CN103655383B - Chinese medicinal herb extract and preparation method and application thereof - Google Patents
Chinese medicinal herb extract and preparation method and application thereof Download PDFInfo
- Publication number
- CN103655383B CN103655383B CN201310751088.6A CN201310751088A CN103655383B CN 103655383 B CN103655383 B CN 103655383B CN 201310751088 A CN201310751088 A CN 201310751088A CN 103655383 B CN103655383 B CN 103655383B
- Authority
- CN
- China
- Prior art keywords
- parts
- herbal medicine
- chinese herbal
- medicine extract
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000284 extract Substances 0.000 title claims abstract description 110
- 238000000605 extraction Methods 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000002453 shampoo Substances 0.000 claims abstract description 38
- 239000000341 volatile oil Substances 0.000 claims abstract description 32
- 239000003814 drug Substances 0.000 claims abstract description 31
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 19
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 19
- 241000931143 Gleditsia sinensis Species 0.000 claims abstract description 19
- 238000003809 water extraction Methods 0.000 claims abstract description 10
- 241000411851 herbal medicine Species 0.000 claims description 88
- 238000003756 stirring Methods 0.000 claims description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 46
- 239000000843 powder Substances 0.000 claims description 36
- 230000001804 emulsifying effect Effects 0.000 claims description 30
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 28
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 28
- -1 polyoxyethylene lauryl ether sodium sulfate Polymers 0.000 claims description 28
- 229940079593 drug Drugs 0.000 claims description 26
- 239000006286 aqueous extract Substances 0.000 claims description 18
- 241000218628 Ginkgo Species 0.000 claims description 17
- 235000013399 edible fruits Nutrition 0.000 claims description 17
- 210000000582 semen Anatomy 0.000 claims description 17
- 244000060011 Cocos nucifera Species 0.000 claims description 16
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 16
- 229920001577 copolymer Polymers 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 16
- 239000000839 emulsion Substances 0.000 claims description 15
- PHTONCQEHLECGK-UHFFFAOYSA-M 3-hydroxypropyl-dimethyl-octadecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCO PHTONCQEHLECGK-UHFFFAOYSA-M 0.000 claims description 14
- 244000303965 Cyamopsis psoralioides Species 0.000 claims description 14
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 14
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 14
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical group CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 claims description 14
- 235000019270 ammonium chloride Nutrition 0.000 claims description 14
- 230000002421 anti-septic effect Effects 0.000 claims description 14
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 14
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 14
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 14
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 14
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 14
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 14
- 229940100608 glycol distearate Drugs 0.000 claims description 14
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 14
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 14
- 229920001296 polysiloxane Polymers 0.000 claims description 14
- 230000008961 swelling Effects 0.000 claims description 13
- 239000006185 dispersion Substances 0.000 claims description 12
- 238000004945 emulsification Methods 0.000 claims description 12
- 239000012530 fluid Substances 0.000 claims description 12
- 239000003921 oil Substances 0.000 claims description 11
- 238000010992 reflux Methods 0.000 claims description 9
- 238000001256 steam distillation Methods 0.000 claims description 9
- 125000002091 cationic group Chemical group 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 238000010792 warming Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 5
- 239000003945 anionic surfactant Substances 0.000 claims description 4
- 239000003093 cationic surfactant Substances 0.000 claims description 4
- 238000000518 rheometry Methods 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 claims description 2
- 229940063953 ammonium lauryl sulfate Drugs 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229940057950 sodium laureth sulfate Drugs 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 2
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 19
- 210000004209 hair Anatomy 0.000 abstract description 18
- 208000001840 Dandruff Diseases 0.000 abstract description 11
- 208000003251 Pruritus Diseases 0.000 abstract description 11
- 230000007803 itching Effects 0.000 abstract description 9
- 201000004384 Alopecia Diseases 0.000 abstract description 6
- 230000017531 blood circulation Effects 0.000 abstract description 6
- 231100000360 alopecia Toxicity 0.000 abstract description 5
- 210000004761 scalp Anatomy 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 abstract 2
- 235000002566 Capsicum Nutrition 0.000 abstract 2
- 241001116742 Drynaria Species 0.000 abstract 2
- 244000286838 Eclipta prostrata Species 0.000 abstract 2
- 244000194101 Ginkgo biloba Species 0.000 abstract 2
- 244000018716 Impatiens biflora Species 0.000 abstract 2
- 235000015912 Impatiens biflora Nutrition 0.000 abstract 2
- 239000006002 Pepper Substances 0.000 abstract 2
- 235000016761 Piper aduncum Nutrition 0.000 abstract 2
- 235000017804 Piper guineense Nutrition 0.000 abstract 2
- 244000203593 Piper nigrum Species 0.000 abstract 2
- 235000008184 Piper nigrum Nutrition 0.000 abstract 2
- 240000002924 Platycladus orientalis Species 0.000 abstract 2
- 244000292697 Polygonum aviculare Species 0.000 abstract 2
- 235000006386 Polygonum aviculare Nutrition 0.000 abstract 2
- 235000005155 Tanacetum balsamita Nutrition 0.000 abstract 2
- 235000007215 black sesame Nutrition 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000030961 allergic reaction Diseases 0.000 abstract 1
- 239000006260 foam Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 11
- 101000575041 Homo sapiens Male-enhanced antigen 1 Proteins 0.000 description 7
- 102100025532 Male-enhanced antigen 1 Human genes 0.000 description 7
- 208000002193 Pain Diseases 0.000 description 6
- 238000010583 slow cooling Methods 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 5
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010011878 Deafness Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000031361 Hiccup Diseases 0.000 description 2
- 101100337414 Mus musculus Golga3 gene Proteins 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 241000130764 Tinea Species 0.000 description 2
- 208000002474 Tinea Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000036783 anaphylactic response Effects 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 229910052785 arsenic Inorganic materials 0.000 description 2
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 208000023513 hiccough Diseases 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037083 Prurigo Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047642 Vitiligo Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000004631 alopecia areata Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000002844 continuous effect Effects 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 150000002012 dioxanes Chemical class 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000003646 hair health Effects 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 231100000286 mucous membrane, eye irritation or corrosion testing Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention disclose a Chinese medicinal herb extract, which is prepared from the following bulk pharmaceuticals in parts by weight: 20-55 parts of vine of multiflower knotweed, 5-25 parts of Chinese honey locust, 15-40 parts of oriental waterplantain rhizome, 5-25 parts of black sesame, 15-40 parts of yerbadetajo herb, 5-25 parts of ginkgo leaf, 5-25 parts of Chinese arborvitae twig, 5-15 parts of pepper, 15-40 parts of fortune's drynaria rhizome and 5-25 parts of garden balsam stem. The preparation method comprises the following steps: extracting pepper volatile oil, performing water extraction on the vine of multiflower knotweed, the Chinese honey locust, the oriental waterplantain rhizome and the garden balsam stem, and performing alcohol extraction on the black sesame, the yerbadetajo herb, the ginkgo leaf, the Chinese arborvitae twig and the fortune's drynaria rhizome. The Chinese medicinal herb extract can prompt scalp blood circulation, has the effects of blackening and growing hairs, preventing and stopping alopecia, removing dandruff and relieving itching, is prepared with the simple preparation method, and is low in cost. Shampoo made of the Chinese medicinal herb extract is uniform and fine, is rich in foam, is easy to flush completely, does not cause any allergic reaction after use, is free from toxic and side effects, helps smoothening and softening hairs, is durable in dandruff removing and itching relieving effects, can blacken and grow hairs and prevent and stop alopecia after long-term use, and is suitable for customers to use in daily life for a long time.
