CN106974938A - 一种具有抗肝癌作用的骨髓间充质干细胞来源的外泌体及其药物制剂 - Google Patents
一种具有抗肝癌作用的骨髓间充质干细胞来源的外泌体及其药物制剂 Download PDFInfo
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- CN106974938A CN106974938A CN201710241785.5A CN201710241785A CN106974938A CN 106974938 A CN106974938 A CN 106974938A CN 201710241785 A CN201710241785 A CN 201710241785A CN 106974938 A CN106974938 A CN 106974938A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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CN201710241785.5A CN106974938B (zh) | 2017-04-14 | 2017-04-14 | 一种具有抗肝癌作用的骨髓间充质干细胞来源的外泌体及其药物制剂 |
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CN201710241785.5A CN106974938B (zh) | 2017-04-14 | 2017-04-14 | 一种具有抗肝癌作用的骨髓间充质干细胞来源的外泌体及其药物制剂 |
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CN106974938A true CN106974938A (zh) | 2017-07-25 |
CN106974938B CN106974938B (zh) | 2020-06-23 |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108373996A (zh) * | 2018-03-29 | 2018-08-07 | 王丽丽 | 一种在面部年轻化中脂肪干细胞外泌体的制备和应用 |
CN108865976A (zh) * | 2018-07-19 | 2018-11-23 | 复旦大学附属中山医院 | 一种离散汲取收集外泌体(exosome)的方法及试剂 |
CN110075122A (zh) * | 2019-05-09 | 2019-08-02 | 复旦大学附属中山医院 | 一种肝癌治疗性外泌体药物 |
CN110124058A (zh) * | 2019-06-06 | 2019-08-16 | 福建医科大学附属第一医院 | 一种来源于骨髓间充质干细胞外泌体-阿霉素纳米靶向药物的制备及体外抗骨肉瘤的研究 |
CN112280734A (zh) * | 2018-05-17 | 2021-01-29 | 广东芙金干细胞再生医学有限公司 | 一种外泌体的制备方法及含有外泌体的干细胞增殖试剂 |
CN112773775A (zh) * | 2021-01-13 | 2021-05-11 | 广东药科大学 | 一种负载去甲斑蝥素外泌体的制备方法及其应用 |
CN113171378A (zh) * | 2021-04-30 | 2021-07-27 | 奥启(深圳)创投科技有限公司 | 一种用于防治男性性功能障碍的干细胞外泌体制剂 |
CN115975036A (zh) * | 2022-08-18 | 2023-04-18 | 北京诺赛国际医学研究院 | 包含干细胞的药物组合物及其治疗癌症的用途 |
Citations (3)
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CN102349998A (zh) * | 2011-10-20 | 2012-02-15 | 天津大学 | 以外泌体为基础的疏水性抗癌药物制剂 |
CN105968111A (zh) * | 2016-07-14 | 2016-09-28 | 华润赛科药业有限责任公司 | 吡啶并咪唑类衍生物、其制备方法和应用 |
CN106083847A (zh) * | 2016-08-03 | 2016-11-09 | 山东大学 | 一种咪唑并吡啶巯乙酸类衍生物及其制备方法与应用 |
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2017
- 2017-04-14 CN CN201710241785.5A patent/CN106974938B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102349998A (zh) * | 2011-10-20 | 2012-02-15 | 天津大学 | 以外泌体为基础的疏水性抗癌药物制剂 |
CN105968111A (zh) * | 2016-07-14 | 2016-09-28 | 华润赛科药业有限责任公司 | 吡啶并咪唑类衍生物、其制备方法和应用 |
CN106083847A (zh) * | 2016-08-03 | 2016-11-09 | 山东大学 | 一种咪唑并吡啶巯乙酸类衍生物及其制备方法与应用 |
Non-Patent Citations (2)
Title |
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HIROTAKA TSUNO等: "Effects of methotrexate and salazosulfapyridine on protein profiles of exosomes derived from a human synovial sarcoma cell line of SW982.", 《PROTEOMICS-CLINICAL APPLICATIONS》 * |
ZHANG H等: "Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis.", 《NATURE COMMUNICATIONS》 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108373996A (zh) * | 2018-03-29 | 2018-08-07 | 王丽丽 | 一种在面部年轻化中脂肪干细胞外泌体的制备和应用 |
CN112280734A (zh) * | 2018-05-17 | 2021-01-29 | 广东芙金干细胞再生医学有限公司 | 一种外泌体的制备方法及含有外泌体的干细胞增殖试剂 |
CN108865976A (zh) * | 2018-07-19 | 2018-11-23 | 复旦大学附属中山医院 | 一种离散汲取收集外泌体(exosome)的方法及试剂 |
CN108865976B (zh) * | 2018-07-19 | 2022-06-28 | 复旦大学附属中山医院 | 一种离散汲取收集外泌体(exosome)的方法及试剂 |
CN110075122A (zh) * | 2019-05-09 | 2019-08-02 | 复旦大学附属中山医院 | 一种肝癌治疗性外泌体药物 |
CN110124058A (zh) * | 2019-06-06 | 2019-08-16 | 福建医科大学附属第一医院 | 一种来源于骨髓间充质干细胞外泌体-阿霉素纳米靶向药物的制备及体外抗骨肉瘤的研究 |
CN110124058B (zh) * | 2019-06-06 | 2021-11-26 | 福建医科大学附属第一医院 | 一种来源于骨髓间充质干细胞外泌体-阿霉素纳米靶向药物的制备及体外抗骨肉瘤的研究 |
CN112773775A (zh) * | 2021-01-13 | 2021-05-11 | 广东药科大学 | 一种负载去甲斑蝥素外泌体的制备方法及其应用 |
CN112773775B (zh) * | 2021-01-13 | 2022-12-20 | 广东药科大学 | 一种负载去甲斑蝥素外泌体的制备方法及其应用 |
CN113171378A (zh) * | 2021-04-30 | 2021-07-27 | 奥启(深圳)创投科技有限公司 | 一种用于防治男性性功能障碍的干细胞外泌体制剂 |
CN115975036A (zh) * | 2022-08-18 | 2023-04-18 | 北京诺赛国际医学研究院 | 包含干细胞的药物组合物及其治疗癌症的用途 |
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Effective date of registration: 20200828 Address after: 132011 south of 2nd floor, Block E, high tech Industrial Development Zone, Jilin City, Jilin Province Patentee after: Zhongke Juyan stem cell Co., Ltd Address before: 132113 south side of the second floor, building e, national entrepreneurship Park, Shenzhen street, high tech Zone, Jilin City, Jilin Province Patentee before: Jilin Huirong Regenerative Medicine Co.,Ltd. |
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Effective date of registration: 20210422 Address after: 132000 south of the second floor, Block E, Pioneer Park, Jilin high tech Industrial Development Zone, Jilin Province Patentee after: Zhongke Juyan (Jilin) stem cell technology Co.,Ltd. Address before: 132011 south of 2nd floor, Block E, high tech Industrial Development Zone, Jilin City, Jilin Province Patentee before: Zhongke Juyan stem cell Co., Ltd |
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