CN107043377A - 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途 - Google Patents
一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途 Download PDFInfo
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- CN107043377A CN107043377A CN201610081899.3A CN201610081899A CN107043377A CN 107043377 A CN107043377 A CN 107043377A CN 201610081899 A CN201610081899 A CN 201610081899A CN 107043377 A CN107043377 A CN 107043377A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610081899.3A CN107043377A (zh) | 2016-02-05 | 2016-02-05 | 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途 |
| TW106103697A TWI778952B (zh) | 2016-02-05 | 2017-02-03 | Ｔｌｒ７促效劑的三氟乙酸鹽、其晶型ｂ、其製備方法、包含其的藥物組合物及其用途 |
| CN201780009751.1A CN108602833B (zh) | 2016-02-05 | 2017-02-04 | 一种tlr7激动剂的三氟乙酸盐、晶型b、制备方法和用途 |
| HUE17747007A HUE052210T2 (hu) | 2016-02-05 | 2017-02-04 | Egy TLR7 agonista trifluoracetát sója és annak B kristályos formája, elõállítási eljárások és alkalmazások |
| ES17747007T ES2834304T3 (es) | 2016-02-05 | 2017-02-04 | Sal de trifluoroacetato de un agonista de TLR7 y forma cristalina B de la misma, métodos de preparación y usos |
| EP17747007.7A EP3412674B1 (en) | 2016-02-05 | 2017-02-04 | Trifluoroacetate salt of a tlr7 agonist and crystalline form b thereof, preparation methods and uses |
| NZ745023A NZ745023A (en) | 2016-02-05 | 2017-02-04 | Tlr7 agonist trifluoroacetate salt and crystalline form b thereof, preparation methods and uses |
| US16/075,303 US10683296B2 (en) | 2016-02-05 | 2017-02-04 | TLR7 agonist trifluoroacetate salt and crystalline form B thereof, preparation methods and uses |
| MYPI2018702700A MY198137A (en) | 2016-02-05 | 2017-02-04 | Tlr7 Agonist Trifluoroacetate Salt and Crystalline form B Thereof, Preparation Methods And Uses |
| AU2017214135A AU2017214135B2 (en) | 2016-02-05 | 2017-02-04 | TLR7 agonist trifluoroacetate salt and crystalline form B thereof, preparation methods and uses |
| CA3013521A CA3013521C (en) | 2016-02-05 | 2017-02-04 | Trifluoroacetate salt of a pyrrolo[3,2-d]pyrimidin compound as tlr7 agonist and crystalline form b thereof |
| JP2018540797A JP6877450B2 (ja) | 2016-02-05 | 2017-02-04 | Ｔｌｒ７アゴニストのトリフルオロ酢酸塩及びその結晶形ｂ、調製方法、並びに使用 |
| DK17747007.7T DK3412674T3 (da) | 2016-02-05 | 2017-02-04 | Trifluoracetatsalt af en TLR7-agonist og krystalform B deraf, fremstillingsfremgangsmåder og anvendelser |
| PCT/CN2017/072894 WO2017133687A1 (zh) | 2016-02-05 | 2017-02-04 | 一种tlr7激动剂的三氟乙酸盐、晶型b、制备方法和用途 |
| HK19101232.5A HK1259182B (zh) | 2016-02-05 | 2017-02-04 | 一种tlr7激动剂的三氟乙酸盐、晶型b、制备方法和用途 |
| MX2018009503A MX374300B (es) | 2016-02-05 | 2017-02-04 | Sal de trifluoroacetato de agonista de tlr7 y forma cristalina b de la misma, métodos de preparación y usos. |
| BR112018015878-0A BR112018015878B1 (pt) | 2016-02-05 | 2017-02-04 | Forma cristalina b de sal de trifluoracetato agonista de tlr7, seu processo de preparação, composições cristalina e farmacêutica, e seus usos |
| EA201891772A EA037048B1 (ru) | 2016-02-05 | 2017-02-04 | Трифторацетатная соль агониста tlr7 и ее кристаллическая форма b, способы получения и использование |
| UAA201809128A UA121276C2 (uk) | 2016-02-05 | 2017-02-04 | Трифторацетатна сіль агоніста tlr7 і її кристалічна форма b, способи одержання і використання |
| SG11201806688QA SG11201806688QA (en) | 2016-02-05 | 2017-02-04 | Tlr7 agonist trifluoroacetate salt and crystalline form b thereof, preparation methods and uses |
| KR1020187024629A KR102393281B1 (ko) | 2016-02-05 | 2017-02-04 | Tlr7 작용제 트리플루오로아세테이트 염 및 이의 결정형 b, 제조방법 및 용도 |
