CN107028839A - Oral care composition and its application, dentifrice composition - Google Patents
Oral care composition and its application, dentifrice composition Download PDFInfo
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- CN107028839A CN107028839A CN201710401120.6A CN201710401120A CN107028839A CN 107028839 A CN107028839 A CN 107028839A CN 201710401120 A CN201710401120 A CN 201710401120A CN 107028839 A CN107028839 A CN 107028839A
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- Prior art keywords
- oral care
- composition
- care composition
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
Oral care composition and dentifrice composition that the present invention is provided, including epithelical cell growth factor, ascorbic acid, flavonoids, the reparation of oral mucosa lesion tissue can be promoted, canker sore healing is fast, and pain relief speed is fast, can effectively prevent the recurrence of tumor radiotherapy patient's later stage canker sore, gingivitis mitigates, bleeding gums symptom is obviously improved and taken a turn for the better, and oral peculiar smell is eliminated, while also enhancing the constitution of patient.
Description
Technical field
The present invention relates to daily necessities field, a kind of oral care composition and its application, toothpaste group are especially related to
Compound.
Background technology
Epithelical cell growth factor (Epidermai GrowthFactor), abbreviation EGF；It is a kind of to be widely present in people
The biologically active polypeptide being made up of 53 amino acid in Skin Cell, body fluid, kidney and brain tissue is a kind of with physiology work(
The bioactive substance of energy, with very strong biological effect.In human body, the epithelical cell growth factor of denier can just rise
To very big biological action, propagation and the growth of skin tissue cell can be promoted, make the cell of newborn youth replace declining rapidly
Old and dead cell.Periodically epithelical cell growth factor is supplemented for Skin Cell, it is possible to persistently promote the synthesis of cell, keep
The vigorous metabolism of epidermal cell, also promotes skin and mucous membrane wound healing, anti-inflammatory analgetic, the effect for preventing and treating ulcer.
Ascorbic acid is also known as vitamin C, is a kind of acid polyol containing 6 carbon atoms, and molecular formula is
C6H8O6, molecular weight is 176.1.Naturally occurring ascorbic acid has 2 kinds of L-type and D types, the latter's inactive.Vitamin C is
It is soluble in water in the flat crystal of no color or smell, insoluble in organic solvent.It is stable in sour environment, meet oxygen in air, heat,
Light, alkaline matter, particularly in the presence of the metal ion such as oxidizing ferment and copper trace, iron, can promote its Oxidative demage.
Bioflavonoid (bioflavonoids) is also known as flavone compound, also known as citrin.Often with vitamin C companion
Deposit, distributed in nature extensively, platymiscium secondary metabolite, be one group be present in veterinary antibiotics, flower and cereal it is natural
Pigment, claims bioflavonoid more because being in yellow.Bioflavonoid have multiple biological activities effect, particularly Green Tea Extract and
Effect in terms of anti-cancer and cancer-preventing.
At present, although be documented and ascorbic acid, epithelical cell growth factor are used alone in oral care product；
But due to ascorbic acid, the stability problem of epithelical cell growth factor and limit its application.The A of CN 105012173 are disclosed
A kind of toothpaste that ascorbic acid is added in the form of microcapsules, still, because in oral cleaning, toothpaste is in cavity interior
Action time it is very limited, can not be effective by capsulated active ingredient ascorbic acid generally not over 10 minutes
Absorb.
And ascorbic acid, epithelical cell growth factor are used in combination applied to oral care product not correlative study
Report.
The content of the invention
In view of this, the main object of the present invention is provides a kind of oral care composition and dentifrice composition, for body
The weak canker sore patient of matter, can make drug ingedient quick release, promote the reparation of oral mucosa lesion tissue.
The present invention proposes a kind of oral care composition, including epithelical cell growth factor, ascorbic acid, flavonoids
Compound.
Preferably, the mass content of the epithelical cell growth factor in the composition is 0.0005%~0.001%.
Preferably, the mass content of the ascorbic acid in the composition is 0.1%~2%.
Preferably, the flavonoids is added in the form of flavonoid extract in the composition, the flavonoids
The mass content of extract in the composition is 5%~20%.
Preferably, in the flavonoid extract, the mass content of flavonoids is 40%~99%.
Preferably, in addition to auxiliary material, the auxiliary material includes honey, pectin, D-sorbite, glycerine.
The invention also provides a kind of dentifrice composition, including toothpaste matrix and above-mentioned oral care composition.
Preferably, the toothpaste matrix includes water, SiO 2 powder, D-sorbite, lauryl sodium sulfate, titanium dioxide
Titanium, sodium fluoride.
Preferably, mass content of the oral care composition in dentifrice composition is 5%~20%.
The oral care composition that the present invention is provided, in the production of mouthwash, gel, powder, confectionery and lozenge oral care
Application in product.
Oral care composition and dentifrice composition that the present invention is provided, including epithelical cell growth factor, ascorbic acid,
Flavonoids, can promote the reparation of oral mucosa lesion tissue, and canker sore healing is fast, and pain relief speed is fast, can have
The recurrence of effect prevention tumor radiotherapy patient's later stage canker sore, gingivitis mitigates, and bleeding gums symptom is obviously improved and taken a turn for the better,
Oral peculiar smell is eliminated, while also enhancing the constitution of patient.
Embodiment
It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not intended to limit the present invention.
Embodiment 1
Oral care composition of the present invention constitutes (unit by following mass fraction each component：Wt.%)：
In upper table, epithelical cell growth factor is represented with EGF, and ascorbic acid is represented with VC, what flavonoids was used
It is flavonoid extract, includes three different flavonoid extracts, respectively asparagus flavonoid extract (40%), citrus
Flavonoid extract (80%), chrysanthemum indicum flavonoid extract (99%).
Adjunct ingredient is by mass：6 parts of honey, 9 parts of pectin, 30 parts of D-sorbite, 10 parts of glycerine.
Fully mixed under anaerobic using above-mentioned raw materials, you can obtain the oral care composition of the present invention.
Embodiment 2
Acid stabilizer in oral care composition A, B, C, D, E, F in embodiment 1 is detected, detected
As a result following (unit：%).
| Composition | 0 | 15min | 30min | 1h | 2h | 4h | 12h |
| A | 100 | 92 | 88.7 | 66.2 | 43.8 | 19.1 | 6.9 |
| B | 100 | 95 | 92.4 | 49.7 | 24.8 | 17.8 | 8.4 |
| C | 100 | 93 | 82.7 | 62.4 | 42.4 | 18.4 | 2.9 |
| D | 100 | 91 | 81.0 | 30.8 | 20.7 | 9.0 | 2.3 |
| E | 100 | 97 | 88.6 | 58.0 | 38.1 | 27.0 | 10.6 |
| F | 100 | 99 | 89.6 | 67.5 | 34.3 | 21.8 | 5.7 |
The test condition of above-mentioned experiment is as follows：10g compositions are taken to be placed in the environment of 20 DEG C of temperature, humidity 90%, airbreak
Place.Using ascorbic acid content of the metric measurement under the conditions of each, and divided by initial value, obtain ascorbic acid in table
Surplus.
Embodiment 3
Dentifrice composition is configured with oral care composition E, it is specific as follows：
| Composition | E1 | E2 | E3 |
| Toothpaste matrix | 80 | 90 | 95 |
| Oral care composition E | 20 | 10 | 5 |
Above-mentioned toothpaste matrix, in parts by mass, including 20 parts of water, 50 parts of SiO 2 powder, 30 parts of D-sorbite, 12
2 parts of sodium alkyl sulfate, 5 parts of titanium dioxide, 0.1 part of sodium fluoride.
Embodiment 4
Clinical trial is carried out using the dentifrice composition of embodiment 3.It is specific as follows：
According to standard (Li Bingqi chief editor's Diseases of the Oral Mucosa [M] second editions, Beijing of clinical diagnosis canker sore:The people defend
Bear version 2,003 49-61), the patient of 135 patient's neck radiotherapy is selected in altogether.Wherein 15 in strict accordance with experiment because do not advise
Surely the dentifrice composition of embodiment 3 is used, gives and rejects, remaining 120 qualified complete cases.4 experimental groups are divided into, E1 is real
Test group 30 (man 20, female 10), E2 experimental groups 30 (man 18, female 12), (man 21, female 9 for E3 experimental groups 30
Example), control group 30 (man 22, female 8).Each group needs to have in terms of age, sex, kinds of Diseases and ulcer rank
There was no significant difference (P>0.05), with comparativity.
Canker sore is classified：
1 grade：Callous ulcer, erythema or mild pain, are not required to anodyne
2 grades：Pain moderate pain, need to use anodyne with erythema, oedema or point-like ulcer.But patient can consuming solid food
Thing
3 grades：Pain need to use stronger anodyne with erythema, oedema or sheet ulcer, and patient is unable to consuming solid foods, shadow
Ring rest.
4 grades；Mucous membrane ulcer, severe pain, it is impossible to which feed is, it is necessary to parenteral or EN support
It is all not occur not by the medication of regulation scheme and observer, testing data missing person or during treating during testing
Good reaction can not adhere to that drug user is removed.
Experimental method：
This experiment is designed using random parallel check experiment.E1 experimental groups dentifrice composition E1, starts same day during radiotherapy
Begin to use dentifrice composition E1 to be brushed teeth, once in the morning and once at night, persistently using 3 months, choose different time after radiotherapy and click through
The detection that row canker sore incidence is detected and canker sore is classified.
Likewise, E2 experimental groups dentifrice composition E2, E3 experimental group dentifrice composition E3, enters under identical condition
OK.
The same day begins to use conventional dentifrices (active component without the present invention) to be brushed teeth during control group radiotherapy, without
Extra process, the course for the treatment of is identical with test group.
Observation index
Ulcer occurs at the end of detailed inspection radiotherapy, and a situation arises, and ulcer size, depth, form and surrounding mucosa grade
Situation.Radiotherapy terminates the situation of rear ulcer recurrence.Canker sores degree evaluation is divided into 4 grades:Without pain, score value is 0；Slight pain
Bitterly, score value is 1；Moderate pain, score value is 2；Severe pain, score value is 3.During medication, remember by These parameters whole process observation
Record, healing time is judged with the healing of all ulcer wound surfaces for index.Local irritation is observed during medication and whole body is bad anti-
Should.Visually observed ulcer by observing doctor a situation arises, oral cavity is recurred again after measurement wound healing situation and recurrence healing burst
The time point of ulcer；Percentage occurs for dynamic evaluation ulcer, and heal percentage, using ulcer healing as index, judges healing time.
Patient voluntarily evaluates pain degree by pain measurement standard, by 4 grades of standard recording pain improve situations (painless, mild pain, in
Spend pain, severe pain), using canker sores disappearance as index, record canker sores extinction time.
Statistical analysis and result
Enumeration data uses Chi-square Test, and measurement data mean compares to be examined using t.
At the end of one course for the treatment of of Patients Treated by Radiotherapy of two groups of radiotherapy, the generation of ulcer, experimental group is considerably less than control group, difference
Possesses statistical significance (P ﹤ 0.01), referring to following table：
| Packet | Number of cases | Generation ulcer/number of cases |
| E1 | 30 | 1 |
| E2 | 30 | 2 |
| E3 | 30 | 2 |
| Control group | 30 | 28 |
In experimentation, two groups of ulcer plague grades and after experiment, the mean time that two groups of patient's canker sores disappear
Between and ulcer healing average time situation, experimental group is substantially better than in control group, and difference possesses statistical significance (P ﹤
0.01), referring to following table：
In experimentation, the situation of the different time of two groups of ulcer generations and healing, experimental group is substantially better than in control group,
Following table is that each group different time ulcer healing number of cases situation compares：
In experimentation, at the same detect two groups of patients after the test phase canker sore recurrence situation different time feelings
Condition, experimental group is substantially better than in control group, referring to following table：
Tumor radiotherapy patient clinically easily causes oral cavity large area to be burst because cytotoxicity and immunity of organisms decline
Ulcer, and with bleeding gums and periodontal disease, the relative risk of tumor patient infection is added, while reducing the life matter of patient
Amount.Now there are some researches prove the prostaglandin E Z and EGF in ulcerative stage patient's saliva is significantly lower than normal person, and EGF shortage may
Resistance of the oral mucosa to destructive stimulus is reduced, the mucus thickness on oral epithelium surface is severely impacted, so as to lose
First of protective barrier of skin tissue, so as to cause the generation of canker sore.
From above-mentioned experiment, the dentifrice composition for effectively demonstrating the embodiment of the present invention 3 promotes oral mucosa ulcer to be cured
The effect of conjunction.The oral care composition that the present invention is provided passes through epithelical cell growth factor, ascorbic acid, flavonoids
The synergy of three, promotes the reparation of oral mucosa lesion tissue, and canker sore healing is fast, and pain relief speed is fast.Use
The dentifrice composition of the present invention can effectively prevent the recurrence of tumor radiotherapy patient's later stage canker sore, and gingivitis mitigates, gum
Bleeding is obviously improved and taken a turn for the better, and oral peculiar smell is eliminated, while also enhancing the constitution of patient, further controls secondary sense
Dye, mitigates the financial burden of patient, the chemicotherapy of tumor patient is treated smooth, then improves the existence matter of patient
Amount and clinical survival rate.Allergic reaction and local irritant effect, topical application dentifrice composition object space are not found in the process of the test
Just, safety, the social value promoted with stronger Clinical practicability and daily use is high.
