KR102012019B1

KR102012019B1 - Patch for prevention and treatment of stretch mark

Info

Publication number: KR102012019B1
Application number: KR1020170136450A
Authority: KR
Inventors: 김정희
Original assignee: 김 정희
Priority date: 2017-06-09
Filing date: 2017-10-20
Publication date: 2019-08-19
Also published as: KR20180134730A

Abstract

The present invention provides a composition for preventing and improving stretch marks comprising aloe vera leaf extract, centella extract, portulaca extract, hosttail kelp extract, seaweed extract, tea tree leaf extract, hollyhock extract as an active ingredient and a patch comprising the same. do. The patch according to the present invention promotes collagen production in damaged dermal tissues to activate the regeneration of the skin to easily solve the aging wrinkles after childbirth, weight loss, rapid weight gain, rapid growth, muscle production, and new forms. As a stretcher care product, you can fix stretch marks that you are worried about after giving birth with a patch.

Description

Patch for prevention and treatment of stretch marks {PATCH FOR PREVENTION AND TREATMENT OF STRETCH MARK}

The present invention relates to a patch that can be attached to the skin to prevent, treat and improve stretch marks.

Stretch marks refer to atrophic linear band lesions on the skin of the area damaged by the pulling force. Histologically, the epidermis shrinks and the dermis becomes thinner and rearranged parallel to the skin. Early lesions appear to have red lines or bands on the skin, which, when examined closely, are slightly sunk than normal skin, making them feel bumpy when touched. These lesions are called purple ancestors (striae rubra). Purple ancestors gradually become white over time, becoming less pronounced, turning into wrinkled and atrophic skin, which is called a white ancestor (striae alba).

Stretch marks are most common on the arms, thighs, abdomen, buttocks, and furrows, but they can also occur on other areas of the skin, such as the face, and stretch marks caused by Cushing's syndrome may occur on the skin of the folded area. . In addition, stretch marks caused by pregnancy are common in the abdomen and breasts. Stretch marks in obese patients tend to be less pronounced, less atrophic, and narrower than stretch marks in Cushing's syndrome patients. Rarely, large stretch marks can cause ulcers or cracked skin.

The mechanism of stretch marks is not exactly known, but it is believed that excessive skin elongation results in some breakdown of the bonds between collagen fibers. In most cases, this can happen when the skin stretches rapidly, such as pregnancy, excess corticosteroids, and rapid weight gain. It is speculated that the genetic predisposition may have some effect since stretch marks may occur together in identical twins. Stretching is more common in obese adults and children, and in older adolescents it is more often associated with secondary sexual characteristics such as breast development than obesity.

In 90% of women who are pregnant, stretch marks can be seen, as the abdominal skin increases with pregnancy, which also increases female hormones and corticosteroids. Young men who frequently carry heavy loads or exercise muscles may have stretch marks on both shoulders. Hormones are also associated with stretch marks, which can occur when patients with Cushing's syndrome or with long-term administration or application of corticosteroids.

Stretch marks are not a medical problem, but may require treatment at the cosmetic level. However, there is no known method to cure stretch marks completely. Most of the treatments known to date are not effective for stretch marks that have completely become scar tissue, so early treatment can be expected to be more effective.

Retinoic acid (retinoic acid) coating agents such as tretinoin (tretinoin) is widely used as a primary treatment, and other effects such as glycolic acid (glycolic acid) or trichloroacetic acid (TCA) may be expected to be effective. Even if you lose weight with diet or exercise, your stretch marks will not improve. Applying a moisturizer and oil massage can help to prevent stretch marks.

Recently, various lasers have been used to treat stretch marks. Treatment with a pulsed dye laser (585 nm) is the best known, which works for early red streaks but not for white streaks. There is also research showing that the combination of pigmented laser and high frequency treatment is more effective. A 1064nm Nd: YAG laser can also be used to treat early stretch marks.

