RU2705162C1 - Ointment for treating psoriasis (versions) - Google Patents

Abstract

FIELD: pharmaceutics.SUBSTANCE: invention refers to pharmaceutical industry, namely to an agent for treating psoriasis of various degrees of progressing and stationary stages. Ointment for treating psoriasis containing a fatty base – cup grease – and active substances, wherein as active substances contains salicylic ointment 10 %, aloe latex, synaflan, 1 % salicylic acid solution and alcohol extract of a mixture of plants infused in 96 % alcohol, taken in equal proportions: Bidens leaves and stem, celandine leaves and stem, calendula leaves and stem, Sophora japonica fruits, rose hips, chamomile leaves and stem, eleutherococcus root, nettle leaves and stem, sage leaves and stem, agrimony leaves and stem, valerian root, at certain ratio of components. An ointment for psoriasis treatment contains a fatty base – cup grease – and active substances; as active substances there is an ointment of salicylic 10 %, aloe latex, synaflan and an alcohol extract of a mixture of plants infused in 96 % alcohol, taken in equal proportions: Bidens leaves and stem, celandine leaves and stem, calendula leaves and stem, Sophora japonica fruits, rosehips, chamomile leaves and stem, eleutherococcus root, nettle leaves and stem, sage leaves and stem, agrimony leaves and stem, valerian root, at certain ratio of components. An ointment for psoriasis treatment containing a fatty base – cup grease – and active substances, as active substances contains aloe latex, sulfuric ointment 10 % and alcohol extract of the mixture of plants infused in 96 % alcohol, taken in equal parts: Bidens leaves and stem, celandine leaves and stem, calendula leaves and stem, Sophora japonica fruits, rosehips, chamomile leaves and stem, eleutherococcus root, nettle leaves and stem, sage leaves and stem, agrimony leaves and stem, valerian root, at certain ratio of components. An ointment for psoriasis treatment containing a fatty base – cup grease – and active substances, as active substances contains aloe latex, ichthyol ointment and an alcohol extract of a mixture of plants infused in 96 % alcohol, taken in equal proportions: Bidens leaves and stem, celandine leaves and stem, calendula leaves and stem, Sophora japonica fruits, rosehips, chamomile leaves and stem, eleutherococcus root, nettle leaves and stem, sage leaves and stem, agrimony leaves and stem, valerian root, at certain ratio of components.EFFECT: above described ointment (versions) is effective for psoriasis treatment, its use accelerates the time of achieving a positive result and prolongs the period of primary remission, leads to a sharp decrease in the intensity of clinical manifestations with repeated exacerbation of psoriasis without using internal hormonal, immunosuppressive and photochemotherapy (PUVA-therapy), reduces length of treatment.4 cl, 4 ex

Description

The invention relates to medicine, in particular to dermatology, immunology and can be used in the treatment of patients with psoriasis of varying degrees of prevalence of progressive and stationary stages.

As you know, psoriasis is one of the most common dermatoses in people of working age and affects 2% of the population of our country. People suffering from psoriasis experience limitations in choosing a profession and employment, planning their vacation. Rashes, which are often located on visible, cosmetically significant areas of the skin, disadapt socially affected psoriasis patients and sharply reduce their quality of life

According to the Clinical Recommendations of the Ministry of Health of Russia from 2016, the goals of treating psoriasis:

Stop the sharpness of the process,

Reduce or stabilize the pathological process (lack of fresh rashes) on the skin,

Remove subjective sensations,

Keep working capacity,

Improve the quality of life of patients.

Treatment according to the recommendations of the Ministry of Health should be comprehensive, taking into account the basic aspects of pathogenesis (eliminating inflammation, suppressing the proliferation of keratinocytes, normalizing their differentiation), clinic, severity, complications.

The main therapeutic approaches:

Local therapy is used for all forms of psoriasis. Monotherapy is possible.

Phototherapy: used for all forms of psoriasis.

Systemic therapy: used exclusively for moderate to severe forms of psoriasis.

The recommendations of the Ministry of Health also provide a list of medicines indicating - mandatory, 100% probability - drugs of choice.

This list of drugs includes:

Methotrexate

Cyclosporin,

Infliximab (Remicade),

Ustekinumab,

Means for external therapy: derivatives of vitamin D3 (Calcipotriol), glucocorticosteroid ointments, calcineurin inhibitors, zinc preparations.

The list of additional medicines includes:

antihistamines

sedatives

sorbents

desensitizing drugs

vitamins

glucocorticoids,

potassium and magnesium deficiency supplements

drugs that improve peripheral blood circulation,

agents that help restore the microbiological balance of the intestine,

hepatoprotectors

immunomodulators

biogenic stimulants,

external corticosteroid drugs,

root protectors.

External therapy is the use of hormonal and non-hormonal drugs for external use.

Ointments are particularly effective in the local treatment of psoriasis. They can be hormonal and non-hormonal.

Hormonal drugs give a quick effect: with their help, you can get rid of the symptoms of the disease in a short time. However, the use of these funds has a number of serious drawbacks. Disadvantages of hormonal drugs: the result is short; glucocorticosteroids are addictive, and you have to constantly increase the dosage; hormonal ointments lead to a complication of the disease (for example, the development of psoriatic arthritis) and the manifestation of severe side effects from the cardiovascular, endocrine systems, liver, and kidneys. First of all, prolonged use of external hormone therapy leads to atrophy of the growth layer of the skin.

Due to the aggressive effect on the body, many experts avoid the appointment of glucocorticosteroids, preferring to use non-hormonal ointments for the treatment of psoriasis.

The advantages of these tools: high enough efficiency; lack of addiction and the subsequent effect of withdrawal; a small amount of side effects; safety in terms of maintaining hormonal balance in the body; affordability in terms of price.

When used regularly, hormone-free ointments are an effective way to get rid of the symptoms of psoriasis.

 Depending on the stage of the disease, treatment is carried out in stages. Non-hormonal ointments are prescribed in the initial stages. As a rule, they contain one active component (in rare cases, two), which determines the spectrum of action of the ointment.

