CN106715718B - 用于检测和分析结核分枝杆菌的组合物和方法 - Google Patents

用于检测和分析结核分枝杆菌的组合物和方法 Download PDF

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CN106715718B
CN106715718B CN201580049410.8A CN201580049410A CN106715718B CN 106715718 B CN106715718 B CN 106715718B CN 201580049410 A CN201580049410 A CN 201580049410A CN 106715718 B CN106715718 B CN 106715718B
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sample
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seq
samples
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CN106715718A (zh
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唐宁
G.勒基
V.帕哈拉瓦塔
A.弗兰克
J.兰皮宁
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201580049410.8A 2014-07-24 2015-07-07 用于检测和分析结核分枝杆菌的组合物和方法 Active CN106715718B (zh)

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US201462028527P 2014-07-24 2014-07-24
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PCT/US2015/039362 WO2016014240A2 (en) 2014-07-24 2015-07-07 Compositions and methods for the detection and analysis of mycobacterium tuberculosis

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CN106715718B (zh) 2014-07-24 2021-07-06 雅培分子公司 用于检测和分析结核分枝杆菌的组合物和方法
US10526664B2 (en) * 2015-07-14 2020-01-07 Abbott Molecular Inc. Compositions and methods for identifying drug resistant tuberculosis
EP3501282A1 (en) * 2017-12-22 2019-06-26 F. Hoffmann-La Roche AG Composition for processing a sputum sample
EP3880364B1 (en) * 2018-11-13 2024-04-17 The University of North Carolina at Chapel Hill Analysis system for microfluidic devices
KR102368506B1 (ko) * 2019-11-12 2022-02-28 에이비아이(주) 결핵균과 비결핵 항산균 검출을 위한 객담의 전처리 조성물과 그 방법 및 프라이머와 프로브, 이를 이용한 장치
USD1084017S1 (en) * 2021-06-10 2025-07-15 Zimmer Surgical, Inc. Display screen or portion thereof with an animated graphical user interface
CN115747300A (zh) * 2022-05-19 2023-03-07 首都医科大学附属北京朝阳医院 一种下呼吸道样本处理试剂、诺卡菌检测试剂盒及核酸扩增方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101023170A (zh) * 2004-04-26 2007-08-22 和光纯药工业株式会社 结核菌检测用的引物和探针以及使用它们检测人型结核菌的方法
CN101868542A (zh) * 2007-06-22 2010-10-20 凯津公司 具有改进的经修饰的寡核苷酸的定向核苷酸交换
EP2514838A1 (en) * 2007-04-13 2012-10-24 Abbott Laboratories Primer and probe sequences for detecting chlamydia trachomatis
CN103635575A (zh) * 2011-06-15 2014-03-12 盖立复治疗公司 用于测定人免疫缺陷病毒（hiv）的方法、组合物和试剂盒
CN103687961A (zh) * 2011-05-06 2014-03-26 赛卢拉有限公司 用于等温全基因组扩增的方法和组合物

