CN107115247B - Anti-inflammatory and antipruritic traditional Chinese medicine shower gel - Google Patents
Anti-inflammatory and antipruritic traditional Chinese medicine shower gel Download PDFInfo
- Publication number
- CN107115247B CN107115247B CN201710504123.2A CN201710504123A CN107115247B CN 107115247 B CN107115247 B CN 107115247B CN 201710504123 A CN201710504123 A CN 201710504123A CN 107115247 B CN107115247 B CN 107115247B
- Authority
- CN
- China
- Prior art keywords
- traditional chinese
- chinese medicine
- shower gel
- mouse
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to an anti-inflammatory and antipruritic traditional Chinese medicine shower gel, which consists of effective components and auxiliary materials, and is characterized in that each liter of traditional Chinese medicine shower gel is mainly prepared from the following raw material medicines in parts by weight: 30-40 g of radix sophorae flavescentis and 10-20 g of fructus kochiae; wherein the sum of the weight of the radix sophorae flavescentis and the weight of the fructus kochiae is 50 g. The traditional Chinese medicine shower gel provided by the invention has the effects of resisting inflammation and relieving itching. The traditional Chinese medicine composition has few medicinal ingredients, is beneficial to quality control, has simple and special medicinal effects and has obvious effect.
Description
Technical Field
The present invention relates to medical preparations, and more particularly to pharmaceutical preparations containing undefined structures derived from plants, which are suitable for inflammation and itching of the skin.
Technical Field
The medicated bath method is one of external treatment methods, that is, a method of bathing the whole body or part of the body with a liquid medicine or water containing the liquid medicine, and has various forms: the bath for the whole body is called 'liquid medicine bath'; local bath includes "scalding", "fumigating", "hip bath" and "foot bath". The general theory of action of medicated bath is that the herbs act on the superficial, local and affected parts of the body, and are absorbed by the meridians and collaterals, blood vessels, and viscera, and from the exterior to the interior, thus generating the effect. The medicated bath has effects of dredging channels and collaterals, promoting blood circulation for removing blood stasis, dispelling pathogenic wind and cold, clearing away heat and toxic materials, relieving swelling and pain, regulating yin and yang, coordinating viscera, promoting qi and blood circulation, and nourishing body. Modern pharmacology also proves that the content of certain immunoglobulin in blood can be increased after medicated bath, and the elasticity and the vitality of skin can be enhanced.
With the role of traditional Chinese medicine in modern wash products being recognized by more and more people, skin-care traditional Chinese medicine products are highly concerned by the industry.
The patent application with the publication number of CN103932948A discloses a traditional Chinese medicine shower gel and a preparation method thereof, wherein the traditional Chinese medicine shower gel comprises the following components in parts by weight: the traditional Chinese medicine is prepared from calamus, chrysanthemum, folium artemisiae argyi, white sandalwood, elecampane, fructus cnidii, radix sophorae flavescentis, cortex dictamni, fructus kochiae, safflower, borneol and the like, has the effects of eliminating eczema, miliaria and dermatitis of human skin and achieving cleaning and skin care, but has more medicinal flavors and is difficult to control quality.
The patent application with the publication number of CN 101284066A discloses a suppository for treating gynecological inflammation, which is prepared from phellodendron, sophora flavescens, fructus kochiae, agrimony and borneol, has certain antibacterial activity on common vaginal infectious bacteria such as staphylococcus aureus, staphylococcus epidermidis, gonococcus, escherichia coli, streptococcus type B, candida albicans and the like, has obvious antibacterial effect on staphylococcus aureus, staphylococcus epidermidis and streptococcus type B, has obvious anti-inflammatory and itching relieving effects, but has relatively more medicinal flavors, and has an unobvious improvement effect on skin inflammation with unknown pathology and pruritus symptoms generated by the skin inflammation.
