CN106854604A - A kind of mosquito repellent antibacterial toilet soap and preparation method thereof - Google Patents
A kind of mosquito repellent antibacterial toilet soap and preparation method thereof Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/02—Compositions of detergents based essentially on soap on alkali or ammonium soaps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/30—Organic compounds, e.g. vitamins containing nitrogen
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/32—Organic compounds, e.g. vitamins containing sulfur
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/38—Products in which the composition is not well defined
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Abstract
The invention belongs to daily chemical product technical field, and in particular to a kind of mosquito repellent antibacterial toilet soap and preparation method thereof.The mosquito repellent antibacterial toilet soap that the present invention is provided includes following components and its mass fraction：36 parts of cocinic acid, 0.2 0.5 parts of sodium chloride, 7 14 parts of potassium hydroxide, 48 62 parts of base oil, 0.1 0.3 parts of glutathione, 0.02 0.07 parts of disodium ethylene diamine tetraacetate, 0.6 1 parts of sodium carboxymethylcellulose, 12 parts of palmitic acid, 0.02 0.05 parts of azone, 0.4 0.6 parts of 13 parts of lauryl sodium sulfate, 0.03 0.05 parts of Geranium Essential, 0.8 1.3 parts of culicifuge and antiseptic.The mosquito repellent antibacterial toilet soap that the present invention is provided has the antibacterial effect of mosquito repellent, can alleviate and bite pain, using safe, non-stimulated.
Description
Technical field
The invention belongs to daily chemical product technical field, and in particular to a kind of mosquito repellent antibacterial toilet soap and preparation method thereof.
Background technology
Perfumed soap is essential washing and nursing article in daily life, based on sodium soap and other surfaces activating agent
Raw material is wanted, quality improver and appearance modifying agents is added, by the product being made after machine-shaping.With development, the people of society
Growth in the living standard and the enhancing to skin care consciousness, people have requirement higher to the function and kind of perfumed soap,
Wish that perfumed soap also has sterilized, deodorant, moisturizing effect during cleaning.In order to tackle the high request of consumer, some factories
Business adds the plant essences such as plant extracts and plants essential oil in soap, soap is possessed moisturizing, the work(such as flavouring and skin care
Effect.Degerming and parasite-expelling toilet soap can prevent infection and bite by mosquitos of the animal particularly people from bacterium.
Chinese patent application CN102329703A discloses a kind of Antibacterial soaps, and the raw material components for being made perfumed soap include：Coconut palm
Seed oil：5-15%, palm oil：10-20%, olive oil：3-10%, butter：15-30%, NaOH：5-15%, liquorice beverage
Extract：2-8%, neopelex：1-3% and titanium dioxide：3-8%.Chinese patent CN101928654B is disclosed
A kind of natural herbal degerming and parasite-expelling toilet soap and preparation method thereof, the percentage by weight of the component of the perfumed soap is：91%~94% fat
Fat acid saponification thing, 2%~3% surfactant, 0.1%~2% extract of lysimachiae foenum-graeci herba, 1%~3% spices and 1%~
1.5% natural dye.
At present, the chemical insecticides, its safety such as pyrethroid and toluamide are mostly used in degerming and parasite-expelling toilet soap
And applicability is troubling.Although in addition, some degerming and parasite-expelling toilet soaps do not add the chemistry such as pyrethroid and toluamide
Insecticide, but, there is a problem of that mosquito repellent fungistatic effect is undesirable.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of mosquito repellent antibacterial toilet soap and preparation method thereof.
The mosquito repellent antibacterial toilet soap that the present invention is provided can not only carry out careful, gentle, deep layer conditioning to skin, and cleaning simultaneously can be with
Fully nutrition needed for supplement skin, assigns elasticity of skin, and with the antibacterial effect of mosquito repellent, pain is bitten in mosquito repellent anti-inflammatory, alleviation
Bitterly, also with using safe, non-stimulated the features such as.
The technical scheme is that：
A kind of mosquito repellent antibacterial toilet soap, including following components and its mass fraction：
Cocinic acid 3-6 parts, sodium chloride 0.2-0.5 parts, potassium hydroxide 7-14 parts, base oil 48-62 parts, glutathione
0.1-0.3 parts, disodium ethylene diamine tetraacetate 0.02-0.07 parts, sodium carboxymethylcellulose 0.6-1 parts, palmitic acid 1-2 parts, bay
Azone 0.02-0.05 parts, lauryl sodium sulfate 1-3 parts, Geranium Essential 0.03-0.05 parts, culicifuge 0.8-1.3 parts and anti-
Microbial inoculum 0.4-0.6 parts.
Further, the mosquito repellent antibacterial toilet soap includes following components and its mass fraction：
5 parts of cocinic acid, 0.4 part of sodium chloride, 9 parts of potassium hydroxide, 52 parts of base oil, 0.2 part of glutathione, ethylenediamine tetraacetic
0.04 part of acetic acid disodium, 0.8 part of sodium carboxymethylcellulose, 1.3 parts of palmitic acid, 0.03 part of azone, lauryl sodium sulfate 2
0.5 part of part, 0.04 part of Geranium Essential, 1 part of culicifuge and antiseptic.