Salicylic ointment

With psoriasis, this non-hormonal ointment is used as a locally irritating, distracting, drying, antiseptic, keratolytic agent. Helps to improve tissue trophism, has anti-inflammatory and antipruritic effect. The tool is quite effective and safe. The ointment is applied to cleansed skin and a sterile dressing is applied. It needs to be changed twice a day, until the complete elimination of psoriatic plaques. Salicylic ointment and the products containing it are not used in the following cases: Hypersensitivity to the drug. Kidney problems. Age to 3 years. Pregnancy and lactation. In some cases, topical application of salicylic acid provokes undesirable effects: increased itching, burning; hyperemia in the treated area; allergic reaction Ointment should not be applied to warts, birthmarks, face, genital area. In the treatment of psoriasis in children, it is not recommended to treat the drug with several sites at the same time.

Zinc ointment

This drug has an astringent, drying, antiseptic, anti-inflammatory, adsorbing effect. With psoriasis it reduces itching, irritation, exudation, eliminates areas of inflammation, protects against external stimuli by creating an external barrier. Zinc ointment is applied to the localization sites of psoriatic rashes 2 or 3 times a day. Apply until symptoms are resolved. The tool is not indicated for hypersensitivity to zinc oxide. The manifestation of an allergic reaction in the form of itching, redness and intensification of the skin rash is possible.

Tsinokap

This is a non-hormonal dermatoprotective ointment, the active substance of which is zinc pyrithione. Reviews of experts indicate its pronounced anti-inflammatory, antibacterial and antifungal activity in psoriasis. With regular use, relieves of the symptoms of the disease, such as peeling, itching, irritation, prevents the attachment of a secondary infection. It is also used to localize the lesion on the scalp. The cream should be applied in a thin layer to areas covered with psoriatic plaques and rashes up to 2 times a day. Treatment can be continued for 1-1.5 months. If necessary, it is possible to prescribe a second course (for example, with an exacerbation of the disease). Tsinokap is not used: with increased sensitivity to individual components of the drug; when applying hormonal ointments of local action. The drug is not indicated in the treatment of psoriasis in children under 1 year old. As a rule, Zinocap is well tolerated by patients. In some cases, an allergic reaction may occur.

Dayvonex

The basis of the therapeutic effect of the ointment is the stimulation of morphological differentiation and the suppression of the proliferation of keratocytes. Reduces the activity of T-lymphocytes. Used in the treatment of vulgar psoriasis. The maximum daily dose is 15 g. The total dose of the drug during the week should not exceed 100 g. The ointment is applied to the affected areas 1-2 times a day. As a rule, a positive effect is observed after 7-15 days. The duration of the course is 1.5-2 months. Dayvoneks not prescribed: with increased sensitivity to calcipotriol or excipients ointments; in the presence of diseases leading to a violation of calcium metabolism; during pregnancy. The drug is used with extreme caution in the following conditions: hypercalcemia; hypercalciuria; renal failure; liver failure; The use of non-hormonal ointment Dayvoneks is not recommended in the treatment of psoriasis in the elderly over 65 years old and children and adolescents under 18 years of age. According to experts, the drug can lead to a complication of symptoms while being used with products containing salicylic acid. Side effects: skin irritation, itching, rash, increased dryness and peeling, burning sensation, hyperpigmentation, depigmentation; possible development of contact dermatitis, eczema, exacerbation of the symptoms of psoriasis, facial edema; urticaria, allergies, angioedema; increased concentration of calcium in the blood, which leads to the manifestation of the following symptoms: fatigue; trouble concentrating; constipation decreased muscle tone; constant thirst. The ointment is not intended to treat psoriasis on the face. Dayvoneks is not recommended to be applied to large areas of the skin (more than 30% of the entire skin surface). In severe forms of psoriasis, the drug is used extremely rarely (due to the increased risk of developing hypercalcemia), while the level of calcium in the urine and blood is constantly monitored. During treatment, exposure to sunlight or artificial UV exposure on the skin should be limited.

Losterin

The therapeutic effect is due to the properties of the components included in the ointment: Naftalan - has a pronounced anti-inflammatory, vasodilating, antibacterial, desensitizing effect, improves skin trophism, helps normalize microcirculation and metabolic processes. Urea - effectively moisturizes the skin, relieves itching, irritation, improves absorption of other components of the ointment. It has exfoliating, keratolytic, wound healing and bacteriostatic effects. Salicylic acid - has an antiseptic, wound healing, keratolytic effect. D-panthenol, or provitamin B5 - accelerates the regeneration of the skin, improves cellular metabolism, relieves inflammation. Japanese Sophora extract - increases the strength of the walls of blood vessels, has an anti-inflammatory effect, inhibits the proliferation of keratocytes, thereby reducing peeling. Almond oil - contains valuable vitamins and fatty acids. Regulates water and lipid balance, stimulates the skin regeneration process, has a softening, anti-inflammatory, antipruritic effect. The ointment is applied in a thin layer up to 3 times a day. It is perfectly absorbed and leaves no residue on clothing. The duration of the course of treatment depends on the severity of the symptoms of psoriasis, the frequency of exacerbations. On average, the drug is used for 15-30 days. The effect in the form of reduction of itching and inflammation is achieved quite quickly, but the regenerating effect begins to appear no sooner than a week or 10 days later. Ointment is not used for hypersensitivity to the components. Side effects are not marked.

Psoriatic

Effective non-hormonal homeopathic ointment for psoriasis. It contains an extract of mahonia holly, which includes alkaloids and berberine. It has a pronounced anti-inflammatory and antiproliferative effect. Berberine regulates calcium metabolism in cells and affects the processes of cell growth and reproduction. Three times a day, Psoriaten is applied in a thin layer to areas of localization of psoriatic rashes and gently rubbed for better absorption. The drug is not recommended for hypersensitivity to alcohol based on lanolin and other components. Its use is also undesirable during pregnancy and breastfeeding. The use of ointment can lead to a temporary deterioration in the patient's condition. In this case, the course must be interrupted. If there is no improvement in the patient's condition within 20 days, the drug is canceled.