Disclosure of Invention
The invention aims to solve the problem of providing the anti-inflammatory and antipruritic traditional Chinese medicine shower gel which is less in medicine flavor, stable in quality and remarkable in effect.
The technical scheme for solving the problems is as follows:
the traditional Chinese medicine shower gel is composed of effective components and auxiliary materials, and is characterized in that each liter of the traditional Chinese medicine shower gel is prepared from the following raw material medicines in parts by weight: 30-40 g of radix sophorae flavescentis and 10-20 g of fructus kochiae; wherein the sum of the weight of the radix sophorae flavescentis and the weight of the fructus kochiae is 50 g.
As a preferred scheme, each liter of the traditional Chinese medicine shower gel is prepared from the following raw material medicines in parts by weight: 35g of radix sophorae flavescentis and 15g of fructus kochiae.
The aqueous extract in the scheme is extract powder prepared by a conventional method, and the method recommended by the inventor is as follows:
extracting the raw materials with water for 2-3 times, adding 6-10 times of water each time, and extracting for 1-3 h; mixing filtrates, standing overnight, collecting supernatant, filtering, concentrating to obtain extract, drying, and pulverizing to obtain extract powder.
The traditional Chinese medicine shower gel provided by the invention comprises auxiliary materials including a surfactant, a thickening agent, a cosolvent, a preservative, an antioxidant and a pH regulator, wherein:
the surfactant is at least three of ammonium laureth sulfate, sodium laureth sulfate, ammonium lauryl sulfate, coconut oil fatty acid diethanolamide, cocamidopropyl betaine, PEG-20 methyl glucose sesquistearate, sodium cocoamphoacetate, cocamidopropyl hydroxysultaine, sodium laureth sulfate, potassium laurylphosphate MA24PK and decyl glucoside;
the thickening agent is at least one of polyoxyethylene sorbitan tristearate, PEG-120 methyl glucose dioleate and PEG-150 distearate;
the cosolvent is one or more than two of tween-60, tween-80, cetyl alcohol, stearyl alcohol and propylene glycol;
the preservative is one or more than two of sorbic acid, benzyl alcohol, ethylparaben, phenoxyethanol, benzalkonium chloride and sodium benzoate;
the antioxidant is one or more than two of vitamin C, disodium ethylene diamine tetraacetate, sodium sulfite and sodium bisulfite;
the pH regulator is one or more than two of boric acid, citric acid and sodium citrate.
The adjuvants also comprise humectant glycerol and flavoring agent flos Rosae Davuricae essence.
The preparation method of the traditional Chinese medicine shower gel comprises the following steps:
adding appropriate amount of water to dilute the obtained extract powder, adding cosolvent to dissolve at 50-70 deg.C, cooling, adding antiseptic, antioxidant and pH regulator, mixing, adding surfactant and thickener, mixing, and sterilizing to obtain the final product.
When the auxiliary materials also comprise glycerin and wild rose essence, the preparation method comprises the steps of adding the surfactant and the thickening agent, and adding the glycerin and the wild rose essence after uniformly mixing.
The use method of the traditional Chinese medicine shower gel provided by the invention is as follows:
the body skin is wetted by warm water, rich bubbles are made by the traditional Chinese medicine shower gel by means of a foaming tool and are spread on the whole body, the skin is properly massaged by hands, and finally the bubbles on the body and the traditional Chinese medicine shower gel are thoroughly washed.
Compared with the prior art, the traditional Chinese medicine shower gel has the following advantages:
the traditional Chinese medicine composition is only prepared from radix sophorae flavescentis and fructus kochiae, is simple and special in medicine, has an obvious curative effect and is beneficial to quality control.
To facilitate a better understanding of the present invention by the public, the beneficial effects of the present invention are further illustrated below by animal experiments examining the drug of the present invention.