Further, the base oil is by coconut oil, macadimia nut oil and Seabuckthorn Oil 8-11: 3-5: 1-3 group in mass ratio
Into.
Further, the base oil is made up of coconut oil, macadimia nut oil and Seabuckthorn Oil in mass ratio 9: 4: 2.
Further, the culicifuge is made up of toosendanin, citronellal and eugenol in mass ratio 2-4: 5-7: 6-8.
Further, the culicifuge is made up of toosendanin, citronellal and eugenol in mass ratio 3: 6: 7.
Further, the antiseptic is made up of magnolol and Paeoniflorin in mass ratio 4-6: 11-15.
Further, the antiseptic is made up of magnolol and Paeoniflorin in mass ratio 5: 13.
It is a further object of the present invention to provide the preparation method of the mosquito repellent antibacterial toilet soap, comprise the following steps：
Base oil is heated to 45-60 DEG C by S1, is fully mixed, and obtains miscella；
Potassium hydroxide is added to the water dissolving by S2, controls the mass concentration of potassium hydroxide for 20-30%, and by above-mentioned solution
45-60 DEG C is cooled to, alkali lye is obtained；
Be added to step S2 gained alkali lye in step S1 gained miscellas in three times by S3, and each interval time is 15 points
Clock, mixing speed is 450-620r/min, and mixing time is 40-60 minutes, obtains soap lye；
S4 by cocinic acid, sodium chloride, glutathione, disodium ethylene diamine tetraacetate, sodium carboxymethylcellulose, palmitic acid,
Azone, lauryl sodium sulfate and culicifuge are added in step S3 gained soap lyes, and mixing speed is 480-560r/min,
Mixing time is 25-36 minutes, adds Geranium Essential and antiseptic, is stirred, and obtains mixed material；
S5 by step S4 gained mixed material injection mould in, by mould be placed in -20 DEG C freeze 12 hours, it is to be solidified after from
Taken out in mould, the cool soap of room temperature is obtained final product.
Further, base oil is heated to 52 DEG C by the step S1.
Further, it is 26% that the step S2 controls the mass concentration of potassium hydroxide.
Further, the step S2 and above-mentioned solution is cooled to 52 DEG C.
Further, the step S3 mixing speeds are 540r/min.
Further, the step S2 mixings time are 53 minutes.
Further, the step S2 mixing speeds are 520r/min.
Further, the step S2 mixings time are 32 minutes.
The raw materials used Main Function of the present invention：
Cocinic acid：No. CAS：61788-47-4.Purposes：For textile auxiliary, butadiene-styrene rubber emulsifying agent, senior perfumed soap
Soap base, synthesizes the intermediate of various surfactants.
Glutathione：No. CAS：70-18-8, molecular formula：C10H17N3O6S, molecular weight：307.32348.Glutathione has
Wide spectrum detoxication, cannot be only used for medicine, in anti-aging, strengthen immunity, can more resist as the base-material of functional food
The functional food extensive use such as tumour.
Sodium carboxymethylcellulose：No. CAS：9004-32-4, molecular formula：C8H16NaO8, molecular weight 265.204.White fiber
Shape or particulate powder.Odorless, it is tasteless, it is tasteless, there is hygroscopicity, insoluble in organic solvent.Sodium carboxymethylcellulose can be used as wadding
Solidifying agent, chelating agent, emulsifying agent, thickener, water-loss reducer, sizing agent, filmogen etc., are also widely used for electronics, agricultural chemicals, skin
The fields such as leather, plastics, printing, ceramics, toothpaste, daily-use chemical industry.
Azone：No. CAS：59227-89-3, molecular formula：C18H35NO, molecular weight：281.4766.As bleeding agent,
For all kinds of creams and hair care product in cosmetics；The penetrating agent smeared as external used medicine, massaged；For agricultural chemicals, as plant
Rush vapor and sterilization, the penetrating agent of insecticide of growth regulator；In addition, it may also be used for the coloring in the field such as leather and printing and dyeing promotees
Enter agent.
Geranium Essential：No. CAS：8000-46-2.By the fresh stem of Long Niuer seedlings section plant Pelargonium roseum, leaf or
Whole strain is obtained through steam distillation.Primary efficacy：Analgesic, antibacterial, enhancing cytophylaxis function, deodorant, hemostasis, benefit body；There is depth
Layer purification and convergence effect, balance sebum secretion；Promote Skin Cell newborn, repair scar, striae of pregnancy.
Toosendanin：No. CAS：58812-37-6, molecular formula：C30H38O11, molecular weight：574.63.Toosendanin is from toosendanin
The active ingredient that root skin and bark are proposed.Toosendanin has drive ascarid, the poisoning of anti-creotoxin, antibacterial, anticancer and antiinflammation.
Citronellal：No. CAS：106-23-0, molecular formula：C10H18O, molecular weight：154.25.Can be used as flavoring essence preparation
Raw material, can be used as the aromatizing agent of perfumed soap, cosmetics and food.
Eugenol：No. CAS：97-53-0, chemical formula：C10H12O2, molecular weight：164.20.It is mainly used in antibacterial, hypotensive；
Can also be used in perfume fragrance and various cosmetic essences and fragrance for detergents formula, can be also used for the allotment of flavoring essence.
Magnolol：No. CAS：528-43-8, molecular formula：C18H18O2, molecular weight：266.32.With special, lasting flesh
Meat relexation and strong antibacterial action, can suppress platelet aggregation.Clinically it is mainly used as antibacterial, antifungal.
Paeoniflorin：No. CAS：23180-57-6, molecular formula：C23H28O11, molecular weight：480.45.Paeoniflorin derives from Herba Ranunculi Japonici
Section plant peony root, tree peony root, Paeonia delavayi root, with expansion of blood vessels, antalgic and sedative, anti-inflammatory antiulcer, antipyretic spasmolysis, diuresis
Effect.
Coconut oil：No. CAS：8001-31-8.For detergent, resin, paint, textile finish oil, soap, food etc..
Macadimia nut oil：No. CAS：129811-19-4.Nutrient essential to grease protective layer, temperature are formed containing skin
With do not stimulate skin；Moisturiser can be made, skin can be made soft and vibrant, protection cell membrane and moisten, moisturizing；Also may be used
Add macadimia nut oil with body facial treatment milk, increase lubricity and nourishing degree；Ductility is good, has greasy feeling, while oozing
Permeability is good.
Seabuckthorn Oil：No. CAS：90106-68-6.Seabuckthorn Oil steams for the dry mature fruit of Elaeangnaceae plant sea-buckthorn through water
The volatile oil that gas distillation is extracted；With relieving dyspepsia, strengthening spleen and nourishing stomach, dispersing stagnated hepatoqi, relieving cough and asthma, sharp lung resolving sputum effect.
The mosquito repellent antibacterial toilet soap that the present invention is provided is prepared by raw materials such as cocinic acid, glutathione, culicifuge and antiseptics
Form.In mosquito repellent antibacterial toilet soap of the present invention, there is saponification in base oil with potassium hydroxide, generate perfumed soap, and formed to skin
Skin has the natural glycerin of strong moisture-keeping function.In mosquito repellent antibacterial toilet soap of the present invention, the addition of sodium chloride can effectively reduce system
The toughness of the mosquito repellent antibacterial toilet soap for obtaining.In mosquito repellent antibacterial toilet soap of the present invention, cocinic acid is mainly used as fatting agent, on the one hand,
The addition of cocinic acid can neutralize the free alkali in the antibacterial perfume of mosquito repellent of preparation, reduce stimulation；On the other hand, after shower
It stays in skin surface, makes skin moisturizing smooth.In mosquito repellent antibacterial toilet soap of the present invention, disodium ethylene diamine tetraacetate is used as chelating
Agent, it can prevent autocatalysis of the trace meter brought into perfumed soap soap base to soap body from aoxidizing.In the antibacterial perfume (or spice) of mosquito repellent of the present invention
In soap, sodium carboxymethylcellulose is mainly used as emulsifying agent and stabilizer, it is possible to increase the stability of the mosquito repellent antibacterial toilet soap of preparation,
In addition serve as chelating agent.In mosquito repellent antibacterial toilet soap of the present invention, lauryl sodium sulfate as surfactant, with good
Emulsification, foaming, infiltration, decontamination and dispersive property, with the present invention in other compositions synergy, by increasing capacitance it is possible to increase the drive of preparation
The foaming power of mosquito antibacterial toilet soap, washing force and resistance to hard water.In mosquito repellent antibacterial toilet soap of the present invention, glutathione is mainly used as
Antioxidant, in addition, can also be combined with lead, mercury, arsenic etc., with detoxication.In mosquito repellent antibacterial toilet soap of the present invention, fish pelargonium
Essential oil can cover the smell of soap base raw material, the perfumed soap of preparation is distributed pure and fresh pleasant fragrance.
Found through bacteriostatic test, mosquito repellent antibacterial toilet soap prepared by the present invention is to Escherichia coli, bacillus subtilis, golden yellow
Staphylococcus and Candida albicans are respectively provided with obvious inhibitory action, and the fungistatic effect of comparative example 1 and comparative example 2 is than the present invention
The effect of mosquito repellent antibacterial toilet soap prepared by embodiment 1-3 is poor, illustrates mutually to have cooperateed with enhancing antibacterial between each raw material of the invention
Effect.Tested through mosquito repellent and found, compared with comparative example, there is mosquito repellent antibacterial toilet soap prepared by the present invention good mosquito repelling to imitate
Really, collaboration plays a part of to strengthen mosquito repellent between illustrating each composition of the invention.
The mosquito repellent antibacterial toilet soap formula that the present invention is provided is reasonable, using safe, non-stimulated, is made by the collaboration of various composition
With simultaneously cleaning can also fully supplement nutrition needed for skin, elasticity of skin be assigned, with significant mosquito repellent fungistatic effect, energy
Pain is bitten in the anti-inflammatory of enough mosquito repellents, alleviation.
Compared with prior art, the mosquito repellent antibacterial toilet soap that the present invention is provided has the advantage that：
(1) confirmed through safety testing, the mosquito repellent antibacterial toilet soap that the present invention is provided uses safe, non-stimulated.