Description
Technical field
The invention belongs to technical field of Chinese medicines and daily cosmetics technical field, relate to a kind of Chinese herbal medicine extract and preparation method thereof, and this Chinese herbal medicine extract is preparing the application in shampoo.
Background technology
According to the healthy standard of World Health Organization's definition, " hair is flexible, has natural gloss, does not have dandruff " is wherein very important one.And increase the weight of by environmental pollution at present, chemistry shampoo frequently uses, and rhythm of life is accelerated, the impact of the factors such as operating pressure increasing, withered jag, dull very easily appear in hair, grow dandruff and disconnected loss of hairs the situation such as to send out, and brings worry to daily life.Alopecia and dandruff have become two large hair health problems of puzzlement consumer.And along with environmental protection in recent years, low-carbon (LC), green and natural tendency popular, have blackening and generating hair, anticreep anti-avulsion, anti-dandruff and itching-relieving efficacies Chinese herbal medicine liquid shampoo will be following trend.
Summary of the invention
In view of this, an object of the present invention is to provide a kind of Chinese herbal medicine extract, has effect of blackening and generating hair, anticreep anti-avulsion, removing scurf and relieving itching, with its cleaning hair after without anaphylaxis, have no side effect, be suitable for long term consumer use; Two of object is the preparation method providing this Chinese herbal medicine extract, simple operation, and cost is low, is suitable for industrialization large-scale production; Three of object is to provide this Chinese herbal medicine extract preparing the application in shampoo; Four of object is to provide a kind of shampoo containing this Chinese herbal medicine extract, homogeneous exquisiteness, and foaming abundancy, easily rinses well, smooth with rear hair, removing scurf and relieving itching, and effect is lasting, life-time service energy blackening and generating hair, anticreep anti-avulsion; Five of object is to provide a kind of method preparing this shampoo, simple operation, and cost is low, is suitable for industrialization large-scale production.
After deliberation, the invention provides following technical scheme:
1. Chinese herbal medicine extract, is made up of following crude drug by weight: Caulis Polygoni Multiflori 20 ~ 55 parts, Chinese honey locust (fruit) 5 ~ 25 parts, Rhizoma Alismatis 15 ~ 40 parts, Semen Sesami Nigrum 5 ~ 25 parts, Herba Ecliptae 15 ~ 40 parts, Folium Ginkgo 5 ~ 25 parts, Cacumen Platycladi 5 ~ 25 parts, 5 ~ 15 parts, Pericarpium Zanthoxyli, Rhizoma Drynariae 15 ~ 40 parts, Herba speranskiae tuberculatae 5 ~ 25 parts.
Preferably, described Chinese herbal medicine extract is made up of following crude drug by weight: Caulis Polygoni Multiflori 30 parts, Chinese honey locust (fruit) 10 parts, Rhizoma Alismatis 20 parts, Semen Sesami Nigrum 10 parts, Herba Ecliptae 20 parts, Folium Ginkgo 10 parts, Cacumen Platycladi 10 parts, 6 parts, Pericarpium Zanthoxyli, Rhizoma Drynariae 20 parts, Herba speranskiae tuberculatae 10 parts.
In above-mentioned raw materials medicine, Caulis Polygoni Multiflori has tranquilizing by nourishing the heart, effect of dispelling wind and removing obstruction in the collateral, for insomnia and dreamful sleep, and blood deficiency general pain, rheumatic arthralgia, external treatment skin wind skin ulcer prurigo, can receive effect of dispelling wind for relieving itching; Chinese honey locust (fruit) has expelling phlegm for arresting cough, logical closing of having one's ideas straightened out, effect of parasite killing eliminating stagnation, for productive cough dyspnea with fullness of the chest, apoplexy locked mouth, accumulation and obstruction of sputum, coma in silence, epilepsy, sore throat, constipation and anuresis, carbuncle scabies; Rhizoma Alismatis has diuresis, effect of clearing away damp-heat, for dysuria, and edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery disease of pyretic stranguria, hyperlipidemia; Semen Sesami Nigrum has invigorating the liver and kidney, benefiting essence-blood, effect that intestine moistening is dry, for dizziness and blurred vision, and Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation; Herba Ecliptae has nourishing the liver and kidney, effect of cooling blood for hemostasis, for odontoseisis, and early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, spits blood, ware blood, hematuria, dysentery, metrostaxis, traumatic hemorrhage; Folium Ginkgo has blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringes the lung and relievings asthma, and changes effect of turbid blood fat reducing, for obstruction of collaterals by blood stasis, and obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, cough and asthma due to lung deficiency, hyperlipemia etc.; Cacumen Platycladi has cooling blood for hemostasis, effect of growing and blacking hair, and for spitting blood, spitting of blood, has blood in stool, metrostaxis, heat in blood alopecia, early whitening of beard and hair; Pericarpium Zanthoxyli has warming middle-JIAO to relieve pain, effect of killing parasites for relieving itching, and for coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascarid, external treatment eczema pruritus, and Pericarpium Zanthoxyli volatile oil has certain suppression and killing action to various skin tinea bacterium and deep fungal; Rhizoma Drynariae has the kidney invigorating bone strengthening, continuous effect of hindering pain relieving, for lumbago due to renal deficiency, and Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone, external treatment alopecia areata, vitiligo; Herba speranskiae tuberculatae has wind-damp dispelling, relaxing muscles and tendons, invigorates blood circulation, effect of pain relieving, and for rheumatalgia, muscles and bones contracture, the diseases such as numb limbs and tense tendons, water decoction external has antiinflammatory, sterilization, the effect of convergence wound surface, is suitable for general skin ulcer tinea toxic swelling.Each medicine reasonable compatibility above, play altogether invigorate blood circulation, dredging collateral, dispel the wind, antibacterial, antipruritic merit, scalp blood circulation can be promoted, blackening and generating hair, anticreep anti-avulsion, removing scurf and relieving itching.
2. the preparation method of Chinese herbal medicine extract described in, comprises the following steps:
1) volatile oil is drawn: get Pericarpium Zanthoxyli, adds water, and uses extraction by steam distillation volatile oil, and obtain Pericarpium Zanthoxyli volatile oil and Chinese herbal medicine extract A, Aqueous extracts is for subsequent use;
2) water extraction: get Caulis Polygoni Multiflori, Chinese honey locust (fruit), Rhizoma Alismatis and Herba speranskiae tuberculatae, be ground into coarse powder, add water, soak 20-60 minute, decoct and extract, collect extracting solution, medicinal residues decoct with water and extract 1-3 time, merge extractive liquid, then merge with step 1) gained Aqueous extracts, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract B;
3) alcohol extraction: get Semen Sesami Nigrum, Herba Ecliptae, Folium Ginkgo, Cacumen Platycladi and Rhizoma Drynariae, be ground into coarse powder, be alcohol reflux 2-4 time of 50-80% by volume fraction, merge extractive liquid, reclaims ethanol, is concentrated into 2/3 of crude drug weight, obtains Chinese herbal medicine extract C;
Chinese herbal medicine extract A, B and C and described Chinese herbal medicine extract.
