504123.2A CN201710504123A CN107115247A CN 107115247 A CN107115247 A CN 107115247A CN 201710504123 A CN201710504123 A CN 201710504123A CN 107115247 A CN107115247 A CN 107115247A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The present invention relates to a kind of Chinese medicine bath cream of inflammation-resisting itch-stopping, the Chinese medicine bath cream is made up of active ingredient and auxiliary material, it is characterised in that every liter of Chinese medicine bath cream is mainly made up of the bulk drug of following weight proportion：30~40g of kuh-seng, 10~20g of the fruit of summer cypress；Wherein, the weight sum of described kuh-seng and the fruit of summer cypress is 50g.Chinese medicine bath cream of the present invention has anti-inflammatory, antipruritic effect.Not only flavour of a drug are few for the Chinese traditional medicine composition, are conducive to quality control, and the simple power of medicine is specially, and effect is notable.
Description
Invention field
The present invention relates to medicinal preparation, and in particular to contains the pharmaceutical preparation for not determining structure from plant, the medicine
Thing preparation is applied to the inflammation and itch of skin.
Technical background
Dipping method is one of external therapy, i.e., a kind of method with decoction or containing decoction water washing bath whole body or part, its shape
Formula is varied：Full bath is had to claim " liquid medicine bath "；Local bathing has " scalding ", " smoked wash ", " hip bath ", " lavipeditum " etc. again.Medicine
Bathe the mechanism of action in general, be that medicine acts on whole body fleshy exterior, part, affected part, and through absorbing, circulation channels and collaterals blood vessels are interior up to dirty
Internal organs, from outward appearance to inner essence, thus produces effect.Dipping bathing, can play dredging the channel, promoting blood circulation and removing blood stasis, wind dispelling cold dispelling, it is clearing heat and detoxicating,
Swelling and pain relieving, adjustment negative and positive, coordinate internal organs, current qi and blood, moisten the health maintenance effects such as foster whole body.Modern pharmacology is also confirmed that, after dipping
The content of some immunoglobulins in blood can be improved, strengthens the elasticity and vigor of skin.
As effect of the Chinese Traditional Medicine in modern rinse product is accepted by increasing people, the Chinese medicine production of skin care
The highest attention of product extremely industry.
Publication No. CN103932948A patent application discloses a kind of Chinese medicine bath cream and preparation method thereof, the medicine
By：The Chinese medicines such as calamus, chrysanthemum, folium artemisiae argyi, Santalum album, the banksia rose, frutus cnidii, kuh-seng, the root bark of shaggy-fruited dittany, the fruit of summer cypress, safflower, borneol are made,
With eczema, prickly heat, dermatitis, the effect for reaching cleaning, skin care for eliminating human body skin, but flavour of a drug are on the high side, and quality control is more difficult.
Publication No. CN 101284066A patent application discloses a kind of suppository for treating gynaecological imflammation, the suppository by
Golden cypress, kuh-seng, the fruit of summer cypress, hairyvein agrimony and borneol are made, to staphylococcus aureus, MRSE, gonococcus, large intestine bar
The vagina frequent infectious bacteria such as bacterium, beta streptococcus, candida albicanses has certain antibacterial activity, especially to golden yellow Portugal
Grape coccus, MRSE, beta streptococcus antibacterial effect it is significant, with obvious anti-inflammatory, itching-relieving action, but not only
Flavour of a drug are relatively more, and the scytitis and its improvement of the pruritis of generation failed to understand some pathology be not obvious.
The content of the invention
Problem to be solved by this invention is to provide a kind of Chinese medicine bath cream of inflammation-resisting itch-stopping, flavour of a drug contained by the shower cream
Less, steady quality, effect are notable.
Technical proposal that the invention solves the above-mentioned problems is as described below：
A kind of Chinese medicine bath cream of inflammation-resisting itch-stopping, the Chinese medicine bath cream is made up of active ingredient and auxiliary material, it is characterised in that
Every liter of Chinese medicine bath cream is mainly made up of the bulk drug of following weight proportion：30~40g of kuh-seng, 10~20g of the fruit of summer cypress；Wherein,
Described kuh-seng and the weight sum of the fruit of summer cypress are 50g.
