CA2947022A1 - Process for the preparation of opioid compounds - Google Patents

Process for the preparation of opioid compounds Download PDF

Info

Publication number
CA2947022A1
CA2947022A1 CA2947022A CA2947022A CA2947022A1 CA 2947022 A1 CA2947022 A1 CA 2947022A1 CA 2947022 A CA2947022 A CA 2947022A CA 2947022 A CA2947022 A CA 2947022A CA 2947022 A1 CA2947022 A1 CA 2947022A1
Authority
CA
Canada
Prior art keywords
compound
formula
amount
range
molar equivalents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2947022A
Other languages
English (en)
French (fr)
Inventor
Jessica Cardot
Wen-Chun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noramco LLC
Original Assignee
Noramco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noramco LLC filed Critical Noramco LLC
Publication of CA2947022A1 publication Critical patent/CA2947022A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2947022A 2014-05-05 2015-04-28 Process for the preparation of opioid compounds Abandoned CA2947022A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988508P 2014-05-05 2014-05-05
US61/988,508 2014-05-05
US14/689,610 US9701687B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
US14/689,610 2015-04-17
PCT/US2015/027906 WO2015171353A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (1)

Publication Number Publication Date
CA2947022A1 true CA2947022A1 (en) 2015-11-12

Family

ID=54354747

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2947022A Abandoned CA2947022A1 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Country Status (7)

Country Link
US (1) US9701687B2 (https=)
EP (1) EP3140307A2 (https=)
JP (2) JP2017514845A (https=)
CN (1) CN107074869A (https=)
AU (1) AU2015256507B2 (https=)
CA (1) CA2947022A1 (https=)
WO (1) WO2015171353A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017066249A1 (en) * 2015-10-12 2017-04-20 Noramco, Inc. Process for the preparation of (s)-2-((4r,4as, 6r,7ar,12bs)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4, 12-methanobenzofuro[3,2-e] isoquinolin-6-yl)-3,3-dimethylbutan-2-ol
EP4686721A1 (en) 2024-08-01 2026-02-04 Siegfried AG Crystalline naloxone-dimethylformamide solvate, methods for its preparation and its use as a reagent in a method of making naloxone

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
US20080176884A1 (en) 2006-11-22 2008-07-24 Progenics Pharmaceuticals, Inc. 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
CN101610770A (zh) * 2006-11-22 2009-12-23 普罗基因制药公司 7,8-饱和-4,5-环氧-吗啡烷离子类似物
ES2356412T3 (es) * 2007-05-04 2011-04-07 Mallinckrodt Inc. Procedimiento mejorado para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados.
CA2637610A1 (en) 2007-05-04 2008-11-04 Mallinckrodt Inc. Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
JP5436222B2 (ja) 2007-11-20 2014-03-05 日産化学工業株式会社 ２−アザアダマンタン類の製造方法
WO2009122436A2 (en) * 2008-03-31 2009-10-08 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
WO2010017573A1 (en) 2008-08-11 2010-02-18 Tasmanian Alkaloids Pty Limited PROCESS FOR MAKING MORPHINAN-6α-OLS
EP2344507B2 (en) 2008-09-30 2021-05-26 Mallinckrodt LLC Processes for increasing the yield of the hydrolysis of the 3-o-methyl and 17-n-nitrile group in the preparation of opiate alkaloid derivatives
US8232398B2 (en) 2008-09-30 2012-07-31 Mallinckrodt Llc Recycling process for increasing the yield of opiate alkaloid derivatives
WO2010039209A2 (en) * 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the synthesis of tertiary amines
CA2738758C (en) 2008-09-30 2016-11-29 Mallinckrodt Inc. Processes for the alkylation of norbuprenorphine with reduced impurity formation
WO2010039210A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the hydrogenation of opiate alkaloid derivatives
PL2398808T3 (pl) 2009-02-17 2014-04-30 Mallinckrodt Llc Sposób redukcyjnego alkilowania normorfinanów
KR20120088537A (ko) 2009-04-24 2012-08-08 브럭 유니버시티 모르피난 및 모르피논 화합물의 제조방법
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
RS55777B1 (sr) * 2010-11-05 2017-07-31 H Lundbeck As Postupak za proizvodnju naltreksona
CA2833283A1 (en) * 2011-05-02 2012-11-08 Brock University Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents
EP2763996B1 (en) 2011-10-03 2018-07-25 Johnson Matthey PLC Process for preparing buprenorphine
US8981098B2 (en) 2012-02-03 2015-03-17 Brock University Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
US20140155608A1 (en) * 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone

Also Published As

Publication number Publication date
CN107074869A (zh) 2017-08-18
AU2015256507B2 (en) 2019-11-21
AU2015256507A1 (en) 2016-11-24
WO2015171353A3 (en) 2016-03-10
WO2015171353A2 (en) 2015-11-12
JP2017514845A (ja) 2017-06-08
US9701687B2 (en) 2017-07-11
US20150315204A1 (en) 2015-11-05
JP2020203872A (ja) 2020-12-24
EP3140307A2 (en) 2017-03-15

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20211123