(2) the mosquito repellent antibacterial toilet soap that the present invention is provided can carry out careful, gentle, deep layer conditioning to skin, and cleaning is same
When can also fully supplement nutrition needed for skin, assign elasticity of skin.
(3) the mosquito repellent antibacterial toilet soap that the present invention is provided has the antibacterial effect of mosquito repellent, and pain is bitten in mosquito repellent anti-inflammatory, alleviation,
And mosquito repellent fungistatic effect is notable.
Specific embodiment
Below by way of the description of specific embodiment, the invention will be further described, but this is not to limit of the invention
System, those skilled in the art's basic thought of the invention, various modifications may be made or improves, but without departing from this
The basic thought of invention, within the scope of the present invention.
Embodiment 1, a kind of mosquito repellent antibacterial toilet soap
The mosquito repellent antibacterial toilet soap includes following components and its mass fraction (every part is 3000g)：
3 parts of cocinic acid, 0.2 part of sodium chloride, 7 parts of potassium hydroxide, 48 parts of base oil, 0.1 part of glutathione, ethylenediamine tetraacetic
0.02 part of acetic acid disodium, 0.6 part of sodium carboxymethylcellulose, 1 part of palmitic acid, 0.02 part of azone, lauryl sodium sulfate 1
0.4 part of part, 0.03 part of Geranium Essential, 0.8 part of culicifuge and antiseptic；The base oil by coconut oil, macadimia nut oil and
Seabuckthorn Oil in mass ratio 8: 5: 3 is constituted；The culicifuge is made up of toosendanin, citronellal and eugenol in mass ratio 2: 7: 8；Institute
Antiseptic is stated to be made up of magnolol and Paeoniflorin in mass ratio 4: 15.
Preparation method：
Base oil is heated to 45 DEG C by S1, is fully mixed, and obtains miscella；
Potassium hydroxide is added to the water dissolving by S2, and it is 20% to control the mass concentration of potassium hydroxide, and above-mentioned solution is cold
But to 45 DEG C, alkali lye is obtained；
Be added to step S2 gained alkali lye in step S1 gained miscellas in three times by S3, and each interval time is 15 points
Clock, mixing speed is 450r/min, and mixing time is 40 minutes, obtains soap lye；
S4 by cocinic acid, sodium chloride, glutathione, disodium ethylene diamine tetraacetate, sodium carboxymethylcellulose, palmitic acid,
Azone, lauryl sodium sulfate and culicifuge are added in step S3 gained soap lyes, and mixing speed is 480r/min, stirring
Time is 25 minutes, adds Geranium Essential and antiseptic, is stirred, and obtains mixed material；
S5 by step S4 gained mixed material injection mould in, by mould be placed in -20 DEG C freeze 12 hours, it is to be solidified after from
Taken out in mould, the cool soap of room temperature is obtained final product.
Embodiment 2, a kind of mosquito repellent antibacterial toilet soap
The mosquito repellent antibacterial toilet soap includes following components and its mass fraction (every part is 3000g)：
6 parts of cocinic acid, 0.5 part of sodium chloride, 14 parts of potassium hydroxide, 62 parts of base oil, 0.3 part of glutathione, ethylenediamine
0.07 part of tetraacethyl disodium, 1 part of sodium carboxymethylcellulose, 2 parts of palmitic acid, 0.05 part of azone, lauryl sodium sulfate 3
0.6 part of part, 0.05 part of Geranium Essential, 1.3 parts of culicifuge and antiseptic；The base oil by coconut oil, macadimia nut oil and
Seabuckthorn Oil in mass ratio 11: 3: 1 is constituted；The culicifuge is made up of toosendanin, citronellal and eugenol in mass ratio 4: 5: 6；
The antiseptic is made up of magnolol and Paeoniflorin in mass ratio 6: 11.
Preparation method：
Base oil is heated to 60 DEG C by S1, is fully mixed, and obtains miscella；
Potassium hydroxide is added to the water dissolving by S2, and it is 30% to control the mass concentration of potassium hydroxide, and above-mentioned solution is cold
But to 60 DEG C, alkali lye is obtained；
Be added to step S2 gained alkali lye in step S1 gained miscellas in three times by S3, and each interval time is 15 points
Clock, mixing speed is 620r/min, and mixing time is 60 minutes, obtains soap lye；
S4 by cocinic acid, sodium chloride, glutathione, disodium ethylene diamine tetraacetate, sodium carboxymethylcellulose, palmitic acid,
Azone, lauryl sodium sulfate and culicifuge are added in step S3 gained soap lyes, and mixing speed is 560r/min, stirring
Time is 36 minutes, adds Geranium Essential and antiseptic, is stirred, and obtains mixed material；
S5 by step S4 gained mixed material injection mould in, by mould be placed in -20 DEG C freeze 12 hours, it is to be solidified after from
Taken out in mould, the cool soap of room temperature is obtained final product.
