CN1068816A - 吲哚类衍生物 - Google Patents

吲哚类衍生物 Download PDF

Info

Publication number
CN1068816A
CN1068816A CN92108675A CN92108675A CN1068816A CN 1068816 A CN1068816 A CN 1068816A CN 92108675 A CN92108675 A CN 92108675A CN 92108675 A CN92108675 A CN 92108675A CN 1068816 A CN1068816 A CN 1068816A
Authority
CN
China
Prior art keywords
formula
compound
group
alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN92108675A
Other languages
English (en)
Chinese (zh)
Inventor
J·布拉格
K·库珀
P·L·施帕戈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CN1068816A publication Critical patent/CN1068816A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN92108675A 1991-07-24 1992-07-24 吲哚类衍生物 Pending CN1068816A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9115951.7 1991-07-24
GB919115951A GB9115951D0 (en) 1991-07-24 1991-07-24 Indoles

Publications (1)

Publication Number Publication Date
CN1068816A true CN1068816A (zh) 1993-02-10

Family

ID=10698873

Family Applications (2)

Application Number Title Priority Date Filing Date
CN92108675A Pending CN1068816A (zh) 1991-07-24 1992-07-24 吲哚类衍生物
CN92108665A Pending CN1068817A (zh) 1991-07-24 1992-07-24 吲哚类衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN92108665A Pending CN1068817A (zh) 1991-07-24 1992-07-24 吲哚类衍生物

Country Status (20)

Country Link
EP (2) EP0598750A1 (pt)
JP (2) JPH06509336A (pt)
CN (2) CN1068816A (pt)
AU (2) AU2327192A (pt)
BR (1) BR9206306A (pt)
CA (2) CA2112678A1 (pt)
CZ (1) CZ13694A3 (pt)
FI (2) FI940310A (pt)
GB (1) GB9115951D0 (pt)
HU (1) HU9400199D0 (pt)
IE (2) IE922386A1 (pt)
IL (2) IL102545A0 (pt)
MX (1) MX9204342A (pt)
NO (1) NO940237D0 (pt)
NZ (1) NZ243687A (pt)
PT (2) PT100718A (pt)
SK (1) SK8494A3 (pt)
TW (1) TW223060B (pt)
WO (2) WO1993002051A1 (pt)
ZA (2) ZA925546B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9204024D0 (en) * 1992-02-25 1992-04-08 Fujisawa Pharmaceutical Co Indole derivatives
GB9302577D0 (en) * 1993-02-10 1993-03-24 Fujisawa Pharmaceutical Co Indole derivatives
WO1994022821A1 (en) * 1993-04-05 1994-10-13 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives as testosterone 5 alpha-reductase inhibitors
GB9310092D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co Indole derivatives
GB9317096D0 (en) * 1993-08-17 1993-09-29 Pfizer Ltd Indoles
PT753511E (pt) 1994-03-30 2001-11-30 Zeria Pharm Co Ltd Derivados de acido 4-indol-1-butirico, sua preparacao e utilizacao como inibidores dos receptores alfa-1-adrenergicos e das 5-alfa-redutases da testosterona
GB9409583D0 (en) * 1994-05-13 1994-07-06 Pfizer Ltd Indoles
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
EA009370B1 (ru) 1997-05-14 2007-12-28 Атеродженикс, Инк. Соединение и фармацевтическая композиция для ингибирования экспрессии vcam-1
US7417063B2 (en) 2004-04-13 2008-08-26 Bristol-Myers Squibb Company Bicyclic heterocycles useful as serine protease inhibitors
FR2893615B1 (fr) * 2005-11-18 2008-03-07 Sanofi Aventis Sa Derives de 3-acylindole, leur preparation et leur application en therapeutique
PE20090159A1 (es) 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
WO2008118948A1 (en) 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
US10703969B2 (en) * 2016-09-27 2020-07-07 Kaohsiung Medical University Detection method for quaternary ammonium compound having γ-carboxyl group

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9011335D0 (en) * 1990-05-21 1990-07-11 Fujisawa Pharmaceutical Co Indolebutyric acid derivatives and process for preparation thereof
WO1993005020A1 (en) * 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase

Also Published As

Publication number Publication date
NZ243687A (en) 1994-12-22
PT100718A (pt) 1993-08-31
EP0598750A1 (en) 1994-06-01
ZA925546B (en) 1994-01-24
BR9206306A (pt) 1994-11-08
CZ13694A3 (en) 1994-07-13
AU655662B2 (en) 1995-01-05
FI940311A0 (fi) 1994-01-21
HU9400199D0 (en) 1994-05-30
NO940237L (no) 1994-01-24
TW223060B (pt) 1994-05-01
JPH06509336A (ja) 1994-10-20
ZA925547B (en) 1994-01-24
AU2327192A (en) 1993-02-23
EP0598754A1 (en) 1994-06-01
PT100717A (pt) 1993-08-31
CN1068817A (zh) 1993-02-10
NO940237D0 (no) 1994-01-24
CA2112689A1 (en) 1993-02-04
JPH06511483A (ja) 1994-12-22
AU2327092A (en) 1993-02-23
SK8494A3 (en) 1994-11-09
FI940310A0 (fi) 1994-01-21
IL102544A0 (en) 1993-01-14
WO1993002051A1 (en) 1993-02-04
MX9204342A (es) 1994-03-31
IE922386A1 (en) 1993-01-27
FI940311A (fi) 1994-01-21
IE922387A1 (en) 1993-01-27
WO1993002050A1 (en) 1993-02-04
IL102545A0 (en) 1993-01-14
FI940310A (fi) 1994-01-21
GB9115951D0 (en) 1991-09-11
CA2112678A1 (en) 1993-02-04

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Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication