AU2015292356B2 - Novel GLP-1 receptor modulators - Google Patents
Novel GLP-1 receptor modulators Download PDFInfo
- Publication number
- AU2015292356B2 AU2015292356B2 AU2015292356A AU2015292356A AU2015292356B2 AU 2015292356 B2 AU2015292356 B2 AU 2015292356B2 AU 2015292356 A AU2015292356 A AU 2015292356A AU 2015292356 A AU2015292356 A AU 2015292356A AU 2015292356 B2 AU2015292356 B2 AU 2015292356B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- mmol
- chr
- jan
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *N*(C1CCCCCCC1)=O Chemical compound *N*(C1CCCCCCC1)=O 0.000 description 10
- LGXIKPSWGSAWEP-BKEGDCIJSA-N CC[C@H](CC1)CC[C@@H]1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N(C3)CC3C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 Chemical compound CC[C@H](CC1)CC[C@@H]1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N(C3)CC3C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 LGXIKPSWGSAWEP-BKEGDCIJSA-N 0.000 description 2
- PDJMDRXLKSOZGR-NRFANRHFSA-N CC(C)(C)OC([C@H](Cc(cc1)ccc1-c(nc1)ncc1Br)NC(OCc1ccccc1)=O)=O Chemical compound CC(C)(C)OC([C@H](Cc(cc1)ccc1-c(nc1)ncc1Br)NC(OCc1ccccc1)=O)=O PDJMDRXLKSOZGR-NRFANRHFSA-N 0.000 description 1
- DIGHFXIWRPMGSA-NSHDSACASA-N CC(C)(C)OC([C@H](Cc(cc1)ccc1O)N)=O Chemical compound CC(C)(C)OC([C@H](Cc(cc1)ccc1O)N)=O DIGHFXIWRPMGSA-NSHDSACASA-N 0.000 description 1
- LMQRECWRBPFEQK-QFIPXVFZSA-N CC(C)(C)OC([C@H](Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1)NC(OCc1ccccc1)=O)=O Chemical compound CC(C)(C)OC([C@H](Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1)NC(OCc1ccccc1)=O)=O LMQRECWRBPFEQK-QFIPXVFZSA-N 0.000 description 1
- VFVWYCLETXIGSV-HMMYKYKNSA-N CC(C)(C)c1ccc(C(N/C=C(\Cc(cc2)ccc2-c2ncc(C)cn2)/C(C)=O)=O)[s]1 Chemical compound CC(C)(C)c1ccc(C(N/C=C(\Cc(cc2)ccc2-c2ncc(C)cn2)/C(C)=O)=O)[s]1 VFVWYCLETXIGSV-HMMYKYKNSA-N 0.000 description 1
- QXFQRNPJRRIVQV-UHFFFAOYSA-N CC(C)(C)c1ccc(C(NC(Cc(cc2)ccc2-c(nc2)ncc2Br)C(O)=O)=O)[s]1 Chemical compound CC(C)(C)c1ccc(C(NC(Cc(cc2)ccc2-c(nc2)ncc2Br)C(O)=O)=O)[s]1 QXFQRNPJRRIVQV-UHFFFAOYSA-N 0.000 description 1
- ANEHHGBGUNHWCC-AINGQBQZSA-N CC(C)(C)c1ccc(C(NCC(Cc(cc2)ccc2/C(/N=C)=N/C=C(\C)/Br)C(C)=O)=O)[s]1 Chemical compound CC(C)(C)c1ccc(C(NCC(Cc(cc2)ccc2/C(/N=C)=N/C=C(\C)/Br)C(C)=O)=O)[s]1 ANEHHGBGUNHWCC-AINGQBQZSA-N 0.000 description 1
- ZFBCVTDIBHOURT-VXPBITRUSA-N CC(C)(C)c1ccc(C(N[C@@H](Cc(cc2)ccc2-c(nc2)ncc2C(CC2)=CCC2C2CCCCC2)C(N(C2)CC2C(O)=O)=O)=O)[s]1 Chemical compound CC(C)(C)c1ccc(C(N[C@@H](Cc(cc2)ccc2-c(nc2)ncc2C(CC2)=CCC2C2CCCCC2)C(N(C2)CC2C(O)=O)=O)=O)[s]1 ZFBCVTDIBHOURT-VXPBITRUSA-N 0.000 description 1
- NMFWNZPXOPTIJS-INIZCTEOSA-N CC(C)(C)c1ccc(C(N[C@@H](Cc(cc2)ccc2O)C(OC(C)(C)C)=O)=O)[s]1 Chemical compound CC(C)(C)c1ccc(C(N[C@@H](Cc(cc2)ccc2O)C(OC(C)(C)C)=O)=O)[s]1 NMFWNZPXOPTIJS-INIZCTEOSA-N 0.000 description 1
- GLMWZZGFPYAZBP-FQEVSTJZSA-N CC(C)(C)c1ccc(C(N[C@@H](Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C(OC(C)(C)C)=O)=O)[s]1 Chemical compound CC(C)(C)c1ccc(C(N[C@@H](Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)C(OC(C)(C)C)=O)=O)[s]1 GLMWZZGFPYAZBP-FQEVSTJZSA-N 0.000 description 1
- PJCRUUFBYZHATI-UHFFFAOYSA-O CC(C)(C)c1ccc(C([NH2+]CC(Cc(cc2)ccc2-c2ncc(C)cn2)C(OC(C)(C)C)=[U])=O)[s]1 Chemical compound CC(C)(C)c1ccc(C([NH2+]CC(Cc(cc2)ccc2-c2ncc(C)cn2)C(OC(C)(C)C)=[U])=O)[s]1 PJCRUUFBYZHATI-UHFFFAOYSA-O 0.000 description 1