Preferably, every liter of Chinese medicine bath cream is mainly made up of the bulk drug of following weight proportion：Kuh-seng 35g, ground
Skin 15g.
Water extract described in such scheme is obtained extract powder according to a conventional method, and the method that the present inventor recommends is such as
Under：
Take described bulk drug extracting in water 2-3 times, 6-10 times is added every time and measures water, 1-3h is extracted；Merging filtrate, stands
Overnight, take supernatant liquid filtering and be concentrated into medicinal extract, dry, pulverize and produce extract powder.
Chinese medicine bath cream of the present invention, wherein described auxiliary material includes surfactant, thickener, cosolvent, anti-corrosion
Agent, antioxidant and pH adjusting agent, wherein：
Described surfactant is laureth ammonium sulfate, laureth sodium sulfovinate, Texapon Special, coconut palm
Seed oil fatty diglycollic amide, Cocoamidopropyl betaine, PEG-20 methyls sesquistearate, cocounut oil acyl both sexes
Guanidine-acetic acid sodium, cocamidopropyl propyl amide hydroxy sulfo lycine, laureth sodium sulphate, Tryfac 5573 sylvite MA24PK and the last of the ten Heavenly stems
At least three kinds in base glucoside；
Described thickener be the stearate of polyoxyethylene sorbitol acid anhydride three, PEG-120 methyls dioleate,
At least one of PEG-150 distearates；
Described cosolvent be Tween-60, Tween-80, hexadecanol, octadecanol, propane diols it is one or two kinds of with
On；
Described preservative is sorbic acid, benzyl alcohol, nipalgin in ester, phenethyl alcohol, benzalkonium chloride and sodium benzoate
One or more；
Described antioxidant is one kind in vitamin C, disodium ethylene diamine tetraacetate, sodium sulfite and sodium hydrogensulfite
Or it is two or more；
Described is more than one or both of boric acid, citric acid and sodium citrate for pH adjusting agent.
Above-mentioned auxiliary material also includes NMF glycerine and flavouring agent wild rose essence.
The preparation method of above-mentioned Chinese medicine bath cream comprises the following steps：
Take obtained extract powder first to add appropriate water dilution, add cosolvent molten under conditions of 50 DEG C -70 DEG C
Solution, adds preservative, antioxidant and pH adjusting agent and is well mixed, then add surfactant and thickener, mix after cooling
Even, sterilization, is made Chinese medicine bath cream.
When described auxiliary material also includes glycerine and wild rose essence, above-mentioned preparation method is adding surfactant and increasing
Thick dose, the step of also including adding glycerine and wild rose essence after being mixed.
The application method of Chinese medicine bath cream of the present invention is as described below：
First drench body skin with warm water, by Chinese medicine bath cream by foaming tool get abundant bubble fill whole body with
Afterwards, with the hands appropriate massaging skin, finally by all thoroughly wash cleans of the bubble and Chinese medicine bath cream on body.
Chinese medicine bath cream of the present invention has advantages below compared with prior art：
Chinese medicine composition of the present invention is only made up of kuh-seng and the fruit of summer cypress, and medicine letter power is specially, evident in efficacy, and favorably
In quality control.
The present invention is more fully understood for the ease of the public, comes further below by the zoopery for investigating medicine of the present invention
Illustrate beneficial effects of the present invention.
First, the screening of inflammation-resisting itch-stopping prescription：
Golden cypress, kuh-seng, the root bark of shaggy-fruited dittany, the fruit of summer cypress, Chinese prickly ash, dandelion, radix scutellariae, the capsule of weeping forsythia, the coptis, rhizome of cyrtomium, the bark of ash, chrysanthemum and plate
Blue root etc. is that have the common drug that inflammation-resisting itch-stopping is acted in Chinese medicine, the effect experiment of anti-inflammatory is carried out to different pharmaceutical prescription and small
Mouse skin skin itch is tested, and filters out the optimal drug combination with inflammation-resisting itch-stopping.There is provided 3 dosage levels：Not medication, medication
10 grams and 20 grams of medication, according to L27(313) orthogonal arrage is configured to 27 kinds of medicines, by the decoction that every kind of medicine water extraction is 1000ml.