Firstly, screening an anti-inflammatory and itching-relieving formula:
phellodendron, sophora flavescens, cortex dictamni, fructus kochiae, pepper, dandelion, scutellaria baicalensis, fructus forsythiae, coptis chinensis, cyrtomium rhizome, ash bark, chrysanthemum, isatis root and the like are common medicines with anti-inflammatory and itching relieving effects in traditional Chinese medicines, anti-inflammatory effect experiments and mouse skin itch experiments are carried out on different medicine compositions, and the optimal medicine combination with anti-inflammatory and itching relieving effects is screened out. 3 dose levels were set: 10g of the medicine is not used and 20g of the medicine is used according to L27(313) The orthogonal table is configured into 27 medicines, and each medicine is extracted by water to form 1000ml liquid medicine. The dose is 0.1ml/g and 2 times/day according to the body weight of the mice. The administration method is topical administration. The results were analyzed by range analysis.
(first) anti-inflammatory Effect test
1. Mouse ear swelling test
SPF-grade KM mice, 18-22g, male and female halves. The groups were randomized into 27 groups of 10 individuals each. Before inflammation, the back of the mouse is unhaired, the medicine is applied to the back of the mouse according to the weight of the mouse, 0.1ml/g is applied, the medicine is externally applied for 7 days for 2 times/day, after the last administration is carried out for 0.5h, 0.02ml of 100% dimethylbenzene is applied to the two sides of the left ear of each mouse to cause inflammation, and the right ear is used as a control. The animals were sacrificed after 2h of inflammation, two ears were cut along the auricle base line, the same part wafer of the two ears was punched out with a puncher with a diameter of 9mm, weighed with an electronic analytical balance, and the swelling degree was calculated: swelling degree is the weight of left ear piece to right ear piece.
2. Capillary permeability test in mice
SPF-grade KM mice, half male and half female, weighing 18-22 g. The groups were randomized into 27 groups of 10 individuals each. The back of the mouse is unhaired, the medicine is applied to the back of the mouse according to the weight of the mouse, the medicine is administered for 7 days 2 times/day, and 0.5 hour after the last medicine is administered, 0.5 percent (normal saline is added) of Yiwenlan is injected into the tail vein of the mouse, wherein the Iwenlan is 0.1ml/10g of the weight. Then, 0.2 ml/vial of 0.6% glacial acetic acid solution was immediately intraperitoneally injected. Killing the animal after 20min, cutting off abdominal skin muscle, washing abdominal cavity with 6ml physiological saline several times, sucking out washing liquid with suction tube, mixing washing liquids, adding physiological saline to 10ml, centrifuging at 3000 rpm for 30min, collecting supernatant at 590nm, and measuring OD value.
(II) Effect on dextran-induced skin itch model in mice
SPF-grade KM mice, half male and half female, weighing 18-22 g. The groups were randomized into 27 groups of 10 individuals each. The back of the mouse is unhaired, and the medicine is applied to the back of the mouse according to the weight of the mouse, wherein the medicine is 0.1ml/g, and is administered for 2 times/day for 7 days. 30min after the last administration, dextran (mw 40000) injected into tail vein of each group of mice at 1.25mg/kg (0.025%, 0.05ml/10g) resulted in an animal model of paroxysmal skin itch. The head of the mouse is grabbed by the front paw, the trunk of the mouse is scratched by the back paw, and all parts of the whole body are bitten by the mouth to serve as pruritus indications. The number of itching episodic episodes of the mice within 30min was recorded.