We see

Ointment refers to dermatoprotective drugs. The main active ingredient is vitamin A. It takes an active part in redox processes, maintains a healthy skin condition, ensures normal differentiation of epithelial tissue, regulates cell division processes, inhibits keratinization (keratinization). The ointment is applied to the affected areas twice a day. With significant peeling, an occlusive dressing can be applied. Pre-damaged skin is recommended to be treated with an antiseptic composition. On average, the course lasts from 1 to 3 months. The use of non-hormonal ointment Wedestim for psoriasis is not recommended: for acute skin diseases; with renal failure; during the first trimester of pregnancy. In the treated area, itching and severe hyperemia are possible. Prolonged use of the ointment sometimes leads to hypervitaminosis A. In this case, there are: lethargy; drowsiness; sweating headache; skin rashes.

Cartalin

This is an effective non-hormonal ointment for psoriasis and other chronic dermatoses. It has keratolytic, regenerative and anti-inflammatory effects. The drug was developed over 15 years ago. It contains solidol, extracts of chamomile, string, lavender, eucalyptus, natural honey, vitamins A, D, salicylic acid. The ointment is applied evenly on the skin and left for at least 12 hours. Do not rub it. At the initial period of treatment, a slight exacerbation of symptoms is possible in the form of an increase in rash and itching. As a rule, these phenomena pass quickly. A positive result is noticeable after a week. The treatment is carried out in stages. The first stage lasts until the disappearance of psoriatic plaques and the formation of dyschromic spots. The purpose of the second stage, which lasts up to 1 month, is to consolidate the result. During treatment, it is recommended to adhere to a special diet: exclude fatty, spicy foods and alcohol. Kartalin is not used for individual intolerance of its components and during pregnancy. There are some limitations: ointment can not be applied to the skin of the face; during its use, it is necessary to avoid prolonged exposure to the sun to prevent hypervitaminosis D. Side effects In some cases, allergic dermatitis may occur. If you are prone to allergies, along with Kartalin it is recommended to use antihistamines of the II and III generation (Cetirizine, Loratadin, Ebastin

Magnipsor

This is a unique non-hormonal remedy for psoriasis containing fatty solidol, extracts of medicinal herbs, mineral components, healthy oils and salts. Ointment has antiseptic, keratolytic, resolving and reducing effects. It is used at all stages of the disease. The ointment is intended for daily use (up to 2 times a day). It is applied in a thin layer to the foci of psoriatic plaques. In the first few days, the appearance of irritation, itching, tingling is possible. In this case, it is necessary to avoid combing of plaques and not to remove tightly fitting crusts. The itching gradually disappears, and the plaques flatten. Redness mainly disappears after 15 days, but sometimes it can persist up to 1.5-2 months. The course of treatment is continued until the plaque is removed. In their place are pigmented spots. The use of ointment is not indicated: for allergies to components; during pregnancy; for the treatment of children under 7 years. Itching, hives may occur. In rare cases, patients have a fever.

Acrustal

The cream is intended to eliminate skin manifestations of psoriasis and other dermatological diseases. Due to the lack of artificial additives, the product is hypoallergenic. In the production of Akrustal, new patented methods for extracting plant materials are used, which allow to preserve the maximum amount of biologically active substances. The cream includes: cedar oil, yarrow, eucalyptus; oil extracts of wheat germ and medicinal herbs (calendula, chamomile); juniper and licorice extracts; fat solidol; honey; beeswax. The ointment has an antibacterial, anti-inflammatory effect, effectively eliminates itching, improves local metabolism, accelerates skin regeneration. If you believe the reviews of experts, the non-hormonal ointment Akrustal removes not only psoriatic plaques, but also dyschromic spots. A significant improvement in skin condition can be seen after 7-9 days. The course lasts approximately 2-3 months. The cream is applied with light movements and is not rubbed into the skin. In the presence of extensive lesions, it is recommended to start therapy with treatment of the skin of the lower extremities, after a few days go to the hands, after a couple of days, the ointment can be applied to the remaining affected areas. If the rashes are localized on the head, Acrustal is used every other day, applying to the skin in the direction of hair growth. During the first week, the plaques are smeared once every two days and leave the cream for at least 6 hours. From the eighth day, Acrustal is used daily. The duration of the course is up to 3 months, until plaques disappear. While maintaining hyperpigmentation, the use of herbal cream is extended for another 1 month. Acrustal is not recommended for hypersensitivity to one or more components. In rare cases, a local reaction in the form of allergic contact dermatitis is possible.

Psoriasin

An effective anti-psoriatic agent with a local irritant effect. The active substance is dichlorodiethyl sulfide, which has anti-inflammatory, analgesic, distracting, sensitizing properties. Psoriasin is used in the stationary phase of the disease. The ointment is applied twice a day. In the initial period of treatment (5-6 days), a bandage is not applied. From the eighth day (after a one-day break, when the patient takes a bath and changes clothes), waxed paper is applied to the treated surface and the bandage is fixed with bandages. After a 14-day treatment, a break is again arranged (5-6-day. Psoriasin is not used for hypersensitivity to the components, in the presence of wounds, in the progressive stage of psoriasis and for some diseases, which include kidney and liver pathologies; pyoderma; dermatitis. The ointment cannot be combined with UV therapy.In some cases, it is possible: exacerbation of psoriasis and its transition to erythroderma, the occurrence of an allergic reaction of the bullous type, and increased pigmentation of the skin.

From the prior art it is known to use various therapeutic ointments for the treatment of skin diseases, in particular psoriasis. So in auth. St. USSR N 198530, class A 61 K 9/06, 1965 describes an ointment containing fine sulfur 5% emulsifier N 1 18% glycerol 2.8% citric acid 0.003% brown alcohol 0.15% and distilled water 74.047%.

It is also known the use of "Emulsol" mixture of 90% emulsion solidol and 10% petroleum jelly (ed. St. USSR N 351544, class A 61 K 9/06, 1970) and 2-10% ointments or 1-2% oil solutions based on the means "Hrizaborin" (ed. St. N 704619, class A 61 K 35/78, 1968) for the treatment of skin diseases, including psoriasis.