Preferably, the preparation method of described Chinese herbal medicine extract comprises the following steps:
1) volatile oil is drawn: get Pericarpium Zanthoxyli, adds the water of 6-15 times amount, uses extraction by steam distillation volatile oil, and obtain Pericarpium Zanthoxyli volatile oil and Chinese herbal medicine extract A, Aqueous extracts is for subsequent use;
2) water extraction: get Caulis Polygoni Multiflori, Chinese honey locust (fruit), Rhizoma Alismatis and Herba speranskiae tuberculatae, be ground into coarse powder, adds the water being equivalent to medicated powder gross weight 8-15 times amount, soaks 30 minutes, decocts and extracts 1-3 hour, collects extracting solution; Medicinal residues add the water being equivalent to medicated powder gross weight 6-15 times amount, decoct and extract 1-3 hour, collect extracting solution; Merge extractive liquid, then merge with step 1) gained Aqueous extracts, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract B;
3) alcohol extraction: get Semen Sesami Nigrum, Herba Ecliptae, Folium Ginkgo, Cacumen Platycladi and Rhizoma Drynariae, be ground into coarse powder, adding the volume fraction being equivalent to medicated powder gross weight 6-15 times amount is the ethanol of 50-80%, reflux, extract, 2-4 time, each extraction 1-3 hour, merge extractive liquid, reclaims ethanol, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract C.
Preferred, the preparation method of described Chinese herbal medicine extract comprises the following steps:
1) volatile oil is drawn: get Pericarpium Zanthoxyli, adds the water of 10 times amount, uses extraction by steam distillation volatile oil, and obtain Pericarpium Zanthoxyli volatile oil and Chinese herbal medicine extract A, Aqueous extracts is for subsequent use;
2) water extraction: get Caulis Polygoni Multiflori, Chinese honey locust (fruit), Rhizoma Alismatis and Herba speranskiae tuberculatae, be ground into coarse powder, adds the water being equivalent to medicated powder gross weight 15 times amount, soaks 30 minutes, decocts extraction 2 hours, collects extracting solution; Medicinal residues add the water being equivalent to medicated powder gross weight 10 times amount, decoct extraction 2 hours, collect extracting solution; Merge extractive liquid, then merge with step 1) gained Aqueous extracts, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract B;
3) alcohol extraction: get Semen Sesami Nigrum, Herba Ecliptae, Folium Ginkgo, Cacumen Platycladi and Rhizoma Drynariae, be ground into coarse powder, adding the volume fraction being equivalent to medicated powder gross weight 8 times amount is the ethanol of 60%, reflux, extract, 2 times, each extraction 2 hours, merge extractive liquid, reclaims ethanol, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract C.
3. Chinese herbal medicine extract described in is preparing the application in shampoo.
4. the shampoo containing described Chinese herbal medicine extract.
Preferably, described shampoo is also containing following composition: chelating agen, surfactant, rheology control agent, pearling agent, thickening agent, conditioner, antiseptic and quintessence oil or essence.
Preferably, described chelating agen is disodiumedetate or tetrasodium ethylenediamine tetraacetate; Described surfactant comprises cationic surfactant and anion surfactant, described cationic surfactant is any one or more mixing in Polyquaternium-10, polyquaternary ammonium salt-47 and guar hydroxypropyltrimonium ammonium chloride, and described anion surfactant is any one or more mixing in laureth sulfuric ester ammonium, sodium laureth sulfate, sodium lauryl sulfate, polyoxyethylene lauryl ether sodium sulfate and ammonium lauryl sulfate; Described rheology control agent is coconut oleoyl amine MEA and/or coconut oleoyl amine DEA; Described pearling agent is glycol distearate, ethylene glycol monostearate or Pearl Concentrate; Described thickening agent is any one or more mixing in acrylate copolymer, acrylic acid esters co-polymer, hydroxyethyl-cellulose, hydroxypropyl emthylcellulose, cocamido propyl betaine and hydroxy sulfo lycine; Described conditioner is any one or more mixing in polydimethylsiloxane, silicone, cationic albumen, cetearyl alcohol and pantothenylol base hydroxypropyl stearyldimethylammonium chloride.
Preferably, described shampoo is grouped into by following one-tenth by mass percentage: Chinese herbal medicine extract 1-10%, disodiumedetate 0.1-0.5%, Polyquaternium-10 0.1-1.0%, guar hydroxypropyltrimonium ammonium chloride 0.1-1.0%, laureth sulfuric ester ammonium 10-25%, coconut oleoyl amine MEA1-3%, glycol distearate 0.5-3%, acrylic acid esters co-polymer 1-5%, polyquaternary ammonium salt-471-5%, aqueous emulsion of dimethyl polysiloxane fluid 1-5%, silicone, cationic albumen 0.5-3%, cocamido propyl betaine 2-8%, cetearyl alcohol 0.5-3%, pantothenylol base hydroxypropyl stearyldimethylammonium chloride 0.5-2%, antiseptic 0.01-1%, quintessence oil or essence 0.1-1%, surplus is water.
Preferred, described shampoo is grouped into by following one-tenth by mass percentage: Chinese herbal medicine extract 5%, disodiumedetate 0.1%, Polyquaternium-10 0.3%, guar hydroxypropyltrimonium ammonium chloride 0.15%, laureth sulfuric ester ammonium 18%, coconut oleoyl amine MEA2%, glycol distearate 1%, acrylic acid esters co-polymer 2%, polyquaternary ammonium salt-472%, aqueous emulsion of dimethyl polysiloxane fluid 2.5%, silicone, cationic albumen 0.8%, cocamido propyl betaine 5%, cetearyl alcohol 1.0%, pantothenylol base hydroxypropyl stearyldimethylammonium chloride 1.0%, antiseptic 0.3%, quintessence oil or essence 0.3%, surplus is water.
5. the preparation method of shampoo described in, comprise the following steps: in container, add water and disodiumedetate, be stirred to dissolve, add the aqueous dispersions of Polyquaternium-10, stirring makes fully swelling, add the aqueous dispersions of guar hydroxypropyltrimonium ammonium chloride again, stirring makes fully swelling, when system presents clear state, be warming up to 60-85 DEG C, in temperature-rise period, add laureth sulfuric ester ammonium, be stirred to dissolve, add Chinese herbal medicine extract B and Chinese herbal medicine extract C again, stir, add coconut oleoyl amine MEA again, glycol distearate and cetearyl alcohol, after the two dissolving is uniformly dispersed, 60-85 DEG C of insulated and stirred 10-30 minute, then, system is cooled to 40-50 DEG C, add acrylic acid esters co-polymer, stir, then add polyquaternary ammonium salt-47, aqueous emulsion of dimethyl polysiloxane fluid and polysiloxanes ion-protein successively, stir after 10-30 minute, start emulsifying to stir, emulsification times is 5-20 minute, and emulsifying speed of agitator is 50-100Hz, and repetition, intermittently operated complete emulsifying 2-3 time, then, system is cooled to less than 40 DEG C, add pantothenylol base hydroxypropyl stearyldimethylammonium chloride, Chinese herbal medicine extract A, quintessence oil or essence and antiseptic successively, stir, then add cocamido propyl betaine, stir, start emulsifying to stir, emulsification times is 5-20 minute, and emulsifying speed of agitator is 50-100Hz, stop when system presents uniform and smooth state, obtain shampoo.
