CN106967172B - 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 - Google Patents

抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 Download PDF

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Publication number
CN106967172B
CN106967172B CN201610705624.2A CN201610705624A CN106967172B CN 106967172 B CN106967172 B CN 106967172B CN 201610705624 A CN201610705624 A CN 201610705624A CN 106967172 B CN106967172 B CN 106967172B
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seq
antibody
amino acid
variable region
acid sequence
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Chinese (zh)
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CN106967172A (zh
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李百勇
夏瑜
王忠民
张鹏
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Akeso Pharmaceuticals Inc
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Akeso Pharmaceuticals Inc
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Priority to CN201610705624.2A priority Critical patent/CN106967172B/zh
Publication of CN106967172A publication Critical patent/CN106967172A/zh
Priority to EA201990571A priority patent/EA201990571A1/ru
Priority to SG11201901583WA priority patent/SG11201901583WA/en
Priority to MX2019002254A priority patent/MX2019002254A/es
Priority to IL264964A priority patent/IL264964B2/en
Priority to EP17842896.7A priority patent/EP3511346A4/en
Priority to BR112019003695-4A priority patent/BR112019003695A2/pt
Priority to PCT/CN2017/098466 priority patent/WO2018036473A1/zh
Priority to KR1020197008463A priority patent/KR102503084B1/ko
Priority to US16/327,076 priority patent/US11578128B2/en
Priority to NZ791621A priority patent/NZ791621A/en
Priority to AU2017317124A priority patent/AU2017317124B2/en
Priority to CA3034850A priority patent/CA3034850A1/en
Priority to JP2019531513A priority patent/JP7425604B2/ja
Priority to NZ751904A priority patent/NZ751904A/en
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Publication of CN106967172B publication Critical patent/CN106967172B/zh
Priority to JP2022089567A priority patent/JP2022130393A/ja
Priority to US18/067,669 priority patent/US12479919B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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CN201610705624.2A 2016-08-23 2016-08-23 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 Active CN106967172B (zh)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CN201610705624.2A CN106967172B (zh) 2016-08-23 2016-08-23 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
KR1020197008463A KR102503084B1 (ko) 2016-08-23 2017-08-22 항-ctla4 및 항-pd-1 이작용성 항체, 이의 약제학적 조성물 및 이의 용도
NZ791621A NZ791621A (en) 2016-08-23 2017-08-22 Anti-CTLA4 and anti-PD-1 bifunctional antibody, pharmaceutical composition thereof and use thereof
MX2019002254A MX2019002254A (es) 2016-08-23 2017-08-22 Anticuerpo bifuncional anti-ctla4 y anti-pd-1, composicion farmaceutica y uso de este.
IL264964A IL264964B2 (en) 2016-08-23 2017-08-22 Anti-CTLA4 and anti-PD1 bifunctional antibody, pharmaceutical preparation thereof and use thereof
EP17842896.7A EP3511346A4 (en) 2016-08-23 2017-08-22 BIFUNCTIONAL ANTI-CTLA4 AND ANTI-PD-1 ANTIBODIES, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
BR112019003695-4A BR112019003695A2 (pt) 2016-08-23 2017-08-22 anticorpo bifuncional anti-ctla4 e anti-pd-1, composição farmacêutica do mesmo e uso do mesmo
PCT/CN2017/098466 WO2018036473A1 (zh) 2016-08-23 2017-08-22 抗ctla4-抗pd-1双功能抗体、其药物组合物及其用途
EA201990571A EA201990571A1 (ru) 2016-08-23 2017-08-22 Бифункциональное антитело против ctla4 и против pd-1, его фармацевтическая композиция и их применение
US16/327,076 US11578128B2 (en) 2016-08-23 2017-08-22 Anti-CTLA4 and anti-PD-1 bifunctional antibody, pharmaceutical composition thereof and use thereof
SG11201901583WA SG11201901583WA (en) 2016-08-23 2017-08-22 Anti-ctla4 and anti-pd-1 bifunctional antibody, pharmaceutical composition thereof and use thereof
AU2017317124A AU2017317124B2 (en) 2016-08-23 2017-08-22 Anti-CTLA4 and anti-PD-1 bifunctional antibody, pharmaceutical composition thereof and use thereof
CA3034850A CA3034850A1 (en) 2016-08-23 2017-08-22 Anti-ctla4 and anti-pd-1 bifunctional antibody, pharmaceutical composition thereof and use thereof
JP2019531513A JP7425604B2 (ja) 2016-08-23 2017-08-22 抗ｃｔｌａ４－抗ｐｄ－１二機能性抗体、その医薬組成物および使用
NZ751904A NZ751904A (en) 2016-08-23 2017-08-22 Anti-ctla4 and anti-pd-1 bifunctional antibody, pharmaceutical composition thereof and use thereof
JP2022089567A JP2022130393A (ja) 2016-08-23 2022-06-01 抗ｃｔｌａ４－抗ｐｄ－１二機能性抗体、その医薬組成物および使用
US18/067,669 US12479919B2 (en) 2016-08-23 2022-12-16 Anti-CTLA4 and anti-PD-1 bifunctional antibody, pharmaceutical composition thereof and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610705624.2A CN106967172B (zh) 2016-08-23 2016-08-23 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途