TABLE 1L27(313) Results of orthogonal experiments
From the above experimental data, in L27(313) In orthogonal experiment, when radix Sophorae Flavescentis, Kochiae fructus, cortex Fraxini, and radix Isatidis have main effects on ear swelling degree, optimal combination is adoptedIs B3D2K3M3C2L3F3H3A3G3J3E3I 2. The optimized composition is B3D2C3E2F3G3A3H3K3I3J3L1M3 when the sophora flavescens, the fructus kochiae and the cortex dictamni play a main role in capillary permeability. The optimal combination of the radix sophorae flavescentis, the fructus kochiae, the fructus forsythiae and the cyrtomium fortunei is B3D2H3J3C2A3E2L3G3F3M3I3K3 when the main effects are exerted on the skin itch times. In comprehensive comparison, in common medicaments with anti-inflammatory and antipruritic effects, such as phellodendron amurense, sophora flavescens, cortex dictamni, fructus kochiae, pepper, dandelion, scutellaria baicalensis, fructus forsythiae, coptis chinensis, cyrtomium fortunei, cortex fraxini, chrysanthemum, isatis root and the like, the composition of the sophora flavescens and the fructus kochiae has the minimum medicinal flavor and has the optimal anti-inflammatory and antipruritic medicinal composition.
Second, drug effect experiment
The tested drugs are:
blank group: physiological saline.
Experimental group 1: the shower gel was prepared as described in the first example below.
Experimental group 2: a body wash made by the method described in example two below.
Experimental group 3: the shower gel was prepared as described in example five below.
Control group 1: the preparation method of the shower gel prepared from the belvedere fruit extract comprises the following steps:
taking 50g of broom cypress fruit, and preparing 1000ml of shower gel according to the method described in the first embodiment.
Control group 2: the preparation method of the bath lotion prepared from the sophora flavescens extract comprises the following steps:
taking 50g of radix sophorae flavescentis, and preparing 1000ml of shower gel according to the method in the embodiment I.
Control group 3: the shower gel is prepared by the following method according to the mixture ratio of the raw material medicines in the patent application with the publication number of CN 101284066A in the embodiment 1:
taking 16.6 g of phellodendron, 16.6 g of sophora flavescens, 11.0 g of fructus kochiae, 5.5 g of hairyvein agrimony and 0.3 g of borneol, and preparing 1000ml of shower gel according to the method described in the embodiment one. Administration dose:
the blank group was given physiological saline, and the experimental group 1-3 and the control group 1-3 were each given a dose of 0.1ml/g, 2 times/day, based on the body weight of the mouse. The administration method is topical administration.
(first) anti-inflammatory Effect test
1. Mouse ear swelling test
SPF-grade KM mice, 18-22g, male and female halves. The test groups 1-3, the control groups 1-3 and the blank group are randomly divided into 7 groups, and 10 groups are included in each group. Before inflammation, the back of the mouse is unhaired, the medicine is applied to the back of the mouse according to the weight of the mouse, 0.1ml/g is applied, the medicine is externally applied for 7 days for 2 times/day, after the last administration is carried out for 0.5h, 0.02ml of 100% dimethylbenzene is applied to the two sides of the left ear of each mouse to cause inflammation, and the right ear is used as a control. The animals were sacrificed after 2h of inflammation, two ears were cut along the auricle base line, the same part wafer of the two ears was punched out with a puncher with a diameter of 9mm, weighed with an electronic analytical balance, and the swelling degree was calculated: swelling degree is the weight of left ear piece to the weight of right ear piece; the percent inhibition of swelling is (swelling degree of blank group-swelling degree of administration group)/swelling degree of blank group × 100%.
The results of the ear swelling degree and swelling degree inhibition rate of each group of mice are shown in Table 2.
TABLE 2 Effect of each group on ear swelling caused by xylene
Statistical results show P <0.05 compared to the blank group; compared with experimental group 1, # P < 0.05.
2. Capillary permeability test in mice
SPF-grade KM mice, half male and half female, weighing 18-22 g. And (3) random grouping: the test groups 1-3, the control groups 1-3 and the blank group are randomly divided into 7 groups, and 10 groups are included in each group. The back of the mouse is unhaired, the medicine is applied to the back of the mouse according to the weight of the mouse, the medicine is externally applied for 7 days for 2 times/day, and 0.5 percent (by normal saline) Yiwenlan is injected into the tail vein of the mouse 0.1ml/10g of the weight after the medicine is applied for the last time. Then, 0.2 ml/vial of 0.6% glacial acetic acid solution was immediately intraperitoneally injected. Killing the animal after 20min, cutting off abdominal skin muscle, washing abdominal cavity with 6ml physiological saline several times, sucking out washing liquid with suction tube, mixing washing liquids, adding physiological saline to 10ml, centrifuging at 3000 rpm for 30min, collecting supernatant at 590nm, and measuring OD value.