It is 0.1ml/g, 2 times/day by mouse weight dosage.Medication is topical administration.As a result entered using extremum difference analysis
Row analysis.
(1) effect experiment of anti-inflammatory
1st, mice ear is tested
SPF grades of KM mouse, 18-22g, male and female half and half.It is randomly divided into 27 groups, every group 10.Scorching preceding mouse back depilation is caused,
By mouse weight back coating 0.1ml/g, 2 times/day of topical administration 7d, after last dose 0.5h, per mouse, left ear two sides applies 100%
Dimethylbenzene 0.02ml causes inflammation, and auris dextra is compared.Animal is put to death after causing inflammation 2h, two ears are cut along auricle baseline, is punched with diameter 9mm
Device lays the same position disk of ears, and electronic analytical balance is weighed, and calculates swelling：Swelling=left auricle weight-auris dextra piece weight.
2nd, mouse capillary permeability is tested
SPF grades of KM mouse, male and female half and half, body weight 18-22g.It is randomly divided into 27 groups, every group 10.Mouse back loses hair or feathers, and presses
After mouse weight back coating 0.1ml/g, 2 times/day of administration 7d, last medicine after 0.5h, (the physiology of mouse tail vein injection 0.5%
Salt solution is matched somebody with somebody) her Wen's orchid 0.1ml/10g body weight.Then, 0.6% glacial acetic acid solution 0.2ml/ is injected intraperitoneally at once only.After 20min
Sacrificed by decapitation animal, abdominal cut integumentary musculature, with 6ml physiological saline fraction time washing abdominal cavity, suction pipe suctions out cleaning solution, merged
Cleaning solution adds physiological saline and centrifuges 3000 revs/min to 10ml, and 30min, supernatant surveys OD values in 590nm.
(2) to the influence of dextran induced mice skin skin itch model
SPF grades of KM mouse, male and female half and half, body weight 18-22g.It is randomly divided into 27 groups, every group 10.Mouse back loses hair or feathers, and presses
Mouse weight back coating 0.1ml/g, 2 times/day of administration 7d.After last dose 30min, each group mouse tail vein injection dextrose
Acid anhydride (mw=40000) 1.25mg/kg (0.025%, 0.05ml/10g) causes paroxysmal pruitus animal model.Before mouse
Pawl grappling fixture portion, rear solid end scratches trunk, and mouth stings each position of whole body as itch indication.Record the mouse itch paroxysmal hair in 30min
The number of times of work.
The L of table 127(313) orthogonal experiments
From experimental data above, in L27(313) in orthogonal test, kuh-seng, the fruit of summer cypress, the bark of ash, Radix Isatidis are swollen to ear
When expansibility plays a major role, optimum organization is B3D2K3M3C2L3F3H3A3G3J3E3I2.Kuh-seng, the fruit of summer cypress, the root bark of shaggy-fruited dittany are to hair
Optimum organizations are B3D2C3E2F3G3A3H3K3I3J3L1M3 when thin vasopermeability plays a major role.Kuh-seng, the fruit of summer cypress, company
Stick up, when rhizome of cyrtomium plays a major role to skin itch number of times, optimum organization is B3D2H3J3C2A3E2L3G3F3M3I3K3.Integrated comparative,
In golden cypress, kuh-seng, the root bark of shaggy-fruited dittany, the fruit of summer cypress, Chinese prickly ash, dandelion, radix scutellariae, the capsule of weeping forsythia, the coptis, rhizome of cyrtomium, the bark of ash, chrysanthemum and Radix Isatidis etc.
In the common drug acted on inflammation-resisting itch-stopping, the combination of kuh-seng and the fruit of summer cypress is that flavour of a drug are minimum, and with inflammation-resisting itch-stopping
Optimal drug is combined.
2nd, effect experiment
Test medicine：
Blank group：Physiological saline.
Experimental group 1：The shower cream that following methods describeds of embodiment one are made.
Experimental group 2：The shower cream that following methods describeds of embodiment two are made.
