CN106795117B - 杂双环化合物及其用于治疗结核病的用途 - Google Patents

杂双环化合物及其用于治疗结核病的用途 Download PDF

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Publication number
CN106795117B
CN106795117B CN201580045974.4A CN201580045974A CN106795117B CN 106795117 B CN106795117 B CN 106795117B CN 201580045974 A CN201580045974 A CN 201580045974A CN 106795117 B CN106795117 B CN 106795117B
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China
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group
fluoro
methoxy
dihydroquinolin
compound
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Chinese (zh)
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CN106795117A (zh
Inventor
清水洋
川野芳和
石川俊平
植松幸崇
篠原俊夫
丝谷元宏
原口佳和
竹村勋
兼重笃谨
中井雄野
播口德充
林阳平
松本真
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
CN201580045974.4A 2014-08-28 2015-08-28 杂双环化合物及其用于治疗结核病的用途 Active CN106795117B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014174528 2014-08-28
JP2014-174528 2014-08-28
PCT/JP2015/004371 WO2016031255A1 (en) 2014-08-28 2015-08-28 Heterobicyclic compounds and their use for the treatment of tuberculosis

Publications (2)

Publication Number Publication Date
CN106795117A CN106795117A (zh) 2017-05-31
CN106795117B true CN106795117B (zh) 2020-06-26

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ID=54105947

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CN201580045974.4A Active CN106795117B (zh) 2014-08-28 2015-08-28 杂双环化合物及其用于治疗结核病的用途

Country Status (29)

Country Link
US (2) US10053446B2 (OSRAM)
EP (1) EP3186240B9 (OSRAM)
JP (1) JP6625612B2 (OSRAM)
KR (1) KR102418413B1 (OSRAM)
CN (1) CN106795117B (OSRAM)
AP (1) AP2017009788A0 (OSRAM)
AR (1) AR101704A1 (OSRAM)
AU (1) AU2015307873B2 (OSRAM)
BR (1) BR112017003231B1 (OSRAM)
CA (1) CA2959478C (OSRAM)
CY (1) CY1122286T1 (OSRAM)
DK (1) DK3186240T3 (OSRAM)
EA (1) EA038414B1 (OSRAM)
ES (1) ES2743788T3 (OSRAM)
HR (1) HRP20191486T2 (OSRAM)
HU (1) HUE045025T2 (OSRAM)
IL (1) IL250484B (OSRAM)
LT (1) LT3186240T (OSRAM)
MX (1) MX2017002312A (OSRAM)
MY (1) MY189098A (OSRAM)
NZ (1) NZ729064A (OSRAM)
PH (1) PH12017500290B1 (OSRAM)
PL (1) PL3186240T3 (OSRAM)
PT (1) PT3186240T (OSRAM)
SG (1) SG11201700882XA (OSRAM)
SI (1) SI3186240T1 (OSRAM)
TW (1) TWI687409B (OSRAM)
WO (1) WO2016031255A1 (OSRAM)
ZA (1) ZA201700916B (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101704A1 (es) * 2014-08-28 2017-01-04 Otsuka Pharma Co Ltd Compuestos heterocíclicos fusionados
WO2017146246A1 (ja) * 2016-02-26 2017-08-31 大塚製薬株式会社 ピペリジン誘導体
US20210292333A1 (en) 2018-06-15 2021-09-23 Cadila Healthcare Limited Condensed azaheteroaryl compounds having antibacterial activity against tuberculosis bacteria
JP2023085582A (ja) * 2020-05-11 2023-06-21 大塚製薬株式会社 ジヒドロキノリノン化合物の共結晶
EP4201407A4 (en) * 2020-08-19 2024-07-31 MitoImmune Therapeutics Inc. ANTIOXIDANT TARGETING MITOCHONDRIA AS AN AGENT FOR THE TREATMENT OF PATHOLOGICAL INFLAMMATION CAUSED BY MABC-R INFECTION
CN116102537B (zh) * 2021-11-10 2024-10-01 四川大学 一种喹啉酮类衍生物及其制备方法和用途
CN116589448B (zh) * 2023-04-24 2025-10-28 西南交通大学 一种3,4-二氢喹啉酮衍生物及其应用
WO2025183016A1 (ja) * 2024-02-26 2025-09-04 大塚製薬株式会社 Ｑｕａｂｏｄｅｐｉｓｔａｔ含有組成物
WO2025183017A1 (ja) * 2024-02-26 2025-09-04 大塚製薬株式会社 Ｑｕａｂｏｄｅｐｉｓｔａｔ含有組成物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1878777A (zh) * 2003-10-31 2006-12-13 大塚制药株式会社 治疗结核病的2,3－二氢－6－硝基咪唑并[2,1－b]噁唑化合物
WO2010045987A1 (en) * 2008-10-23 2010-04-29 Glaxo Group Limited Substituted (aza) -1-methyl-1h-quin0lin-2-0nes as antibacterials
CN101891680A (zh) * 2004-06-24 2010-11-24 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
CN102131778A (zh) * 2008-07-10 2011-07-20 普洛希典有限公司 杂环gpcr激动剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2608788B2 (ja) * 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
TWI347946B (en) 2002-10-11 2011-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
GB0319150D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
WO2005042542A1 (en) 2003-10-31 2005-05-12 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis
JP4761756B2 (ja) 2003-10-31 2011-08-31 大塚製薬株式会社 ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物
WO2007099828A1 (ja) 2006-02-23 2007-09-07 Shionogi & Co., Ltd. 環式基で置換された含窒素複素環誘導体
EP2459570B1 (en) 2009-07-31 2014-12-24 Global Alliance For Tb Drug Development Nitroimidazooxazine analogues and their uses
EP2697232B1 (en) 2011-04-15 2016-05-18 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo[2,1-b][1,3]oxazine bactericides
AR101704A1 (es) * 2014-08-28 2017-01-04 Otsuka Pharma Co Ltd Compuestos heterocíclicos fusionados
WO2017146246A1 (ja) * 2016-02-26 2017-08-31 大塚製薬株式会社 ピペリジン誘導体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1878777A (zh) * 2003-10-31 2006-12-13 大塚制药株式会社 治疗结核病的2,3－二氢－6－硝基咪唑并[2,1－b]噁唑化合物
CN101891680A (zh) * 2004-06-24 2010-11-24 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
CN102131778A (zh) * 2008-07-10 2011-07-20 普洛希典有限公司 杂环gpcr激动剂
WO2010045987A1 (en) * 2008-10-23 2010-04-29 Glaxo Group Limited Substituted (aza) -1-methyl-1h-quin0lin-2-0nes as antibacterials