Preferred, the preparation method of described shampoo comprises the following steps: in container, add water and disodiumedetate, be stirred to dissolve, add the aqueous dispersions of Polyquaternium-10 again, stirring makes fully swelling, add the aqueous dispersions of guar hydroxypropyltrimonium ammonium chloride again, stirring makes fully swelling, when system presents clear state, be warming up to 75-80 DEG C, in temperature-rise period, add laureth sulfuric ester ammonium, be stirred to dissolve, add Chinese herbal medicine extract B and Chinese herbal medicine extract C again, stir, add coconut oleoyl amine MEA again, glycol distearate and cetearyl alcohol, after the two dissolving is uniformly dispersed, 75-80 DEG C of insulated and stirred 20 minutes, then, system is cooled to 45 DEG C, add acrylic acid esters co-polymer, stir, then add polyquaternary ammonium salt-47, aqueous emulsion of dimethyl polysiloxane fluid and polysiloxanes ion-protein successively, stir after 20 minutes, start emulsifying to stir, emulsification times is 10 minutes, and emulsifying speed of agitator is 80Hz, and repetition, intermittently operated complete emulsifying 2-3 time, then, system is cooled to less than 40 DEG C, add pantothenylol base hydroxypropyl stearyldimethylammonium chloride, Chinese herbal medicine extract A, quintessence oil or essence and antiseptic successively, stir, then add cocamido propyl betaine, stir, start emulsifying to stir, emulsification times is 10 minutes, and emulsifying speed of agitator is 100Hz, stop when system presents uniform and smooth state, obtain shampoo.
Beneficial effect of the present invention is: Chinese herbal medicine extract of the present invention can promote scalp blood circulation, have effect of blackening and generating hair, anticreep anti-avulsion, removing scurf and relieving itching, and preparation method is simple, cost is low, and it is made shampoo further, homogeneous exquisiteness, foaming abundancy, easily rinse well, with rear without anaphylaxis, have no side effect, hair is smooth submissive, removing scurf and relieving itching effect is lasting, and life-time service can also blackening and generating hair, anticreep anti-avulsion, is suitable for that consumer is daily, life-time service.
Detailed description of the invention
In order to make object of the present invention, technical scheme and beneficial effect clearly, will be described in detail the preferred embodiments of the present invention below.
Preparation embodiment 1
The crude drug formula of Chinese herbal medicine extract: Caulis Polygoni Multiflori 30 parts, Chinese honey locust (fruit) 10 parts, Rhizoma Alismatis 20 parts, Semen Sesami Nigrum 10 parts, Herba Ecliptae 20 parts, Folium Ginkgo 10 parts, Cacumen Platycladi 10 parts, 6 parts, Pericarpium Zanthoxyli, Rhizoma Drynariae 20 parts, Herba speranskiae tuberculatae 10 parts.
The preparation method of Chinese herbal medicine extract, comprises the following steps:
1) volatile oil is drawn: the Pericarpium Zanthoxyli getting formula ratio, adds the water of 10 times amount, uses extraction by steam distillation volatile oil, and obtain Pericarpium Zanthoxyli volatile oil and Chinese herbal medicine extract A, Aqueous extracts is for subsequent use;
2) water extraction: get the Caulis Polygoni Multiflori of formula ratio, Chinese honey locust (fruit), Rhizoma Alismatis and Herba speranskiae tuberculatae, be ground into coarse powder, adds the water being equivalent to medicated powder gross weight 15 times amount, soak 30 minutes, decoct extraction 2 hours, filter, medicinal residues add the water being equivalent to medicated powder gross weight 10 times amount, decoct extraction 2 hours, filter, merging filtrate, extracts the Aqueous extracts after volatile oil with Pericarpium Zanthoxyli and merges, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract B;
3) alcohol extraction: get the Semen Sesami Nigrum of formula ratio, Herba Ecliptae, Folium Ginkgo, Cacumen Platycladi and Rhizoma Drynariae, be ground into coarse powder, add 60% (v/v) ethanol being equivalent to medicated powder gross weight 8 times amount, reflux, extract, 2 times, each extraction 2 hours, merge extractive liquid, reclaims ethanol, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract C.
Shampoo prescription: consist of the following composition by mass percentage: Chinese herbal medicine extract (comprises Chinese herbal medicine extract A, B and C) 5%, disodiumedetate 0.1%, Polyquaternium-10 0.3%, guar hydroxypropyltrimonium ammonium chloride 0.15%, laureth sulfuric ester ammonium 18%, coconut oleoyl amine MEA2%, glycol distearate 1%, acrylic acid esters co-polymer 2%, polyquaternary ammonium salt-472%, aqueous emulsion of dimethyl polysiloxane fluid 2.5%, silicone, cationic albumen 0.8%, cocamido propyl betaine 5%, cetearyl alcohol 1.0%, pantothenylol base hydroxypropyl stearyldimethylammonium chloride 1.0%, antiseptic 0.3%, quintessence oil or essence 0.3%, surplus is water.
The preparation method of shampoo, comprises the following steps:
Water and disodiumedetate is added in vacuum emulsion mixer, be stirred to dissolve, add the aqueous dispersions of Polyquaternium-10 again, stirring makes fully swelling, add the aqueous dispersions of guar hydroxypropyltrimonium ammonium chloride again, stirring makes fully swelling, when system presents clear state, be warming up to 75-80 DEG C, in temperature-rise period, add laureth sulfuric ester ammonium, be stirred to dissolve, add Chinese herbal medicine extract B and Chinese herbal medicine extract C again, stir, add coconut oleoyl amine MEA again, glycol distearate and cetearyl alcohol, after said components dissolving is uniformly dispersed, 75-80 DEG C of insulated and stirred 20 minutes, then, the mode of circulating water is adopted to make system slow cooling to 45 DEG C, add acrylic acid esters co-polymer, stir, then add polyquaternary ammonium salt-47, aqueous emulsion of dimethyl polysiloxane fluid and polysiloxanes ion-protein successively, stir after 20 minutes, start emulsifying to stir, emulsification times is 10 minutes, and emulsifying speed of agitator is 80Hz, and repetition, intermittently operated complete emulsifying 2-3 time, then, adopt the mode of circulating water to make below system slow cooling to 40 DEG C, add pantothenylol base hydroxypropyl stearyldimethylammonium chloride, Chinese herbal medicine extract A, essence and antiseptic successively, stir, add cocamido propyl betaine again, stir, start emulsifying and stir, emulsification times is 10 minutes, emulsifying speed of agitator is 100Hz, observe system cosmetic variation situation at any time, stops when system presents uniform and smooth state, obtains shampoo.
