CN110693941A - Composition for sterilizing, relieving itching and treating neurodermatitis and preparation method thereof - Google Patents

Abstract

The application relates to a composition for sterilizing, relieving itching and treating neurodermatitis in the technical field of medical care, which comprises the following raw materials in parts by weight: 10-35 parts of phenol, 2-5 parts of menthol, 75-150 parts of glycerol, 144-270 parts of ethanol, 50-100 parts of radix sophorae flavescentis extract and 60-130 parts of fructus kochiae extract.

Description

Composition for sterilizing, relieving itching and treating neurodermatitis and preparation method thereof

Technical Field

The invention relates to the technical field of medical care, in particular to a composition for sterilizing, relieving itching and treating neurodermatitis and a preparation method thereof.

Background

Neurodermatitis is also called as chronic simple moss; is a chronic skin disease characterized by paroxysmal cutaneous pruritus and cutaneous lichenification. Neurodermatitis is a common skin disease, is commonly seen in adults, and is not commonly seen in children. The skin is only scratchy but has no primary skin damage, and due to scratching and rubbing, the skin gradually appears flat papules from millet grains to mung bean in size, is round or polygonal, hard and glossy, and is pale red or normal in skin color and scattered in distribution. Neurodermatitis is a common skin disease in daily life. At present, although various preparations for treating the disease comprise dermatitis ointment, compound dexamethasone acetate ointment and the like, most of the preparations are western medicines or chemical preparations, the problems of long treatment course, quick response, easy relapse after medicine withdrawal and easy generation of drug resistance exist, and the long-term use can generate side effects on human bodies. If pure traditional Chinese medicines are used, the problem of slow effect can be solved radically, so how to combine traditional Chinese medicine with western medicine, overcoming the defects of the western medicine/chemical preparation and the traditional Chinese medicine, and finding an external traditional Chinese medicine and western medicine preparation with good effect of treating neurodermatitis is very necessary.

Disclosure of Invention

The invention aims to provide a composition for treating neurodermatitis by sterilizing and relieving itching and a preparation method thereof, which combine traditional Chinese medicines and chemical preparations to achieve the purposes of quick response and relapse prevention.

The composition for sterilizing, relieving itching and treating neurodermatitis comprises the following raw materials in parts by weight: 10-35 parts of phenol, 2-5 parts of menthol, 75-150 parts of glycerol, 144-270 parts of ethanol, 50-100 parts of a sophora flavescens extract and 60-130 parts of a fructus kochiae extract.

Preferably, the raw materials comprise the following components in parts by weight: 20-35 parts of phenol, 3-5 parts of menthol, 100-150 parts of glycerol, 200-270 parts of ethanol, 80-100 parts of a sophora flavescens extract and 90-130 parts of a fructus kochiae extract.

Preferably, the raw materials comprise the following components in parts by weight: 10 parts of phenol, 2 parts of menthol, 75 parts of glycerol, 144 parts of ethanol, 50 parts of a sophora flavescens extract and 60 parts of a belvedere fruit extract.

Preferably, the raw materials comprise the following components in parts by weight: 35 parts of phenol, 5 parts of menthol, 150 parts of glycerol, 270 parts of ethanol, 100 parts of a sophora flavescens extract and 130 parts of a belvedere fruit extract.

Further, the content of matrine in the sophora flavescens extract is more than 20 percent; the fructus Kochiae extract has water content of less than 50%.

The invention also aims to provide a preparation method of the composition for treating neurodermatitis, which comprises the following steps: taking the raw materials in parts, dissolving phenol in glycerol, adding a proper amount of water for dilution, dissolving menthol in ethanol, combining the two solutions, slowly adding the sophora flavescens extract and the fructus kochiae extract into the combined solution, finally adding purified water to 800-1500 parts, and stirring to obtain the composition.

Wherein the radix Sophorae Flavescentis extract is ethanol extract or water extract, preferably ethanol extract.

Kochiae fructus can be extracted with water, ethanol, methanol, etc. under reflux, and the extractive solution is concentrated, preferably ethanol.

The invention combines traditional Chinese medicines and chemical preparations, has the advantage of quick effect of the traditional Chinese medicine treatment chemical preparation, has the characteristics of less adverse reaction, mild action, lasting curative effect, no side effect and no relapse after stopping taking the medicine, has the efficacy of sterilizing and relieving itching, and particularly has a remarkable effect on neurodermatitis and skin pruritus.