| ARP170100299A AR107550A1 (es) | 2016-02-05 | 2017-02-06 | Un trifluoroacetato de agonista de tlr7, la forma cristalina b, proceso de preparación y su utilización |
| PH12018501641A PH12018501641B1 (en) | 2016-02-05 | 2018-08-02 | Tlr7 agonist trifluoroacetate salt and crystalline form b thereof, preparation methods and uses |
| CL2018002101A CL2018002101A1 (es) | 2016-02-05 | 2018-08-03 | Un trifluoroacetato de agonista de tlr7, la forma cristalina b, proceso de preparación y su utilización |
| ZA2018/05240A ZA201805240B (en) | 2016-02-05 | 2018-08-03 | Tlr7 agonist trifluoroacetate salt and crystalline form b thereof, preparation methods and uses |
| IL260981A IL260981B (en) | 2016-02-05 | 2018-08-05 | The trifluoroacetate salt of the tlr7 agonist type b crystal structure, preparation, and methods of use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610081899.3A CN107043377A (zh) | 2016-02-05 | 2016-02-05 | 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107043377A true CN107043377A (zh) | 2017-08-15 |
Family
ID=59500539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610081899.3A Pending CN107043377A (zh) | 2016-02-05 | 2016-02-05 | 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途 |
| CN201780009751.1A Active CN108602833B (zh) | 2016-02-05 | 2017-02-04 | 一种tlr7激动剂的三氟乙酸盐、晶型b、制备方法和用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780009751.1A Active CN108602833B (zh) | 2016-02-05 | 2017-02-04 | 一种tlr7激动剂的三氟乙酸盐、晶型b、制备方法和用途 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10683296B2 (https=) |
| EP (1) | EP3412674B1 (https=) |
| JP (1) | JP6877450B2 (https=) |
| KR (1) | KR102393281B1 (https=) |
| CN (2) | CN107043377A (https=) |
| AR (1) | AR107550A1 (https=) |
| AU (1) | AU2017214135B2 (https=) |
| CA (1) | CA3013521C (https=) |
| CL (1) | CL2018002101A1 (https=) |
| DK (1) | DK3412674T3 (https=) |
| EA (1) | EA037048B1 (https=) |
| ES (1) | ES2834304T3 (https=) |
| HU (1) | HUE052210T2 (https=) |
| IL (1) | IL260981B (https=) |
| MX (1) | MX374300B (https=) |
| MY (1) | MY198137A (https=) |
| NZ (1) | NZ745023A (https=) |
| PH (1) | PH12018501641B1 (https=) |
| SG (1) | SG11201806688QA (https=) |
| TW (1) | TWI778952B (https=) |
| UA (1) | UA121276C2 (https=) |
| WO (1) | WO2017133687A1 (https=) |
| ZA (1) | ZA201805240B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019223788A1 (zh) * | 2018-05-25 | 2019-11-28 | 正大天晴药业集团股份有限公司 | 用于治疗肺癌的tlr7激动剂及其药物组合 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107043378A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
| CN107043380A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| MA44007A (fr) | 2016-02-05 | 2018-12-19 | Denali Therapeutics Inc | Inhibiteurs du récepteur interagissant avec protéine kinase 1 |
| JP7287708B2 (ja) | 2019-02-08 | 2023-06-06 | プロジェニア インコーポレイテッド | Ｔｏｌｌ－ｌｉｋｅ受容体７または８アゴニストとコレステロールの結合体およびその用途 |
| JP7811014B2 (ja) | 2020-03-02 | 2026-02-04 | プロジェニア インコーポレイテッド | 病原菌外壁成分基盤の生病原体模倣ナノ粒子及びその製造方法 |
| CN116322751A (zh) | 2020-08-04 | 2023-06-23 | 蛋白科技先锋 | 包含能够动力学控制的佐剂的mRNA疫苗 |
| JP2023536954A (ja) | 2020-08-04 | 2023-08-30 | プロジェニア インコーポレイテッド | 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途 |
| US20230355750A1 (en) | 2020-08-04 | 2023-11-09 | Progeneer Inc. | Kinetically acting adjuvant ensemble |
| IL314082A (en) | 2022-01-12 | 2024-09-01 | Denali Therapeutics Inc | Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide |
| CN119431359A (zh) * | 2023-07-28 | 2025-02-14 | 苏州申拓医药科技有限公司 | 一种tlr7/8激动剂的可药用盐、晶型及其制备方法、药物组合物和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3376479B2 (ja) * | 1991-08-12 | 2003-02-10 | 武田薬品工業株式会社 | 縮合ピリミジン誘導体、その製造法および用途 |