The disadvantage of these drugs is that their use requires long-term hospitalization of patients and subsequent maintenance therapy. In addition, in the treatment with the above drugs, relapses are quite often observed.

Also known is an ointment for the treatment of psoriasis, containing powder from the seeds of psoralea drupacea (Psoralea drupaceo Bye), penicillin and petroleum jelly in the following ratio, wt. h: powder from the seeds of psoralea Kostyankovoy 2.0 2.5, penicillin 4.5 5.5 ml Vaseline up to 100% (see RF patent N 1787033, IPC 7 A 61 K 35/78, 1993)

The disadvantage of this ointment is that it contains penicillin, which imposes restrictions on the area of use of this ointment due to allergic reactions. In addition, the duration of treatment with a known ointment is quite large on average seven weeks.

External treatment of skin diseases is carried out depending on the severity of the inflammatory process by various means exhibiting bactericidal and anti-inflammatory properties. Such drugs are naphthalan oil, as well as ointments and liniment based on it, ointment "psoriasin", ointment heliomycin, ointment tetracycline, etc.

Among the medicines used, medicinal plants with anti-inflammatory, antipruritic, anti-allergic effects, as well as normalizing carbohydrate and lipid metabolism, increasing the body's resistance and immunological reactivity are of no small importance.

Local treatment of skin diseases boils down to swelling, hyperemia, and itching. For this, liniments, lotions and ointments based on components of medicinal plant materials are used.

As you know, the medicinal value of plant materials is determined by the presence of biologically active substances in it.

The most optimal will be the selection of those medicinal plants and their parts that create the most complete and powerful reserve of the necessary biologically active substances, and the selected ointment base contributes to the effective exit of the active substances from it and their penetration into the tissue when applying the product to the skin. The introduction of additional components enhances the effectiveness of the ointment.

Known ointment, which consists of a fat base (bearish and / or mink, and / or badger, and / or pork, and / or calendula oil, and / or St. John's wort oil, and / or milk thistle oil, and / or peppermint oil and / or safflower oil and / or olive oil) and the active component of plant origin (10% aqueous-alcoholic extracts of yarrow and / or hops, and / or calamus, and / or thyme, and / or nettle, and / or calendula, and / or celandine, and / or stonecrop, and / or St. John's wort, and / or burdock, and / or gorse) in the following ratio of components, wt.%: 10% aqueous-alcoholic ec paths - 20-25, fat basis - the rest. For the treatment of psoriasis, it contains mercury in an amount of 0.001 wt.% (See RF patent No. 2151594, IPC A 61 K 9/06, A 61 K 35/78 (2000.01), 2000).

Known ointment for the treatment of psoriasis. The ointment includes products of natural origin: a three-part series, large celandine, tar birch and horse sorrel (see RF patent No. 2171682, IPC A 61 K 9/06; A 61 K 35/78 (2000.01), 2001).

The above ointments are not effective enough.

The closest in composition and therapeutic purpose is an ointment for the treatment of psoriasis containing a fat base (medical solidol), and as active substances a large number of components of natural origin (see RF patent N 2091065, IPC A 61 K 9/06; 35/78 91997.01), 1997).

The composition of the ointment includes:

Aralia Manchurian 0.9 1.0
Felted agrimony 0.9 1.1
Three-part sequence 0.95 1.1
Celandine large 0.9 1.15
Flax flowers 0.4 0.6
Anfelzia 1.0 1.1
Gum Arabic 0.4 0.6
Glucomaniac mucus 0.4 0.6
Chitin crab 1.9 2.0
Tar birch 0.5 0.6
White fir essential oil 0.4 0.5
Sublimated fir white water 0.4 0.6
Solidol medical Else

Based on the presence of a large number of components, the known ointment is quite universal in the field of its application for the treatment, in addition to psoriasis, a wide variety of skin diseases.

However, the preparation of the starting materials is significantly complicated and rather complicated due to the large number of components that are not readily available. In addition, the ointment is not equally effective for the treatment of psoriasis in the progressive, stationary and regressive stages. The facts of ineffective use are recorded in 5 patients. The timing of sustained remission is not shown.

The technical problem solved by the claimed invention is the creation of ointments with greater efficacy for the treatment of psoriasis and reduce the overall treatment time. In addition, simplification is achieved by creating an ointment that is stable in composition from products of natural origin without chemical or special synthetic additives with a long shelf life. The presence of mostly readily available components in the composition of the ointment improves the manufacturability of its manufacture and preparation of the starting materials.

The technical result of using all the essential features of the claimed variants of the ointment is the stabilization of the clinical manifestations of psoriasis, accelerating the achievement of a positive result and lengthening the time of primary remission, a sharp decrease in the intensity of clinical manifestations with repeated exacerbation of psoriasis without the use of internal hormonal, immunosuppressive and photochemotherapy (PUV therapy), shortening the time treatment.

The term PUV-therapy is an abbreviation of the first letters of words in English that make up the names of the components of the method (PUVA): P - psoralen (photosensitizing drug), HC - ultraviolet rays, A - long-wave spectrum of electromagnetic rays.

The problem posed in the first embodiment is solved by the fact that the ointment for the treatment of psoriasis containing a fat base - fat solidol and active substances, according to the invention, contains aloe juice, salicylic acid solution 1%, salicylic ointment 10%, sinaflan and alcoholic extract mixture as active substances plants: leaves and stalks of a string, leaves and stalks of celandine, leaves and stems of calendula, fruits of Japanese sophora, rose hips, leaves and stalks of chamomile officinalis, eleutherococcus root, leaf and stalk of nettle, leaf and stalk of sage her, leaf and stalk of repeshka, valerian root in the following ratio of components, grams:

Fat solidol - 3 000,

Salicylic ointment 10% - 200,

Aloe juice 15,

Sinaflan - 15,

A solution of salicylic acid 1% - 30,

Alcoholic extract of a mixture of plants - until saturated.