In the invention, phenol has itching relieving and sterilizing effects, mint is a local irritant and has cooling and itching relieving effects, glycerin has skin moistening effects, and ethanol has disinfection and sterilization effects; the sophora flavescens extract has a strong inhibiting effect on staphylococcus aureus and the like, and the belvedere fruit extract has a phagocytic function of inhibiting a mononuclear phagocyte system; the combination of the medicines has strong permeability, can kill pathogenic bacteria from the outside, the inside to the deep layer, and has strong stripping effect. The composition is applied to a pathological change part, the medicine is cool and comfortable, the pruritus stops, the red swelling gradually disappears, lesion tissues can be thoroughly removed after five days, pathogenic bacteria can be killed, the propagation of the pathogenic bacteria can be stopped, the pathological change part begins to scab and fall off, the peripheral circulation of the skin can be improved, the metabolism is promoted, the normal structure and functions of the damaged tissues on the surface layer and the deep layer can be recovered, a vascular network can be rebuilt, the normal blood circulation is recovered, the focus is further removed, and the recurrence is avoided.

The composition can also be prepared into antipruritic, and is used for treating other pruritus caused by fungal or bacterial infection and mosquito bite.

Detailed Description

Example 1: a composition for sterilizing, relieving itching and treating neurodermatitis comprises the following steps: preparing materials, namely selecting 10 parts of phenol, 2 parts of menthol, 75 parts of glycerol, 144 parts of ethanol, 50 parts of sophora flavescens extract, 60 parts of fructus kochiae extract and purified water for later use; wherein, 1 part is equal to 1g, the sophora flavescens extract and the broom cypress fruit extract can be purchased commercially or prepared in a laboratory, as long as the content of the matrine in the sophora flavescens extract is more than 20 percent; the fructus Kochiae extract has water content of less than 50%.

Mixing: dissolving phenol in glycerol, adding appropriate amount of purified water for dilution, dissolving Mentholum in ethanol, mixing the two solutions, slowly adding radix Sophorae Flavescentis extract and Kochiae fructus extract, adding purified water to 800 parts, and stirring to obtain the composition.

Example 2: a composition for sterilizing, relieving itching and treating neurodermatitis comprises the following steps: preparing materials, namely selecting 25 parts of phenol, 4 parts of menthol, 120 parts of glycerol, 220 parts of ethanol, 70 parts of sophora flavescens extract, 100 parts of fructus kochiae extract and purified water for later use; wherein, 1 part is equal to 1g, the sophora flavescens extract and the broom cypress fruit extract can be purchased commercially or prepared in a laboratory, as long as the content of the matrine in the sophora flavescens extract is more than 20 percent; the effective content of the fructus Kochiae extract is more than 50%.

Mixing: dissolving phenol in glycerol, adding appropriate amount of purified water for dilution, dissolving Mentholum in ethanol, mixing the two solutions, slowly adding radix Sophorae Flavescentis extract and Kochiae fructus extract, adding purified water to 1200 parts, and stirring to obtain the composition.

Example 3: a composition for sterilizing, relieving itching and treating neurodermatitis comprises the following steps: preparing materials, namely selecting 35 parts of phenol, 5 parts of menthol, 150 parts of glycerol, 270 parts of ethanol, 100 parts of radix sophorae flavescentis extract, 130 parts of fructus kochiae extract and purified water for later use; wherein, 1 part is equal to 1g, the sophora flavescens extract and the broom cypress fruit extract can be purchased commercially or prepared in a laboratory, as long as the content of the matrine in the sophora flavescens extract is more than 20 percent; the effective content of the fructus Kochiae extract is more than 50%.

Mixing: dissolving phenol in glycerol, adding appropriate amount of purified water for dilution, dissolving Mentholum in ethanol, mixing the two solutions, slowly adding radix Sophorae Flavescentis extract and Kochiae fructus extract, adding purified water to 1500 parts, and stirring to obtain the composition.

Comparative example 1: taking 35 parts of phenol, 5 parts of menthol, 150 parts of glycerol and 270 parts of ethanol for later use, dissolving the phenol in the glycerol, adding a proper amount of purified water for dilution, taking the menthol to dissolve in the ethanol, combining the two solutions, and adding the purified water to 1200 parts to obtain the chemical preparation.