- HRDNRISTBWFDOW-UHFFFAOYSA-N CC(CC1)CC1C(C)=O Chemical compound CC(CC1)CC1C(C)=O HRDNRISTBWFDOW-UHFFFAOYSA-N 0.000 description 1
- JVILWQKPJIFCBE-XACRMZRZSA-N CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(NC(C(C)C)C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 Chemical compound CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(NC(C(C)C)C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 JVILWQKPJIFCBE-XACRMZRZSA-N 0.000 description 1
- ILNZPBRTOUGLGI-XNUIQKFGSA-N CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(NCC(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 Chemical compound CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(NCC(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 ILNZPBRTOUGLGI-XNUIQKFGSA-N 0.000 description 1
- CGYPLWCEKXSWSV-CFLIDMSFSA-N CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(NCCC(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 Chemical compound CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(NCCC(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 CGYPLWCEKXSWSV-CFLIDMSFSA-N 0.000 description 1
- QKVSCOBXFQKFMN-OZXATSTMSA-N CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N[C@@H](CCN)C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 Chemical compound CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N[C@@H](CCN)C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 QKVSCOBXFQKFMN-OZXATSTMSA-N 0.000 description 1
- HLFFUSXLNRFNGT-KYZXZLHSSA-N CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 Chemical compound CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 HLFFUSXLNRFNGT-KYZXZLHSSA-N 0.000 description 1
- OCCAVUFXYOLCTK-PLCZSAGUSA-N CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N[C@H](C)C(OC(C)(C)C)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 Chemical compound CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N[C@H](C)C(OC(C)(C)C)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 OCCAVUFXYOLCTK-PLCZSAGUSA-N 0.000 description 1
- OKSJAHCXOVYOFK-JBDHEKBJSA-N CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N[C@H](Cc3cnc[nH]3)C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 Chemical compound CCCC(CC1)CCC1C(CC1)CC=C1c1cnc(-c2ccc(C[C@@H](C(N[C@H](Cc3cnc[nH]3)C(O)=O)=O)NC(c3ccc(C(C)(C)C)[s]3)=O)cc2)nc1 OKSJAHCXOVYOFK-JBDHEKBJSA-N 0.000 description 1
- AGCWPLOROVJHLG-UHFFFAOYSA-N CCCc1ccc(C(CC2)CC=C2c2cnc(-c3ccc(CC(C(N(C4)CC4C(O)=O)=O)NC(c4ccc(C(C)(C)C)[s]4)=O)cc3)nc2)cc1 Chemical compound CCCc1ccc(C(CC2)CC=C2c2cnc(-c3ccc(CC(C(N(C4)CC4C(O)=O)=O)NC(c4ccc(C(C)(C)C)[s]4)=O)cc3)nc2)cc1 AGCWPLOROVJHLG-UHFFFAOYSA-N 0.000 description 1
- GQKPLGZEPYJIHJ-OWBHPGMISA-N CCNC(C1CC(C)(C)C/C=C\CCCCCCCCC1)=O Chemical compound CCNC(C1CC(C)(C)C/C=C\CCCCCCCCC1)=O GQKPLGZEPYJIHJ-OWBHPGMISA-N 0.000 description 1
- ZCGBKACFMUVQHA-FQEVSTJZSA-N Cc1cnc(-c2ccc(C[C@@H](C(NS(C)(=O)=O)=O)NC(OCc3ccccc3)=O)cc2)nc1 Chemical compound Cc1cnc(-c2ccc(C[C@@H](C(NS(C)(=O)=O)=O)NC(OCc3ccccc3)=O)cc2)nc1 ZCGBKACFMUVQHA-FQEVSTJZSA-N 0.000 description 1
- NISGSNTVMOOSJQ-UHFFFAOYSA-N NC1CCCC1 Chemical compound NC1CCCC1 NISGSNTVMOOSJQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028962P | 2014-07-25 | 2014-07-25 | |