Embodiment 3, a kind of mosquito repellent antibacterial toilet soap
The mosquito repellent antibacterial toilet soap includes following components and its mass fraction (every part is 3000g)：
5 parts of cocinic acid, 0.4 part of sodium chloride, 9 parts of potassium hydroxide, 52 parts of base oil, 0.2 part of glutathione, ethylenediamine tetraacetic
0.04 part of acetic acid disodium, 0.8 part of sodium carboxymethylcellulose, 1.3 parts of palmitic acid, 0.03 part of azone, lauryl sodium sulfate 2
0.5 part of part, 0.04 part of Geranium Essential, 1 part of culicifuge and antiseptic；The base oil is by coconut oil, macadimia nut oil and sand
Spine oil in mass ratio 9: 4: 2 is constituted；The culicifuge is made up of toosendanin, citronellal and eugenol in mass ratio 3: 6: 7；It is described
Antiseptic is made up of magnolol and Paeoniflorin in mass ratio 5: 13.
Preparation method：
Base oil is heated to 52 DEG C by S1, is fully mixed, and obtains miscella；
Potassium hydroxide is added to the water dissolving by S2, and it is 26% to control the mass concentration of potassium hydroxide, and above-mentioned solution is cold
But to 52 DEG C, alkali lye is obtained；
Be added to step S2 gained alkali lye in step S1 gained miscellas in three times by S3, and each interval time is 15 points
Clock, mixing speed is 540r/min, and mixing time is 53 minutes, obtains soap lye；
S4 by cocinic acid, sodium chloride, glutathione, disodium ethylene diamine tetraacetate, sodium carboxymethylcellulose, palmitic acid,
Azone, lauryl sodium sulfate and culicifuge are added in step S3 gained soap lyes, and mixing speed is 520r/min, stirring
Time is 32 minutes, adds Geranium Essential and antiseptic, is stirred, and obtains mixed material；
S5 by step S4 gained mixed material injection mould in, by mould be placed in -20 DEG C freeze 12 hours, it is to be solidified after from
Taken out in mould, the cool soap of room temperature is obtained final product.
Comparative example 1, a kind of mosquito repellent antibacterial toilet soap
The mosquito repellent antibacterial toilet soap includes following components and its mass fraction (every part is 3000g)：
5 parts of cocinic acid, 0.4 part of sodium chloride, 9 parts of potassium hydroxide, 52 parts of base oil, 0.2 part of glutathione, ethylenediamine tetraacetic
0.04 part of acetic acid disodium, 0.8 part of sodium carboxymethylcellulose, 1.3 parts of palmitic acid, 0.03 part of azone, lauryl sodium sulfate 2
0.5 part of part, 0.04 part of Geranium Essential, 1 part of culicifuge and antiseptic；The base oil is by coconut oil, macadimia nut oil and sand
Spine oil in mass ratio 9: 4: 2 is constituted；The culicifuge is made up of citronellal and eugenol in mass ratio 1: 1；The antiseptic by
Magnolol and Paeoniflorin in mass ratio 5: 13 are constituted.
Preparation method is similar to Example 3.
As different from Example 3, the culicifuge is made up of citronellal and eugenol in mass ratio 1: 1.Comparative example 2,
A kind of mosquito repellent antibacterial toilet soap
The mosquito repellent antibacterial toilet soap includes following components and its mass fraction (every part is 3000g)：
5 parts of cocinic acid, 0.4 part of sodium chloride, 9 parts of potassium hydroxide, 52 parts of base oil, 0.2 part of glutathione, ethylenediamine tetraacetic
0.04 part of acetic acid disodium, 0.8 part of sodium carboxymethylcellulose, 1.3 parts of palmitic acid, 0.03 part of azone, lauryl sodium sulfate 2
0.5 part of part, 0.04 part of Geranium Essential, 1 part of culicifuge and antiseptic；The base oil is by coconut oil, macadimia nut oil and sand
Spine oil in mass ratio 9: 4: 2 is constituted；The culicifuge is made up of toosendanin, citronellal and eugenol in mass ratio 1: 1: 1；It is described
Antiseptic is made up of magnolol and Paeoniflorin in mass ratio 5: 13.
Preparation method is similar to Example 3.
As different from Example 3, the culicifuge is made up of toosendanin, citronellal and eugenol in mass ratio 1: 1: 1.
Comparative example 3, a kind of mosquito repellent antibacterial toilet soap
The mosquito repellent antibacterial toilet soap includes following components and its mass fraction (every part is 3000g)：
5 parts of cocinic acid, 0.4 part of sodium chloride, 9 parts of potassium hydroxide, 52 parts of base oil, 0.2 part of glutathione, ethylenediamine tetraacetic
0.04 part of acetic acid disodium, 0.8 part of sodium carboxymethylcellulose, 1.3 parts of palmitic acid, 0.03 part of azone, lauryl sodium sulfate 2
0.5 part of part, 0.04 part of Geranium Essential, 1 part of culicifuge and antiseptic；The base oil is by coconut oil, macadimia nut oil and sand
Spine oil in mass ratio 9: 4: 2 is constituted；The culicifuge is made up of toosendanin, citronellal and eugenol in mass ratio 3: 6: 7；It is described
Antiseptic is made up of magnolol and Paeoniflorin in mass ratio 1: 1.
Preparation method is similar to Example 3.