The oral care composition that the present invention is provided, can also be protected in mouthwash, gel, powder, confectionery and lozenge oral cavity
Applied in reason product.The product of variant type, can be obtained by conventional preparation method, just do not repeated herein.
Oral care composition and dentifrice composition that the present invention is provided, including epithelical cell growth factor, ascorbic acid,
Flavonoids, can promote the reparation of oral mucosa lesion tissue, and canker sore healing is fast, and pain relief speed is fast, can have
The recurrence of effect prevention tumor radiotherapy patient's later stage canker sore, gingivitis mitigates, and bleeding gums symptom is obviously improved and taken a turn for the better,
Oral peculiar smell is eliminated, while also enhancing the constitution of patient.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize
Equivalent structure or equivalent flow conversion that description of the invention is made, or directly or indirectly it is used in other related technology necks
Domain, is included within the scope of the present invention.
Claims (10)
1. a kind of oral care composition, it is characterised in that including epithelical cell growth factor, ascorbic acid, flavonoids chemical combination
Thing.
2. oral care composition according to claim 1, it is characterised in that the epithelical cell growth factor is in combination
Mass content in thing is 0.0005%~0.001%.
3. oral care composition according to claim 1, it is characterised in that the matter of the ascorbic acid in the composition
It is 0.1%~2% to measure content.
4. oral care composition according to claim 1, it is characterised in that the flavonoids is in the composition
Added in the form of flavonoid extract, the mass content of the flavonoid extract in the composition is 5%~20%.
5. oral care composition according to claim 4, it is characterised in that in the flavonoid extract, flavonoids
Mass content be 40%~99%.
6. oral care composition according to claim 1, it is characterised in that also including auxiliary material, the auxiliary material includes honeybee
Honey, pectin, D-sorbite, glycerine.
7. a kind of dentifrice composition, it is characterised in that including the oral cavity shield described in toothpaste matrix and claim 1-6 any one
Manage composition.
8. dentifrice composition according to claim 7, it is characterised in that the toothpaste matrix includes water, silicon dioxide powder
End, D-sorbite, lauryl sodium sulfate, titanium dioxide, sodium fluoride.
9. dentifrice composition according to claim 7, it is characterised in that the oral care composition is in dentifrice composition
In mass content be 5%~20%.
10. the oral care composition described in claim 1-6 any one, in mouthwash, gel, powder, confectionery and ingot
Application in agent oral care product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710401120.6A CN107028839A (en) | 2017-05-31 | 2017-05-31 | Oral care composition and its application, dentifrice composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710401120.6A CN107028839A (en) | 2017-05-31 | 2017-05-31 | Oral care composition and its application, dentifrice composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107028839A true CN107028839A (en) | 2017-08-11 |
Family
ID=59539135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710401120.6A Pending CN107028839A (en) | 2017-05-31 | 2017-05-31 | Oral care composition and its application, dentifrice composition |
Country Status (1)
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101495089A (en) * | 2006-07-20 | 2009-07-29 | 奥雷登特有限公司 | Oral compositions, their preparation and use |
| CN103463627A (en) * | 2013-09-11 | 2013-12-25 | 拉芳家化股份有限公司 | Oral care composition containing heat-resistant superoxide dismutase and growth factors |
-
2017
- 2017-05-31 CN CN201710401120.6A patent/CN107028839A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101495089A (en) * | 2006-07-20 | 2009-07-29 | 奥雷登特有限公司 | Oral compositions, their preparation and use |
| CN103463627A (en) * | 2013-09-11 | 2013-12-25 | 拉芳家化股份有限公司 | Oral care composition containing heat-resistant superoxide dismutase and growth factors |
Non-Patent Citations (2)
| Title |
|---|
| 朱述琳等: "《重组人表皮生长因子凝胶治疗肿瘤患者口腔溃疡临床研究》", 《齐鲁护理杂》 * |
| 高敏等: "《维生素C片剂外用治疗血液病合并口腔溃疡的疗效观察》", 《护理实践与研究》 * |
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