Experimental group 3：The shower cream that following methods describeds of embodiment five are made.
Control group 1：The shower cream that Fructus Kochiae extract is made, its preparation method is as follows：
Take 50 grams of methods as described in embodiment one of the fruit of summer cypress that 1000ml shower cream is made.
Control group 2：The shower cream that shrubby sophora extract is made, its preparation method is as follows：
Take 50 grams of methods as described in embodiment one of kuh-seng that 1000ml shower cream is made.
Control group 3：The proportioning of bulk drug, is adopted as described in embodiment 1 in Publication No. CN 101284066A patent application
The shower cream being made using the following method：
0.3 gram of 16.6 grams of golden cypress, 16.6 grams of kuh-seng, 11.0 grams of the fruit of summer cypress, 5.5 grams of hairyvein agrimony and borneol are taken, by embodiment
1000ml shower cream is made in method described in one.Dosage：
Blank group gives physiological saline, and experimental group 1-3 and control group 1-3 are 0.1ml/g by mouse weight dosage,
2 times/day.Medication is topical administration.
(1) effect experiment of anti-inflammatory
1st, mice ear is tested
SPF grades of KM mouse, 18-22g, male and female half and half.Experimental group 1-3, control group 1-3 and blank group are randomly divided into, totally 7
Group, every group 10.Scorching preceding mouse back depilation is caused, by mouse weight back coating 0.1ml/g, 2 times/day of topical administration 7d, end
After secondary administration 0.5h, per mouse, left ear two sides applies 100% dimethylbenzene 0.02ml and causes inflammation, and auris dextra is compared.Animal is put to death after causing inflammation 2h,
Two ears are cut along auricle baseline, the same position disk of ears is laid with diameter 9mm card punch, electronic analytical balance is weighed, are calculated
Swelling：Swelling=left auricle weight-auris dextra piece weight；Swelling inhibiting rate %=(blank group swelling-administration group swelling)/sky
White group swelling × 100%.
Each group mice ear degree and swelling inhibiting rate the results are shown in Table 2.
The influence of ear swelling degree caused by each group paraxylene of table 2
Statistical result showed, is compared with blank group, * P<0.05；Compared with experimental group 1, #P<0.05.
2nd, mouse capillary permeability is tested
SPF grades of KM mouse, male and female half and half, body weight 18-22g.Random packet：It is randomly divided into experimental group 1-3, control group 1-3
And blank group, totally 7 groups, every group 10.Mouse back loses hair or feathers, by mouse weight back coating 0.1ml/g, 2 times/day of topical administrations
After 7d, last medicine after 0.5h, her Wen's orchid 0.1ml/10g body weight of mouse tail vein injection 0.5% (physiological saline is matched somebody with somebody).Then,
0.6% glacial acetic acid solution 0.2ml/ is injected intraperitoneally at once only.Sacrificed by decapitation animal after 20min, abdominal cut integumentary musculature is used
6ml physiological saline fraction time washing abdominal cavity, suction pipe suctions out cleaning solution, merges cleaning solution and adds physiological saline to 10ml centrifugations 3000
Rev/min, 30min, supernatant surveys OD values in 590nm.
Each group mouse capillary permeability the results are shown in Table 3.
The each group of table 3 is tested on mouse capillary permeability to be influenceed
Statistical result showed, is compared with blank group, * P<0.05；Compared with experimental group 1, #P<0.05.
(2) to the influence of dextran induced mice skin skin itch model
SPF grades of KM mouse, male and female half and half, body weight 18-22g.Random packet：It is randomly divided into experimental group 1-3, control group 1-3
And blank group, totally 7 groups, every group 10.Mouse back loses hair or feathers, by mouse weight back coating 0.1ml/g, 2 times/day of topical administrations
7d.After last dose 30min, each group mouse tail vein injection dextran (mw=40000) 1.25mg/kg (0.025%,
0.05ml/10g) cause paroxysmal pruitus animal model.With mouse fore paw grappling fixture portion, rear solid end scratches trunk, and it is each that mouth stings whole body
Position is used as itch indication.The number of times of mouse itch paroxysmal breaking-out in record 30min and the duration of breaking-out.