Gained shampoo is entrusted food and medicine inspection institute of Chongqing City to be permitted [2010] No. 456 civilian adnexaes 7 according to Ministry of Public Health " cosmetics health specification " (version in 2007) and state of State Food and Drug Administration food medicine salt and is checked following project: microorganism, lead, arsenic, hydrargyrum, acute skin irritation test, acute eye irritation test, 'alpha '-hydroxy acids, hydroquinone, phenol, dioxanes.Testing result shows, and the microorganism of gained shampoo, lead, arsenic, hydrargyrum, 'alpha '-hydroxy acids, hydroquinone, phenol, Contents of Dioxane all meet relevant regulations, to no skin irritation, have subexcite to eye.
1000 testers through professional training are allowed by gained shampoo to use 3 months.Tester uses during sample and carries out according to identical method, and marks to shampoo effect according to identical standards of grading.The results are shown in Table 1.
Table 1 shampoo measure of merit result (percentage ratio)
Preparation embodiment 2
The crude drug formula of Chinese herbal medicine extract: Caulis Polygoni Multiflori 20 parts, Chinese honey locust (fruit) 5 parts, Rhizoma Alismatis 15 parts, Semen Sesami Nigrum 5 parts, Herba Ecliptae 15 parts, Folium Ginkgo 5 parts, Cacumen Platycladi 5 parts, 5 parts, Pericarpium Zanthoxyli, Rhizoma Drynariae 15 parts, Herba speranskiae tuberculatae 5 parts.
The preparation method of Chinese herbal medicine extract, comprises the following steps:
1) volatile oil is drawn: the Pericarpium Zanthoxyli getting formula ratio, adds the water of 6 times amount, uses extraction by steam distillation volatile oil, and obtain Pericarpium Zanthoxyli volatile oil and Chinese herbal medicine extract A, Aqueous extracts is for subsequent use;
2) water extraction: get the Caulis Polygoni Multiflori of formula ratio, Chinese honey locust (fruit), Rhizoma Alismatis and Herba speranskiae tuberculatae, be ground into coarse powder, adds the water being equivalent to medicated powder gross weight 12 times amount, soak 30 minutes, decoct extraction 3 hours, filter, medicinal residues add the water being equivalent to medicated powder gross weight 8 times amount, decoct extraction 1.5 hours, filter, merging filtrate, extracts the Aqueous extracts after volatile oil with Pericarpium Zanthoxyli and merges, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract B;
3) alcohol extraction: get the Semen Sesami Nigrum of formula ratio, Herba Ecliptae, Folium Ginkgo, Cacumen Platycladi and Rhizoma Drynariae, be ground into coarse powder, add 80% (v/v) ethanol being equivalent to medicated powder gross weight 6 times amount, reflux, extract, 2 times, each extraction 3 hours, merge extractive liquid, reclaims ethanol, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract C.
Shampoo prescription: consist of the following composition by mass percentage: Chinese herbal medicine extract (comprises Chinese herbal medicine extract A, B and C) 2%, disodiumedetate 0.1%, Polyquaternium-10 0.1%, guar hydroxypropyltrimonium ammonium chloride 0.1%, laureth sulfuric ester ammonium 10%, coconut oleoyl amine MEA1%, glycol distearate 0.5%, acrylic acid esters co-polymer 1%, polyquaternary ammonium salt-471%, aqueous emulsion of dimethyl polysiloxane fluid 1%, silicone, cationic albumen 0.5%, cocamido propyl betaine 2%, cetearyl alcohol 0.5%, pantothenylol base hydroxypropyl stearyldimethylammonium chloride 0.5%, antiseptic 0.01%, quintessence oil or essence 0.1%, surplus is water.
The preparation method of shampoo, comprises the following steps:
Water and disodiumedetate is added in vacuum emulsion mixer, be stirred to dissolve, add the aqueous dispersions of Polyquaternium-10 again, stirring makes fully swelling, add the aqueous dispersions of guar hydroxypropyltrimonium ammonium chloride again, stirring makes fully swelling, when system presents clear state, be warming up to 60-65 DEG C, in temperature-rise period, add laureth sulfuric ester ammonium, be stirred to dissolve, add Chinese herbal medicine extract B and Chinese herbal medicine extract C again, stir, add coconut oleoyl amine MEA again, glycol distearate and cetearyl alcohol, after said components dissolving is uniformly dispersed, 60-65 DEG C of insulated and stirred 15 minutes, then, the mode of circulating water is adopted to make system slow cooling to 45 DEG C, add acrylic acid esters co-polymer, stir, then add polyquaternary ammonium salt-47, aqueous emulsion of dimethyl polysiloxane fluid and polysiloxanes ion-protein successively, stir after 15 minutes, start emulsifying to stir, emulsification times is 5 minutes, and emulsifying speed of agitator is 100Hz, and repetition, intermittently operated complete emulsifying 2-3 time, then, adopt the mode of circulating water to make below system slow cooling to 40 DEG C, add pantothenylol base hydroxypropyl stearyldimethylammonium chloride, Chinese herbal medicine extract A, essence and antiseptic successively, stir, add cocamido propyl betaine again, stir, start emulsifying and stir, emulsification times is 5 minutes, emulsifying speed of agitator is 100Hz, observe system cosmetic variation situation at any time, stops when system presents uniform and smooth state, obtains shampoo.
Preparation embodiment 3
The crude drug formula of Chinese herbal medicine extract: Caulis Polygoni Multiflori 55 parts, Chinese honey locust (fruit) 25 parts, Rhizoma Alismatis 40 parts, Semen Sesami Nigrum 25 parts, Herba Ecliptae 40 parts, Folium Ginkgo 25 parts, Cacumen Platycladi 25 parts, 15 parts, Pericarpium Zanthoxyli, Rhizoma Drynariae 40 parts, Herba speranskiae tuberculatae 25 parts.
The preparation method of Chinese herbal medicine extract, comprises the following steps:
1) volatile oil is drawn: the Pericarpium Zanthoxyli getting formula ratio, adds the water of 15 times amount, uses extraction by steam distillation volatile oil, and obtain Pericarpium Zanthoxyli volatile oil and Chinese herbal medicine extract A, Aqueous extracts is for subsequent use;
2) water extraction: get the Caulis Polygoni Multiflori of formula ratio, Chinese honey locust (fruit), Rhizoma Alismatis and Herba speranskiae tuberculatae, be ground into coarse powder, adds the water being equivalent to medicated powder gross weight 15 times amount, soak 60 minutes, decoct extraction 1 hour, filter, medicinal residues add the water being equivalent to medicated powder gross weight 15 times amount, decoct extraction 1 hour, filter, merging filtrate, extracts the Aqueous extracts after volatile oil with Pericarpium Zanthoxyli and merges, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract B;
3) alcohol extraction: get the Semen Sesami Nigrum of formula ratio, Herba Ecliptae, Folium Ginkgo, Cacumen Platycladi and Rhizoma Drynariae, be ground into coarse powder, add 50% (v/v) ethanol being equivalent to medicated powder gross weight 15 times amount, reflux, extract, 2 times, each extraction 1 hour, merge extractive liquid, reclaims ethanol, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract C.