As different from Example 3, the antiseptic is made up of magnolol and Paeoniflorin in mass ratio 1: 1.
The bacteriostatic experiment of test example one, mosquito repellent antibacterial toilet soap
1st, test material：Mosquito repellent prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1, comparative example 2 and comparative example 3
Antibacterial toilet soap.
2nd, for examination bacterium：Escherichia coli, bacillus subtilis, staphylococcus aureus and Candida albicans.
3rd, culture medium：Using beef extract-peptone solid medium, beef extract 3.0g, peptone 10.0g, sodium chloride are taken
5.0g, agar 20.0g, distilled water 1000mL, heating for dissolving, it is 7.0 to adjust pH value, is sub-packed in triangular flask, with 121 DEG C, 20min
Autoclaving, it is standby.
4th, test method：
Slant activation will be carried out for examination strain, and take the examination bacterium that supplies for having activated and cultivated in being incorporated with the test tube of fluid nutrient medium
24h, respectively takes 1mL bacteria suspensions, puts respectively into the test tube containing 9mL soap lyes (labeled as 10-1), this is 10 times of dilutions.Bacterium solution is abundant
After mixing, 10 are drawn-1Bacterium solution 1mL, puts into the test tube containing 9mL distilled water (10-2), remaining carries out gradient dilute by that analogy
Release.0.2mL bacteria suspensions are taken, each flat board is spread evenly across respectively, be then inverted, in 48h is cultivated at 37 DEG C, every kind of strain does 3 times
Repeat, be control with distilled water.After culture 48h, culture plate is taken out, count the clump count on each dilution factor flat board, calculate same
Bacterium colony average on one flat board of dilution factor 3, is calculated by following formula.
Average colony number × the extension rate of CFU (cfu)=repetition of same dilution factor three times in every milliliter ×
5
5th, result of the test
Result of the test is as shown in table 1.
Table 1：The bacteriostatic test result of mosquito repellent antibacterial toilet soap
As it can be seen from table 1 mosquito repellent antibacterial toilet soap prepared by the present invention is to Escherichia coli, bacillus subtilis, golden yellow
Staphylococcus and Candida albicans are respectively provided with obvious inhibitory action, and the fungistatic effect of comparative example 1, comparative example 2 and comparative example
The effect of the mosquito repellent antibacterial toilet soap prepared than embodiment of the present invention 1-3 is poor, illustrates mutually to have cooperateed with increasing between each raw material of the invention
Strong antibacterial effect.
Test example two, mosquito repellent antibacterial toilet soap are tested mosquito repelling
1st, test material：Mosquito repellent prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1, comparative example 2 and comparative example 3
Antibacterial toilet soap.
2nd, for examination mosquito：Experiment mosquito used is aedes albopictus, takes the female adult mosquito that 5d does not suck blood after sprouting wings, and is incubated at
In the sarong of 40cm × 30cm × 30cm, cultivation temperature is 25 DEG C, and relative humidity is 65%.
3rd, test method：
Detected by the detection method of GB GB-T17322.10-1998.(40cm in 320 mosquitoes threading mosquito cages
× 30cm × 30cm), volunteer's the back of the hand exposure 4cm × 4cm skins, remainder tightly covers, and is placed during hand is stretched into mosquito cage
2min, the mosquito for coming to suck blood is that attack is qualified more than 30 persons, and the volunteer and this cage mosquito can be used for repellent experiment.
It is qualified each stroke of skin area of 5cm × 5cm of volunteer's both hands back to attack for 3, wherein a hand is blank, it is another
Hand presses 1.5 μ L/cm2Dose uniformity smear perfumed soap liquid, the exposure wherein skin of 4cm × 4cm tightly covers remainder.
1h after repellant is smeared, hand is stretched into and is placed with 2min in the cage of the qualified mosquito of attack, observation whether there is mosquito is come to suck blood, after
Tested once per 15min.As long as have 1 mosquito come to suck blood sentence make repellant fail.Record mosquito repellent antibacterial toilet soap repellant
Effective protecting time.
4th, result of the test
Result of the test is as shown in table 2.
Table 2：Mosquito repellent antibacterial toilet soap is to mosquito repelling result of the test
From table 2 it can be seen that compared with comparative example 1, comparative example 2 and comparative example 3, drive prepared by embodiment of the present invention 1-3
Mosquito antibacterial toilet soap has good mosquito repelling effect, and collaboration plays a part of to strengthen mosquito repellent between illustrating each composition of the invention.
Test example three：The safety testing of mosquito repellent antibacterial toilet soap
1st, test material：Mosquito repellent prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1, comparative example 2 and comparative example 3
Antibacterial toilet soap.
2nd, subjects：It is the healthy adult Wistar rats of 400g to choose 108 body weight, and male and female half and half give basis
Forage feed 1 week, observation skin is without carrying out follow-up test after breakage.