The results of capillary permeability in each group of mice are shown in table 3.
Table 3 influence of groups on mouse capillary permeability experiments
Statistical results show P <0.05 compared to the blank group; compared with experimental group 1, # P < 0.05.
(II) Effect on dextran-induced skin itch model in mice
SPF-grade KM mice, half male and half female, weighing 18-22 g. And (3) random grouping: the test groups 1-3, the control groups 1-3 and the blank group are randomly divided into 7 groups, and 10 groups are included in each group. The back of the mouse is unhaired, and the medicine is applied to the back of the mouse according to the weight of the mouse, wherein the medicine is externally applied for 2 times/day for 7 days. 30min after the last administration, dextran (mw 40000) injected into tail vein of each group of mice at 1.25mg/kg (0.025%, 0.05ml/10g) resulted in an animal model of paroxysmal skin itch. The head of the mouse is grabbed by the front paw, the trunk of the mouse is scratched by the back paw, and all parts of the whole body are bitten by the mouth to serve as pruritus indications. The number of itching episodic episodes and the duration of the episodes were recorded in the mice over 30 min.
The results of the number of skin itch and the duration of itch in the skin of each group of mice are shown in Table 4.
Table 4 Effect of groups on mouse skin itch test
Statistical results show P <0.05 compared to the blank group; compared with experimental group 1, # P < 0.05.
(III) Effect on mouse skin histology
SPF-grade KM mice, half male and half female, weighing 18-22 g. And (3) random grouping: the test groups are randomly divided into 7 groups of blank groups of 1-3 experimental groups and 1-3 control groups, and each group contains 10 animals. The back of the mouse is unhaired, and the medicine is applied to the back of the mouse according to the weight of the mouse, wherein the medicine is externally applied for 30 days for 2 times per day. The mice were sacrificed by decapitation 30min after the last administration, and skin tissue blocks of approximately 1.0X1.0cm of the depilated area were cut out and fixed with 10% formalin. Sections were routinely paraffin-embedded, stained with hematoxylin-eosin, 2 serial sections per case, and observed under light. The observation indexes are as follows: (l) The thickness of the dermis. The dermal thickness (distance from basement membrane to subcutaneous tissue) was measured for each section using a micrometer, and the average of the dermal thickness for each section was taken at three locations. The mean value of the thickness of the dermis was determined for each group of mice. (2) Hair follicle count. The number of hair follicles in 3 high-power fields (x400) per case was averaged to obtain the number of hair follicles in the case, and the number of hair follicles in each group of mice was averaged.
The results of dermal thickness and number of follicles in the skin of each group of mice are shown in Table 5.
Table 5 experimental effect of groups on mouse skin histology
Statistical results show that there were no significant differences between groups.
Statistical treatment
All data were statistically analyzed using SPSS 19.0 statistical software, and the mean. + -. standard deviation was used for data measurement
And (4) showing.
The experiments show that the traditional Chinese medicine shampoo disclosed by the invention has the effect of inhibiting the ear swelling of mice; can reduce the capillary permeability of mice; can reduce the frequency of paroxysmal pruritus attacks of mice. The traditional Chinese medicine shampoo disclosed by the invention has the effects of resisting inflammation and relieving itching. In addition, compared with the blank group, the traditional Chinese medicine shampoo has no significant difference in the thickness of the dermis, and the side effect of the traditional Chinese medicine shampoo on the skin is not damaged.
