CN107001405B - 制备坎格雷洛中间体的方法 - Google Patents

制备坎格雷洛中间体的方法 Download PDF

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Publication number
CN107001405B
CN107001405B CN201680003950.7A CN201680003950A CN107001405B CN 107001405 B CN107001405 B CN 107001405B CN 201680003950 A CN201680003950 A CN 201680003950A CN 107001405 B CN107001405 B CN 107001405B
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CN
China
Prior art keywords
cangrelor
cangrelor intermediate
reaction
preparing
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201680003950.7A
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English (en)
Chinese (zh)
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CN107001405A (zh
Inventor
肖玉华
李燕兵
万振江
陈埔
李�荣
孙绍光
吴成龙
黄金昆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Chengdu Suncadia Pharmaceuticals Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Chengdu Suncadia Pharmaceuticals Co Ltd
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Priority to CN201811147540.7A priority Critical patent/CN109232694A/zh
Publication of CN107001405A publication Critical patent/CN107001405A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680003950.7A 2015-11-06 2016-11-01 制备坎格雷洛中间体的方法 Active CN107001405B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811147540.7A CN109232694A (zh) 2015-11-06 2016-11-01 制备坎格雷洛中间体的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2015107521150 2015-11-06
CN201510752115 2015-11-06
PCT/CN2016/104182 WO2017076266A1 (fr) 2015-11-06 2016-11-01 Procédé de préparation du (2r,3s,4r,5r)-2-(hydroxyméthyl)-5-(6-((2-(méthylthio)éthyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9h-purine-9-yl)tétrahydrofuranne-3,4-diol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811147540.7A Division CN109232694A (zh) 2015-11-06 2016-11-01 制备坎格雷洛中间体的方法

Publications (2)

Publication Number Publication Date
CN107001405A CN107001405A (zh) 2017-08-01
CN107001405B true CN107001405B (zh) 2019-03-05

Family

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CN201811147540.7A Pending CN109232694A (zh) 2015-11-06 2016-11-01 制备坎格雷洛中间体的方法
CN201680003950.7A Active CN107001405B (zh) 2015-11-06 2016-11-01 制备坎格雷洛中间体的方法

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CN201811147540.7A Pending CN109232694A (zh) 2015-11-06 2016-11-01 制备坎格雷洛中间体的方法

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CN (2) CN109232694A (fr)
WO (1) WO2017076266A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109912674A (zh) 2017-12-12 2019-06-21 亚宝药业集团股份有限公司 一种坎格雷洛四钠盐的制备方法
CN108586557A (zh) * 2018-01-04 2018-09-28 华东师范大学 一种坎格雷诺中间体的制备方法
CN108033983B (zh) * 2018-02-09 2021-06-08 盐城锦明药业有限公司 一种2‐(3,3,3‐三氟丙基)硫代腺苷的合成方法
CN113943334B (zh) * 2020-06-30 2024-04-09 常州方圆制药有限公司 一种a2a腺苷受体激动剂的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW326045B (en) * 1993-02-10 1998-02-01 Astra Pharma Prod N-alkyl-2-substituted ATP analogues the invention relates to a compound of formula (I) and its pharmaceutically acceptable salt which can be used for inhibition of platelet aggregation.
US8951480B2 (en) * 2008-08-19 2015-02-10 The Regents Of The University Of California Modular radiochemistry synthesis system
ES2714094T3 (es) * 2013-09-06 2019-05-27 Hoffmann La Roche Derivados de triazolo[4,5-d]pirimidina como antagonistas del receptor cb2
CN104610249B (zh) * 2014-12-25 2017-09-15 中国农业科学院植物保护研究所 一种二效价磺酰基异恶唑衍生物及其应用

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Publication number Publication date
CN107001405A (zh) 2017-08-01
WO2017076266A1 (fr) 2017-05-11
CN109232694A (zh) 2019-01-18

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