Treatment of white streak with a 308 nm excimer laser may improve pigmentation and improve atrophy, but it does not restore atrophic skin. IPL (intensive pulsed light) can also improve old stretch marks. Recently, lasers using the principle of fractional photopyrolysis have been shown to be effective in both early and late stretch marks by increasing dermal collagen and elastic fibers. In addition, various treatments such as carbon dioxide lasers, Erbium lasers (Er: YAG laser), microdermabrasion, and radiofrequency therapy have been attempted to treat stretch marks. However, there is still a need for the development of hypoallergenic products, which can be easily applied by the general user, especially for pregnant women, with excellent stretch prevention and improvement effect.

The present invention relates to a patch containing a natural ingredient that can be used by pregnant women, while also preventing, treating and improving the stretch marks when attached to the skin, and a method of manufacturing the same.

In order to achieve the above object, the present invention provides a composition for preventing or improving stretch marks, characterized in that it contains a natural plant-derived extract as an active ingredient.

The natural plant-derived extract is aloe vera leaf extract, Centella asiatica extract, Portulaca extract, hosttail kelp extract, seaweed seaweed extract, tea tree leaf extract, hollyhock extract.

In addition, hydrolyzed collagen (Hydrolyzed Collagen), adenosine, sodium hyaluronate (Sodium Hyaluronate), may further include a peptide.

On the other hand, the aloe vera leaf extract, Centella asiatica extract, Portulaca extract, hostil kelp extract, seaweed seaweed extract, tea tree leaf extract, hollyhock extract is characterized in that 1 to 90 parts by weight based on the dry weight of the total composition. If the composition is less than 1 on a dry weight basis, the skin elasticity, moisturizing, stretch marks improvement effect is insignificant and may not appear synergistic with other attached elasticity improvement components.

Hydrolyzed collagen, adenosine, sodium hyaluronate, and peptite are 0.1-20 parts by weight based on the total composition. The components work together with natural product extracts, in particular, to further increase skin elasticity and moisture improvement effect, thereby increasing the stretch and prevention effect.

Another aspect of the invention is to provide a patch comprising the composition. The patch has a function of preventing and improving stretch marks as well as wrinkle improvement and moisturizing functions. The patch may be manufactured according to a conventional patch manufacturing method, and the through hole may be formed to be attached to the abdomen to fit the navel portion. By forming the through hole

When the patch is attached to the skin is flat, the adhesion is good and smoothly attached, when attached to the navel, such as the abdomen patch there is a problem that the patch is squashed as a whole due to the groove of the navel. Therefore, when the through-hole is formed in the patch can be attached to match the navel portion, and prevents wrinkles are neatly attached and there is an effect that the adhesive force lasts. In addition, the attachment position can be accurately selected by bringing the through-hole to the navel during the abdominal attachment, which is a relatively wide part, so that the active ingredient can be absorbed well in the abdomen.

In addition, when attached to a large area, the adhesion of all patches need not be strong, and for minimal stimulation, the adhesion of the middle part may be slightly weaker than around the edges.

In addition, the patch of the present invention comprises the composition as an active ingredient, characterized in that it further comprises a hydrogel component to increase skin irritation relief and adhesion. Hydrogel is applied after removal to the skin to relieve skin tension, moisturize skin, enhance elasticity, reduce wrinkles, adsorb and remove wastes and contaminants on the skin surface, remove old dead skin cells, remove excess sebum, and smooth the skin. Psychological stability and nutritional function. Not only does it improve the processability of the hydrogel product, it is also excellent in elasticity and softness.

Hydrogels include polyacrylic acid, polyether, polyvinyl alcohol, cellulose derivatives, polysaccharide derivatives, animal and vegetable water-soluble polymers (agar, glucomannan, guar gum, locust bean gum, carrageenan, gellan gum, xantham gum, etc.). ), Cross-linking, or by using the formation of the material itself can be used to select one or more kinds.

Therefore, the patch formulation of the present invention can be attached to a wide area and can be attached conveniently in daily life because there is no stain, as well as natural plant extracts as the main ingredient, there is no skin irritation even after prolonged application can be used for pregnant women. Do.

The patch according to the present invention promotes collagen production in damaged dermal tissues to activate the regeneration of the skin to easily solve the aging wrinkles after childbirth, weight loss, rapid weight gain, rapid growth, muscle production, and new forms. As a stretcher care product, you can fix stretch marks that you are worried about after giving birth with a patch.

