CN101185622B - Oil-controlling, anti-blackening and skin-whitening cream - Google Patents
Oil-controlling, anti-blackening and skin-whitening cream Download PDFInfo
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- CN101185622B CN101185622B CN2007101302333A CN200710130233A CN101185622B CN 101185622 B CN101185622 B CN 101185622B CN 2007101302333 A CN2007101302333 A CN 2007101302333A CN 200710130233 A CN200710130233 A CN 200710130233A CN 101185622 B CN101185622 B CN 101185622B
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Abstract
The invention discloses a cosmetic which can balance oil secreting, resist sunlight and skin aging and essentially consists of rennin, honey, titanium dioxide, carbocisteine, niacin amide, vitamin E, vitamin F, cod liver oil, spironolactone and substrate cream, which are prepared according to certain weight proportion and function coordinately to achieve the effect of whitening and skincare. The invention has the triple effects including skincare, sun block and aging resistance. Firstly, the cosmetics regulates the metabolism of skin oil secretion to balance the secretion of the oil secretion, smoothen pores and reduce the occurrence rate of acne; secondly, the product effectively prevents people from being hurt by ultraviolet and reduces the settlement of melanin, thereby having good sun block and whitening effects; finally, the product slows down the aging of skin, smoothens the skin and provides delicate and fair skin to users. The invention has scientific components, simple fabrication and unique treatment effect and is suitable for large-batch production.
Description
Technical field
The invention discloses and a kind ofly have balance skin oil and fat secretion and product sun-proof, the anti-aging effect is arranged, belong to cosmetic field.
Background technology
Be subjected to the influence of atmospheric pollution, ozone layer suffers to destroy thin day by day, and the ultraviolet energy that arrives ground constantly strengthens, and the daylight ultraviolet radiation more and more is subject to people's attention the harm that human body caused.Ultraviolet radiation (UV) can promote melanin to form, and makes skin chromogenesis calmness, and melanin is difficult for metabolism, can be attached on the epidermis, causes skin pitch-dark, even forms brown patch.UV can also cause xerosis cutis, burn and erythema, and cytoactive is weakened, and the metabolism rate of tissue reduces, and structure is damaged, and impels the skin premature aging.The intense UV rays irradiation also can increase sebaceous secretion, and brings out acne.Especially in summer, the metabolism of human body self can be accelerated, and the activity of intravital sweat gland, sebaceous gland can be strengthened, and causes sebum secretion more and more.Too much sebum is distributed in skin surface, also becomes easily infected by dust, and accumulation is gone down, and sebum just is blocked in the pore deep layer, causes cutin slightly thick, forms acne.
So defend excessive ultraviolet radiation protection human body to escape injury, the while conditioning skin, slow down aging becomes more and more important.At present, the sunscreen on the market is divided into organic sunscreen agent and inorganic sunscreen two big classes, and product category is various.Inorganic sunscreen plays the shielding of ultraviolet effect, and the organic sunscreen agent then is a UV absorbent.But they respectively have its drawback, and the active ingredient of most organic sunscreen agent can produce skin to stimulate, and general light stability is lower, easily decomposes behind ultraviolet radiation, and sun-proof result is poor.Inorganic sunscreen is used separately and is difficult to reach very high sun-proof result and good result of use.And the product of sun-proof at present, anti-skin aging all is independently with the product of conditioning oils and fats balance, acne removing class, so, also do not have now a kind of can sun-proof, anti-aging, again can the conditioning skin fat secretion, prevent the cosmetics of acne.
Summary of the invention
Therefore, still there is demand in the cosmetics that people are better to sun-proof result, side effect is little.Up to now, also do not find the report of any relevant present composition.The inventor is through research repeatedly, and the checking repeatedly by clinical trial, has found the sun-proof care product that better curative effect is arranged finally, thereby has finished the present invention.
Purpose of the present invention just provide a kind of more effective sun-proof and can nursing skin, prevent the cosmetics of skin aging.
The inventor is as follows through long-term practice summary composition of the present invention: feritin, Mel, titanium dioxide, carbocisteine (carbocisteine), niacin amide, vitamin E, vitaminF, cod-liver oil, spiral shell lactone and substrate frost.Make each composition effect produce synergism the combination of these compositions, anti-ly deceive to reach good, whiten, effect of nursing.
