CN107073040A - 子宫内膜病理状况中的干细胞治疗 - Google Patents

子宫内膜病理状况中的干细胞治疗 Download PDF

Info

Publication number
CN107073040A
CN107073040A CN201580043147.1A CN201580043147A CN107073040A CN 107073040 A CN107073040 A CN 107073040A CN 201580043147 A CN201580043147 A CN 201580043147A CN 107073040 A CN107073040 A CN 107073040A
Authority
CN
China
Prior art keywords
endometrial
bmdsc
autologous
endometrium
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580043147.1A
Other languages
English (en)
Chinese (zh)
Inventor
卡洛斯·西蒙
哈维尔·圣玛丽亚
安东尼奥·佩利塞尔
伊雷妮·切尔韦洛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Equipo IVI Investigacion SL
Original Assignee
Equipo IVI Investigacion SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Equipo IVI Investigacion SL filed Critical Equipo IVI Investigacion SL
Priority to CN202310575540.1A priority Critical patent/CN116747241A/zh
Publication of CN107073040A publication Critical patent/CN107073040A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
CN201580043147.1A 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗 Pending CN107073040A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310575540.1A CN116747241A (zh) 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462013121P 2014-06-17 2014-06-17
US62/013,121 2014-06-17
PCT/IB2015/001715 WO2015193737A1 (en) 2014-06-17 2015-06-05 Stem cell therapy in endometrial pathologies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202310575540.1A Division CN116747241A (zh) 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗

Publications (1)

Publication Number Publication Date
CN107073040A true CN107073040A (zh) 2017-08-18

Family

ID=54329860

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580043147.1A Pending CN107073040A (zh) 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗
CN202310575540.1A Pending CN116747241A (zh) 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202310575540.1A Pending CN116747241A (zh) 2014-06-17 2015-06-05 子宫内膜病理状况中的干细胞治疗

Country Status (22)

Country Link
US (1) US11129851B2 (enExample)
EP (3) EP3158057B1 (enExample)
JP (2) JP6920062B2 (enExample)
CN (2) CN107073040A (enExample)
AU (1) AU2015275798B2 (enExample)
BR (1) BR112016029558A2 (enExample)
CA (1) CA2952559C (enExample)
CY (2) CY1122615T1 (enExample)
DK (2) DK3158057T3 (enExample)
ES (3) ES2983444T3 (enExample)
HR (3) HRP20220419T1 (enExample)
HU (3) HUE044823T2 (enExample)
LT (2) LT3158057T (enExample)
MX (1) MX377300B (enExample)
PL (3) PL4012023T3 (enExample)
PT (2) PT3569697T (enExample)
RS (3) RS65719B1 (enExample)
RU (1) RU2725006C2 (enExample)
SI (2) SI3158057T1 (enExample)
SM (3) SMT201900400T1 (enExample)
TR (1) TR201910410T4 (enExample)
WO (1) WO2015193737A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230015832A (ko) 2021-07-23 2023-01-31 차의과학대학교 산학협력단 분리된 미토콘드리아를 유효성분으로 포함하는 아셔만 증후군 예방 또는 치료용 약학 조성물

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
EP3467124A1 (en) 2012-06-06 2019-04-10 Fundació Institut de Recerca Biomèdica IRB (Barcelona) Method for the diagnosis, prognosis and treatment of lung cancer metastasis
US10119171B2 (en) 2012-10-12 2018-11-06 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis
ES2744244T3 (es) 2012-10-12 2020-02-24 Inbiomotion Sl Método para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de próstata usando c-MAF
EP3272880B1 (en) 2013-03-15 2020-11-25 Fundació Institut de Recerca Biomèdica (IRB Barcelona) Method for the diagnosis, prognosis and treatment of metastatic cancer
CA2952559C (en) 2014-06-17 2023-01-24 Igenomix S.L. Stem cell therapy in endometrial pathologies
CA3028422A1 (en) * 2016-06-23 2017-12-28 Tithon Biotech, Inc. Cells expressing parathyroid hormone 1 receptor and uses thereof
RU2699029C1 (ru) * 2018-12-10 2019-09-03 Частное образовательное учреждение дополнительного профессионального образования "Академия медицинского образования имени Федора Ивановича Иноземцева" (ЧОУ ДПО "Академия медицинского образования им. Ф.И. Иноземцева") Способ использования мезенхимальных стволовых клеток для улучшения состояния рубца на матке
RU2741621C1 (ru) * 2020-09-25 2021-01-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации Способ лечения внутриматочных синехий