Also Published As

Publication number Publication date
ES2743788T3 (es) 2020-02-20
AU2015307873A1 (en) 2017-03-09
MX2017002312A (es) 2017-05-08
AR101704A1 (es) 2017-01-04
LT3186240T (lt) 2019-09-10
US20180312488A1 (en) 2018-11-01
DK3186240T3 (da) 2019-08-26
TW201609658A (zh) 2016-03-16
HRP20191486T1 (hr) 2019-11-15
MY189098A (en) 2022-01-25
HUE045025T2 (hu) 2019-12-30
EP3186240B1 (en) 2019-06-12
ZA201700916B (en) 2019-06-26
BR112017003231A2 (pt) 2017-11-28
AP2017009788A0 (en) 2017-02-28
JP6625612B2 (ja) 2019-12-25
CA2959478C (en) 2023-09-26
BR112017003231B1 (pt) 2022-10-11
SI3186240T1 (sl) 2019-10-30
KR102418413B1 (ko) 2022-07-06
PL3186240T3 (pl) 2020-03-31
KR20170043644A (ko) 2017-04-21
PH12017500290B1 (en) 2023-07-19
IL250484B (en) 2020-04-30
US10464926B2 (en) 2019-11-05
PT3186240T (pt) 2019-09-06
WO2016031255A1 (en) 2016-03-03
EP3186240B9 (en) 2019-12-04
PH12017500290A1 (en) 2017-06-28
AU2015307873B2 (en) 2020-01-16
NZ729064A (en) 2022-09-30
EA201790464A1 (ru) 2017-06-30
EP3186240A1 (en) 2017-07-05
TWI687409B (zh) 2020-03-11
JP2017525697A (ja) 2017-09-07
CA2959478A1 (en) 2016-03-03
CY1122286T1 (el) 2021-01-27
US20170253576A1 (en) 2017-09-07
HRP20191486T2 (hr) 2021-09-17
IL250484A0 (en) 2017-03-30
CN106795117A (zh) 2017-05-31
SG11201700882XA (en) 2017-03-30
US10053446B2 (en) 2018-08-21
EA038414B1 (ru) 2021-08-25

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