The consumption of constituent of the present invention is that the inventor draws through a large amount of exploration summaries, each amounts of components all has better curative effect in the following weight parts scope: 500～800 parts of 0.3～2 part of feritin, Mel 4～60,000 part, titanium dioxide 7～90,000 part, carbocisteine 2～50,000 part, niacin amide 0.2～30,000 part, vitamin E 0.5～30,000 part, vitaminF 3～60,000 part, cod-liver oil 0.1～20,000 part, spiral shell lactone, substrate frost 70～830,000 part.
Be preferably: 1 part of feritin, 50,000 parts of Mel, 80,000 parts of titanium dioxide, 30,000 parts of carbocisteine, 10,000 parts of niacin amide, ten thousand parts of vitamin e1s, 50,000 parts of vitaminFs, 0.5 ten thousand parts of cod-liver oil, 700 parts of spiral shell lactone, 760,000 parts of substrate frosts.
1, feritin: feritin is by renal secretion, and its most important effect can activate proangiotensin (non-activity) exactly and become angiotensin I.Be subjected to the feritin effect to form angiotensin I by the synthetic proangiotensin of liver,, form Angiotensin II, become Angiotensin II I through enzymatic conversion again through the effect of invertase (kininase II).Vasotonia have intensive vasoconstrictive effect, can regulate effective filtration pressure.Its mechanism of action is: act on target receptor (top layer vasoganglion, sebum body of gland, peripheral lymphoid pipe network) → target receptor contraction → contraction metarteriole → contraction blood capillary → make big what blood capillary of Interstitial Fluid Pressure intrinsic pressure → impel intercellular fluid to ooze to be back in the blood capillary → product fat that sebaceous gland raw material supply pressure reduce → directly suppresses sebum output and secretion → the alleviate sebaceous gland retention sebaceous matter of loading → alleviate.So feritin is nursing skin fundamentally, eliminate the reason that the youth flower bud is taken place, make blood circulation recover normal, it is normal that sebum secretion keeps.Clinical confirmation, the feritin exceptional function adds that other antibiotics act synergistically on acne lesions, collapsible pore, pore is attenuated, impel acne to alleviate and disappear, to the various abnormal symptoms of acne, more effectual than other cosmetics really, can reach the effect of quick detumescence fitness, have no side effect.
2, Mel: the history in more than 1700 year is arranged with the Mel cosmetology.Mel is that Skin Cell grows agent, and external can be absorbed by the human epidermal cell, thereby has strengthened the vigor of epidermis cell, promotes the metabolism of Skin Cell, improves the nutriture of skin.Mel contains rich nutrient substances.Scientist confirms, has found to contain all listed in mendeleev periodic table of elements trace element in the Mel.Saccharide in the Mel accounts for 3/4ths of total composition, and wherein fructose and glucose account for 85%～95% of total sugar amount again.The vitamin that contains in the Mel mainly is vitamin B group and vitamin C.Glucose in the Mel, fructose, protein, aminoacid, vitamin, mineral etc. directly act on epidermis and corium, for cell provides nutrient, impel cell division, growth.Mel has very strong bactericidal action, can protect skin, cleaning skin and some skin diseases of treatment and wound.Mel is the sugar juice of high concentration, and a lot of mushrooms are had inhibitory action; Because the glucose peroxidase that contains in the Mel acts on glucose, can produce hydrogen peroxide, certain density hydrogen peroxide has sterilization and bacteriostasis.Can prevent skin generation bacterial infection, reduce the occurrence probability of acne.
After Mel added the dilution of 2-3 times of water, every day, coating was facial, cleaned with clear water then.Can improve the skin-nourishing situation, promote skin metabolism, strengthen the vigor and the antimicrbial power of skin, reduce pigmentation, prevent xerosis cutis, make skin exquisiteness, smooth, high resilience, and can reduce wrinkle and prevent and treat dermatopathy such as acne, play the skin maintenance effect.
3, titanium dioxide: titanium dioxide is a kind of inorganic sunscreen.Report according to the study, 50 nano titanium oxides have the favorable protection effect to ultraviolet (UV) A and UVB, are one of best physical sunscreen agent.The thin titanium dioxide fine particles of nanometer can increase surface area at epidermis, ventilative heat radiation, and the absorption sebum, compound with sebum film, the skin-protecting function of reinforcement sebum film makes skin pale, lubricious, delicate.The energy pore refining suppresses smegma, impels the rehabilitation of acne flower bud pox.