The problem posed in the second embodiment is solved by the fact that the ointment for the treatment of psoriasis containing a fat base - fat solidol and active substances, according to the invention, contains aloe juice, salicylic ointment 10%, sinaflan and alcoholic extract of a mixture of plants: leaves and stem of the train as active substances , leaves and stalk of celandine, leaves and stalk of calendula, fruits of Japanese sophora, rose hips, leaves and stalk of chamomile, eleutherococcus root, leaf and stalk of nettle, leaf and stalk of sage, leaf and stalk of repeshka, bark s valerian the following component ratio, g:

Fat solidol - 3 000,

Salicylic ointment 10% - 200,

Aloe juice - 15,

Sinaflan - 15,

Alcoholic extract of a mixture of plants - until saturated.

The posed problem in the third embodiment is solved by the fact that the ointment for the treatment of psoriasis containing a fat base - fat solidol and active substances, according to the invention, contains aloe juice, 10% sulfuric ointment and an alcoholic extract of a mixture of plants as leaves and stem of a succession, leaves as active substances and stalk of celandine, leaves and stalk of calendula, fruits of Japanese sophora, rose hips, leaves and stalk of chamomile, eleutherococcus root, leaf and stalk of nettle, leaf and stalk of sage, leaf and stalk of repes, root of valerian the following ratio of components, grams:

Fat solidol - 3 000,

Aloe juice - 15,

Sulfur ointment 10% - 100,

Alcoholic extract of a mixture of plants - until saturated.

The problem posed in the fourth embodiment is solved by the fact that the ointment for the treatment of psoriasis containing a fat base - fat solidol and active substances, according to the invention, contains aloe juice, ichthyol ointment and alcoholic extract of a mixture of plants as leaves and stem of a string, leaves and celandine stalk, leaves and stalk of calendula, Japanese Sophora fruits, rose hips, leaves and stalk of chamomile officinale, eleutherococcus root, leaf and stalk of nettle, leaf and stalk of sage, leaf and stalk of repes, root of valerian s with the following ratio of components, grams:

Fat solidol - 3 000,

Aloe juice - 15,

Ichthyol ointment 100,

Alcoholic extract of a mixture of plants - until saturated.

The presented independent variants of the formulations of the developed ointment for the treatment of psoriasis are most effective in joint sequential use.

Option No. 1– is used in the progressive stage of psoriasis, in the palmar - plantar form, drop-shaped form, as well as during an exacerbation of on-duty plaques before the transition to the stationary stage.

Option No. 2 - is used in the stationary stage of vulgar psoriasis, with not a massive exacerbation of on-duty plaques.

Option No. 3 - is used for the palmar-plantar form of psoriasis with severe hyperkeratosis, for "old" plaques with severe hyperkeratosis, psoriatic lesions of the scalp with severe hyperkeratosis.

Option No. 4 - is used in the regressive stage of psoriasis, with hyperpigmentation at the site of psoriatic plaques, as well as on plaques in the absence of hyperkeratosis.

Introduction to the ointment as an active substance of an alcoholic extract of plants: leaves and stalk of a string, leaves and stalk of celandine, leaves and stalk of calendula, fruits of Japanese Sophora, rose hips, leaves and stalk of chamomile, eleutherococcus root, leaf and stalk of nettle, leaf and stalk sage, leaf and stalk of a reposhka, valerian root allows to accelerate the achievement of a positive result and lengthen the time of primary remission, a sharp decrease in the intensity of clinical manifestations with repeated exacerbation of psoriasis. The selection of plant components was carried out taking into account the pharmacological action of each plant. A positive result from the introduction into the ointment of additional components and an alcoholic extract of the active substance consisting of these plants is confirmed in practice in the treatment of patients.

All four variants of the ointment are prepared identically, taking into account the changes in the individual components, as follows.

The composition of the oily base of the ointment is solid fat.

In all versions of the ointment, aloe juice and alcohol extract of a mixture of plants are used.

To prepare the ointment, an alcoholic extract of the plants is first made.

For cooking, the following herbs are used in approximately equal proportions:

Leaves and stem of a string

Leaves and stalk of celandine

Leaves and stalk of calendula

Fruits of Sophora Japanese

Dog-rose fruit

Leaves and stem of chamomile officinalis

Eleutherococcus Root

Nettle leaf and stalk

Sage leaf and stem

Leaf and stalk repeshka

Valerian root.

Finely chopped grass, root and fruits are poured with 96% alcohol until wet and a “spirit lake” appears, insist for 7 days in a dark place at room temperature. Before use, the alcohol part is squeezed and used, the remains of leaves, roots and fruits are removed after pressing.

Solid oil is heated to a liquid mass over low heat, removed from the heat and add the ingredients corresponding to each of the developed options:

According to option 1, salicylic ointment 10%, aloe juice, sinaflan and salicylic acid solution 1% are added to the molten solidol. All thoroughly mixed until a homogeneous mass. The prepared alcoholic extract of the plant mixture is mixed into the prepared mixture until saturation, that is, until the base absorbs the alcoholic extract.

In option 2, salicylic ointment 10%, aloe juice, sinaflan are added to the molten solidol. All thoroughly mixed until a homogeneous mass. In the prepared mixture, the alcoholic extract of the plant mixture is mixed until saturated, that is, until the base absorbs the alcoholic extract.

In option 3, aloe juice and sulfuric ointment 10% are added to the molten solid oil. All thoroughly mixed until a homogeneous mass. In the prepared mixture, the alcoholic extract of the plant mixture is mixed until saturated, that is, until the base absorbs the alcoholic extract.

According to option 4, aloe juice and ichthyol ointment - 95-105 are added to the molten solidol. All thoroughly mixed until a homogeneous mass. In the prepared mixture, the alcoholic extract of the plant mixture is mixed until saturated, that is, until the base absorbs the alcoholic extract.

The shelf life of the ointment is up to 2 years in a cool dark place in sealed packaging.

The ointment has a soft, uniform consistency with a slight smell of herbs of various colors, depending on the color of its constituent components and the dried raw material.

The prepared ointment can exfoliate during storage, which does not affect its pharmaceutical properties, therefore, before use, it must always be thoroughly mixed.

Mode of application.

Lubricate the plaques with a thin layer of ointment and leave for 3-24 hours. Wash off the ointment based on solidol from the affected areas of the skin without a piece of soap, and preferably with kefir.