| US62/028,962 | 2014-07-25 | ||
| US201462090040P | 2014-12-10 | 2014-12-10 | |
| US62/090,040 | 2014-12-10 | ||
| US201562161650P | 2015-05-14 | 2015-05-14 | |
| US62/161,650 | 2015-05-14 | ||
| PCT/US2015/042114 WO2016015014A1 (en) | 2014-07-25 | 2015-07-24 | Novel glp-1 receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015292356A1 AU2015292356A1 (en) | 2017-02-02 |
| AU2015292356B2 true AU2015292356B2 (en) | 2020-02-06 |
Family
ID=53777037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015292356A Ceased AU2015292356B2 (en) | 2014-07-25 | 2015-07-24 | Novel GLP-1 receptor modulators |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9474755B2 (enExample) |
| EP (1) | EP3172199B1 (enExample) |
| JP (2) | JP6556237B2 (enExample) |
| KR (1) | KR102564946B1 (enExample) |
| CN (2) | CN107074820B (enExample) |
| AU (1) | AU2015292356B2 (enExample) |
| CA (1) | CA2955836C (enExample) |
| EA (1) | EA032525B1 (enExample) |
| ES (1) | ES2819534T3 (enExample) |
| IL (1) | IL249896B (enExample) |
| MX (1) | MX382502B (enExample) |
| SG (1) | SG11201700364PA (enExample) |
| WO (1) | WO2016015014A1 (enExample) |
| ZA (1) | ZA201700342B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6007417B2 (ja) | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| JP6573604B2 (ja) | 2013-06-11 | 2019-09-11 | セルジーン インターナショナル ツー エスエーアールエル | 新規なｇｌｐ−１レセプターモジュレーター |
| CN107074820B (zh) * | 2014-07-25 | 2021-05-18 | 赛尔基因第二国际有限公司 | Glp-1受体调节剂 |
| CA2969944A1 (en) * | 2014-12-10 | 2016-06-16 | Celgene International Ii Sarl | Glp-1 receptor modulators |
| SI3519407T1 (sl) * | 2016-09-30 | 2022-01-31 | Receptos Llc | Dimetilaminoetanolna sol modulatorja receptorja GLP-1 |
| JP7116745B2 (ja) * | 2017-04-28 | 2022-08-10 | レセプトス・リミテッド・ライアビリティ・カンパニー | 新規なｇｌｐ－１受容体モジュレーター |
| WO2020210582A1 (en) * | 2019-04-11 | 2020-10-15 | University Of The Sciences | Allosteric agonists and positive allosteric modulators of glucagon-like peptide 1 receptor |
| PT4097099T (pt) | 2020-02-07 | 2024-07-19 | Gasherbrum Bio Inc | Agonistas heterocíclicos de glp-1 |
| WO2021219019A1 (en) | 2020-04-29 | 2021-11-04 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| PE20231181A1 (es) | 2020-08-06 | 2023-08-11 | Gasherbrum Bio Inc | Agonistas del glp-1 heterociclicos |
| CN112121152B (zh) * | 2020-09-25 | 2021-06-22 | 南京大学 | 利司那肽在制备抗肿瘤药物中的应用 |
| CN112898133B (zh) * | 2021-01-27 | 2022-11-15 | 河北迈尔斯通电子材料有限公司 | 一种反式酮类中间体的制备方法 |
| EP4490155A1 (en) | 2022-03-09 | 2025-01-15 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| JP2025510741A (ja) | 2022-03-21 | 2025-04-15 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式ｇｌｐ－１アゴニスト |
| US20250250269A1 (en) | 2022-04-14 | 2025-08-07 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| EP4777197A2 (en) | 2023-09-14 | 2026-07-22 | Ascletis Pharma (China) Co., Limited | Glp-1r agonist and therapeutic method thereof |
| WO2025109387A1 (en) | 2023-11-24 | 2025-05-30 | Ascletis Pharma (China) Co., Limited | Glp-1r agonist and therapeutic method thereof |
| KR20250113341A (ko) | 2024-01-18 | 2025-07-25 | 주식회사 티에치팜 | 나트륨 포도당 운반체-2 저해제 및 안지오텐신 ⅱ 수용체 차단제를 함유하는 비만 예방 또는 치료용 약학적 조성물 |