Shampoo prescription: consist of the following composition by mass percentage: Chinese herbal medicine extract (comprises Chinese herbal medicine extract A, B and C) 10%, disodiumedetate 0.5%, Polyquaternium-10 1.0%, guar hydroxypropyltrimonium ammonium chloride 1.0%, laureth sulfuric ester ammonium 25%, coconut oleoyl amine MEA3%, glycol distearate 3%, acrylic acid esters co-polymer 5%, polyquaternary ammonium salt-475%, aqueous emulsion of dimethyl polysiloxane fluid 5%, silicone, cationic albumen 3%, cocamido propyl betaine 8%, cetearyl alcohol 3%, pantothenylol base hydroxypropyl stearyldimethylammonium chloride 2%, antiseptic 1%, quintessence oil or essence 1%, surplus is water.
The preparation method of shampoo, comprises the following steps:
Water and disodiumedetate is added in vacuum emulsion mixer, be stirred to dissolve, add the aqueous dispersions of Polyquaternium-10 again, stirring makes fully swelling, add the aqueous dispersions of guar hydroxypropyltrimonium ammonium chloride again, stirring makes fully swelling, when system presents clear state, be warming up to 80-85 DEG C, in temperature-rise period, add laureth sulfuric ester ammonium, be stirred to dissolve, add Chinese herbal medicine extract B and Chinese herbal medicine extract C again, stir, add coconut oleoyl amine MEA again, glycol distearate and cetearyl alcohol, after said components dissolving is uniformly dispersed, 80-85 DEG C of insulated and stirred 30 minutes, then, the mode of circulating water is adopted to make system slow cooling to 45 DEG C, add acrylic acid esters co-polymer, stir, then add polyquaternary ammonium salt-47, aqueous emulsion of dimethyl polysiloxane fluid and polysiloxanes ion-protein successively, stir after 30 minutes, start emulsifying to stir, emulsification times is 20 minutes, and emulsifying speed of agitator is 50Hz, and repetition, intermittently operated complete emulsifying 2-3 time, then, adopt the mode of circulating water to make below system slow cooling to 40 DEG C, add pantothenylol base hydroxypropyl stearyldimethylammonium chloride, Chinese herbal medicine extract A, essence and antiseptic successively, stir, add cocamido propyl betaine again, stir, start emulsifying and stir, emulsification times is 20 minutes, emulsifying speed of agitator is 50Hz, observe system cosmetic variation situation at any time, stops when system presents uniform and smooth state, obtains shampoo.
What finally illustrate is, above preferred embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although by above preferred embodiment to invention has been detailed description, but those skilled in the art are to be understood that, various change can be made to it in the form and details, and not depart from claims of the present invention limited range.
Claims (10)
1. Chinese herbal medicine extract, it is characterized in that, be made up of following crude drug by weight: Caulis Polygoni Multiflori 20 ~ 55 parts, Chinese honey locust (fruit) 5 ~ 25 parts, Rhizoma Alismatis 15 ~ 40 parts, Semen Sesami Nigrum 5 ~ 25 parts, Herba Ecliptae 15 ~ 40 parts, Folium Ginkgo 5 ~ 25 parts, Cacumen Platycladi 5 ~ 25 parts, 5 ~ 15 parts, Pericarpium Zanthoxyli, Rhizoma Drynariae 15 ~ 40 parts, Herba speranskiae tuberculatae 5 ~ 25 parts;
Preparation method comprises the following steps:
1) volatile oil is drawn: get Pericarpium Zanthoxyli, adds water, and uses extraction by steam distillation volatile oil, and obtain Pericarpium Zanthoxyli volatile oil and Chinese herbal medicine extract A, Aqueous extracts is for subsequent use;
2) water extraction: get Caulis Polygoni Multiflori, Chinese honey locust (fruit), Rhizoma Alismatis and Herba speranskiae tuberculatae, be ground into coarse powder, add water, soak 20-60 minute, decoct and extract, collect extracting solution, medicinal residues decoct with water and extract 1-3 time, merge extractive liquid, then merge with step 1) gained Aqueous extracts, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract B;
3) alcohol extraction: get Semen Sesami Nigrum, Herba Ecliptae, Folium Ginkgo, Cacumen Platycladi and Rhizoma Drynariae, be ground into coarse powder, be alcohol reflux 2-4 time of 50-80% by volume fraction, merge extractive liquid, reclaims ethanol, is concentrated into 2/3 of crude drug weight, obtains Chinese herbal medicine extract C;
Chinese herbal medicine extract A, B and C are described Chinese herbal medicine extract.
2. Chinese herbal medicine extract as claimed in claim 1, it is characterized in that, be made up of following crude drug by weight: Caulis Polygoni Multiflori 30 parts, Chinese honey locust (fruit) 10 parts, Rhizoma Alismatis 20 parts, Semen Sesami Nigrum 10 parts, Herba Ecliptae 20 parts, Folium Ginkgo 10 parts, Cacumen Platycladi 10 parts, 6 parts, Pericarpium Zanthoxyli, Rhizoma Drynariae 20 parts, Herba speranskiae tuberculatae 10 parts.
3. the preparation method of Chinese herbal medicine extract described in claim 1 or 2, is characterized in that, comprises the following steps:
1) volatile oil is drawn: get Pericarpium Zanthoxyli, adds water, and uses extraction by steam distillation volatile oil, and obtain Pericarpium Zanthoxyli volatile oil and Chinese herbal medicine extract A, Aqueous extracts is for subsequent use;
2) water extraction: get Caulis Polygoni Multiflori, Chinese honey locust (fruit), Rhizoma Alismatis and Herba speranskiae tuberculatae, be ground into coarse powder, add water, soak 20-60 minute, decoct and extract, collect extracting solution, medicinal residues decoct with water and extract 1-3 time, merge extractive liquid, then merge with step 1) gained Aqueous extracts, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract B;
3) alcohol extraction: get Semen Sesami Nigrum, Herba Ecliptae, Folium Ginkgo, Cacumen Platycladi and Rhizoma Drynariae, be ground into coarse powder, be alcohol reflux 2-4 time of 50-80% by volume fraction, merge extractive liquid, reclaims ethanol, is concentrated into 2/3 of crude drug weight, obtains Chinese herbal medicine extract C;
Chinese herbal medicine extract described in Chinese herbal medicine extract A, B and C and claim 1 or 2.
4. the preparation method of Chinese herbal medicine extract as claimed in claim 3, is characterized in that, comprise the following steps:
1) volatile oil is drawn: get Pericarpium Zanthoxyli, adds the water of 6-15 times amount, uses extraction by steam distillation volatile oil, and obtain Pericarpium Zanthoxyli volatile oil and Chinese herbal medicine extract A, Aqueous extracts is for subsequent use;
2) water extraction: get Caulis Polygoni Multiflori, Chinese honey locust (fruit), Rhizoma Alismatis and Herba speranskiae tuberculatae, be ground into coarse powder, adds the water being equivalent to medicated powder gross weight 8-15 times amount, soaks 30 minutes, decocts and extracts 1-3 hour, collects extracting solution; Medicinal residues add the water being equivalent to medicated powder gross weight 6-15 times amount, decoct and extract 1-3 hour, collect extracting solution; Merge extractive liquid, then merge with step 1) gained Aqueous extracts, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract B;
3) alcohol extraction: get Semen Sesami Nigrum, Herba Ecliptae, Folium Ginkgo, Cacumen Platycladi and Rhizoma Drynariae, be ground into coarse powder, adding the volume fraction being equivalent to medicated powder gross weight 6-15 times amount is the ethanol of 50-80%, reflux, extract, 2-4 time, each extraction 1-3 hour, merge extractive liquid, reclaims ethanol, be concentrated into 2/3 of crude drug weight, obtain Chinese herbal medicine extract C.
