CN107108640A - 布鲁顿酪氨酸激酶抑制剂的合成 - Google Patents

布鲁顿酪氨酸激酶抑制剂的合成 Download PDF

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Publication number
CN107108640A
CN107108640A CN201680005456.4A CN201680005456A CN107108640A CN 107108640 A CN107108640 A CN 107108640A CN 201680005456 A CN201680005456 A CN 201680005456A CN 107108640 A CN107108640 A CN 107108640A
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CN
China
Prior art keywords
compound
formula
buddhist nun
shandong
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680005456.4A
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English (en)
Chinese (zh)
Inventor
西里尔·本海姆
陈伟
艾瑞克·戈德曼
A·霍尔瓦思
菲利普·派伊
马克·S·斯麦思
埃里克·J·弗纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Pharmacyclics LLC
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Janssen Pharmaceutica NV
Pharmacyclics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Janssen Pharmaceutica NV, Pharmacyclics LLC filed Critical Janssen Pharmaceutica NV
Priority to CN202110485400.6A priority Critical patent/CN113816962A/zh
Publication of CN107108640A publication Critical patent/CN107108640A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201680005456.4A 2015-01-14 2016-01-14 布鲁顿酪氨酸激酶抑制剂的合成 Pending CN107108640A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110485400.6A CN113816962A (zh) 2015-01-14 2016-01-14 布鲁顿酪氨酸激酶抑制剂的合成

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562103507P 2015-01-14 2015-01-14
US62/103,507 2015-01-14
PCT/US2016/013424 WO2016115356A1 (en) 2015-01-14 2016-01-14 Synthesis of a bruton's tyrosine kinase inhibitor

Related Child Applications (1)

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CN202110485400.6A Division CN113816962A (zh) 2015-01-14 2016-01-14 布鲁顿酪氨酸激酶抑制剂的合成

Publications (1)

Publication Number Publication Date
CN107108640A true CN107108640A (zh) 2017-08-29

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CN201680005456.4A Pending CN107108640A (zh) 2015-01-14 2016-01-14 布鲁顿酪氨酸激酶抑制剂的合成
CN202110485400.6A Pending CN113816962A (zh) 2015-01-14 2016-01-14 布鲁顿酪氨酸激酶抑制剂的合成

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Country Status (16)

Country Link
US (6) US20180009814A1 (enExample)
EP (1) EP3245208A4 (enExample)
JP (2) JP2018502077A (enExample)
KR (1) KR20170102887A (enExample)
CN (2) CN107108640A (enExample)
AU (2) AU2016206693A1 (enExample)
BR (1) BR112017015206B1 (enExample)
CA (2) CA2971460C (enExample)
HK (1) HK1246293A1 (enExample)
IL (4) IL322449A (enExample)
MA (1) MA41350A (enExample)
MX (2) MX366827B (enExample)
RU (1) RU2017128308A (enExample)
SG (2) SG11201705678YA (enExample)
WO (1) WO2016115356A1 (enExample)
ZA (1) ZA201704338B (enExample)

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CN107814804A (zh) * 2017-10-27 2018-03-20 广州科锐特生物科技有限公司 依鲁替尼的制备方法
CN109988175A (zh) * 2019-04-28 2019-07-09 梯尔希（南京）药物研发有限公司 一种依鲁替尼-d5的制备方法
CN113874378A (zh) * 2019-05-21 2021-12-31 詹森药业有限公司 用于制备btk抑制剂的方法和中间体
CN113906011A (zh) * 2019-05-21 2022-01-07 詹森药业有限公司 用于制备btk抑制剂的方法和中间体
CN114853662A (zh) * 2021-02-05 2022-08-05 四川青木制药有限公司 手性肼基哌啶衍生物的制备方法

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WO2016127915A1 (zh) * 2015-02-12 2016-08-18 上海度德医药科技有限公司 伊布替尼的制备方法
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
KR102793563B1 (ko) 2016-03-04 2025-04-11 다이호야쿠힌고교 가부시키가이샤 악성 종양 치료용 제제 및 조성물
CN109206426B (zh) * 2017-07-06 2021-10-08 上海复星星泰医药科技有限公司 吡唑并嘧啶类化合物的制备方法
JP7166331B2 (ja) 2017-08-01 2022-11-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中間体化合物及び方法
EP4353222A1 (en) 2018-03-19 2024-04-17 Taiho Pharmaceutical Co., Ltd. Use of sodium alkyl sulfate
EP3787751A1 (en) 2018-05-03 2021-03-10 Juno Therapeutics, Inc. Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
JP6944496B2 (ja) 2018-10-22 2021-10-06 ファイザー・インク ピロロ［２，３−ｄ］ピリミジントシル酸塩、その結晶形態、ならびにその製造方法および中間体
KR102742083B1 (ko) 2018-11-09 2024-12-16 다이호야쿠힌고교 가부시키가이샤 디메톡시벤젠 화합물의 제조 방법
EP4281454B1 (en) 2021-01-21 2025-03-05 Synthon B.V. Process for making ibrutinib
US20250302954A1 (en) 2022-05-11 2025-10-02 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
WO2023242384A1 (en) 2022-06-17 2023-12-21 Krka, D.D., Novo Mesto Crystalline form of ibrutinib

