CN106795221B - 用于癌症免疫治疗的cd33特异性嵌合抗原受体 - Google Patents
用于癌症免疫治疗的cd33特异性嵌合抗原受体 Download PDFInfo
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470171 | 2014-04-03 | ||
| DKPA201470171 | 2014-04-03 | ||
| PCT/EP2015/057331 WO2015150526A2 (en) | 2014-04-03 | 2015-04-02 | Cd33 specific chimeric antigen receptors for cancer immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106795221A CN106795221A (zh) | 2017-05-31 |
| CN106795221B true CN106795221B (zh) | 2022-06-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580027233.3A Active CN106795221B (zh) | 2014-04-03 | 2015-04-02 | 用于癌症免疫治疗的cd33特异性嵌合抗原受体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9944702B2 (enExample) |
| EP (1) | EP3126390B1 (enExample) |
| JP (1) | JP6673848B2 (enExample) |
| KR (1) | KR102170533B1 (enExample) |
| CN (1) | CN106795221B (enExample) |
| AU (1) | AU2015239069B2 (enExample) |
| CA (1) | CA2944528C (enExample) |
| DK (1) | DK3126390T3 (enExample) |
| ES (1) | ES2765710T3 (enExample) |
| IL (1) | IL247917B (enExample) |
| MX (1) | MX370788B (enExample) |
| RU (1) | RU2701341C2 (enExample) |
| WO (1) | WO2015150526A2 (enExample) |
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| US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
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| CA3133545C (en) | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| ES2765710T3 (es) * | 2014-04-03 | 2020-06-10 | Cellectis | Receptores de antígeno quimérico específicos de CD33 para la inmunoterapia del cáncer |
| EP3131927B8 (en) * | 2014-04-14 | 2020-12-23 | Cellectis | Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy |
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2015
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- 2015-04-02 WO PCT/EP2015/057331 patent/WO2015150526A2/en not_active Ceased
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2016
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2018
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2023
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Patent Citations (1)
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|---|---|---|---|---|
| WO2012079000A1 (en) * | 2010-12-09 | 2012-06-14 | The Trustees Of The University Of Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
Non-Patent Citations (1)
| Title |
|---|
| Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCRζ chain;Helene M. Finney等;《The Journal of Immunology》;20040101;第172卷(第1期);第105页右栏第4段,第106页左栏第4段-右栏第1段,图3-E * |
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| Publication number | Publication date |
|---|---|
| WO2015150526A3 (en) | 2015-11-26 |
| ES2765710T3 (es) | 2020-06-10 |
| JP2017515460A (ja) | 2017-06-15 |
| IL247917A0 (en) | 2016-11-30 |
| CA2944528A1 (en) | 2015-10-08 |
| JP6673848B2 (ja) | 2020-03-25 |
| US20170145094A1 (en) | 2017-05-25 |
| DK3126390T3 (da) | 2020-01-20 |
| MX2016012855A (es) | 2016-12-12 |
| KR20170002412A (ko) | 2017-01-06 |
| EP3126390B1 (en) | 2019-10-16 |
| US20190002561A1 (en) | 2019-01-03 |
| MX370788B (es) | 2020-01-06 |
| EP3126390A2 (en) | 2017-02-08 |
| AU2015239069B2 (en) | 2020-02-20 |
| AU2015239069A1 (en) | 2016-10-06 |
| RU2016143155A (ru) | 2018-05-04 |
| WO2015150526A2 (en) | 2015-10-08 |
| IL247917B (en) | 2020-11-30 |
| BR112016022369A2 (pt) | 2017-10-10 |
| US20240182565A1 (en) | 2024-06-06 |
| KR102170533B1 (ko) | 2020-10-27 |
| CA2944528C (en) | 2021-08-10 |
| RU2701341C2 (ru) | 2019-09-25 |
| CN106795221A (zh) | 2017-05-31 |
| RU2016143155A3 (enExample) | 2018-10-23 |
| US9944702B2 (en) | 2018-04-17 |
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