4, carbocisteine (carbocisteine): can make super oxyradical disproportionation, sealing or not produce oxygen, be good oxygen free radical scavenger, but delaying decrepitude of skin.Skin also there is speckle dispelling, brightens beautification function, can prevent pachylosis.
5, niacin amide: niacin amide claims vitamin B again
3, vitamin PP, nicotiamide.Being the important component that constitutes nadide (NAD+) and coenzyme II (NADP+), is the coenzyme of dehydrogenase, and the niacin amide in these two kinds of coenzyme structures partly has the reversibly characteristic of hydrogenation and dehydrogenation, plays a part hydrogen carrier in biological oxidation process.Can utilize carbohydrate, fat and protein to come produce power, also can promote biosynthesis protein and fat.Can participate in forming the haemachrome in the erythrocyte, participate in hematopoiesis, make telangiectasis, blood circulation is accelerated, and enhances metabolism, and increases the nutrition regeneration function of skin.Can keep nervous system, blood circulation and skin normal physiological function, the protection skin health is prevented and treated pellagra (mouth, glossitis disease, symmetry dermatitis appears in the exposed position of body surfaces such as two handss, two cheeks) function, so claim antipellagra factor.The character of niacin amide is more stable, is difficult for by acid, alkali and heat damage.
6, vitamin E (tocopherol): being a kind of fatsoluble vitamin, is to claim the tocopherol antioxidant.Processes such as human body is breathed normally, metabolism all can produce Oxidation, and intravital oxygen can change into a kind of extremely unsettled material--free radical.If free-radical generating is excessive, can destroy healthy cell membrane, quicken the aging of body.The vitamin E protein catabolism that can slow down, the delaying skin blood capillary is aging, and the antioxidation of vitamin E can protect polyunsaturated fatty acid on the cell membrane to avoid the attack of free radical, keeps the integrity of cell membrane.Can reduce the oxidation of vitamin A and polybasic unsaturated fatty acid, the control cellular oxidation prevents that unsaturated fatty acid, sex hormone and fat-soluble vitamin are destroyed, promotes the acne wound healing.VE and VC merge and use and can complement each other, and potentiation suppresses the skin sunburn reaction, prevent that skin from because of burning or inflammation causes the cicatrix fiber, impelling the cicatrix of acne flower bud pox level and smooth, beautify skin.Oil-controlling, anti-blackening and skin-whitening cream contains the high concentration vitamin E, and can keep skin lubrication, prevent wrinkle, increase skin elasticity, be to preserve the youth vitamin.Can make the pore perisporium lubricious unobstructed, unlikely sebum stops up, and reaches to prevent acne inflammation effect.
7, vitaminF (linoleic acid, arachic acid, VF): vitaminF is a unsaturated fatty acid.Can prevent the deposition of cholesterol, calcium can be utilized by cell, thereby improve health and grow up.Can prevent the microcirculation degeneration, the function of defying age, wrinkle resistant skin Caring is arranged.Can regulate the secretion of body of gland, the nutrition epidermis cell moistens horny layer, the acne that lipotropism matter thromboembolism causes.
8, cod-liver oil (VAD, vitamin AD): cod-liver oil claims Squalene again, and for efficiently taking oxygen species, energy strengthening immune system and inhibition tumor cell improve cytoactive, make tissue keep best vigor state.The effect similar to Radix Ginseng of many structures arranged after deliberation, as defying age, can foster growth and enhancing body.The Squalene Stability Analysis of Structures is not subject to the attack of peroxylradicals and destroys, and has very strong free radical scavenging activity, is applied in skin surface, can effectively block the Oxidation of single oxygen-derived free radicals, thereby protection skin lipid cell is not subjected to damage of radicals.