When applying the ointment to the scalp, it is recommended to wear a rubber or plastic cap and leave the ointment for 8-12 hours.

On “on duty” plaques, it is better to use the ointment under occlusive dressings (grease the lesion with a thin layer, wrap it with wax paper, bandage it). The ointment under the dressing can be kept from 3 to 24 hours.

To achieve a fast lasting effect in case of exacerbation of psoriasis or treatment of a patient with widespread psoriasis during a progressive or stationary period with plaques with hyperkeratosis, apply the ointment according to var. 1 daily until the scales and hyperkeratosis disappear. Then switch to the ointment according to var. 2 and use it daily until persistent pigmentation appears inside the plaque, then switch to ointment according to var. 4 and use it first every other day, and as hyperemia and pigmentation disappear at the site of the plaque, reduce by a factor be use (after two days, three days, once a week) to a total skin purity.

Ointment according to var. 3 should be used on duty plaques with dense hyperkeratosis and the presence of scales on smooth skin and scalp.

The best effect in the treatment of psoriasis was obtained by combining the external use of the ointment with general and local cryotherapy and pathogenetic drug therapy.

Example 1. Patient Vladimir Ilyich G., 70 years old, was admitted to treatment in 2002 with a diagnosis of widespread psoriasis of a progressive stage of a mixed form, often recurring. Sick for 30 years.

Upon receipt of a complaint of a rash on the skin of the back, buttocks, hips, legs, abdomen, forearms, itching. Dermatological status: rashes are localized on the skin of the back, buttocks, hips, legs, abdomen, forearms. Presented: epidermal-dermal papules, silver-white scales, plaques, accompanied by the appearance of new small rashes of a deep pink color, peripheral growth of elements with the presence of an erythematic border, a positive isomorphic reaction, a psoriatic triad is clearly defined, moderate itching.

Previous treatment led to short remissions (2-3 months) with preservation of plaques on duty on the outer surface of the elbow bends and scalp on the patient’s skin. Relapse was accompanied by the development of a common process with vivid clinical manifestations.

Against the background of drug therapy (detoxification (Reamberin 400.0) intravenous drip therapy No. 5 daily, sodium thiosulfate 30% - 10.0 No. 10 in 200 ml of saline intravenously drip daily, cycloferon 2.0 to 10.0 physiological solution No. 10 according to the scheme: 1,2,4,6 , 8,11, 14,17,20, 23 days of treatment, hepatoprotectors (Essential 5.0 intravenously, jet 5 procedures daily, hofitol, 1 table. 3 times a day), the patient under the control of blood pressure received general cryotherapy and external ointment therapy according to var. 1 daily. After the second day of treatment, the scales covering Oriental plaques. After the fourth day from the start of treatment, small plaques - hyperkeratosis disappeared, the plaques took the form of hyperemic spots on the skin, in the center of large plaques there appeared foci of pigmentation at the skin level, increasing after each combination of general cryotherapy and applying ointment according to var. the end of the primary course of general cryotherapy, the patient on the background of ongoing drug therapy: riboxin 1 tab. 3 times a day, adsorbents (lactofiltrum), hepatoprotectors (hepar compositum, hepel), Krebs activators (coenzyme compositum, ubiquinone compositum), received local dry air cryotherapy procedures with an outlet temperature of up to - 170 ° C and ointment according to var. 2 in mode of reduction in the frequency of procedures - every day until the onset of persistent pigmentation at the site of psoriatic plaques, every other day (day - local cryotherapy, day - ointment according to var. 2) until stable pigmentation appears, and then 1-2 times a week with ointment according to var .4 until completely cleaned Nia skin. After 45 days from the start of treatment, a complete cleansing of the patient’s skin from psoriatic plaques, including on-duty plaques, was achieved. Over the next month, the patient visited the clinic for a complete examination of the skin. Hyperpigmentation that occurred on the skin at the site of large plaques disappeared completely two months after the start of treatment. The duration of primary remission was two years. The small plaques that appeared appeared to be treated once by the method of non-contact local cryotherapy using an ointment according to var. 1, after which the patient continued to be observed weekly, but no additional treatment of the plaques was required. Hyperemia after local cryotherapy disappeared within two weeks. Secondary remission lasted 4 years, while the patient came to the clinic once a month for a clinical examination and, if necessary, a single cryodestruction of plaques. Secondary exacerbation due to stress (inpatient treatment for extensive myocardial infarction) was rapid - many small hyperemic plaques appeared, due to the prevalence of skin lesions, a course of general cryotherapy with cryodestruction of plaques by contact cryotherapy was immediately prescribed against the background of daily use of var. 1 ointment and medication recommended by a cardiologist. The secondary course of treatment lasted no more than 1 month, and the subsequent remission (with the complete disappearance of plaques on duty) lasted more than 5 years.

Example 2. The patient Vasily Anatolyevich B., 60 years old, was admitted to treatment in 2009 with a diagnosis of Psoriasis is a common period of progressive manifestations, often recurring course; psoriatic polyarthritis. Sick for 7 years.

