CN107074820B - Glp-1受体调节剂 - Google Patents

Glp-1受体调节剂 Download PDF

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Publication number
CN107074820B
CN107074820B CN201580046095.3A CN201580046095A CN107074820B CN 107074820 B CN107074820 B CN 107074820B CN 201580046095 A CN201580046095 A CN 201580046095A CN 107074820 B CN107074820 B CN 107074820B
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compound
tert
butyl
phenyl
certain embodiments
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Expired - Fee Related
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CN107074820A (zh
Inventor
马库斯·F·勃姆
埃丝特·马丁伯勒
玛妮莎·穆尔加尼
田宫淳子
黄黎明
亚当·R·耶格尔
埃努格尔斯伊·布拉哈马查理
托马斯·福勒
安德鲁·诺瓦克
普拉姆基·玛格哈尼
迈克尔·科奈格斯
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Receptos LLC
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
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CN201580046095.3A 2014-07-25 2015-07-24 Glp-1受体调节剂 Expired - Fee Related CN107074820B (zh)

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US201462028962P 2014-07-25 2014-07-25
US62/028,962 2014-07-25
US201462090040P 2014-12-10 2014-12-10
US62/090,040 2014-12-10
US201562161650P 2015-05-14 2015-05-14
US62/161,650 2015-05-14
PCT/US2015/042114 WO2016015014A1 (en) 2014-07-25 2015-07-24 Novel glp-1 receptor modulators

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US12234236B1 (en) 2023-09-14 2025-02-25 Ascletis Pharma (China) Co., Limited GLP-1R agonist and therapeutic method thereof
US12291530B1 (en) 2023-11-24 2025-05-06 Ascletis Pharma (China) Co., Limited GLP-1R agonist and therapeutic method thereof

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DK2713722T3 (en) 2011-05-31 2017-07-03 Celgene Int Ii Sarl Newly known GLP-1 receptor stabilizers and modulators
KR102271179B1 (ko) 2013-06-11 2021-07-01 셀진 인터내셔널 Ii 에스에이알엘 신규의 glp-1 수용체 조절제
AU2015292356B2 (en) * 2014-07-25 2020-02-06 Receptos Llc Novel GLP-1 receptor modulators
CA2969944A1 (en) 2014-12-10 2016-06-16 Celgene International Ii Sarl Glp-1 receptor modulators
ES2901599T3 (es) * 2016-09-30 2022-03-23 Receptos Llc Sal de dimetilaminoetanol de un modulador del receptor GLP-1
EP3615524B1 (en) * 2017-04-28 2022-11-09 Receptos Llc Novel glp-1 receptor modulators
WO2020210582A1 (en) * 2019-04-11 2020-10-15 University Of The Sciences Allosteric agonists and positive allosteric modulators of glucagon-like peptide 1 receptor
FI4097099T3 (fi) 2020-02-07 2024-07-30 Gasherbrum Bio Inc Heterosyklisiä glp-1-agonisteja
CR20230066A (es) 2020-08-06 2023-05-29 Gasherbrum Bio Inc Agonistas del glp-1 heterocíclicos
CN112121152B (zh) * 2020-09-25 2021-06-22 南京大学 利司那肽在制备抗肿瘤药物中的应用
CN112898133B (zh) * 2021-01-27 2022-11-15 河北迈尔斯通电子材料有限公司 一种反式酮类中间体的制备方法
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EP4496797A1 (en) 2022-03-21 2025-01-29 Gasherbrum Bio, Inc. 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes
EP4508047A1 (en) 2022-04-14 2025-02-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
KR20250113341A (ko) 2024-01-18 2025-07-25 주식회사 티에치팜 나트륨 포도당 운반체-2 저해제 및 안지오텐신 ⅱ 수용체 차단제를 함유하는 비만 예방 또는 치료용 약학적 조성물
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Publication number Priority date Publication date Assignee Title
US12234236B1 (en) 2023-09-14 2025-02-25 Ascletis Pharma (China) Co., Limited GLP-1R agonist and therapeutic method thereof
US12291530B1 (en) 2023-11-24 2025-05-06 Ascletis Pharma (China) Co., Limited GLP-1R agonist and therapeutic method thereof

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AU2015292356A1 (en) 2017-02-02
JP2019142984A (ja) 2019-08-29
ZA201700342B (en) 2018-12-19
WO2016015014A1 (en) 2016-01-28
MX382502B (es) 2025-03-13
EP3172199A1 (en) 2017-05-31
CN112457301A (zh) 2021-03-09
KR102564946B1 (ko) 2023-08-08
IL249896A0 (en) 2017-03-30
ES2819534T3 (es) 2021-04-16
US20160038487A1 (en) 2016-02-11
MX2017000972A (es) 2017-07-27
US9474755B2 (en) 2016-10-25
JP6556237B2 (ja) 2019-08-07
US9839664B2 (en) 2017-12-12
CA2955836C (en) 2023-02-14
AU2015292356B2 (en) 2020-02-06
JP2017526734A (ja) 2017-09-14
EA201790254A1 (ru) 2017-07-31
SG11201700364PA (en) 2017-02-27
EA032525B1 (ru) 2019-06-28
CN107074820A (zh) 2017-08-18
KR20170040233A (ko) 2017-04-12
EP3172199B1 (en) 2020-07-01

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