9, spiral shell lactone (spironolactone): be inhibitor for androgen, it is synthetic to suppress ovary and adrenal androgen, the androgen receptor of competition hair follicle, the activity of inhibition 5a-reductase, the mechanism of spiral shell lactone treatment acne is relevant with its androgen antagonist effect, has and significantly falls androgenic effect.The androgen secretion increases, and it is vigorous to impel sebaceous gland to grow, and sebum secretion increases, and the follicular orifice keratinization is blocked in addition, causes acne easily.The spiral shell lactone can suppress the secretory action of androgen to sebaceous gland, and the too much output of blocking-up sebum keeps the skin oil and fat balance, and pore is unimpeded, and acne is disappeared.
Cream is made in the said medicine combination routinely promptly obtained this product.Through clinical verification, beneficial effect of the present invention has:
1, the present invention can resist the stimulation of ultraviolet to skin, anti-photosensitivity, anti-solar dermatitis, the photoaging phenomenon of control skin.
2, the present invention can suppress the secretion of skin basal layer melanin, fundamentally prevents the generation of chloasma, makes skin pale.
3, the present invention can suppress sebum secretion, regulates the skin oil and fat balance, eliminates keratotic plug, makes pore unobstructed, so prevent and treat the acne produce effects.
4, the present invention can skin nutrition, enhances metabolism, and the microcirculation improvement stasis of blood stagnates, anoxia, situation that complexion is gloomy, and the effect that suppresses active substance, anti-senile plaque is arranged.Life-time service can lubricate skin, makes skin exquisiteness, ruddy, bright and clean, and the effect of antioxidation base is arranged, can slow down aging.
5, prescription science of the present invention, dosage is fit to, and is cheap, and curative effect is rapidly, significantly.
The specific embodiment
Embodiment one:
Weigh each raw material according to following weight parts:
0.3 part of feritin, 40,000 parts of Mel, 70,000 parts of titanium dioxide, 20,000 parts of carbocisteine, 0.2 ten thousand parts of niacin amide, 0.5 ten thousand parts of vitamin Es, 30,000 parts of vitaminFs, 0.1 ten thousand parts of cod-liver oil, 500 parts of spiral shell lactone, 700,000 parts of substrate frosts.
Cream is made in the said medicine combination routinely.
Using method: 1, severe patient, the high warm season, put on the skin every day 3 times;
2, after two weeks, take a turn for the better obviously, put on the skin every day 2 times;
3, every day 1 time (preceding, the full face of sleeping is put on the skin) after the recovery from illness;
4, sleep before maintenance property put on the skin once;
5, normal skin of face is used: sterilization, antiallergic are arranged, keep healthy, whiten, the effect of skin protection.
Embodiment two:
Weigh each raw material according to following weight parts:
2 parts of feritins, 60,000 parts of Mel, 90,000 parts of titanium dioxide, 50,000 parts of carbocisteine, 30,000 parts of niacin amide, 30,000 parts of vitamin Es, 60,000 parts of vitaminFs, 20,000 parts of cod-liver oil, 800 parts of spiral shell lactone, 830,000 parts of substrate frosts.
Preparation and using method are with embodiment one.
Embodiment three:
Weigh each raw material according to following weight parts:
1 part of feritin, 50,000 parts of Mel, 80,000 parts of titanium dioxide, 30,000 parts of carbocisteine, 10,000 parts of niacin amide, ten thousand parts of vitamin e1s, 50,000 parts of vitaminFs, 0.5 ten thousand parts of cod-liver oil, 700 parts of spiral shell lactone, 760,000 parts of substrate frosts.
Preparation and using method are with embodiment one.
In order to show the present invention at the beneficial effect aspect whitening sun protection, the anti-flower bud, the inventor has carried out clinical trial.In therapeutic process, randomly drawed 92 routine patients, its therapeutic process has been carried out systematic observation.Male's 50 examples wherein, women's 42 examples, age distribution: 15～24 years old 37 example, 25～34 years old 41 example, 35～44 years old 10 example, 45～54 years old 4 example.The patient is divided into experimental group 53 people and matched group 39 people at random.The present invention 7 days was a course of treatment, and process of the test is 4 courses of treatment.
The condition that this test patient is selected in is: belong to oily skin, length has the youth flower bud.
Efficacy assessment standard is:
Cure: healthy looking is ruddy, and the skin oil and fat balance after the various acne flower bud pox treatment, is observed 3 months no recidivists.
Effectively: the colour of skin takes a turn for the better, and acne flower bud pox obviously reduces, and new flower bud pox does not appear in red and swollen the disappearance.