Each group mouse skin skin itch itch number of times and itch duration the results are shown in Table 4.
The each group of table 4 is tested on mouse skin skin itch to be influenceed
Statistical result showed, is compared with blank group, * P<0.05；Compared with experimental group 1, #P<0.05.
(3) to the influence of mice skin tissue
SPF grades of KM mouse, male and female half and half, body weight 18-22g.Random packet：It is randomly divided into experimental group 1-3, control group 1-3
Blank group, totally 7 groups, every group 10.Mouse back loses hair or feathers, by mouse weight back coating 0.1ml/g, 2 times/day of topical administrations
30d.Neck is taken off after last dose 30min and puts to death mouse, about 1.0x1.0cm hair removal section skin histology blocks, 10% formal is cut
Woods is fixed.Routine paraffin wax embedded section, the eosin stains of haematoxylin one, every continuous 2 of section, om observation.Observation index is such as
Under：(l) dermis thickness.The dermis thickness (distance of basilar memebrane to hypodermis) of every section is measured with micro- mircrometer gauge, often
Example is surveyed at three, takes the dermis of skin thickness that its average is this.Obtain each group mouse dermis thickness average.(2) hair follicle is counted.Often
The hair follicle number of 3 high power fields (x400) of number of cases, it is this hair follicle number to take its average, obtains the average of each group mouse hair follicles number.
Each group mouse skin dermis thickness and hair follicle number the results are shown in Table 5.
Experiment of each group of table 5 on mice skin tissue influences
There was no significant difference between statistical result showed, each group.
Statistical procedures
Total data carries out statistical analysis, measurement data mean ± standard deviation using the statistics softwares of SPSS 19.0Represent.
Above-mentioned experiment shows that traditional Chinese medicine shampoo of the present invention has the degree for suppressing mice ear；Mouse hair can be reduced
Thin vasopermeability；The number of times of mouse itch paroxysmal breaking-out can be reduced.Show that traditional Chinese medicine shampoo of the present invention has anti-inflammatory, stopped
The effect itched.In addition, traditional Chinese medicine shampoo of the present invention is compared with blank group, dermis thickness does not have significant difference, shows this Chinese medicine
The side effect of shampoo intact skin.
Above-mentioned experiment is also shown that kuh-seng and fruit of summer cypress phase 5 not only have synergistic function, and the effect of inflammation-resisting itch-stopping
Fruit is also slightly above the relatively large number of prior art of flavour of a drug (Publication No. CN 101284066A patent application).
Embodiment
Embodiment one
1st, prescription：35 grams of kuh-seng, 15 grams of the fruit of summer cypress.
2nd, the preparation method of active ingredient：Take described bulk drug extracting in water 3 times, for the first time 8 times of amount water, second 6
Amount water, measures water for 6 times for the third time, each 2h, merging filtrate stands overnight, takes supernatant liquid filtering and be concentrated into medicinal extract, dries again,
Crushing produces extract powder.
3rd, the preparation method of shower cream：Extract powder is added into 2.5 grams of sodium benzoate, nipalgin 1.2 grams of ester, boric acid 12
Gram, 2.2 grams of disodium ethylene diamine tetraacetate, 0.6 gram of citric acid, 6 grams of sodium citrate heating for dissolving, be diluted to 600ml, add bay
160 grams of alcohol polyethers ammonium sulfate, 80 grams of mixings of Texapon Special, by 30 grams of glycerine, 10 grams of propane diols, Tryfac 5573 sylvite
32 grams of MA24PK, 12 grams of cocoanut fatty acid diethanolamide, 16 grams of cocamidopropyl propyl amide hydroxy sulfo lycine add to above-mentioned mixed
Close in liquid, be mixed evenly, add 0.3ml wild rose essence, be eventually adding distilled water and be settled to 1000ml, be made after sterilization
Product.
Embodiment two
1st, prescription：40 grams of kuh-seng, 10 grams of the fruit of summer cypress.
2nd, the preparation method of active ingredient：Take described bulk drug extracting in water 2 times, for the first time 8 times of amount water, second 8
The each 3h of water is measured again, and merging filtrate stands overnight, takes supernatant liquid filtering and be concentrated into medicinal extract, dry, pulverize and produce extract powder.