Comparative example 2: taking 100 parts of sophora flavescens extract and 130 parts of fructus kochiae extract, adding a proper amount of purified water for dilution, and adding the purified water to 300 parts to obtain the traditional Chinese medicine preparation.

Comparative example 3: taking 35 parts of phenol, 5 parts of menthol, 150 parts of glycerol, 270 parts of ethanol and 100 parts of radix sophorae flavescentis extract for later use, dissolving the phenol in the glycerol, adding a proper amount of purified water for dilution, taking the menthol to dissolve in the ethanol, combining the two solutions, slowly adding the radix sophorae flavescentis extract, and then adding the purified water to 1100 parts to obtain the radix sophorae flavescentis-chemical preparation.

Comparative example 4: taking 35 parts of phenol, 5 parts of menthol, 150 parts of glycerol, 270 parts of ethanol and 130 parts of fructus kochiae extract for later use, dissolving the phenol in the glycerol, adding a proper amount of purified water for dilution, taking the menthol to dissolve in the ethanol, combining the two solutions, slowly adding the fructus kochiae extract, and then adding the purified water to 1000 parts to obtain the fructus kochiae-chemical preparation.

Comparative example 5: taking radix Sophorae Flavescentis extract as control group.

Comparative example 6: kochiae fructus extract was used as a control.

Experiment 1:

the experimental animals are 150 healthy male SD rats without Specific Pathogen (SPF), the weight of the rats is (180 +/-20) g, the rats are placed in a small animal autonomous activity instrument for testing after being adaptively raised for 7 days in a laboratory, the number of autonomous activities within 5min is 80-150, the qualified animals are screened and are brought into a formal experiment. The model was prepared using local skin friction stimulation in combination with Chronic mild unpredictable stress method (CUMS) as follows.

(1) Local skin rubbing irritation: after fixation, the rats were depilated with depilatory to expose the skin, with a diameter of 4cm selected on their backs. Rubbing skin with a self-made electric friction instrument (modified by Fei Ke rechargeable clothes depilator with 1000 mesh abrasive paper at front part) until congestion and bleeding point appear locally, 5min each time, 1 time per day.

(2) Chronic mild unpredictable stress: the experiment adopts an unpredictable stress method, and the specific stimulation mode comprises the following steps: 24h fasting, 24h water deprivation, overnight illumination, ultrasonic stimulation (110dB, 1h), tail suspension (1min), thermal stimulation (5 min in a 45 ℃ electric thermostat), and foot sole electric shock for 5min (1mA, 30V, 1 stimulation every 1min, 30s for each time, and 5 times in total). The stimulation mode is that 1 kind of stimulation is randomly given every day, so that the rat cannot expect the stimulation, and the generation of adaptation is prevented. The molding method lasts for 8 weeks, and the success standards of rat local skin lesion thickening, desquamation, reduced activity, reduced normal curl and motility, reduced intake of water, weight loss, anhedonia (reduced preference for sugar water, reduced consumption of sugar cane water), reduced interest and the like are taken as success standards. Before and after molding, the behavioral indexes (open field experiment, sugar water consumption, food consumption and body weight) of the rat are measured respectively.

And selecting qualified models, selecting 100 models, randomly dividing the models into 10 groups, wherein the experimental group is 3 groups, the negative control group is 6 groups, and the blank control group is 1 group.

The experimental groups were coated with the compositions of examples 1-3: the negative control group was coated with the substances of comparative examples 1 to 3, and the treatment was continued for 21 days, while the blank control group was not given any treatment.

After 21 days of treatment, the lesion sites of the model were observed, and it was found that the pruritus disappeared after applying the compositions of examples 1 to 3 and comparative examples 1, 3 and 43 d, that the pimple decreased after 5d using the compositions of examples 1 to 3, that the pimple started to scab and fall off after 10d, that the skin lesion was substantially recovered after 15d, that the pimple decreased after 7d, that the pimple started to scab after 13d and that the pimple fallen off after 20d using the formulations of comparative examples 3 and 4; the formulation of comparative example 1 had reduced pimples after 4 days, the pimples began to scab after 12 days, the scabs fell off after 18 days, the fallen skin lesions were substantially recovered after 21 days, the comparative example 5 and comparative example 6 had started to subside swelling after 5 days, the pimples fell down after 10 days, and the pimples fell off after continued use for 10 days; the lesion sites of the blank control group did not change significantly.