Upon receipt of a complaint of rashes on the skin of the elbows, knees, hips, back, itching. Dermatological status: rashes are localized on the skin of the elbows, knees, hips, and back. Presented: epidermal-dermal papules, silver-white scales, plaques of various sizes. It is accompanied by the appearance of new small rashes of a deep pink color, peripheral growth of elements with the presence of an erythematic border, a positive isomorphic reaction, a psoriatic triad is clearly defined. Accompanied by severe itching. There is pain and swelling in the knee and hip joints. Previously, inpatient treatment was carried out - to no avail. The treatment was carried out: against the background of drug therapy (detoxification (Hemodez 400.0) intravenous drip therapy No. 5 daily, hepar compositum 2.2. Ml in 200 ml saline intravenous drip No. 5 daily, calcium gluconate 10% - 10.0 No. 10 in 200 ml saline intravenously drip daily , cycloferon 2.0 at 10.0 of saline solution No. 10 according to the scheme: 1,2,4,6,8,11, 14,17,20, 23 days of treatment, hepatoprotectors (essentiale 1 tablet 3 times a day, hofitol 1 table 3 times a day) the patient under the control of blood pressure received general cryotherapy and daily external therapy I take it according to var. 1. The course is two weeks after the end of the general cryotherapy course and daily use of the ointment according to var.1 with the transition to the ointment according to var.2 - local cryotherapy with a dry air stream at a temperature of minus 170 degrees according to the decreasing scheme (first daily, then day, then once a week, and if persistent pigmentation occurs - once a week and the use of ointment according to var 4. After 2 months from the start of treatment, a stable remission was achieved with the complete disappearance of plaques on duty. The duration of primary remission is 3 years. A second course of treatment in the event of an exacerbation at the stage of small-scale manifestations that totally affects the skin was carried out against the background of drug therapy: solcoseryl 4.0 per 200.0 ml of sodium chloride 0.9% solution No. 5 every other day, alternated with pentaxifellin 4.0 to 200.0 ml sodium chloride 0.9% No. 5 every other day, sodium thiosulfate 30% 10.0 ml per 10 ml of sodium chloride 0.9% No. 10 daily intravenously, against the background of general cryotherapy with local cryodestruction of plaques and daily use of ointment according to var. 1. General cryotherapy course No. 14 with simultaneous contact cryotherapy, after completion of the general cryotherapy course - local cryotherapy with a dry air jet at a temperature of minus 170 degrees according to the decreasing scheme and ointment according to var. 2 (first daily, then every other day, then once a week, and at the occurrence of persistent pigmentation - once a week). The course of treatment was 1 month until the skin was completely cleansed. The duration of repeated remission is 3 years, after which a single exposure by the method of local cryotherapy with a dry air jet and ointment according to var. 2 gave a complete relief of plaques. For complete control over the course of the disease, the patient visits a cryocabinet with a full examination of the skin weekly. Remission is held for the second year.

Example 3. Patient Sergey T., 43 years old, was admitted for treatment in 2003 with a diagnosis of Psoriasis is a common period of progressive manifestations, recurrent course; psoriatic lesion of the nail plates. Sick for 20 years.

Upon receipt of a complaint of total rashes over the entire surface of the skin, excluding the face, damage to the scalp, nail plates. Dermatological status: rashes in the form of confluent hyperkeratosis, prone to fusion, psoriatic plaques on the skin over the entire surface of the body; total damage to the scalp, ribbing and pimple striation of the nail plates on the hands and thickening of the nail plates on the legs. Presented: epidermal-dermal papules, silver-white scales, plaques of various sizes. It is accompanied by the appearance of new small rashes of a deep pink color, peripheral growth of elements with the presence of an erythematic border, a positive isomorphic reaction, a psoriatic triad is clearly defined. Accompanied by severe itching. Previously, inpatient and outpatient treatment with incomplete short-term (2-3 months) remission was carried out. The treatment was carried out: against the background of drug therapy (detoxification (Reamberin 400.0), intravenous drip No. 5 daily, hepar compositum 2.2. Ml in 200 ml saline intravenous drip No. 5 daily, calcium gluconate 10% - 10.0 No. 10 in 200 ml saline intravenously drip daily , cycloferon 2.0 on 10.0 saline solution No. 10 according to the scheme: 1,2,4,6,8,11, 14,17,20, 23 days of treatment, adsorbents (lactofiltrum), the patient under the control of blood pressure received general cryotherapy. No. 14 with simultaneous contact cryodestruction of plaques and hedgehogs daily use of var. 1 ointment on smooth skin and var. 3 ointment on the scalp, after completion of the course of general cryotherapy - local cryotherapy with a dry air stream at a temperature of minus 170 degrees in a decreasing pattern and var. 2 ointment on smooth skin and hairy part of the head (first daily, then every other day, 1 time per week, and if persistent pigmentation occurs - once a week). After 1 month from the start of treatment, the scalp was cleansed, incomplete pigmentation appeared in place of large psoriatic of their plaques on smooth skin, small psoriatic plaques on smooth skin disappeared. Externally, they began to apply the ointment according to var. 4, after 3 months from the start of treatment, a stable remission was achieved with the plaque plaques completely disappearing, the shape of the nail plates changed: their striation, ribbing and thickening began to disappear. The duration of primary remission is 2 years. A second course of treatment in the event of an exacerbation at the stage of small-point manifestations was carried out without general cryotherapy, only local cryotherapy and external use of ointment according to var. 1. The course of treatment in this case was 1 month until the skin was completely cleansed against the background of drug therapy: adsorbents (lactofiltrum), hepatoprotectors (Hepel, hofitol), vitamin therapy (neuromultivitis, vitamin A and vitamin E). The duration of the second remission is 4 years.

Example 4. Patient Maria Mikhailovna S., 66 years old, was admitted for treatment in 2002 with a diagnosis of Psoriasis is a common period of progressive manifestations, recurrent course. Sick for 60 years.