| WO2025158275A1 (en) | 2024-01-24 | 2025-07-31 | Pfizer Inc. | Combination therapy using glucose-dependent insulinotropic polypeptide receptor antagonist compounds and glp-1 receptor agonist compounds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013090454A2 (en) * | 2011-12-12 | 2013-06-20 | Receptos, Inc. | Novel glp-1 receptor modulators |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1062206B (it) | 1974-02-01 | 1983-09-20 | Rotta Research Lab S P A A S | Derivati della tirosina attivi sulla muscolatura liscia |
| DE2423536A1 (de) | 1974-05-15 | 1975-11-27 | Bayer Ag | 3-amino-phenylessigsaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| JP4798814B2 (ja) | 1997-01-07 | 2011-10-19 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 食物摂取低減用のエキセンジンおよびそのアゴニストの使用 |
| BR9811594A (pt) | 1997-07-31 | 2000-09-05 | Elan Pharm Inc | Compostos de dipeptìdeo sulfonilados que inibem adesão de leucócito mediada por vla-4 |
| US6583139B1 (en) * | 1997-07-31 | 2003-06-24 | Eugene D. Thorsett | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| KR100554815B1 (ko) | 1997-08-22 | 2006-02-22 | 에프. 호프만-라 로슈 아게 | 엔-아로일페닐알라닌 유도체 |
| US6191171B1 (en) | 1997-11-20 | 2001-02-20 | Merck & Co., Inc. | Para-aminomethylaryl carboxamide derivatives |
| PL208751B1 (pl) | 1998-12-07 | 2011-06-30 | Sod Conseils Rech Applic | Związki stanowiące analogi GLP-1, kompozycje zawierające takie związki oraz zastosowanie takich związków |
| RU2242244C2 (ru) | 1999-01-14 | 2004-12-20 | Амилин Фармасьютикалз, Инк. | Новые композиции агонистов эксендина и способы их введения |
| WO2001066531A1 (de) | 2000-03-07 | 2001-09-13 | Aventis Pharma Deutschland Gmbh | Substituierte 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one (und) ihre verwendung zur hemmung der hormonsensitiven lipase |
| WO2003048081A2 (en) | 2001-12-04 | 2003-06-12 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
| WO2003070709A1 (en) | 2002-02-20 | 2003-08-28 | Ajinomoto Co.,Inc. | Novel phenylalanine derivative |
| BRPI0418026A (pt) | 2003-12-22 | 2007-04-17 | Ajinomoto Kk | derivados de fenilalanina ou sais farmaceuticamente aceitáveis destes, composição farmacêutica, antagonista de alfa4 integrina, e, agente terapêutico ou agente preventivo para doenças |
| KR20070004676A (ko) * | 2004-02-10 | 2007-01-09 | 얀센 파마슈티카 엔.브이. | 알파４ 인테그린의 길항제로서의 피리다지논 |
| US7825139B2 (en) | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7816324B2 (en) | 2007-03-13 | 2010-10-19 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by a peptide receptor |
| US8299115B2 (en) | 2007-06-08 | 2012-10-30 | Debnath Bhuniya | Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application |
| EA018225B1 (ru) * | 2008-03-07 | 2013-06-28 | Транстек Фарма, Инк. | Соединения оксадиазоантрацена для лечения диабета |
| WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| WO2011156655A2 (en) | 2010-06-09 | 2011-12-15 | Receptos, Inc. | Novel glp-1 receptor stabilizers and modulators |
| TWI523844B (zh) * | 2011-01-26 | 2016-03-01 | 賽諾菲公司 | 經胺基取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途 |
| JP6007417B2 (ja) | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規ｇｌｐ−１受容体安定剤および調節剤 |
| JP6573604B2 (ja) | 2013-06-11 | 2019-09-11 | セルジーン インターナショナル ツー エスエーアールエル | 新規なｇｌｐ−１レセプターモジュレーター |
| CN107074820B (zh) * | 2014-07-25 | 2021-05-18 | 赛尔基因第二国际有限公司 | Glp-1受体调节剂 |
-
2015