In addition, the heat of the patch increases the basal metabolism and helps the health of the warmed abdomen, and it can be adhered to the skin continuously so that it can improve the elasticity recovery of the skin in a short period of time and restore the stretch / elasticity and super moisturizing effect. Indicates.

And by using safe vegetable raw materials and natural extracts, it is hypoallergenic to the skin and can be used by pregnant women without side effects.

1 is a photograph before and after using directly on the skin of the formula contained in the patch of the present invention,
2 is a schematic diagram of an abdominal patch of the present invention,
3 is a schematic view of the abdomen of the patch of the present invention.

Natural plant-derived extract of the present invention is aloe vera leaf extract, Centella asiatica extract, March extract, hosttail kelp extract, seaweed extract, tea tree leaf extract, hollyhock extract. The natural plant-derived extracts may be preferably added in an amount of 1 to 90.0 parts by weight based on the dry weight of the total composition.

In addition, the present invention may further include a hydrolyzed collagen, adenosine, sodium hyaluronate, and a peptite component. It contains wrinkle-improving functional ingredients such as “adenosine” and natural plant-derived extracts with excellent skin moisturizing effect, so as to firm the areas where partial skin wrinkles are anxious, and promptly increase water absorption and effective patch type formulations. Maximizing strong synergistic effect through fusion creates elasticity, and as a result, prevents, treats and improves stretch marks by the action of wrinkle functional mechanism of safe ingredients.

In addition, the differentiated ingredients help to improve the wrinkles and elasticity reduction site by the effective absorption mechanism, and can be used at any time as a refreshing watery type can be added a large amount of wrinkle improvement functional ingredients.

Meanwhile, the composition of the present invention is a warning agent (PLASTERS), lotion (LOTIONS), linings (LINIMENTS), liquids (LIQUIDS AND SOLUTIONS), aerosols (AEROSOLS), EXTRACTS, ointments (OINTMENTS), FLUIDEXTRACTS, EMULSIONS, SUSPENSIONS, CAPSULES, CREAMS, soft or hard gelatin capsules, patch, sustained release agent.

On the other hand, in the composition of the present invention, the extract is about 2 to 20 times, preferably about 2 to 5 times water or the polarity of the lower (C1-C4) alcohol containing methanol, ethanol to the powder ground powder It can extract by adding a solvent or these mixed solvent.

On the other hand, in the composition of the present invention, the extract is extracted at 10 ~ 30 ℃ temperature by adding one solvent or a mixed solvent of water or lower (C1-C4) alcohol containing methanol, ethanol to the raw material; Filtering the obtained extract, and then concentrating and lyophilizing; And, it may be obtained from the process comprising the step of extracting by adding any one or more solvents selected from purified water, ethanol, butylene glycol, propylene glycol to the obtained concentrate or lyophilisate.

In the composition of the present invention, the extraction may be, for example, any extraction method selected from cold needle extraction, reflux cooling extraction, hot water extraction, ultrasonic extraction and ultra-high pressure extraction.

On the other hand, in the composition of the present invention, the plant extract is preferably added 1 to 90.0 parts by weight on a dry weight basis with respect to the total composition. In addition, for the delivery and stabilization of the active ingredient, etc. may be added to the various components as a subcomponent to be formulated in various forms (formulation).

The efficacy of the natural plant-derived extract of the present invention is as follows.

1) Aloe Vera Leaf Extract

Aloe Vera leaf extract with strong vitality contains about 300 different ingredients such as vitamins A, C, D, E, B12, amino acids, and aloecin, and soothes, moisturizes, softens, softens and conditions skin. It has the effect of improving to healthy skin.

2) Centella extract

Pung Pung Extract has excellent skin regeneration effects such as promoting collagen synthesis, healing wounds, stimulating wrinkles, improving wrinkles, increasing elasticity, reducing pores, preventing invasion of external harmful substances, healing wounds, and promoting blood circulation.

3) March extract

It contains a large amount of natural moisturizing factor (NMF) and water, and it is a natural vegetable moisturizer. It contains amino acids and various functional ingredients (Vitamin B1, C, Carotene, Nicotin acid, Tocopherol, trace minerals, etc.).