The above experiments also show that the compatibility of radix Sophorae Flavescentis and Kochiae fructus not only has synergistic effect, but also has anti-inflammatory and antipruritic effects slightly higher than those of the prior art with relatively more medicinal herbs (patent application with publication No. CN 101284066A).
Detailed Description
Example one
1. Prescription: 35g of sophora flavescens and 15g of fructus kochiae.
2. The preparation method of the effective components comprises the following steps: extracting the raw materials with water for 3 times, the first time with 8 times of water, the second time with 6 times of water, and the third time with 6 times of water, each for 2 hr, mixing filtrates, standing overnight, collecting supernatant, filtering, concentrating to obtain extract, drying, and pulverizing to obtain extract powder.
3. The preparation method of the shower gel comprises the following steps: adding 2.5 g of sodium benzoate, 1.2 g of ethylparaben, 12 g of boric acid, 2.2 g of disodium ethylenediamine tetraacetic acid, 0.6 g of citric acid and 6 g of sodium citrate into the extract powder, heating to dissolve, diluting to 600ml, adding 160 g of laureth ammonium sulfate and 80 g of lauryl ammonium sulfate, mixing uniformly, adding 30 g of glycerol, 10g of propylene glycol, 24PK 32 g of potassium lauryl phosphate MA, 12 g of coconut diethanolamide and 16 g of cocamidopropyl hydroxysulfobetaine into the mixed solution, mixing and stirring uniformly, adding 0.3ml of wild rose essence, finally adding distilled water to reach a constant volume of 1000ml, and sterilizing to obtain the product.
Example two
1. Prescription: 40g of sophora flavescens and 10g of fructus kochiae.
2. The preparation method of the effective components comprises the following steps: extracting the raw materials with water for 2 times, wherein the first time is 8 times of water, the second time is 8 times of water, each time lasts for 3 hours, combining filtrates, standing overnight, collecting supernatant, filtering and concentrating to obtain extract, drying, and pulverizing to obtain extract powder.
3. The preparation method of the shower gel comprises the following steps: adding 2.0 g of sodium benzoate, 1.2 g of ethylparaben, 10g of boric acid, 2.6 g of sodium sulfite, 0.6 g of citric acid and 6 g of sodium citrate into the extract powder, heating to dissolve, diluting to 600ml, adding 160 g of laureth ammonium sulfate and 80 g of cocamidopropyl hydroxysulfobetaine, mixing uniformly, adding 20g of glycerol, 10g of propylene glycol, 24PK 32 g of potassium lauryl phosphate MA, 12 g of coconut oil fatty acid diethanolamide and 16 g of decyl glucoside into the mixed solution, mixing and stirring uniformly, adding 0.3ml of wild rose essence, finally adding distilled water to reach the constant volume of 1000ml, and sterilizing to obtain the product.
EXAMPLE III
1. Prescription: 34 g of sophora flavescens and 16 g of fructus kochiae.
2. The preparation method of the effective components comprises the following steps: extracting the above raw materials with water for 2 times, 10 times of water for the first time and 6 times of water for the second time, each for 3 hr, mixing filtrates, standing overnight, collecting supernatant, filtering, concentrating to obtain extract, drying, and pulverizing to obtain extract powder.
3. The preparation method of the shower gel comprises the following steps: adding 2.5 g of sodium benzoate, 1.2 g of benzalkonium chloride, 12 g of boric acid, 2.0 g of ethylene diamine tetraacetic acid, 0.6 g of citric acid and 6 g of sodium citrate into the extract powder, heating to dissolve, diluting to 600ml, adding 150 g of cocamidopropyl hydroxysulfobetaine and 80 g of sodium laureth sulfate, uniformly mixing, adding 50g of glycerol, 10g of propylene glycol, 30 g of ammonium laureth sulfate, 15g of coconut fatty acid diethanolamide and 16 g of cocamidopropyl hydroxysulfobetaine into the mixed solution, uniformly mixing and stirring, adding 0.3ml of wild rose essence, finally adding distilled water to reach a constant volume of 1000ml, and sterilizing to obtain the product.