Invalid: as not reach improvement standard person.
Through treatment, the gained data are carried out statistical analysis, the result is as follows:
Table two group patient clinical efficacy is [example (%)] relatively
As can be seen from the above table, in 92 patients, the treatment group has 53 examples, matched group 39 examples, and after the distinct methods treatment, the total effective rate of treatment group is 97%, the total effective rate of matched group is 64%.Learn by statistics and handle two groups of cure rate P＜0.01.Above-mentioned analysis shows, apparently higher than matched group, two groups of total effective rate differences have statistical significance with the cure rate of oil-controlling, anti-blackening and skin-whitening cream treatment group.
Safety analysis:
Use treatment group of the present invention not find obvious toxic-side effects and untoward reaction in the experimental observation process, red and swollen or other allergic phenomena of the pox that do not go out to budding shows and uses this product safety, and has no side effect.
By clinical verification, show that the present invention controls prescription rationally, safe and reliable, to various youth flower bud and improve skin matter, sun-proof, anti-aging effect determined curative effect, satisfactory for result.
Claims (2)
1. oil-controlling, anti-blackening and skin-whitening cream is characterized in that this frost is to be made by the raw material components of following weight portion: 0.3～2 part of feritin, Mel 4～60,000 part, titanium dioxide 7～90,000 part, carbocisteine 2～50,000 part, niacin amide 0.2～30,000 part, vitamin E 0.5～30,000 part, vitaminF 3～60,000 part, cod-liver oil 0.1～20,000 part, 500～800 parts of spiral shell lactone, substrate frost 70～830,000 part.
2. a kind of oil-controlling, anti-blackening and skin-whitening cream according to claim 1 is characterized in that the consumption of each raw material is: 1 part of feritin, 50,000 parts of Mel, 80,000 parts of titanium dioxide, 30,000 parts of carbocisteine, 10,000 parts of niacin amide, 10,000 parts of vitamin Es, 50,000 parts of vitaminFs, 0.5 ten thousand parts of cod-liver oil, 700 parts of spiral shell lactone, 760,000 parts of substrate frosts.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101302333A CN101185622B (en) | 2007-07-16 | 2007-07-16 | Oil-controlling, anti-blackening and skin-whitening cream |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101302333A CN101185622B (en) | 2007-07-16 | 2007-07-16 | Oil-controlling, anti-blackening and skin-whitening cream |
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| Publication Number | Publication Date |
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| CN101185622A CN101185622A (en) | 2008-05-28 |
| CN101185622B true CN101185622B (en) | 2011-05-04 |
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| CN2007101302333A Expired - Fee Related CN101185622B (en) | 2007-07-16 | 2007-07-16 | Oil-controlling, anti-blackening and skin-whitening cream |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023126161A1 (en) * | 2021-12-31 | 2023-07-06 | Unilever Ip Holdings B.V. | A personal care or pharmaceutical composition |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935058A (en) * | 2012-11-25 | 2013-02-20 | 商娜杰 | Skin whitening nutrient bath-assisting pearl lotion |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1371274A (en) * | 1999-06-28 | 2002-09-25 | 宝洁公司 | Cosmetic composition |
| WO2005102011A2 (en) * | 2004-04-21 | 2005-11-03 | The Procter & Gamble Company | Personal care compositions that deposit hydrophilic benefit agents |
| CN1713889A (en) * | 2002-11-07 | 2005-12-28 | 株式会社高丝 | Composition for preparation for external use on skin and method of using the same |
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2007
- 2007-07-16 CN CN2007101302333A patent/CN101185622B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1371274A (en) * | 1999-06-28 | 2002-09-25 | 宝洁公司 | Cosmetic composition |
| CN1713889A (en) * | 2002-11-07 | 2005-12-28 | 株式会社高丝 | Composition for preparation for external use on skin and method of using the same |
| WO2005102011A2 (en) * | 2004-04-21 | 2005-11-03 | The Procter & Gamble Company | Personal care compositions that deposit hydrophilic benefit agents |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023126161A1 (en) * | 2021-12-31 | 2023-07-06 | Unilever Ip Holdings B.V. | A personal care or pharmaceutical composition |
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| CN101185622A (en) | 2008-05-28 |
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