3rd, test method：
3.1st, acute dermal toxicity test method
Test method is according to GB GB/T21606-2008《Chemicals acute dermal toxicity test method》Regulation is performed.Drive
Mosquito antibacterial toilet soap dosage is 3.00g/kg (body weight), 0.30g is smashed and weighed, in addition 10.00g vaseline
Mixing.Healthy skin is chosen without damaged adult Wistar rats 36, male and female half and half are randomly divided into 6 groups, respectively embodiment 1
3 groups of group, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example, 2 groups of comparative example and comparative example, every group 6, every group of rat male and female are each
Half.In rat both sides back clip dorsal body setae, expose the skin that size is 2.50cm × 2.50cm.Observation skin is without breakage and oozes
Go out, vaseline intermixture applied into side skin of back, opposite side back applies the vaseline of same dose, does own control,
The Health cost effect that observation animal occurs.
3.2nd, skin irritation test method
According to the above-mentioned international method recommended, dose design is 3.00g/kg (body weight), choose healthy skin without breakage into
The processing method of year rat 36, male and female half and half, perfumed soap and animal is ibid.Perfumed soap coating after with 4 layers of gauze (3.00cm ×
It is 3.00cm) fixed.The reaction of area skin is smeared in 1,24,48 and 72h observations.According to skin wound repair standards of grading, comment
Stimulation of the valency mosquito repellent antibacterial toilet soap to skin.
3.3rd, acute eye irritation test method
Test method is according to GB/T21606-2008《Acute eye irritation/the corrosion test method of chemicals》Regulation is held
OK.Dose design is 0.50g/kg (body weight), chooses healthy adult rat 36, and male and female half and half are randomly divided into 6 groups, respectively
3 groups of 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example, 2 groups of comparative example and comparative example, every group 6, every group of rat
Male and female half and half.Mosquito repellent antibacterial toilet soap is smashed and 0.30g is weighed, adds 10mL physiological saline fully to dissolve.Gently pull open
The palpebra inferior of Rat Right branch hole eyeball, by mosquito repellent antibacterial toilet soap solution 0.1mL instillation conjunctival sacs, makes upper and lower eyelid passively close
1S, left side eyes are not processed, and make own control, are observed after 1h after the stimulation degree of animal eyes, and one is observed every 24h
Secondary, Continuous Observation 7d is scored according to standards of grading.
4th, result of the test：
4.1st, acute dermal toxicity result of the test
Acute dermal toxicity result of the test shows, prepared by embodiment 1-3 and comparative example 1, comparative example 2 and comparative example 3
Mosquito repellent antibacterial toilet soap powder coating area skin color and luster be showed no substantially change, do not observe skin have drying, redness, scar rash,
The symptom such as ooze out.Tested period rat is in good condition, without rows such as appearance disturbance, dispirited, scratching skin, tic and the disturbances of consciousness
It is performance.Mosquito repellent antibacterial toilet soap applies tested rat skin, does not observe there is Acute Toxicity.
4.2nd, skin irritation test result
Skin irritation test result is as shown in table 3.
Table 3：Mosquito repellent antibacterial toilet soap skin irritation test result
From table 3 it can be seen that after mosquito repellent antibacterial toilet soap prepared by embodiment 1-3 applies 1h, all animal subjects are in coating
Do not observe erythema and oedema in position.And mosquito repellent antibacterial toilet soap prepared by comparative example 1, comparative example 2 and comparative example 3 has 5
Animal subject observed slight erythema in coating part, and 2 only have oedema.According to skin irritatin strength grading standard, assert
It is nonirritant to skin irritatin intensity during mosquito repellent antibacterial toilet soap coating 1h.With the extension of observing time, comparative example 1, contrast
Mosquito repellent antibacterial toilet soap skin irritation symptom prepared by example 2 and comparative example 3 is gradually alleviated, and is not observed in sample application group during 72h
Erythema and oedema.Skin irritation test result is pointed out, and mosquito repellent antibacterial toilet soap is contacted and had no stimulation for a long time with skin.
4.3rd, acute eye irritation test result of the test
Acute eye irritation test result is as shown in table 4.
Table 4：Mosquito repellent antibacterial toilet soap acute eye irritation test result
From table 4, it can be seen that mosquito repellent antibacterial toilet soap prepared by embodiment 1-3 is 30g/L normal saline solutions pair in content
Rat eye slits after film contact 1h, and 1 rat eye iris can be observed slight swelling, gauffer occurs；1 rat conjunctiva is visible
Secretion increased, slight oedema；Cornea is less than 1/4 without muddiness, damaged area.It has been observed that eye conjunctiva blood after contact 24h
Pipe is normal congested, and oedema and secretion disappear；Iris is normal, and without there is congested swelling, pupillary light reflex is normal.Contact 7d
Afterwards it has been observed that rat Eye irritation symptom all disappears.Result is pointed out, and mosquito repellent antibacterial toilet soap has no stimulation to rat eye.
Claims (10)
1. a kind of mosquito repellent antibacterial toilet soap, it is characterised in that including following components and its mass fraction：
Cocinic acid 3-6 parts, sodium chloride 0.2-0.5 parts, potassium hydroxide 7-14 parts, base oil 48-62 parts, glutathione 0.1-
0.3 part, disodium ethylene diamine tetraacetate 0.02-0.07 parts, sodium carboxymethylcellulose 0.6-1 parts, palmitic acid 1-2 parts, azone
0.02-0.05 parts, lauryl sodium sulfate 1-3 parts, Geranium Essential 0.03-0.05 parts, culicifuge 0.8-1.3 parts and antiseptic
0.4-0.6 parts.