3rd, the preparation method of shower cream：Extract powder is added into 2.0 grams of sodium benzoate, nipalgin 1.2 grams of ester, boric acid 10
Gram, 2.6 grams of sodium sulfite, 0.6 gram of citric acid, 6 grams of sodium citrate heating for dissolving, be diluted to 600ml, add laureth sulphur
Sour 160 grams of ammonium, the 80 grams of mixings of cocamidopropyl propyl amide hydroxy sulfo lycine, by 20 grams of glycerine, 10 grams of propane diols, Tryfac 5573
32 grams of sylvite MA24PK, 12 grams of cocoanut fatty acid diethanolamide, 16 grams of Plantacare 818 are added in above-mentioned mixed liquor, are mixed
Conjunction stirs, and adds 0.3ml wild rose essence, is eventually adding distilled water and is settled to 1000ml, and product is made after sterilization.
Embodiment three
1st, prescription：34 grams of kuh-seng, 16 grams of the fruit of summer cypress.
2nd, the preparation method of active ingredient：Take described bulk drug extracting in water 2 times, for the first time 10 times of amount water, second 6
Water is measured again, and each 3h, merging filtrate stands overnight, takes supernatant liquid filtering and be concentrated into medicinal extract, dry, pulverize and produce extract powder.
3rd, the preparation method of shower cream：By extract powder add 2.5 grams of sodium benzoate, 1.2 grams of benzalkonium chloride, 12 grams of boric acid,
2.0 grams of disodium ethylene diamine tetraacetate, 0.6 gram of citric acid, 6 grams of heating for dissolving of sodium citrate, are diluted to 600ml, add cocounut oil acyl
150 grams of amine hydroxysultaine, the 80 grams of mixings of laureth sodium sulfovinate, by 50 grams of glycerine, 10 grams of propane diols, bay
30 grams of alcohol polyethers ammonium sulfate, 15 grams of cocoanut fatty acid diethanolamide, 16 grams of cocamidopropyl propyl amide hydroxy sulfo lycine are added to
In above-mentioned mixed liquor, it is mixed evenly, adds 0.3ml wild rose essence, be eventually adding distilled water and be settled to 1000ml, sterilizes
Product is made afterwards.
Example IV
1st, prescription：32 grams of kuh-seng, 18 grams of the fruit of summer cypress.
2nd, the preparation method of active ingredient：Take described bulk drug extracting in water 3 times, for the first time 10 times of amount water, second 8
Amount water, measures water for 6 times for the third time, each 2h, merging filtrate stands overnight, takes supernatant liquid filtering and be concentrated into medicinal extract, dries again,
Crushing produces extract powder.
3rd, the preparation method of shower cream：By extract powder add 2.4 grams of benzyl alcohol, nipalgin 1.5 grams of ester, 10 grams of boric acid,
2.2 grams of disodium ethylene diamine tetraacetate, 0.8 gram of citric acid, 5 grams of heating for dissolving of sodium citrate, are diluted to 600ml, add lauryl
100 grams of ammonium sulfate, 100 grams of mixings of cocoanut fatty acid diethanolamide, by 30 grams of glycerine, 15 grams of propane diols, lauryl phosphoric acid
30 grams of ester sylvite MA24PK, 12 grams of Plantacare 818,16 grams of cocamidopropyl propyl amide hydroxy sulfo lycine add to above-mentioned mixed liquor
In, it is mixed evenly, adds 0.3ml wild rose essence, be eventually adding distilled water and be settled to 1000ml, production is made after sterilization
Product.
Embodiment five
1st, prescription：30 grams of kuh-seng, 20 grams of the fruit of summer cypress.
2nd, the preparation method of active ingredient：Take described bulk drug extracting in water 2 times, for the first time 8 times of amount water, second 8
The each 2h of water is measured again, and merging filtrate stands overnight, takes supernatant liquid filtering and be concentrated into medicinal extract, dry, pulverize and produce extract powder.