4) Hosttail Kelp Extract

It contains abundant moisturizing factor fucoidan, which moisturizes the skin from dryness and protects against invasion of bacteria from wounds.

5) Seaweed Extract

It is rich in vitamin A and is called 'Retinol of the Sea'. It is a plant active ingredient that gives conditioning to the skin and helps vitality of skin care. In addition, it helps to reduce skin activity due to aging and gives young energy and elasticity to the skin. It also helps to maintain healthy skin by protecting the skin from the outside and improving self-growth ability.

6) Tea Tree Leaf Extract

Tea tree leaf extract regulates excessive secretion of sebum, provides moisture, helps improve sensitive skin and oily skin, gives freshness, and manages sensitive problem skin to be clean and moist.

7) Hollyhock Extract

It is an emollient function that keeps the hydrangea extract in the skin to improve the skin's moisturizing ability, prevents the activity of harmful substances from outside, and also helps to improve the troubled skin with anti-inflammatory and anti-viral functions.

On the other hand, the components added to the composition of the present invention with the natural extracts are as follows.

1) Hydrolyzed Collagen

As it helps to make elastic tissue cells, it is not only excellent for preventing aging, but also helps to form a film and gently wraps the skin, and supplies moisture to the skin to help keep it moist.

2) adenosine

Adenosine is a nucleoside that is involved in signal transduction outside the cell and is directly involved in cell growth, differentiation and homeostasis, thereby improving wrinkles, cell activation, and preventing aging.

3) Sodium Hyaluronate

Moisturizes the skin, protects the skin, regenerates the skin, and antibacterials

Increases the moisture in the skin to keep the skin moisturized and fresh. It protects the skin from the causes of skin troubles such as ultraviolet rays, cigarette smoke, and nitrogen oxides, thereby preventing the skin's immunity from degrading and repairing damaged skin. Growth factors, including keratinocyte growth factor and fibroblast growth factor, are included to activate cells.

4) Peptides

It is a functional substance that shows strong activity when it enters the human body and then disappears and has a high binding ability with water. It does not have the characteristic of changing or oxidizing and does not show activity depending on the reducing power of the substitution activity group, but shows activity based on a specific amino acid sequence. Skin anti-aging, skin elasticity regeneration effect.

Hereinafter, the present invention will be described in more detail with reference to Examples.

Example 1 Preparation of Natural Extracts

Aloe vera leaf extract, Centella asiatica extract, Portulaca extract, Hostile kelp extract, Seaweed seaweed extract, Tea tree leaf extract, Dried flower root extract are about 2 to 20 times, preferably about 2 to 5 times the original powder. Was prepared by extracting the mixture with water and methanol.

Example 2: Preparation of stretch marks prevention and improvement composition

To prepare a composition comprising the extract and the elasticity improvement component and other components as shown in Table 1 below.

ingredient Compounding ratio (% by weight) Purified water To 100 Dipropylene glycol 0.01 glycerin 0.01 Dimethicone 0.01 Hydrolyzed Collagen One Horsetail Kelp Extract 5 Seaweed Extract 5 Tea Tree Leaf Extract 5 March extract 5 R-oligopeptide-1 One Hollyhock Extract 5 Aloe Vera Leaf Extract 5 Sodium hyaluronate One Polysorbate 20 2 Cetyl Fiji / Fiji -10/1 dimethicone 2 Sodium chloride 2 Ethylhexylglycerin 0.1 Adenosine One Caprylyl Glycol 0.01 Disodium ID 0.01 1,2-hexanediol 0.01

Example 3 Preparation of Abdominal Patches for Preventing and Improving Stretch Tensile

A patch for skin patch having the same shape as that of FIG. 1 including the composition of Example 2 was prepared. Patches of the invention can be prepared in a hydrogel formulation comprising the composition. Hydrogel is applied after skin removal to reduce skin tension, moisturize skin, increase elasticity, reduce wrinkles, adsorb and remove wastes and contaminants on skin surface, remove old dead skin cells, remove excess sebum, and smooth skin. It has a stable effect and nutrient supply. Not only does it improve the processability of the hydrogel product, it is also excellent in elasticity and softness. Hydrogels include polyacrylic acid, polyether, polyvinyl alcohol, cellulose derivatives, polysaccharide derivatives, animal and vegetable water-soluble polymers (agar, glucomannan, guar gum, locust bean gum, carrageenan, gellan gum, xantham gum, etc.). ), Cross-linking, or by using the formation of the material itself can be used to select one or more kinds.