5. Chinese herbal medicine extract described in claim 1 or 2 is preparing the application in shampoo.
6. shampoo, is characterized in that, containing Chinese herbal medicine extract described in claim 1 or 2.
7. shampoo as claimed in claim 6, is characterized in that, also containing following composition: chelating agen, surfactant, rheology control agent, pearling agent, thickening agent, conditioner, antiseptic and quintessence oil or essence.
8. shampoo as claimed in claim 7, it is characterized in that, described chelating agen is disodiumedetate or tetrasodium ethylenediamine tetraacetate; Described surfactant comprises cationic surfactant and anion surfactant, described cationic surfactant is any one or more mixing in Polyquaternium-10, polyquaternary ammonium salt-47 and guar hydroxypropyltrimonium ammonium chloride, and described anion surfactant is any one or more mixing in laureth sulfuric ester ammonium, sodium laureth sulfate, sodium lauryl sulfate, polyoxyethylene lauryl ether sodium sulfate and ammonium lauryl sulfate; Described rheology control agent is coconut oleoyl amine MEA and/or coconut oleoyl amine DEA; Described pearling agent is glycol distearate, ethylene glycol monostearate or Pearl Concentrate; Described thickening agent is any one or more mixing in acrylate copolymer, acrylic acid esters co-polymer, hydroxyethyl-cellulose, hydroxypropyl emthylcellulose, cocamido propyl betaine and hydroxy sulfo lycine; Described conditioner is any one or more mixing in polydimethylsiloxane, silicone, cationic albumen, cetearyl alcohol and pantothenylol base hydroxypropyl stearyldimethylammonium chloride.
9. shampoo as claimed in claim 8, it is characterized in that, be grouped into by following one-tenth by mass percentage: Chinese herbal medicine extract 1-10%, disodiumedetate 0.1-0.5%, Polyquaternium-10 0.1-1.0%, polyquaternary ammonium salt-47 1-5%, guar hydroxypropyltrimonium ammonium chloride 0.1-1.0%, laureth sulfuric ester ammonium 10-25%, coconut oleoyl amine MEA 1-3%, glycol distearate 0.5-3%, acrylic acid esters co-polymer 1-5%, aqueous emulsion of dimethyl polysiloxane fluid 1-5%, silicone, cationic albumen 0.5-3%, cocamido propyl betaine 2-8%, cetearyl alcohol 0.5-3%, pantothenylol base hydroxypropyl stearyldimethylammonium chloride 0.5-2%, antiseptic 0.01-1%, quintessence oil or essence 0.1-1%, surplus is water.
10. the preparation method of shampoo described in claim 9, it is characterized in that, comprise the following steps: in container, add water and disodiumedetate, be stirred to dissolve, add the aqueous dispersions of Polyquaternium-10, stirring makes fully swelling, add the aqueous dispersions of guar hydroxypropyltrimonium ammonium chloride again, stirring makes fully swelling, when system presents clear state, be warming up to 60-85 DEG C, in temperature-rise period, add laureth sulfuric ester ammonium, be stirred to dissolve, add Chinese herbal medicine extract B and Chinese herbal medicine extract C again, stir, add coconut oleoyl amine MEA again, glycol distearate and cetearyl alcohol, after the two dissolving is uniformly dispersed, 60-85 DEG C of insulated and stirred 10-30 minute, then, system is cooled to 40-50 DEG C, add acrylic acid esters co-polymer, stir, then add polyquaternary ammonium salt-47, aqueous emulsion of dimethyl polysiloxane fluid and polysiloxanes ion-protein successively, stir after 10-30 minute, start emulsifying to stir, emulsification times is 5-20 minute, and emulsifying speed of agitator is 50-100Hz, and repetition, intermittently operated complete emulsifying 2-3 time, then, system is cooled to less than 40 DEG C, add pantothenylol base hydroxypropyl stearyldimethylammonium chloride, Chinese herbal medicine extract A, quintessence oil or essence and antiseptic successively, stir, then add cocamido propyl betaine, stir, start emulsifying to stir, emulsification times is 5-20 minute, and emulsifying speed of agitator is 50-100Hz, stop when system presents uniform and smooth state, obtain shampoo.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310751088.6A CN103655383B (en) | 2013-12-31 | 2013-12-31 | Chinese medicinal herb extract and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310751088.6A CN103655383B (en) | 2013-12-31 | 2013-12-31 | Chinese medicinal herb extract and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103655383A CN103655383A (en) | 2014-03-26 |
| CN103655383B true CN103655383B (en) | 2015-07-08 |
Family
ID=50294950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310751088.6A Active CN103655383B (en) | 2013-12-31 | 2013-12-31 | Chinese medicinal herb extract and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103655383B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919707B (en) * | 2014-05-13 | 2016-04-20 | 广州市科玮生物技术有限公司 | A kind of herb liquid with whitening effect |
| CN104042528B (en) * | 2014-07-09 | 2016-04-13 | 重庆蒙丽朱日化品有限公司 | Draft hair care anticreep anti-dandruff shampoo stock solution and manufacture method |
| CN104146909B (en) * | 2014-08-10 | 2016-08-31 | 兰晶 | Plant antiallergic hair care surfactant |
| CN105411933A (en) * | 2015-12-10 | 2016-03-23 | 泰山医学院 | Hair lotion |
| CN108309905A (en) * | 2018-02-23 | 2018-07-24 | 广州市骄子日化有限公司 | A kind of black hair anti-dandruff and itching-relieving shampoo and preparation method |
| CN108272671A (en) * | 2018-03-13 | 2018-07-13 | 名臣健康用品股份有限公司 | Have effects that the Chinese medicine composition of hair-loss preventing and hair-restoring and its application |
| CN108785198B (en) * | 2018-06-20 | 2021-04-23 | 广州市惠芳日化有限公司 | Hair-strengthening composition, shampoo and preparation method thereof |
| CN109498469B (en) * | 2018-11-28 | 2022-02-08 | 山东师范大学 | Walnut green seedcase hair blackening sunscreen spray and preparation method and application thereof |
| CN110200877B (en) * | 2019-07-18 | 2022-03-25 | 李卓达 | Traditional Chinese medicine shampoo and preparation method thereof |
| CN110772435A (en) * | 2019-11-20 | 2020-02-11 | 曼真实业(广州)有限公司 | Anti-dandruff shampoo and preparation method thereof |
| CN110787114A (en) * | 2019-12-22 | 2020-02-14 | 施建有 | Foam shampoo capable of removing dandruff, relieving itching and controlling oil and preparation method thereof |
| CN111956587B (en) * | 2020-09-16 | 2021-05-04 | 孙开军 | Black-hair and bright-hair shampoo and preparation method thereof |
| CN112791034A (en) * | 2021-01-12 | 2021-05-14 | 山东正基药业有限公司 | Anti-hair loss and hair-nourishing herbal shampoo and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380380A (en) * | 2008-10-20 | 2009-03-11 | 南京荣世医药科技有限公司 | Traditional Chinese medicine for treating seborrheic baldness and its preparation method |