2. mosquito repellent antibacterial toilet soap as claimed in claim 1, it is characterised in that including following components and its mass fraction：
5 parts of cocinic acid, 0.4 part of sodium chloride, 9 parts of potassium hydroxide, 52 parts of base oil, 0.2 part of glutathione, ethylenediamine tetra-acetic acid
0.04 part of disodium, 0.8 part of sodium carboxymethylcellulose, 1.3 parts of palmitic acid, 0.03 part of azone, 2 parts of lauryl sodium sulfate,
0.5 part of 0.04 part of Geranium Essential, 1 part of culicifuge and antiseptic.
3. mosquito repellent antibacterial toilet soap as claimed in claim 1 or 2, it is characterised in that the base oil is by coconut oil, Queensland nut
Oil and Seabuckthorn Oil in mass ratio 8-11: 3-5: 1-3 are constituted.
4. mosquito repellent antibacterial toilet soap as claimed in claim 3, it is characterised in that the base oil is by coconut oil, macadimia nut oil
Constituted with Seabuckthorn Oil in mass ratio 9: 4: 2.
5. mosquito repellent antibacterial toilet soap as claimed in claim 1 or 2, it is characterised in that the culicifuge by toosendanin, citronellal and
Eugenol in mass ratio 2-4: 5-7: 6-8 is constituted.
6. mosquito repellent antibacterial toilet soap as claimed in claim 5, it is characterised in that the culicifuge is by toosendanin, citronellal and fourth
Fragrant phenol in mass ratio 3: 6: 7 is constituted.
7. mosquito repellent antibacterial toilet soap as claimed in claim 1 or 2, it is characterised in that the antiseptic is by magnolol and Paeoniflorin
In mass ratio 4-6: 11-15 composition.
8. mosquito repellent antibacterial toilet soap as claimed in claim 7, it is characterised in that the antiseptic presses matter by magnolol and Paeoniflorin
Amount compares 5: 13 compositions.
9. the preparation method of a kind of mosquito repellent antibacterial toilet soap as described in claim 1-8 is any, it is characterised in that including following step
Suddenly：
Base oil is heated to 45-60 DEG C by S1, is fully mixed, and obtains miscella；
Potassium hydroxide is added to the water dissolving by S2, controls the mass concentration of potassium hydroxide for 20-30%, and above-mentioned solution is cooled down
To 45-60 DEG C, alkali lye is obtained；
Be added to step S2 gained alkali lye in step S1 gained miscellas in three times by S3, and each interval time is 15 minutes, is stirred
Speed is mixed for 450-620r/min, mixing time is 40-60 minutes, obtains soap lye；
S4 is by cocinic acid, sodium chloride, glutathione, disodium ethylene diamine tetraacetate, sodium carboxymethylcellulose, palmitic acid, bay
Azone, lauryl sodium sulfate and culicifuge are added in step S3 gained soap lyes, and mixing speed is 480-560r/min, stirring
Time is 25-36 minutes, adds Geranium Essential and antiseptic, is stirred, and obtains mixed material；
Mould is placed in -20 DEG C and freezed 12 hours by S5 by step S4 gained mixed material injection moulds, it is to be solidified after from mould
Middle taking-up, the cool soap of room temperature, obtains final product.
10. the preparation method of mosquito repellent antibacterial toilet soap as claimed in claim 9, it is characterised in that the step S1 is by base oil
It is heated to 52 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107365643A (en) * | 2017-09-17 | 2017-11-21 | 于洋 | A kind of sea-buckthorn renders ancient method cold process soap and preparation method thereof |
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| CN102277244A (en) * | 2010-06-11 | 2011-12-14 | 单克胜 | Natural plant mosquito repellent soap |
| CN103013701A (en) * | 2012-11-23 | 2013-04-03 | 吴江福茂纺织有限公司 | Wool fabric cleaning agent |
| CN104651096A (en) * | 2013-11-23 | 2015-05-27 | 楚乐然 | Mosquito-repellent soap |
| CN105886141A (en) * | 2016-05-13 | 2016-08-24 | 马鞍山纽盟知识产权管理服务有限公司 | Novel washing machine cleaning agent |
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|---|---|---|---|---|
| CN102277244A (en) * | 2010-06-11 | 2011-12-14 | 单克胜 | Natural plant mosquito repellent soap |
| CN103013701A (en) * | 2012-11-23 | 2013-04-03 | 吴江福茂纺织有限公司 | Wool fabric cleaning agent |
| CN104651096A (en) * | 2013-11-23 | 2015-05-27 | 楚乐然 | Mosquito-repellent soap |
| CN105886141A (en) * | 2016-05-13 | 2016-08-24 | 马鞍山纽盟知识产权管理服务有限公司 | Novel washing machine cleaning agent |
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| CN107365643A (en) * | 2017-09-17 | 2017-11-21 | 于洋 | A kind of sea-buckthorn renders ancient method cold process soap and preparation method thereof |
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