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CN101805341A (zh) * 2006-09-22 2010-08-18 药品循环公司 布鲁顿酪氨酸激酶的抑制剂
CN103319488A (zh) * 2007-03-28 2013-09-25 环状药物公司 布鲁顿氏酪氨酸激酶抑制剂

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US4550214A (en) * 1981-01-05 1985-10-29 Polaroid Corporation Blocked vinyl biphenyl compounds
US4874822A (en) * 1988-04-07 1989-10-17 Minnesota Mining And Manufacturing Company Process for the acrylamidoacylation of alcohols
MXPA06007326A (es) * 2003-12-23 2007-01-26 Astex Therapeutics Ltd Derivados de pirazol como moduladores de proteina cinasa.
US7718662B1 (en) * 2009-10-12 2010-05-18 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
EP2882751B1 (en) * 2012-07-30 2018-06-27 Concert Pharmaceuticals Inc. Deuterated ibrutinib
CN103121999A (zh) * 2012-08-29 2013-05-29 苏州迪飞医药科技有限公司 一种酪氨酸激酶抑制剂pci-32765的合成方法
US9156847B2 (en) * 2013-03-15 2015-10-13 Janssen Pharmaceutica Nv Processes and intermediates for preparing a medicament
US8957080B2 (en) * 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN103626774B (zh) * 2013-11-20 2015-11-04 苏州明锐医药科技有限公司 伊鲁替尼的制备方法
CN105471823B (zh) * 2014-09-03 2018-10-26 阿里巴巴集团控股有限公司 一种敏感信息处理方法、装置、服务器及安全判定系统
EP3248979B1 (en) * 2015-01-21 2021-04-14 Hefei Institutes of Physical Science, Chinese Academy of Sciences Novel inhibitor of flt3 kinase and use thereof

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CN101805341A (zh) * 2006-09-22 2010-08-18 药品循环公司 布鲁顿酪氨酸激酶的抑制剂
CN103319488A (zh) * 2007-03-28 2013-09-25 环状药物公司 布鲁顿氏酪氨酸激酶抑制剂

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DISCLOSED ANONYMOUSLY: "A process for preparing (S)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one", 《IP.COM JOURNAL》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107814804A (zh) * 2017-10-27 2018-03-20 广州科锐特生物科技有限公司 依鲁替尼的制备方法
CN109988175A (zh) * 2019-04-28 2019-07-09 梯尔希（南京）药物研发有限公司 一种依鲁替尼-d5的制备方法
CN113874378A (zh) * 2019-05-21 2021-12-31 詹森药业有限公司 用于制备btk抑制剂的方法和中间体
CN113906011A (zh) * 2019-05-21 2022-01-07 詹森药业有限公司 用于制备btk抑制剂的方法和中间体
CN114853662A (zh) * 2021-02-05 2022-08-05 四川青木制药有限公司 手性肼基哌啶衍生物的制备方法
CN114853662B (zh) * 2021-02-05 2024-01-12 四川青木制药有限公司 手性肼基哌啶衍生物的制备方法

Also Published As

Publication number Publication date
MA41350A (fr) 2017-11-21
SG11201705678YA (en) 2017-08-30
US20220098200A1 (en) 2022-03-31
AU2016206693A1 (en) 2017-07-13
IL322449A (en) 2025-09-01
WO2016115356A1 (en) 2016-07-21
JP2021035947A (ja) 2021-03-04
JP2018502077A (ja) 2018-01-25
US20250197404A1 (en) 2025-06-19
US20240158400A1 (en) 2024-05-16
IL253020A0 (en) 2017-08-31
MX394327B (es) 2025-03-24
EP3245208A1 (en) 2017-11-22
US20200347064A1 (en) 2020-11-05
HK1246293A1 (zh) 2018-09-07
IL274716A (en) 2020-07-30
MX2017009154A (es) 2017-10-12
RU2017128308A3 (enExample) 2019-10-24
CA2971460A1 (en) 2016-07-21
SG10201906517VA (en) 2019-08-27
KR20170102887A (ko) 2017-09-12
US20180009814A1 (en) 2018-01-11
MX2019008815A (es) 2019-09-26
US20190367518A1 (en) 2019-12-05
CA2971460C (en) 2023-10-10
RU2017128308A (ru) 2019-02-14
AU2020230323A1 (en) 2020-10-01
CN113816962A (zh) 2021-12-21
IL308276A (en) 2024-01-01
BR112017015206B1 (pt) 2023-04-11
ZA201704338B (en) 2023-10-25
MX366827B (es) 2019-07-25
CA3210320A1 (en) 2016-07-21
BR112017015206A2 (pt) 2018-06-19
EP3245208A4 (en) 2018-10-17

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Application publication date: 20170829