CN107108581B - 作为强效rock抑制剂的回接苯甲酰胺衍生物 - Google Patents

作为强效rock抑制剂的回接苯甲酰胺衍生物 Download PDF

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CN107108581B
CN107108581B CN201580044710.7A CN201580044710A CN107108581B CN 107108581 B CN107108581 B CN 107108581B CN 201580044710 A CN201580044710 A CN 201580044710A CN 107108581 B CN107108581 B CN 107108581B
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substituted
methoxy
pyrazol
benzoyl
independently selected
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CN107108581A (zh
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胡子伦
D.F.西特科夫
陈丽芬
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Bristol Myers Squibb Co
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201580044710.7A 2014-08-21 2015-08-20 作为强效rock抑制剂的回接苯甲酰胺衍生物 Active CN107108581B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462040044P 2014-08-21 2014-08-21
US62/040044 2014-08-21
PCT/US2015/046032 WO2016028971A1 (en) 2014-08-21 2015-08-20 Tied-back benzamide derivatives as potent rock inhibitors

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CN107108581A CN107108581A (zh) 2017-08-29
CN107108581B true CN107108581B (zh) 2020-06-23

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US (1) US10112939B2 (https=)
EP (1) EP3183248B1 (https=)
JP (1) JP6633618B2 (https=)
CN (1) CN107108581B (https=)
ES (1) ES2838573T3 (https=)
WO (1) WO2016028971A1 (https=)

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WO2022100614A1 (zh) * 2020-11-11 2022-05-19 南京明德新药研发有限公司 苯并脲环衍生物及其制备方法和应用
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