| CN101829230A (en) * | 2010-05-19 | 2010-09-15 | 邓云 | Hair anti-dropping and growing lotion |
| CN101829034A (en) * | 2009-12-23 | 2010-09-15 | 泰一和浦（北京）中医药研究院有限公司 | External Chinese medicinal composition with functions of blackening hair and dressing hair and preparation method thereof |
| CN102000207A (en) * | 2010-10-29 | 2011-04-06 | 毛成艺 | External liniment for treating psilosis |
| CN102247428A (en) * | 2011-08-13 | 2011-11-23 | 成都绿迪科技有限公司 | Chinese medicine formula for growing hair |
| CN102973727A (en) * | 2012-12-27 | 2013-03-20 | 赵龙伟 | Hair follicle nutrient activating liquid and preparation method thereof |
-
2013
- 2013-12-31 CN CN201310751088.6A patent/CN103655383B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380380A (en) * | 2008-10-20 | 2009-03-11 | 南京荣世医药科技有限公司 | Traditional Chinese medicine for treating seborrheic baldness and its preparation method |
| CN101829034A (en) * | 2009-12-23 | 2010-09-15 | 泰一和浦（北京）中医药研究院有限公司 | External Chinese medicinal composition with functions of blackening hair and dressing hair and preparation method thereof |
| CN101829230A (en) * | 2010-05-19 | 2010-09-15 | 邓云 | Hair anti-dropping and growing lotion |
| CN102000207A (en) * | 2010-10-29 | 2011-04-06 | 毛成艺 | External liniment for treating psilosis |
| CN102247428A (en) * | 2011-08-13 | 2011-11-23 | 成都绿迪科技有限公司 | Chinese medicine formula for growing hair |
| CN102973727A (en) * | 2012-12-27 | 2013-03-20 | 赵龙伟 | Hair follicle nutrient activating liquid and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103655383A (en) | 2014-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103655383B (en) | Chinese medicinal herb extract and preparation method and application thereof | |
| CN107536749B (en) | Traditional Chinese medicine shampoo and preparation process thereof | |
| CN103169631B (en) | A kind of submissive glossy shampoo and preparation method containing Chinese medicine composition | |
| CN103565692B (en) | A kind of conditioning liquid for cleaning and processing technology thereof containing various plants extract | |
| CN102614102B (en) | Dandruff-removing medicinal composition and preparation method thereof | |
| CN101890080B (en) | Hair-loss preventing and hair-restoring medicinal composition and preparation method thereof, shampoo containing medicinal composition and preparation method thereof | |
| CN108096117A (en) | A kind of composition and its preparation method and application | |
| CN104606106A (en) | Natural plant nano-emulsion bath lotion | |
| CN110327271A (en) | A kind of anti-dandruff and itching-relieving plant composition, preparation method and application | |
| CN111467285A (en) | Plant anti-dandruff shampoo and preparation method thereof | |
| CN108685769A (en) | A kind of herbal mixture black hair anticreep shampoo and preparation method thereof | |
| CN102038626A (en) | Traditional Chinese medicinal hair-restoring and anti-alopecia shampoo and preparation method thereof | |
| CN104107375A (en) | Traditional Chinese medicinal composition for nourishing and solidifying hair, as well as preparation method and application of traditional Chinese medicinal composition | |
| CN101804188B (en) | Composition for controlling atrichia and manufacture method thereof | |
| CN105919900A (en) | Hair re-growing and hair loss preventing shampoo and preparation method thereof | |
| CN101288635A (en) | Natural back hair antidandruff shampoo | |
| CN102727658A (en) | Chinese herbal extract with anti-dropping and oil-controlling effects, preparation method and application thereof | |
| CN101637440A (en) | Traditional Chinese medicine antidandruff and antipruritic shampoo and preparation method thereof | |
| CN103462855B (en) | Cosmetic containing American ginseng and longan and preparation method thereof | |
| CN108703929A (en) | It is a kind of that there is the shampoo and preparation method thereof for nourishing scalp efficacy | |
| CN105434279A (en) | Panax notoginseng massage cream and preparation method thereof | |
| CN108434051A (en) | Hair follicle transdermal absorption traditional Chinese medicinal blood, preparation method and the application in shampoo | |
| CN105560109A (en) | Shampoo salt with bacterium inhibiting and itch relieving efficacy, and preparation method thereof | |
| CN108355042A (en) | A kind of anti-inflammatory analgetic ointment and preparation method thereof | |
| CN115006336A (en) | Plant shampoo capable of preventing hair loss, strengthening hair, removing dandruff and relieving itching and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wang Yongyan Inventor after: Jiang Yanxia Inventor after: Lin Bangjian Inventor after: Hu Linfeng Inventor after: Jin Sicen Inventor after: Zhao Yijun Inventor after: Bai Lixi Inventor after: Qin Shaorong Inventor after: Qin Yuwen Inventor after: Qing Yuling Inventor after: Tang Fuli Inventor after: Huang Jing Inventor after: Dong Ziliang Inventor before: Wang Yongyan Inventor before: Jiang Yanxia Inventor before: Lin Bangjian Inventor before: Hu Linfeng Inventor before: Zhao Yijun Inventor before: Bai Lixi Inventor before: Qin Shaorong Inventor before: Qin Yuwen Inventor before: Qing Yuling Inventor before: Tang Fuli Inventor before: Huang Jing Inventor before: Dong Ziliang |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: WANG YONGYAN ZHAO YIJUN BAI LIXI QIN SHAORONG QIN YUWEN QING YULING TANG FULI HUANG JING DONG ZILIANG JIANG YANXIA LIN BANGJIAN HU LINFENG TO: WANG YONGYAN ZHAO YIJUN BAI LIXI QIN SHAORONG QIN YUWEN QING YULING TANG FULI HUANG JING DONG ZILIANG JIANG YANXIA LIN BANGJIAN HU LINFENG JIN SICEN |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180605 Address after: No. 8, Baihua Road, Fuling, Chongqing Co-patentee after: Taiji Group Chongqing Fuling Pharmaceutical Factory Co., Ltd. Patentee after: Chongqing Dayi Technology Investment Co., Ltd. Address before: No. 8, Baihua Road, Fuling District, Chongqing City, Chongqing Patentee before: Chongqing Dayi Technology Investment Co., Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190222 Address after: 408099 1 Tai Chi Road, Fuling District, Chongqing Patentee after: Chongqing Taiji Industry (Group) Co., Ltd. Address before: No. 8, Baihua Road, Fuling, Chongqing Co-patentee before: Taiji Group Chongqing Fuling Pharmaceutical Factory Co., Ltd. Patentee before: Chongqing Dayi Technology Investment Co., Ltd. |