3rd, the preparation method of shower cream：Extract powder is added into 2.0 grams of phenethyl alcohol, 1.5 grams of sorbic acid, 15 grams of boric acid, Asia
2.5 grams of sodium sulphate, 1.0 grams of citric acid, 5 grams of heating for dissolving of sodium citrate, are diluted to 600ml, add cocamidopropyl propyl amide beet
150 grams of alkali, the 70 grams of mixings of laureth sodium sulphate, by 40 grams of glycerine, 20 grams of propane diols, sodium cocoamphoacetate 30
Gram, 12 grams of cocoanut fatty acid diethanolamide, 18 grams of cocamidopropyl propyl amide hydroxy sulfo lycine add in above-mentioned mixed liquor, mix
Conjunction stirs, and adds 0.3ml wild rose essence, is eventually adding distilled water and is settled to 1000ml, and product is made after sterilization.
Claims (2)
1. a kind of Chinese medicine bath cream of inflammation-resisting itch-stopping, the Chinese medicine bath cream is made up of active ingredient and auxiliary material, it is characterised in that every
Chinese medicine bath cream is risen mainly to be made up of the bulk drug of following weight proportion：30~40g of kuh-seng, 10~20g of the fruit of summer cypress；Wherein, institute
The kuh-seng and the weight sum of the fruit of summer cypress stated are 50g.
2. a kind of Chinese medicine bath cream of inflammation-resisting itch-stopping according to claim 1, it is characterised in that every liter of Chinese medicine bath cream master
To be made up of the bulk drug of following weight proportion：Kuh-seng 35g, fruit of summer cypress 15g.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017103143513 | 2017-05-06 | ||
| CN201710314351 | 2017-05-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107115247A true CN107115247A (en) | 2017-09-01 |
| CN107115247B CN107115247B (en) | 2020-06-02 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710504123.2A Active CN107115247B (en) | 2017-05-06 | 2017-06-28 | Anti-inflammatory and antipruritic traditional Chinese medicine shower gel |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693941A (en) * | 2019-11-07 | 2020-01-17 | 遵义医学院附属医院 | Composition for sterilizing, relieving itching and treating neurodermatitis and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048660A (en) * | 2009-10-28 | 2011-05-11 | 杨杰 | Health-care shampoo for bathing |
| CN103393554A (en) * | 2010-06-25 | 2013-11-20 | 张红雨 | Bath lotion |
| CN103479737A (en) * | 2013-08-06 | 2014-01-01 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating senile cutaneous pruritus and application thereof |
| CN105055232A (en) * | 2015-08-12 | 2015-11-18 | 苏州卫生职业技术学院 | Traditional Chinese medicine bath shampoo and preparation method thereof |
-
2017
- 2017-06-28 CN CN201710504123.2A patent/CN107115247B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048660A (en) * | 2009-10-28 | 2011-05-11 | 杨杰 | Health-care shampoo for bathing |
| CN103393554A (en) * | 2010-06-25 | 2013-11-20 | 张红雨 | Bath lotion |
| CN103479737A (en) * | 2013-08-06 | 2014-01-01 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating senile cutaneous pruritus and application thereof |
| CN105055232A (en) * | 2015-08-12 | 2015-11-18 | 苏州卫生职业技术学院 | Traditional Chinese medicine bath shampoo and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 何天富等: "《中药快速记忆法》", 30 April 2015, 金盾出版社 * |
| 高学敏等: "《临床中药学》", 31 January 2006, 河北科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693941A (en) * | 2019-11-07 | 2020-01-17 | 遵义医学院附属医院 | Composition for sterilizing, relieving itching and treating neurodermatitis and preparation method thereof |
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| CN107115247B (en) | 2020-06-02 |
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Effective date of registration: 20230104 Address after: Room 101, Building 5, No. 439, Xinxing Road, Conghua District, Guangzhou, Guangdong 510000 Patentee after: Haoxiu Daily Chemical Products Co.,Ltd. Address before: 510660 3rd floor, 55 Huangcun Road, Tianhe District, Guangzhou City, Guangdong Province Patentee before: GAOKANG DAILY CHEMICAL GROUP CO.,LTD. |