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920700648A (ko) 1989-05-05 1992-08-10 오닐 크리스토퍼 가임성 향상
US6979533B2 (en) 1992-06-12 2005-12-27 The Trustees Of The University Of Pennsylvania Determination of endometrial receptivity toward embryo implantation
CA2203718A1 (en) 1997-04-25 1998-10-25 University Of British Columbia Cadherin-11 as an indicator of viable pregnancy
IL127896A0 (en) 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
WO2001066786A1 (en) 2000-03-08 2001-09-13 Kliman Harvey J Methods of diagnosing and monitoring endometrial glandular development
AU2001264900A1 (en) 2000-05-24 2001-12-03 Schering Aktiengesellschaft Pharmaceutical use of fibulin-1
US6780594B2 (en) 2000-09-25 2004-08-24 Schering Aktiengesellschaft Method for in vitro diagnosis of endometriosis
AUPR673001A0 (en) 2001-07-31 2001-08-23 Prince Henry's Institute Of Medical Research Pregnancy-related enzyme activity
DE10139874A1 (de) 2001-08-10 2003-04-30 Schering Ag Humane Mater-Proteine
GB0201284D0 (en) 2002-01-21 2002-03-06 Isis Innovation Screening methods for contraceptive and fertility agents
US20030186300A1 (en) 2002-03-20 2003-10-02 Ali Akoum Methods and products for modulation of reproductive processes and for diagnosis, prognostication and treatment of related conditions
CA2489568A1 (en) 2002-05-14 2004-07-22 The Board Of Trustees Of The Leland Stanford Junior University Endometrial genes in endometrial disorders
DE10236405A1 (de) 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
AU2003255355A1 (en) 2002-08-02 2004-02-25 Schering Aktiengesellschaft Progesterone receptor modulators having an increased antigonadotropic activity for use in female fertility testing and hormone replacement therapy
DE10361928A1 (de) 2002-12-21 2004-07-01 Universität Leipzig Verfahren und Mittel zur Bestimmung von bestimmten Zuständen bzw. Veränderungen im Uterusepithel und im Epithel anderer Organe
WO2005018796A1 (en) 2003-08-21 2005-03-03 Pamgene B.V. Microarray support for bioprobe synthesis
CN1863905A (zh) 2003-09-08 2006-11-15 得克萨斯系统大学董事会 通过用前列腺素或前列腺素类似物补充培养基加强体外胚发育的方法以及组合物
WO2005026324A2 (en) 2003-09-08 2005-03-24 The Board Of Regents Of The University Of Texas System Method and composition for enhancing in vitro embryo development by supplementing culture medium with prostaglandin or a prostaglandin analog
EP2251695B1 (en) 2003-12-23 2013-07-17 Mount Sinai Hospital Corporation Markers associated with endometrial disease
EP1765083A4 (en) 2004-05-28 2008-08-20 Serono Lab USE OF IL-17 TO TREAT FERTILITY DISORDERS
US20090111140A1 (en) * 2006-03-31 2009-04-30 Koninklijke Philips Electronics N.V. Systems and methods for cell measurement utilizing ultrashort t2*
JP2007278750A (ja) 2006-04-04 2007-10-25 Ono Pharmaceut Co Ltd プロスタグランジン類及びその類縁体の定量方法
WO2008036374A2 (en) * 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
GB0703683D0 (en) * 2007-02-26 2007-04-04 Ark Therapeutics Ltd The treatment of complications in pregnancy
US9259233B2 (en) * 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
US8673850B2 (en) 2008-05-30 2014-03-18 Institut De Recherches Cliniques De Montreal PCSK9 inhibitors and methods of use thereof
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
WO2013166281A1 (en) * 2012-05-02 2013-11-07 Cedars-Sinai Medical Center Bi-functional compositions for targeting cells to diseased tissues and methods of using same
EP2348318A1 (en) 2010-01-21 2011-07-27 Equipo Ivi Investigación, S.L. Diagnostic method for endometrial receptivity
ES2662571T3 (es) 2011-10-21 2018-04-09 Institut National De La Santé Et De La Recherche Médicale (Inserm) Métodos de evaluación de la receptividad endometrial de una paciente tras una hiperestimulación ovárica controlada
CN104053668B (zh) 2011-11-30 2020-09-11 新加坡科技研究局 用于生物学检测的gm1神经节苷脂与膜联蛋白v的微粒多肽比例
ES2681238T3 (es) 2012-06-27 2018-09-12 F. Hoffmann-La Roche Ag Medios y métodos de aplicación de la relación sFlt-1/PIGF o Endoglina/PIGF para descartar la aparición de preeclampsia en un cierto periodo de tiempo
RU2515475C1 (ru) * 2012-11-15 2014-05-10 Федеральное государственное бюджетное учреждение науки ИНСТИТУТ ЦИТОЛОГИИ РОССИЙСКОЙ АКАДЕМИИ НАУК Способ стимуляции образования децидуальной оболочки эндометрия в эксперименте
BR112016021630A2 (pt) 2014-03-21 2020-02-27 Igenomix, S.L. Composição para tratar pré-eclampsia, método de uso do nível de anexina a2 (anxa2) como indicador de pré-eclampsia e método para avaliar a eficácia da terapia de glicosaminoglicano para pré-eclampsia
CA2952559C (en) 2014-06-17 2023-01-24 Igenomix S.L. Stem cell therapy in endometrial pathologies

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230015832A (ko) 2021-07-23 2023-01-31 차의과학대학교 산학협력단 분리된 미토콘드리아를 유효성분으로 포함하는 아셔만 증후군 예방 또는 치료용 약학 조성물