| ES2467108T3 (es) | 2008-12-09 | 2014-06-11 | Gilead Sciences, Inc. | Moduladores de receptores tipo toll |
| EP2670244B1 (en) * | 2011-02-04 | 2018-04-11 | Duquesne University of The Holy Spirit | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient |
| EP2800569B1 (en) * | 2012-01-05 | 2018-07-25 | Northeastern University | Allosteric modulators of cb1 cannabinoid receptors |
| LT2906563T (lt) * | 2012-10-10 | 2018-06-11 | Janssen Sciences Ireland Uc | Pirolo[3,2-d]pirimidino dariniai virusinių infekcijų ir kitų ligų gydymui |
| US9550785B2 (en) * | 2012-11-20 | 2017-01-24 | Glaxosmithkline Llc | Pyrrolopyrimidines as therapeutic agents for the treatment of diseases |
| JP6484253B2 (ja) * | 2014-05-01 | 2019-03-13 | ノバルティス アーゲー | Ｔｏｌｌ様受容体７アゴニストとしての化合物および組成物 |
| EA032487B1 (ru) * | 2014-05-01 | 2019-06-28 | Новартис Аг | Соединения и композиции в качестве агонистов toll-подобного рецептора 7 |
| CN105367576A (zh) * | 2014-08-15 | 2016-03-02 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
| HUE054672T2 (hu) * | 2014-08-15 | 2021-09-28 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | TLR7 agonistaként alkalmazott pirrolopirimidin vegyületek |
| CN105732635A (zh) * | 2014-12-29 | 2016-07-06 | 南京明德新药研发股份有限公司 | 一类Toll样受体7激动剂 |
-
2016
- 2016-02-05 CN CN201610081899.3A patent/CN107043377A/zh active Pending
-
2017
- 2017-02-03 TW TW106103697A patent/TWI778952B/zh active
- 2017-02-04 KR KR1020187024629A patent/KR102393281B1/ko active Active
- 2017-02-04 NZ NZ745023A patent/NZ745023A/en unknown
- 2017-02-04 WO PCT/CN2017/072894 patent/WO2017133687A1/zh not_active Ceased
- 2017-02-04 SG SG11201806688QA patent/SG11201806688QA/en unknown
- 2017-02-04 HU HUE17747007A patent/HUE052210T2/hu unknown
- 2017-02-04 AU AU2017214135A patent/AU2017214135B2/en active Active
- 2017-02-04 EP EP17747007.7A patent/EP3412674B1/en active Active
- 2017-02-04 UA UAA201809128A patent/UA121276C2/uk unknown
- 2017-02-04 JP JP2018540797A patent/JP6877450B2/ja active Active
- 2017-02-04 CN CN201780009751.1A patent/CN108602833B/zh active Active
- 2017-02-04 DK DK17747007.7T patent/DK3412674T3/da active
- 2017-02-04 US US16/075,303 patent/US10683296B2/en active Active
- 2017-02-04 MY MYPI2018702700A patent/MY198137A/en unknown
- 2017-02-04 ES ES17747007T patent/ES2834304T3/es active Active
- 2017-02-04 EA EA201891772A patent/EA037048B1/ru not_active IP Right Cessation
- 2017-02-04 MX MX2018009503A patent/MX374300B/es active IP Right Grant
- 2017-02-04 CA CA3013521A patent/CA3013521C/en active Active
- 2017-02-06 AR ARP170100299A patent/AR107550A1/es not_active Application Discontinuation
-
2018
- 2018-08-02 PH PH12018501641A patent/PH12018501641B1/en unknown
- 2018-08-03 CL CL2018002101A patent/CL2018002101A1/es unknown
- 2018-08-03 ZA ZA2018/05240A patent/ZA201805240B/en unknown
- 2018-08-05 IL IL260981A patent/IL260981B/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019223788A1 (zh) * | 2018-05-25 | 2019-11-28 | 正大天晴药业集团股份有限公司 | 用于治疗肺癌的tlr7激动剂及其药物组合 |
| CN112105620A (zh) * | 2018-05-25 | 2020-12-18 | 正大天晴药业集团股份有限公司 | 用于治疗肺癌的tlr7激动剂及其药物组合 |
| US12128047B2 (en) | 2018-05-25 | 2024-10-29 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | TLR7 agonist and pharmaceutical combination thereof for treating lung cancer |
| CN112105620B (zh) * | 2018-05-25 | 2026-02-24 | 正大天晴药业集团股份有限公司 | 用于治疗肺癌的tlr7激动剂及其药物组合 |
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Application publication date: 20170815 |