CN107074869A - 制备阿片类化合物的方法 - Google Patents

制备阿片类化合物的方法 Download PDF

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Publication number
CN107074869A
CN107074869A CN201580035275.1A CN201580035275A CN107074869A CN 107074869 A CN107074869 A CN 107074869A CN 201580035275 A CN201580035275 A CN 201580035275A CN 107074869 A CN107074869 A CN 107074869A
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China
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formula
compound
amount
molar equivalents
present
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CN201580035275.1A
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English (en)
Chinese (zh)
Inventor
J.卡多
W-C.张
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Noramco LLC
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Noramco LLC
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Publication of CN107074869A publication Critical patent/CN107074869A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580035275.1A 2014-05-05 2015-04-28 制备阿片类化合物的方法 Pending CN107074869A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988508P 2014-05-05 2014-05-05
US61/988508 2014-05-05
US14/689610 2015-04-17
US14/689,610 US9701687B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
PCT/US2015/027906 WO2015171353A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (1)

Publication Number Publication Date
CN107074869A true CN107074869A (zh) 2017-08-18

Family

ID=54354747

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580035275.1A Pending CN107074869A (zh) 2014-05-05 2015-04-28 制备阿片类化合物的方法

Country Status (7)

Country Link
US (1) US9701687B2 (https=)
EP (1) EP3140307A2 (https=)
JP (2) JP2017514845A (https=)
CN (1) CN107074869A (https=)
AU (1) AU2015256507B2 (https=)
CA (1) CA2947022A1 (https=)
WO (1) WO2015171353A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017066249A1 (en) * 2015-10-12 2017-04-20 Noramco, Inc. Process for the preparation of (s)-2-((4r,4as, 6r,7ar,12bs)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e] isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
EP4686721A1 (en) 2024-08-01 2026-02-04 Siegfried AG Crystalline naloxone-dimethylformamide solvate, methods for its preparation and its use as a reagent in a method of making naloxone

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CN101636160A (zh) * 2006-11-22 2010-01-27 普罗基因制药公司 7,8-饱和-4,5-环氧-吗啡烷离子类似物的(r)-n-立体异构体
US20100036128A1 (en) * 2008-08-11 2010-02-11 Robert Rezaie PROCESS FOR MAKING MORPHINAN-6alpha-OLS
CN102227433A (zh) * 2008-09-30 2011-10-26 马林克罗特公司 烷基化吗啡喃衍生物的仲胺基团的方法
US20110313163A1 (en) * 2007-06-29 2011-12-22 Tomas Hudlicky Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids
WO2013050748A2 (en) * 2011-10-03 2013-04-11 Johnson Matthey Plc An improved method of preparing buprenorphine
CN103596962A (zh) * 2011-05-02 2014-02-19 布鲁克大学 通过使用环化脱水试剂的n-氧化物的n-脱甲基化制备吗啡类似物的方法和中间体

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CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
US20080176884A1 (en) 2006-11-22 2008-07-24 Progenics Pharmaceuticals, Inc. 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
CA2637610A1 (en) 2007-05-04 2008-11-04 Mallinckrodt Inc. Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
JP5436222B2 (ja) 2007-11-20 2014-03-05 日産化学工業株式会社 ２−アザアダマンタン類の製造方法
WO2009122436A2 (en) * 2008-03-31 2009-10-08 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
EP2344507B2 (en) 2008-09-30 2021-05-26 Mallinckrodt LLC Processes for increasing the yield of the hydrolysis of the 3-o-methyl and 17-n-nitrile group in the preparation of opiate alkaloid derivatives
US8232398B2 (en) 2008-09-30 2012-07-31 Mallinckrodt Llc Recycling process for increasing the yield of opiate alkaloid derivatives
CA2738758C (en) 2008-09-30 2016-11-29 Mallinckrodt Inc. Processes for the alkylation of norbuprenorphine with reduced impurity formation
WO2010039210A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the hydrogenation of opiate alkaloid derivatives
PL2398808T3 (pl) 2009-02-17 2014-04-30 Mallinckrodt Llc Sposób redukcyjnego alkilowania normorfinanów
KR20120088537A (ko) 2009-04-24 2012-08-08 브럭 유니버시티 모르피난 및 모르피논 화합물의 제조방법
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
RS55777B1 (sr) * 2010-11-05 2017-07-31 H Lundbeck As Postupak za proizvodnju naltreksona
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CN101636160A (zh) * 2006-11-22 2010-01-27 普罗基因制药公司 7,8-饱和-4,5-环氧-吗啡烷离子类似物的(r)-n-立体异构体
CN101541808A (zh) * 2007-05-04 2009-09-23 马林克罗特公司 制备6-α-羟基-N-烷基化的阿片的改进的方法
US20110313163A1 (en) * 2007-06-29 2011-12-22 Tomas Hudlicky Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids
US20100036128A1 (en) * 2008-08-11 2010-02-11 Robert Rezaie PROCESS FOR MAKING MORPHINAN-6alpha-OLS
CN102227433A (zh) * 2008-09-30 2011-10-26 马林克罗特公司 烷基化吗啡喃衍生物的仲胺基团的方法
CN103596962A (zh) * 2011-05-02 2014-02-19 布鲁克大学 通过使用环化脱水试剂的n-氧化物的n-脱甲基化制备吗啡类似物的方法和中间体
WO2013050748A2 (en) * 2011-10-03 2013-04-11 Johnson Matthey Plc An improved method of preparing buprenorphine

Non-Patent Citations (2)

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章思规 等: "《精细有机化工制备手册》", 30 April 1994, 科学技术文献出版社 *

Also Published As

Publication number Publication date
AU2015256507B2 (en) 2019-11-21
AU2015256507A1 (en) 2016-11-24
WO2015171353A3 (en) 2016-03-10
WO2015171353A2 (en) 2015-11-12
JP2017514845A (ja) 2017-06-08
US9701687B2 (en) 2017-07-11
CA2947022A1 (en) 2015-11-12
US20150315204A1 (en) 2015-11-05
JP2020203872A (ja) 2020-12-24
EP3140307A2 (en) 2017-03-15

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