Example four
1. Prescription: 32 g of sophora flavescens and 18 g of fructus kochiae.
2. The preparation method of the effective components comprises the following steps: extracting the raw materials with water for 3 times, 10 times of water for the first time, 8 times of water for the second time, and 6 times of water for the third time, each for 2h, mixing filtrates, standing overnight, collecting supernatant, filtering, concentrating to obtain extract, drying, and pulverizing to obtain extract powder.
3. The preparation method of the shower gel comprises the following steps: adding 2.4 g of benzyl alcohol, 1.5 g of ethylparaben, 10g of boric acid, 2.2 g of ethylene diamine tetraacetic acid, 0.8 g of citric acid and 5g of sodium citrate into the extract powder, heating to dissolve, diluting to 600ml, adding 100 g of ammonium lauryl sulfate and 100 g of coconut fatty acid diethanolamide, mixing uniformly, adding 30 g of glycerol, 15g of propylene glycol, 24 g of potassium lauryl phosphate MA24PK 30, 12 g of decyl glucoside and 16 g of cocamidopropyl hydroxysulfobetaine into the mixed solution, mixing and stirring uniformly, adding 0.3ml of wild rose essence, finally adding distilled water to reach a constant volume of 1000ml, and sterilizing to obtain the product.
EXAMPLE five
1. Prescription: 30 g of sophora flavescens and 20g of fructus kochiae.
2. The preparation method of the effective components comprises the following steps: extracting the raw materials with water for 2 times, wherein the first time is 8 times of water, the second time is 8 times of water, each time lasts for 2 hours, combining filtrates, standing overnight, collecting supernatant, filtering and concentrating to obtain extract, drying, and pulverizing to obtain extract powder.
3. The preparation method of the shower gel comprises the following steps: adding 2.0 g of phenoxyethanol, 1.5 g of sorbic acid, 15g of boric acid, 2.5 g of sodium sulfite, 1.0 g of citric acid and 5g of sodium citrate into the extract powder, heating to dissolve, diluting to 600ml, adding 150 g of cocamidopropyl betaine and 70 g of sodium laureth sulfate, uniformly mixing, adding 40g of glycerol, 20g of propylene glycol, 30 g of sodium cocoamphoacetate, 12 g of coconut fatty acid diethanolamide and 18 g of cocamidopropyl hydroxysulfobetaine into the mixed solution, uniformly mixing and stirring, adding 0.3ml of wild rose essence, finally adding distilled water to reach a constant volume of 1000ml, and sterilizing to obtain the product.
Claims (1)
1. The anti-inflammatory traditional Chinese medicine shower gel is composed of effective components and auxiliary materials, and is characterized in that each liter of traditional Chinese medicine shower gel is prepared from the following raw material medicines in parts by weight: 35g of radix sophorae flavescentis and 15g of fructus kochiae.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017103143513 | 2017-05-06 | ||
| CN201710314351 | 2017-05-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107115247A CN107115247A (en) | 2017-09-01 |
| CN107115247B true CN107115247B (en) | 2020-06-02 |
Family
ID=59719593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710504123.2A Active CN107115247B (en) | 2017-05-06 | 2017-06-28 | Anti-inflammatory and antipruritic traditional Chinese medicine shower gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107115247B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693941A (en) * | 2019-11-07 | 2020-01-17 | 遵义医学院附属医院 | Composition for sterilizing, relieving itching and treating neurodermatitis and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048660A (en) * | 2009-10-28 | 2011-05-11 | 杨杰 | Health-care shampoo for bathing |
| CN103393554A (en) * | 2010-06-25 | 2013-11-20 | 张红雨 | Bath lotion |
| CN105055232A (en) * | 2015-08-12 | 2015-11-18 | 苏州卫生职业技术学院 | Traditional Chinese medicine bath shampoo and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479737A (en) * | 2013-08-06 | 2014-01-01 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating senile cutaneous pruritus and application thereof |