Also Published As

Publication number Publication date
ES2736117T3 (es) 2019-12-26
LT3569697T (lt) 2022-04-25
PL3158057T3 (pl) 2020-05-18
EP3569697B8 (en) 2022-04-27
CY1122615T1 (el) 2021-03-12
HRP20220419T1 (hr) 2022-05-27
TR201910410T4 (tr) 2019-08-21
SMT202400270T1 (it) 2024-07-09
JP6920062B2 (ja) 2021-08-18
EP3158057B1 (en) 2019-04-17
RU2017101147A (ru) 2018-07-17
EP4012023B1 (en) 2024-05-15
LT3158057T (lt) 2019-09-25
EP3569697B1 (en) 2022-01-05
DK3569697T3 (da) 2022-04-04
HRP20240798T1 (hr) 2024-09-27
EP4012023C0 (en) 2024-05-15
CA2952559A1 (en) 2015-12-23
EP4012023A1 (en) 2022-06-15
SMT201900400T1 (it) 2019-09-09
PT3569697T (pt) 2022-05-02
JP2017522288A (ja) 2017-08-10
AU2015275798A1 (en) 2017-02-02
MX377300B (es) 2025-03-07
CA2952559C (en) 2023-01-24
HUE067463T2 (hu) 2024-10-28
PT3158057T (pt) 2019-07-19
RS59210B1 (sr) 2019-10-31
RU2725006C2 (ru) 2020-06-29
CN116747241A (zh) 2023-09-15
HUE044823T2 (hu) 2019-11-28
AU2015275798B2 (en) 2021-03-25
JP2020138984A (ja) 2020-09-03
SMT202200155T1 (it) 2022-05-12
PL4012023T3 (pl) 2024-09-02
US11129851B2 (en) 2021-09-28
RS63093B1 (sr) 2022-04-29
HRP20191240T1 (hr) 2019-11-01
ES2910306T3 (es) 2022-05-12
SI3158057T1 (sl) 2019-10-30
SI3569697T1 (sl) 2022-05-31
CY1125938T1 (el) 2024-02-16
HUE058328T2 (hu) 2022-07-28
BR112016029558A2 (pt) 2017-08-22
RU2017101147A3 (enExample) 2019-02-06
RS65719B1 (sr) 2024-08-30
US20170128492A1 (en) 2017-05-11
MX2016016756A (es) 2017-11-02
ES2983444T3 (es) 2024-10-23
DK3158057T3 (da) 2019-07-29
WO2015193737A1 (en) 2015-12-23
PL3569697T3 (pl) 2022-07-04
EP3569697A1 (en) 2019-11-20
EP3158057A1 (en) 2017-04-26

Similar Documents

Publication Publication Date Title
AU2015275798B2 (en) Stem cell therapy in endometrial pathologies
Santamaria et al. Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study
Saribas et al. Effects of uterus derived mesenchymal stem cells and their exosomes on asherman’s syndrome
Tan et al. Autologous menstrual blood-derived stromal cells transplantation for severe Asherman's syndrome
Gao et al. Uterine artery embolization followed by dilation and curettage within 24 hours compared with systemic methotrexate for cesarean scar pregnancy
Singh et al. Autologous bone marrow-derived stem cell therapy for Asherman's syndrome and endometrial atrophy: a 5-year follow-up study
Zhang et al. Using 17β‐estradiol heparin‐poloxamer thermosensitive hydrogel to enhance the endometrial regeneration and functional recovery of intrauterine adhesions in a rat model
Singh et al. Autologous stem cell transplantation in refractory Asherman's syndrome: a novel cell based therapy
Puente Gonzalo et al. Intrauterine infusion of platelet-rich plasma for severe Asherman syndrome: a cutting-edge approach
Hu et al. Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions
Ferrero et al. Three-month treatment with ulipristal acetate prior to laparoscopic myomectomy of large uterine myomas: a retrospective study
US12350292B2 (en) Bioactive renal cells for the treatment of chronic kidney disease
Pandey et al. Intrauterine instillation of autologous platelet-rich plasma in infertile females with thin endometrium undergoing intrauterine insemination: an open-label randomized controlled trial
Santamaria et al. Should we consider alternative therapies to operative hysteroscopy for the treatment of Asherman syndrome?
de Miguel‐Gómez et al. Strategies for managing Asherman's syndrome and endometrial atrophy: since the classical experimental models to the new bioengineering approach
HK40075844A (en) Stem cell therapy in endometrial pathologies
HK40075844B (en) Stem cell therapy in endometrial pathologies
HK1242600A1 (en) Stem cell therapy in endometrial pathologies
Delis AMD3100 Administration for the Treatment of Asherman’s Syndrome in a Murine Model
Seifer et al. Stem cell therapies for atrophic endometrium and Asherman's syndrome
CN116440164A (zh) 一种用于哺乳动物生殖系统抗衰的生物制品及其制备方法和应用
Maegawa et al. A case of placental polyp treated with an intraoperative injection of prostaglandin F2α followed by hysteroscopic resection

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1242600

Country of ref document: HK