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CN106967172A CN106967172A (zh) 2017-07-21
CN106967172B true CN106967172B (zh) 2019-01-08

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US (2) US11578128B2 (cg-RX-API-DMAC7.html)
EP (1) EP3511346A4 (cg-RX-API-DMAC7.html)
JP (2) JP7425604B2 (cg-RX-API-DMAC7.html)
KR (1) KR102503084B1 (cg-RX-API-DMAC7.html)
CN (1) CN106967172B (cg-RX-API-DMAC7.html)
AU (1) AU2017317124B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019003695A2 (cg-RX-API-DMAC7.html)
CA (1) CA3034850A1 (cg-RX-API-DMAC7.html)
EA (1) EA201990571A1 (cg-RX-API-DMAC7.html)
IL (1) IL264964B2 (cg-RX-API-DMAC7.html)
MX (1) MX2019002254A (cg-RX-API-DMAC7.html)
NZ (2) NZ751904A (cg-RX-API-DMAC7.html)
SG (1) SG11201901583WA (cg-RX-API-DMAC7.html)
WO (1) WO2018036473A1 (cg-RX-API-DMAC7.html)

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US10513558B2 (en) 2015-07-13 2019-12-24 Cytomx Therapeutics, Inc. Anti-PD1 antibodies, activatable anti-PD1 antibodies, and methods of use thereof

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IL263542B2 (en) 2016-06-14 2024-10-01 Xencor Inc Bispecific antibodies inhibit immunological checkpoint
CN106967172B (zh) * 2016-08-23 2019-01-08 康方药业有限公司 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
CN106977602B (zh) 2016-08-23 2018-09-25 中山康方生物医药有限公司 一种抗pd1单克隆抗体、其药物组合物及其用途
WO2018035710A1 (en) 2016-08-23 2018-03-01 Akeso Biopharma, Inc. Anti-ctla4 antibodies
CN108866635B (zh) * 2017-05-09 2021-11-26 安升（上海）医药科技有限公司 多特异性蛋白药物及其文库、以及制备方法和应用
WO2019042153A1 (zh) 2017-09-01 2019-03-07 四川科伦博泰生物医药股份有限公司 重组双特异性抗体
CA3069238A1 (en) * 2017-11-02 2019-05-09 Systimmune, Inc. Bispecific antibodies and methods of making and using thereof
WO2019179421A1 (en) * 2018-03-19 2019-09-26 Wuxi Biologics (Shanghai) Co., Ltd. Novel bispecific pd-1/ctla-4 antibody molecules
CN110407942B (zh) * 2018-04-27 2022-02-22 苏州康宁杰瑞生物科技有限公司 针对kn044的单域抗体
TWI831789B (zh) 2018-06-05 2024-02-11 大陸商江蘇康寧杰瑞生物製藥有限公司 二聚體及其用途
CN110684113A (zh) * 2018-07-06 2020-01-14 复旦大学 一种抗PD-1抗原和抗c-Met抗原的双特异性抗体及其构建方法
CN109762068A (zh) * 2018-08-09 2019-05-17 源道隆（苏州）医学科技有限公司 一种可靶向ctla4和pd-1的单基因双特异性抗体及其应用
CN109053895B (zh) * 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
WO2020057610A1 (en) * 2018-09-20 2020-03-26 Wuxi Biologics (Shanghai) Co., Ltd. Novel bispecific anti-ctla-4/pd-1 polypeptide complexes
WO2020057611A1 (en) * 2018-09-20 2020-03-26 Wuxi Biologics (Shanghai) Co., Ltd. Novel bispecific ctla-4/pd-1 polypeptide complexes
CN111763261B (zh) * 2019-04-02 2022-08-09 杭州尚健生物技术有限公司 一种融合蛋白及其用途
CN112175087B (zh) * 2019-07-02 2022-05-13 深圳市迈加瑞生物技术有限公司 一种抗CD4和TGFβ的双特异性抗体、其药物组合及其用途
KR20220044748A (ko) * 2019-07-11 2022-04-11 우한 이지 바이오파마 씨오., 엘티디. 4가 대칭 이중 특이적 항체
JP7753186B2 (ja) * 2019-08-02 2025-10-14 シーティーティーキュー－アケソ（シャンハイ） バイオメド テク カンパニー リミテッド 抗ｐｄ－１抗体およびその医学的使用
CA3146780A1 (en) * 2019-08-02 2021-02-11 Akeso Pharmaceuticals, Inc. Anti-ctla4/anti-pd-1 bispecific antibody and use thereof
CN112442126B (zh) * 2019-09-04 2022-07-29 杭州济元基因科技有限公司 一种抗人cs1抗原的单克隆抗体及其car-t细胞
CN110563845A (zh) * 2019-09-12 2019-12-13 滨州医学院 抗igsf9抗体、药物组合物及其应用
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