- 2015-07-24 CN CN201580046095.3A patent/CN107074820B/zh not_active Expired - Fee Related
- 2015-07-24 EA EA201790254A patent/EA032525B1/ru not_active IP Right Cessation
- 2015-07-24 CA CA2955836A patent/CA2955836C/en active Active
- 2015-07-24 ES ES15745738T patent/ES2819534T3/es active Active
- 2015-07-24 US US14/809,020 patent/US9474755B2/en active Active
- 2015-07-24 AU AU2015292356A patent/AU2015292356B2/en not_active Ceased
- 2015-07-24 WO PCT/US2015/042114 patent/WO2016015014A1/en not_active Ceased
- 2015-07-24 KR KR1020177003172A patent/KR102564946B1/ko active Active
- 2015-07-24 EP EP15745738.3A patent/EP3172199B1/en active Active
- 2015-07-24 SG SG11201700364PA patent/SG11201700364PA/en unknown
- 2015-07-24 JP JP2017525324A patent/JP6556237B2/ja not_active Expired - Fee Related
- 2015-07-24 CN CN202011261790.0A patent/CN112457301A/zh active Pending
- 2015-07-24 MX MX2017000972A patent/MX382502B/es unknown
-
2016
- 2016-09-13 US US15/263,637 patent/US9839664B2/en active Active
-
2017
- 2017-01-02 IL IL249896A patent/IL249896B/en active IP Right Grant
- 2017-01-16 ZA ZA2017/00342A patent/ZA201700342B/en unknown
-
2019
- 2019-06-10 JP JP2019107866A patent/JP2019142984A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013090454A2 (en) * | 2011-12-12 | 2013-06-20 | Receptos, Inc. | Novel glp-1 receptor modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017526734A (ja) | 2017-09-14 |
| EP3172199B1 (en) | 2020-07-01 |
| AU2015292356A1 (en) | 2017-02-02 |
| EA201790254A1 (ru) | 2017-07-31 |
| US20160038487A1 (en) | 2016-02-11 |
| EP3172199A1 (en) | 2017-05-31 |
| SG11201700364PA (en) | 2017-02-27 |
| EA032525B1 (ru) | 2019-06-28 |
| JP6556237B2 (ja) | 2019-08-07 |
| US9474755B2 (en) | 2016-10-25 |
| MX382502B (es) | 2025-03-13 |
| WO2016015014A1 (en) | 2016-01-28 |
| CA2955836C (en) | 2023-02-14 |
| CN112457301A (zh) | 2021-03-09 |
| US20170216392A1 (en) | 2017-08-03 |
| CA2955836A1 (en) | 2016-01-28 |
| US9839664B2 (en) | 2017-12-12 |
| JP2019142984A (ja) | 2019-08-29 |
| IL249896A0 (en) | 2017-03-30 |
| CN107074820B (zh) | 2021-05-18 |
| MX2017000972A (es) | 2017-07-27 |
| KR102564946B1 (ko) | 2023-08-08 |
| ES2819534T3 (es) | 2021-04-16 |
| ZA201700342B (en) | 2018-12-19 |
| CN107074820A (zh) | 2017-08-18 |
| KR20170040233A (ko) | 2017-04-12 |
| IL249896B (en) | 2021-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2955836C (en) | Glp-1 receptor modulators | |
| EP2791112B1 (en) | Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes | |
| AU2014278183B2 (en) | Novel GLP-1 receptor modulators | |
| EP3615524B1 (en) | Novel glp-1 receptor modulators | |
| KR102497644B1 (ko) | Glp-1 수용체 조절제 | |
| WO2020210582A1 (en) | Allosteric agonists and positive allosteric modulators of glucagon-like peptide 1 receptor | |
| HK40042919A (en) | Novel glp-1 receptor modulators | |
| NZ626122B2 (en) | Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes | |
| HK1202864B (en) | Carboxylic acid derivatives comprising four cycles acting as glp-1 receptor modulators for therapy of diseases such as diabetes | |
| NZ715006B2 (en) | Novel glp-1 receptor modulators |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: RECEPTOS LLC Free format text: FORMER OWNER(S): CELGENE INTERNATIONAL II SARL |
|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |