RU2091065C1 - Ointment for psoriasis treatment - Google Patents

Abstract

FIELD: chemical and pharmaceutical industry, medicine. SUBSTANCE: ointment has the following components, wt.-%: Aralia mandschurica (Lat.) 0.9-1.0; agrimony tomentose 0.9-1.1; bur-marigold 0.95-1.1; celandine major 0.9-1.15; toadflax flowers 0.4-0.6; Ahnfeltia 1.0-1.1; gum arabic 0.4-0.6; glucomannane mucus 0.4-0.6; crab chitin 0.9-2.0; birch tar 0.5-0.6; white bark fir essential oil 0.4-0.5; white bark fir distilled water 0.4-0.6, and medicinal lubricant grease - the rest. EFFECT: enhanced effectiveness of clinical recovery.

Description

 The invention relates to the pharmaceutical industry; mi can be used to treat skin diseases, mainly psoriasis.

 From the prior art it is known to use various therapeutic ointments for the treatment of skin diseases, in particular psoriasis. So in auth. St. USSR N 198530, class A 61 K 9/06, 1965 describes an ointment containing finely divided sulfur 5% emulsifier N 1 18% glycerol 2.8% citric acid 0.003% brown alcohol 0.15% and distilled water 74.047% The use of Emulsol is also known a mixture of 90% emulsion solidol and 10% petroleum jelly (autosw. USSR N 351544, class A 61 K 9/06, 1970) and 2 10% ointments or 1 2% oil solutions based on "Khrizaborin" (ed. St. N 704619, class A 61 K 35/78, 1968) for the treatment of skin diseases, including psoriasis.

 The disadvantage of these drugs is that their use requires long-term hospitalization of patients and subsequent maintenance therapy. In addition, in the treatment with the above drugs, relapses are quite often observed.

Also known is an ointment for the treatment of psoriasis (RF patent N 1787033, class A 61 K 35/78, 1993), taken as a prototype and containing powder from the seeds of psoralea drupes (Psoralea drupaceo Bye), penicillin and petroleum jelly in the following ratio of components, wt . h: powder from the seeds of psoralea stone fruit 2.0 2.5, penicillin 4.5 5.5 ml petroleum jelly up to 100%
The disadvantage of this ointment is that it contains penicillin, which imposes restrictions on the area of use of this ointment due to allergic reactions. In addition, the duration of treatment with a well-known ointment is quite large on average seven weeks.

 The basis of the invention is the task of developing an ointment for the treatment of psoriasis that does not contain antibiotics and provides a high percentage of clinical recovery within 4 to 6 weeks.

 The problem is solved in that the ointment for the treatment of psoriasis, containing a fat base and active substances, according to the invention, additionally contains subliminal water of white fir (Abies album), glucomannan mucus obtained from archidium tubers, contains solidol as a fat base, and As active substances, Manchu aralia (Aralia mandshurica), felt burdock (Avetium tomentosum), three-part series (Bidens tvipartita), large celandine (Chelidonium majus), flaxseed flowers (Linaria), white fir essential oil (Abies album, money) e) gum arabic, anfelium and crab chitin in the following ratio of components, wt.

Aralia Manchurian 0.9 1.0
Felted agrimony 0.9 1.1
Three-part sequence 0.95 1.1
Celandine large 0.9 1.15
Flax flowers 0.4 0.6
Anfelzia 1.0 1.1
Gum Arabic 0.4 0.6
Glucomaniac mucus 0.4 0.6
Chitin crab 1.9 2.0
Tar birch 0.5 0.6
White fir essential oil 0.4 0.5
Sublimated fir white water 0.4 0.6
Solidol medical Else
The ointment is prepared as follows. Dried in the shade at a temperature of 25-30 ^o C leaves of Manchurian Aralia 9.5 g, stalks of felt burdock 10.0 g, leafy stems and leaves of a series of tripartite 10.0 g, celandine grass 10.5 g large and flaxseed flowers 5.0 g is pulverized using, for example, a porcelain ball mill with wooden balls. The grinding process lasts 11 to 12 hours. The resulting powder is sieved through a sieve with a hole size of 1.0 to 1.2 mm, and then mixed with sublimated water of white fir, taken in an amount of 5.0 g. The resulting mixture is added to the fatty oil heated to 100 ^o C basis, which is used medical solidol in an amount of 900.0 g, after which 10.5 g of anfelia, 5.0 g of gum arabic, 50.0 g of glucomaniac mucus, 19.5 g of crab chitin, 5.5 are added with constant stirring g of birch tar and 4.5 g of white fir essential oil. The mixture is kept for 6-7 hours at a temperature of 100 ^o C and with constant stirring, after which the resulting mass is also cooled with constant stirring at a speed of 10 20 ^o C h to 30 ^o C. The ointment is packaged in a standard package with sealed lids.

 Method of application of ointment: rubbed into the lesions and the area of the main peripheral lymph nodes according to the following scheme. Before the start of the treatment cycle, the skin is steamed in a bath, sauna, bathtub or under a hot shower. Then the skin is rinsed with a weak solution of sodium chloride, and after drying, the ointment is rubbed tightly until completely absorbed 1 2 times a day for 3 4 days, during which water procedures are forbidden to patients. On the fourth or fifth day, the ointment is washed off, and after a one-day break, the treatment cycle described above is repeated. On the 3rd 5th day after the start of treatment, itching, edema and hyperemia of the skin appear in the area of the lesion foci and around them.

 Example 1. Patient J., 44 years old, has been suffering from psoriasis for twenty years and over the past five years, despite the treatment, there was no remission, the plaques slightly fluctuated in size. Upon receipt, there were complaints of a feeling of tightening the skin, itching. Objectively: on the scalp and forehead, on the extremities and trunk, extensive plaques are saturated red with a tendency to peripheral growth, covered with grayish scales, along the periphery of the plaques the triad of symptoms is positive, the process occupies more than 50% of the skin. The very next day after lubrication, the plaque on the forehead brightened. The treatment lasted 29 days, with discharge on the site of plaques only hyperpigmentation.

 Example 2. Patient O. 60 years old, complaints of rashes throughout the skin, periodic skin itching. Sick for 22 years, and the onset of the disease is associated with nervous stress. The first psoriasatic rashes appeared on the scalp, on the legs and in the forearms. Notes exacerbation of dermatosis in the autumn-winter period. He was treated on an outpatient and inpatient basis with temporary improvement. Gradually, over the years, the area of skin lesion increased, and remissions became shorter even after long courses of therapy. Objectively: the process is widespread. On the skin of the scalp, trunk, extensor surface of the forearms and lower legs there are multiple "geographical" plaques of a deep red color with a tendency to peripheral growth. The foci are covered with abundant silver scales. On the periphery of large plaques there are small bright red papules. Kebner's isomorphic reaction is noted, the psoriatic triad is positive, pink dermographism is unstable. Diagnosis: common psoriasis, plaque variety, progressive stage, autumn-winter form. The rejection reaction began four days after the start of treatment with the proposed ointment and lasted ten days. When examined on the 14th day after the start of treatment, psoriatic plaques remain edematous and hyperemic, almost no peeling. She feels well. On the twenty-first day, areas of skin enlightenment appeared in the focal area. Subsequently, the "regression zones" steadily increased. 50 days after treatment, the skin was completely cleansed.

 The results of treatment of psoriasis patients with the proposed ointment.

 Under observation were 24 patients with psoriasis aged 14 to 66 years (13 men, 11 women). Common plaque psoriasis with lesions of more than 50% of the skin affected 15 people, drop-shaped psoriasis 4, arthropathic psoriasis 1, palmar-plantar form of psoriasis 1, exudative psoriasis 2, psoriatic erythroderma 1. Progressive stage of the disease was observed in 18 patients, stationary 6. the disease ranged from 3 months to 30 years. In patients with a long psoriatic history in recent years, remissions were not observed even against the background of inpatient and outpatient treatment. Treatment was prescribed to patients after a thorough clinical and laboratory examination (medical history, identification of intercurrent pathology, general blood tests, urine tests, biochemical blood tests). Monotherapy with the drug was carried out in 10 patients, against the backdrop of complex pathogenetic therapy in 14 (30% sodium thiosulfate solution, B vitamins, aevit, ascorbic acid, autohemotherapy, Castellani fluid, common quartz, in patients with somatic pathology were prescribed appropriate therapy). The treatment results were as follows: clinical recovery was recorded in 14 patients, significant improvement in 3 patients, improvement in 2 patients. Ointment therapy was ineffective in 5 patients. At the same time, 2 out of 5 patients noted alcohol abuse, in 3 patients chronic persistent hepatitis was diagnosed.

Claims (1)

 An ointment for the treatment of psoriasis containing a fat base and active substances, characterized in that it additionally contains subliminal water of white fir (Abies album), glucomannan mucus obtained from archidic tubers, contains a medical solidol as a fat base, and aralia as active substances Manchurian (Aralia mandshurica), felt burdock (Aretium tomentosum), three-part series (Bidens tripartita), large celandine (Chelidonium majus), flax flowers (Zinaria), white fir essential oil (Abies album), birch tar, Betula tar, Betula tar (Betula felony and chitin crab in the following ratio of components, wt. Aralia Manchurian 0.9 1.0
Felted agrimony 0.9 1.1
Three-part sequence 0.95 1.1
Celandine large 0.09 1.15
Flax flowers 0.4 0.6
Anfelzia 1.0 1.1
Gum Arabic 0.4 0.6
Glucomaniac mucus 0.4 0.6
Chitin crab 1.9 2.0
Birch tar 0.5 0.6
White fir essential oil 0.4 0.5
Sublimated fir white water 0.4 0.6
Medical solidol Else