Upon receipt of a complaint of a rash on the skin of the back, buttocks, back of the thighs, forearms. Dermatological status: rashes in the form of small hyperkeratous, not prone to fusion, psoriatic plaques. Presented: epidermal-dermal papules, silver-white scales, plaques of various sizes. It is accompanied by the appearance of new small rashes of a deep pink color, peripheral growth of elements with the presence of an erythematic border, a positive isomorphic reaction, a psoriatic triad is clearly defined. Accompanied by severe itching. Previously, inpatient and outpatient treatment with incomplete short-term (2-3 months) remission was carried out. The treatment was carried out: against the background of drug therapy (detoxification (Hemodez 400.0) intravenous drip therapy No. 5 daily, hepar compositum 2.2. Ml in 200 ml saline intravenous drip No. 5 daily, calcium gluconate 10% - 10.0 No. 10 in 200 ml saline intravenously drip daily , cycloferon 2.0 for 10.0 saline solution No. 10 according to the scheme: 1,2,4,6,8,11, 14,17,20, 23 days of treatment, adsorbents (lactofiltrum) general cryotherapy course No. 14 with simultaneous contact cryodestruction of plaques and external use ointment option No. 1, after completion of the course of general cryotherapy - local cryotherapy with a dry air stream at a temperature of minus 170 degrees according to a decreasing scheme and ointment according to var. 2 (first daily, then every other day, then once a week, and if persistent pigmentation occurs - once a week). 1 month after the start of treatment when using ointment according to var.4 1-2 times a week, the skin of the forearms cleansed, incomplete pigmentation appeared on the site of psoriatic plaques on the smooth skin of the back, small psoriatic plaques on the smooth skin of the buttocks disappeared, after 3 months from the start of treatment, persistent remy was achieved And this with the complete disappearance of duty plaques. The duration of primary remission is 3 years. A second course of treatment in the event of an exacerbation at the stage of small-point manifestations on the skin of the same areas was carried out without general cryotherapy, only local cryotherapy and daily use of ointment according to var. 2 with the use of adsorbents (enterosgel), hepatoprotectors (hepel, essentiale), vitamins (aevit ) The course of treatment was 1 month until the skin was completely cleansed. The duration of repeated remission is 3 years. For complete control over the course of the disease, the patient visited a cryocabinet with a full examination of the skin monthly. Remission lasted 3 years. After surgical treatment in 2008 for cancer of the left breast, rashes reappeared in the same places (back, back of the thighs, buttocks). A second course of treatment was carried out without general cryotherapy, only local cryotherapy against the background of therapy recommended by oncologists and external therapy - ointment according to var. 2. The course of treatment was 1 month until the skin was completely cleansed. For complete control over the course of the disease, the patient visited a cryo office with a full examination of the skin weekly against the background of eight courses of chemotherapy and the use of ointment according to var. 4. Remission lasted until 2010, when after surgical treatment for extirpation of the uterus, small rashes reappeared at the previous sites of localization of plaques. A second course of treatment was carried out without general cryotherapy, only local cryotherapy and the use of ointment according to var. 2. For complete control over the course of the disease, the patient visited a cryocabinet with a full examination of the skin weekly. In 2016 (remission of 5 years), psoriatic eruptions again appeared on the sites of the previous localization. The treatment was carried out: against the background of drug therapy: solcoseryl 4.0 per 200.0 ml of sodium chloride 0.9% No. 5 every other day, alternated with pentaxifellin 4.0 to 200.0 ml sodium chloride 0.9% No. 5 every other day, sodium thiosulfate 30% 10.0 ml per 10 ml of sodium chloride 0.9% No. 10 daily intravenously by stream, a course of general cryotherapy No. 14 (as agreed with oncologists) with simultaneous contact cryodestruction of plaques and external ointment therapy according to var. 1, after completion of a course of general cryotherapy –1 times a week general cryotherapy procedure for 6 months and outdoor tera Ia ointment on var.3. Remission with complete cleansing of the skin was achieved after 1.5 months from the start of treatment.

The inventive ointment refers to effective agents for the treatment of psoriasis. It is used in the progressive, stationary and regressive stages of psoriasis and has anti-inflammatory, keratolytic, antiseptic, antiproliferative, sensitizing, resolving effects.

The inventive ointment can be prepared from the listed components in the laboratory.

In total, 155 patients have been monitored since 2002 with a diagnosis of psoriasis of varying degrees of prevalence, localization.

Claims (23)

1. An ointment for the treatment of psoriasis containing a fat base - fat solidol - and active substances, characterized in that the active substances include salicylic ointment 10%, aloe juice, sinaflan, salicylic acid solution 1% and alcohol extract infused in 96% alcohol mixtures of plants taken in equal proportions: leaves and stem of a string, leaves and stem of celandine, leaves and stem of calendula, fruits of Japanese cofora, rose hips, leaves and stem of chamomile, eleutherococcus root, leaves and stem of sage, leaves and stem of sage, leaf I stalk Repeshko, valerian root, in the following ratio, gram: Fat solidol - 3000, Salicylic ointment 10% - 200, Aloe juice 15, Sinaflan - 15, A solution of salicylic acid 1% - 30, Alcoholic extract of a mixture of plants - until saturated. 2. An ointment for the treatment of psoriasis containing a fat base - fat solidol - and active substances, characterized in that as active substances it contains 10% salicylic ointment, aloe juice, sinaflan and alcoholic extract of a mixture of plants taken in 96% alcohol taken in equal lobes: leaves and stem of a succession, leaves and stem of celandine, leaves and stem of calendula, fruits of Japanese sufor, rose hips, leaves and stem of chamomile, eleutherococcus root, leaves and stem of nettle, leaves and stem of sage, leaves and stem of burr, root root iany, with the following component ratio, g: Fat solidol - 3000, Salicylic ointment 10% - 200, Aloe juice - 15, Sinaflan - 15, Alcoholic extract of a mixture of plants - until saturated. 3. An ointment for the treatment of psoriasis containing a fat base - fat solidol - and active substances, characterized in that the active substances contain aloe juice, 10% sulfuric ointment and alcohol extract of a mixture of plants infused in 96% alcohol, taken in equal proportions: leaves and the stalk of the succession, leaves and stalk of celandine, the leaves and stalk of calendula, the fruits of Japanese sophora, the hips, the leaves and stalk of chamomile, the root of Eleutherococcus, the leaves and stalk of the nettle, the leaves and stalk of sage, the leaves and stalk of the sage, the root of Valerian, the ratio of components, grams: Fat solidol - 3000, Aloe juice - 15, Sulfur ointment 10% - 100, Alcoholic extract of a mixture of plants - until saturated. 4. An ointment for the treatment of psoriasis, containing a fat base - fat solidol - and active substances, characterized in that it contains aloe juice, ichthyol ointment and alcohol extract of a mixture of plants taken in 96% alcohol, taken in equal proportions: leaves and stem of a string, leaves and stem of celandine, leaves and stem of calendula, fruits of Japanese coffer, rose hips, leaves and stem of chamomile, eleutherococcus root, leaves and stem of nettle, leaves and stem of sage, leaves and stem of sage, Valerian root, with blowing ratio, gram: Fat solidol - 3000, Aloe juice - 15, Ichthyol ointment 100, Alcoholic extract of a mixture of plants - until saturated.