Test Example 1: Tensile Improvement Test

The compositions and patches prepared in Examples 1 and 2 were selected from 30 women with stretch marks in their 20s and 40s and used for 6 months to confirm the treatment of stretch marks.

In the case of the composition, apply 3g to the abdomen every morning and evening in the case of the composition to massage and absorb it sufficiently.In the case of the patch type, take out the patch and apply the ample to the belly sufficiently, and after removing the film in the middle of the patch, heart shape After attaching to the navel first, remove the rest and attach it to the skin to press the patch evenly for 30 seconds. Patches were applied every morning and evening to measure the tenderness, skin color change, and elasticity change on a weekly basis.

(5. Very good, 4. Good, 3. Normal, 2. No difference. 1. Not good)

The evaluation results of 30 subjects averaged 4.8 points, almost all of which resulted in lightening of the stretched skin after 1 week and increased skin elasticity. After 4 weeks, more than 90% of the subjects showed a marked improvement in the stretched skin. .

Test Example 2 skin wrinkle improvement and elasticity recovery test

The same application as in Test Example 1 was tested for skin wrinkle improvement and elasticity recovery test. As in Test Example 1, it was confirmed that after one week from the start of the test, the moisture content was increased and the skin wrinkles were improved. The evaluation result of 30 subjects was an average of 4.75 points, and after 4 weeks, more than 90% of the subjects noticeably improved wrinkles and elasticity.

Test Example 3: skin irritation test

Thirty pregnant women in their 20s to 40s were selected for the composition and the patch prepared in Examples 1 and 2 and used for 6 months to check the elasticity and the prevention of stretch marks and hypoallergenicity. The method of use is the same as Test Examples 1 and 2. As a result of the test, more than 80% of the subjects evaluated no itching or skin color change. In particular, the patch applied to the skin was evaluated as being convenient and effective for long periods of time since there was no irritation and lack of skin irritation, and the patch form of the hydrogel formulation was evaluated as the most desirable because it had the least irritation of the skin.

As a result of the evaluation as described above, the stretch composition and patch for improving and preventing the cosmetic composition according to the present invention has an excellent effect of improving the stretch area, improves skin elasticity and the density of the dermis layer, and has an excellent effect for the user to have satisfaction. Indicated.

In particular, the free radicals generated by UV exposure, environmental pollution, and stress damage the collagen and elastin tissues in the skin to produce wrinkles. The phytochemical and vitamin components of the present invention help to eliminate the free radicals. It protects the skin and helps to promote the synthesis of collagen and elastin in the skin, making the skin elastic, and the action of peptides and phytochemicals to produce a healthy skin texture. In addition, the patch-type can be attached to the entire wide area that is likely to stretch, it can be used easily without the inconvenience of having to be applied to the entire surface or buried, the effect is long-lasting.

Claims

1 ~ 90.0 parts by weight of aloe vera leaf extract, Centella asiatica extract, Portulaca extract, Hostile kelp extract, seaweed seaweed extract, tea tree leaf extract, and hollyhock extract based on dry weight based on 100 parts by weight of the total composition, Preventing stretch marks comprising 0.1-20 parts by weight of one or more selected from the group consisting of rolled collagen, adenosine, sodium hyaluronate, and peptides based on 100 parts by weight of the total composition; and Improvement composition.

delete

A patch comprising the composition of claim 1.

6. The patch of claim 5, wherein the patch further comprises a hydrogel component.

The patch of claim 5, wherein the patch is for wrinkle improvement and moisturizing.

The patch of claim 5, wherein the through hole is formed to be attached to the abdomen by fitting the navel portion.