In conclusion, in terms of action and effect, the examples 1 to 3 have the same quick effect as the chemical preparations of the comparative example 1, the comparative example 3 and the comparative example 4, but the scab falling time is faster than that of the comparative example 1, the comparative example 3 and the comparative example 4, and compared with the single use of the traditional Chinese medicine, the examples of the invention have the characteristic of quick effect.

Experiment 2:

100 patients with neurodermatitis, 50 men and 50 women, the age is 25-73 years, the average age is 49 years, and the course of disease is half year to 2 years.

The following are excluded: 1) patients with severe center of gravity, liver, renal insufficiency; 2) patients allergic to the medicine of the treatment; 3) those who had been treated with glucocorticoid and H1 receptor antagonist within 7 days before treatment; 4) pregnant women in lactation; 5) it is not suitable for the patient who cannot follow the clinic regularly in the late stage. The treatment is carried out by using the composition prepared in the embodiment 1-3 and the chemical preparation of the comparative example 1, three times in 1 day, one treatment course in one week, and 1-3 treatment courses are continuously used. Diagnostic criteria: healing, namely completely removing skin lesions and eliminating pruritus; the effect is shown: the skin damage is reduced by more than 70 percent, and the itching feeling is obviously relieved; the method has the following advantages: the skin damage is reduced by 35-70%, and the itching feeling is relieved; and (4) invalidation: the skin lesions are reduced by less than 35 percent, even no improvement is realized, and the pruritus is obvious. After treatment, 100% of patients are found to have obvious effect, the itching feeling disappears, follow-up visits are carried out after half a year, the patients treated by the composition prepared in the examples 1-3 do not relapse, and the treatment effect of the example 3 is optimal; the patients treated in comparative example 1 were selected and had an average of 1.2 relapses.

The following are the major cases.

Case 1, patient Zhangzhi, male, age 35, sleep suboptimal for 3 months, neck plaque with pruritus for 2 months. Before 3 months, patients have poor sleep due to high working pressure, old neck pruritus before 2 months, particularly old neck pruritus at night, and are frequently scratched repeatedly, and before 3 weeks, the neck has rash, which is hard to endure. The traditional Chinese medicine is healthy and has no familial and hereditary medical history, and no drug allergy and infectious disease history. Dermatological examination: licheniform plaques were observed in the neck, which were reddish with a size of about 3cmx2cm, with a few scales visible. The edges of the small flat papules with the size of rice grains can be seen and are scattered and distributed, and the boundaries are clear. Neurodermatitis was diagnosed. With the composition of example 3, the skin itch was reduced 3 days, the number of pimples decreased after 1 week, the scab on the affected area was removed after 2 weeks, the skin lesions returned to normal after 3 weeks, and no recurrence was observed after 1 year follow-up.

Case 2, patient Sunzhi, female, 28 years old, eyelid, scalp, trunk and limbs skin itch, thickening and desquamation for 10 months. After 10 months of work, the skin itch of eyelids, scalp, trunk and limbs appears, the skin gets worse at night, the skin becomes thicker and harder to desquamate after scratching, the localized brown yellow and flat papules are formed, the itching is hard to endure, and various antibacterial treatments are not improved after spreading to various hospitals. Dermatological examination: lesions of the eyelids, scalp, trunk and limbs appear lichenification. The diagnosis is as follows: neurodermatitis. By using the formula for treatment, the disease gradually improves after 5 days, pruritus is relieved, dryness and scabbing are realized after 1 week, the number of papules is reduced, plaques are thinned, scales are reduced, skin damage parts are basically recovered after 3 weeks, the skin of eyelids, scalp, trunk and limbs are recovered to be normal after 5 weeks, and the disease does not relapse until 1 year.

Case 3, patient Liji, woman, age 35, right elbow rash with pruritus for more than 1 year. No obvious induction exists before 1 year, the right elbow papule is accompanied with pruritus, the pruritus is difficult to be frequently grasped by hands, the local skin is thickened, the denitration is realized, and pustules and pain are avoided. The traditional Chinese medicine is healthy, has no chemical raw material and heavy metal contact history, has no history of acute and chronic infectious diseases, and has no similar history in families. Special skin examination: the skin on the right elbow can be seen as a large papule with a mossy appearance on the skin. The diagnosis is as follows: neurodermatitis. By using the formula for treatment, the number of papules is reduced after 2 weeks, plaques are thinned, the color of erythema is reduced, and the skin damage parts of the hands are recovered after 4 weeks, so far, the disease has been cured for 3 years and no relapse occurs.