-
2017
- 2017-06-28 CN CN201710504123.2A patent/CN107115247B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048660A (en) * | 2009-10-28 | 2011-05-11 | 杨杰 | Health-care shampoo for bathing |
| CN103393554A (en) * | 2010-06-25 | 2013-11-20 | 张红雨 | Bath lotion |
| CN105055232A (en) * | 2015-08-12 | 2015-11-18 | 苏州卫生职业技术学院 | Traditional Chinese medicine bath shampoo and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107115247A (en) | 2017-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110934783B (en) | Dandruff-removing and itching-relieving composition containing Chinese herbal medicines, silicone oil-free amino acid shampoo containing composition, and preparation method and application of silicone oil-free amino acid shampoo | |
| CN103655383B (en) | Chinese medicinal herb extract and preparation method and application thereof | |
| CN103565692B (en) | A kind of conditioning liquid for cleaning and processing technology thereof containing various plants extract | |
| CN111374902A (en) | Anti-hair loss and hair-fixing shampoo composition containing fibroin and preparation method thereof | |
| CN108785185A (en) | A kind of dandruff-removing itching-relieve shampoo and preparation method thereof | |
| CN108938513B (en) | Skin-cleaning acne-removing beauty cream and preparation method thereof | |
| CN105395397A (en) | Antibacterial skin care type traditional Chinese medicine composition and application thereof in daily necessities | |
| CN107308288B (en) | A Chinese medicinal shampoo for preventing and treating alopecia and scalp pruritus | |
| CN111467285A (en) | Plant anti-dandruff shampoo and preparation method thereof | |
| CN108685769A (en) | A kind of herbal mixture black hair anticreep shampoo and preparation method thereof | |
| CN110787114A (en) | Foam shampoo capable of removing dandruff, relieving itching and controlling oil and preparation method thereof | |
| CN113230184A (en) | Scalp composition for 1+1 scalp hair cleaning and preparation method thereof | |
| CN108403611A (en) | A kind of efficient sterilizing anticreep promotees hair tonic shampoo and preparation method thereof | |
| KR101174046B1 (en) | Oriental herbal bathing material and manufacturing method thereof | |
| CN107115247B (en) | Anti-inflammatory and antipruritic traditional Chinese medicine shower gel | |
| CN113456566A (en) | Composition containing naringin and application of composition in shampoo | |
| CN101559035B (en) | Plant extract composition for killing fungi, preparation method thereof and application in preparing antifungal products | |
| CN108434051A (en) | Hair follicle transdermal absorption traditional Chinese medicinal blood, preparation method and the application in shampoo | |
| CN108078864A (en) | A kind of composition comprising tea bran and its preparation method and application | |
| KR101598083B1 (en) | An antifungal composition comprising an natural fermentation material | |
| CN112870133A (en) | Traditional Chinese medicine skin-moistening shower gel and preparation method thereof | |
| CN112618463A (en) | Bacteriostatic skin-care bath foam containing traditional Chinese medicine extract | |
| CN112022767A (en) | Anti-inflammatory antibacterial immunity-enhancing acne-removing composition and application thereof | |
| CN1284324A (en) | Serial products capable of treating seborrheic baldness, eliminating scurf and stopping head itching | |
| CN104706840A (en) | Compound tea tree essential oil for preventing and treating mosquito bite |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230104 Address after: Room 101, Building 5, No. 439, Xinxing Road, Conghua District, Guangzhou, Guangdong 510000 Patentee after: Haoxiu Daily Chemical Products Co.,Ltd. Address before: 510660 3rd floor, 55 Huangcun Road, Tianhe District, Guangzhou City, Guangdong Province Patentee before: GAOKANG DAILY CHEMICAL GROUP CO.,LTD. |