Case 4, patient wangzhi, woman, age 20, restlessness and irritability for 5 months, flat papule with size of needle cap appearing in many parts of waist with skin pruritus for 4 months. Before 5 months, patients are seriously worried and irritative because of the heavy learning task, and clustered millet grains to large, light brown, polygonal and flat papules appear at a plurality of positions in the front waist part after 4 months, accompanied with skin pruritus, and are particularly serious at night, and are not treated. Before 2 months, the skin itch worsened, and the papules were dense and flaky, forming a licheniform change from coins to palmar size. The traditional Chinese medicine is healthy, has no medicine allergy history, no chemical raw material and heavy metal contact history, no acute and chronic infectious disease history, and no similar disease history in families. Special skin examination: the clustered millet grains to the large light brown polygonal papules of rice grains appear at the waist, and even are densely packed and flaky, and form moss-like changes from coins to palm size. The affected part has dry skin, thick infiltration and obvious surface scratches. And (3) diagnosis: neurodermatitis. The medicine is used for treating the diseases, the pruritus is avoided after 1 week, the pimple is reduced, the pimple is scabbed after 2 weeks, the color becomes dark, the color of the base is light, the skin damage is basically recovered after 3 weeks, the skin is completely recovered after the medicine is insisted for 4 weeks, and the disease does not relapse after 1 year of follow-up visit.

In case 5, the patient was old, male, and 37 years old, had insomnia and dreaminess for 3 months, and had rice-sized papules with skin itching for 1 month on the neck. Insomnia and dreaminess caused by life and working pressure of patients 3 months ago. The skin becomes worse before 1 month, and the skin around the neck has pimples with the size of rice grains and skin itch, and the pruritus at night is particularly serious. The traditional Chinese medicine has no medical allergy history, no infectious disease history, no similar diseases in families, and no special chemical and heavy metal material contact history. Dermatological examination: the neck appeared with rice-grain-sized reddish papules with scratches. Neurodermatitis was diagnosed. By using the formula for treatment, the skin itch is relieved within 1 week, the pimple is reduced, the scab is shed after 2 weeks, the skin lesion part begins to recover, the skin completely recovers after 4 weeks of insisting on medication, and the skin does not relapse after one year of follow-up visit.

The above description is only an embodiment of the present invention, and the common general knowledge of the known specific structures and characteristics in the solution is not described too much, and it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the structure of the present invention, and these should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.

Claims (7)

1. A composition for sterilizing, relieving itching and treating neurodermatitis is characterized in that; the raw materials comprise the following components in parts by weight: 10-35 parts of phenol, 2-5 parts of menthol, 75-150 parts of glycerol, 144-270 parts of ethanol, 50-100 parts of a sophora flavescens extract and 60-130 parts of a fructus kochiae extract.

2. The composition for sterilizing, relieving itching and treating neurodermatitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 20-35 parts of phenol, 3-5 parts of menthol, 100-150 parts of glycerol, 200-270 parts of ethanol, 80-100 parts of a sophora flavescens extract and 90-130 parts of a fructus kochiae extract.

3. The composition for sterilizing, relieving itching and treating neurodermatitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 10 parts of phenol, 2 parts of menthol, 75 parts of glycerol, 144 parts of ethanol, 50 parts of a sophora flavescens extract and 60 parts of a belvedere fruit extract.

4. The composition for sterilizing, relieving itching and treating neurodermatitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 35 parts of phenol, 5 parts of menthol, 150 parts of glycerol, 270 parts of ethanol, 100 parts of a sophora flavescens extract and 130 parts of a belvedere fruit extract.

5. The composition for treating neurodermatitis through sterilization, itching relieving and according to any one of claims 1 to 4, wherein the content of matrine in the sophora flavescens extract is more than 20%; the fructus Kochiae extract has water content of less than 50%.

6. The preparation method of the composition for sterilizing, relieving itching and treating neurodermatitis according to claim 5, wherein the raw materials are taken according to the parts by weight, phenol is dissolved in glycerol, a proper amount of water is added for dilution, menthol is further dissolved in ethanol, the two solutions are combined, then the sophora flavescens extract and the fructus kochiae extract are slowly added into the combined solution, finally purified water is added to 800-1500 parts, and the mixture is stirred to obtain the composition.

7. Use of a composition according to any one of claims 1 to 4 in the preparation of an anti-pruritic agent.