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948882A (en) 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
DE3687030T2 (de) 1985-03-15 1993-03-11 Eugene Stirchak Stereoregulare polynukleotiden bindende polymere.
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5491224A (en) 1990-09-20 1996-02-13 Bittner; Michael L. Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture
US5168039A (en) * 1990-09-28 1992-12-01 The Board Of Trustees Of The University Of Arkansas Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5424414A (en) 1991-12-17 1995-06-13 Abbott Laboratories Haptens, tracers, immunogens and antibodies for 3-phenyl-1-adamantaneacetic acids
US5464746A (en) 1991-12-17 1995-11-07 Abbott Laboratories Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives
CA2119188A1 (en) * 1993-04-05 1994-10-06 Patricia A. Spears Detection and identification of mycobacteria
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5714330A (en) 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US5631130A (en) * 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
CA2126952C (en) 1994-06-28 2010-12-14 Sithian Pandian Probe, kit, and method of amplification for increasing the sensitivity of nucleic acid hybridization assays
WO1996006190A2 (en) 1994-08-19 1996-02-29 Perkin-Elmer Corporation Coupled amplification and ligation method
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
DE69738687D1 (de) 1996-04-12 2008-06-26 Phri Properties Inc Sonden, kits und assays
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
WO1999019341A1 (en) 1997-10-10 1999-04-22 President & Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
EP1218543A2 (en) 1999-09-29 2002-07-03 Solexa Ltd. Polynucleotide sequencing
US6642000B1 (en) 1999-11-12 2003-11-04 University Of Chicago PCR amplification on microarrays of gel immobilized oligonucleotides
JP2004513619A (ja) 2000-07-07 2004-05-13 ヴィジゲン　バイオテクノロジーズ　インコーポレイテッド リアルタイム配列決定
US7668697B2 (en) 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US20110111389A1 (en) 2001-11-07 2011-05-12 Diagcor Bioscience Incorporation Limited Rapid genotyping analysis for human papillomavirus and the device thereof
ATE360097T1 (de) * 2002-02-25 2007-05-15 Pasteur Institut Spezifisch vom genom von mycobacterium tuberculosis deletierte sequenzen und deren verwendung in der diagnostik und als vakzine
CA2513535C (en) 2003-01-29 2012-06-12 454 Corporation Bead emulsion nucleic acid amplification
WO2005012560A1 (en) * 2003-07-29 2005-02-10 UNIVERSITé LAVAL Obesity markers and uses thereof
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
RU2338789C2 (ru) * 2003-12-09 2008-11-20 Каунсил Оф Сайентифик Энд Индастриал Рисерч Способ детекции патогенных микобактерий в клинических образцах
GB0403039D0 (en) 2004-02-11 2004-03-17 Health Prot Agency TB resistance assay
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
EP1844162B1 (en) 2005-02-01 2014-10-15 Applied Biosystems, LLC Method for identifying a sequence in a polynucleotide
RU2376387C2 (ru) 2005-12-26 2009-12-20 Учреждение Российской академии наук Институт молекулярной биологии им. В.А. Энгельгардта РАН Способ одновременного обнаружения микобактерий туберкулезного комплекса и идентификации мутаций в днк микобактерий, приводящих к устойчивости микроорганизмов к рифампицину и изониазиду, на биологических микрочипах, набор праймеров, биочип и набор олигонуклеотидных зондов, используемые в способе
EP1966366A4 (en) 2005-12-29 2011-06-15 I Stat Corp AMPLIFICATION SYSTEM AND METHODS FOR MOLECULAR DIAGNOSIS
US7282337B1 (en) 2006-04-14 2007-10-16 Helicos Biosciences Corporation Methods for increasing accuracy of nucleic acid sequencing
JPWO2007141912A1 (ja) * 2006-06-07 2009-10-15 住友ベークライト株式会社 Ｒｎａ検出方法
US20080241951A1 (en) 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Method and apparatus for moving stage detection of single molecular events
US8652782B2 (en) * 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
EP2368568A1 (en) * 2006-11-01 2011-09-28 Immport Therapeutics, INC. Compositions and methods for immunodominant antigens
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
AU2007334393A1 (en) 2006-12-14 2008-06-26 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2008152636A2 (en) * 2007-06-15 2008-12-18 Quark Pharmaceuticals, Inc. Compositions and methods for inhibiting nadph oxidase expression
DK2171088T3 (en) 2007-06-19 2016-01-25 Stratos Genomics Inc Nucleic acid sequencing in a high yield by expansion
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
MX359550B (es) * 2009-05-13 2018-10-02 Immport Therapeutics Inc Composiciones y metodos para antigenos inmunodominantes de mycobacterium tuberculosis.
US20130095489A1 (en) 2010-05-04 2013-04-18 Centers For Disease Control And Prevention Process for detection of multidrug resistant tuberculosis using real-time pcr and high resolution melt analysis
KR101158649B1 (ko) * 2010-05-27 2012-06-26 울산대학교 산학협력단 이중 실시간 중합효소연쇄반응법을 이용한 결핵균과 항산성비결핵균의 검출 방법
KR101152061B1 (ko) * 2010-05-27 2012-06-08 울산대학교 산학협력단 이중 중합효소연쇄반응법을 이용한 결핵균과 항산성비결핵균의 검출 방법
WO2012057904A1 (en) * 2010-10-27 2012-05-03 Infectious Disease Research Institute Mycobacterium tuberculosis antigens and combinations thereof having high seroreactivity
CN102618625B (zh) 2011-01-27 2013-09-11 博奥生物有限公司 一种检测结核分枝杆菌耐药性的方法和试剂盒
US9045803B2 (en) 2012-02-29 2015-06-02 Abbott Molecular Inc. Hepatitis B virus typing and resistance assay
CN103312221A (zh) 2012-03-13 2013-09-18 鸿富锦精密工业（深圳）有限公司 太阳能板清洁系统
US9249398B2 (en) * 2012-05-30 2016-02-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Use of mycobacterium smegmatis trehalose dimycolate hydrolase
CN105392896B (zh) 2013-03-15 2017-10-20 达雅高生命科技有限公司 快速并灵敏基因型鉴定及核酸检测
WO2015077242A1 (en) 2013-11-19 2015-05-28 Brandeis University Multiplex target detection assay
CN106715718B (zh) 2014-07-24 2021-07-06 雅培分子公司 用于检测和分析结核分枝杆菌的组合物和方法
JP6599606B2 (ja) 2014-10-24 2019-10-30 アサヒビール株式会社 非発酵ビール様発泡性飲料
US10582714B2 (en) 2015-07-10 2020-03-10 Mead Johnson Nutrition Company Nutritional compositions and methods for promoting cognitive development
US10526664B2 (en) 2015-07-14 2020-01-07 Abbott Molecular Inc. Compositions and methods for identifying drug resistant tuberculosis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101023170A (zh) * 2004-04-26 2007-08-22 和光纯药工业株式会社 结核菌检测用的引物和探针以及使用它们检测人型结核菌的方法
EP2514838A1 (en) * 2007-04-13 2012-10-24 Abbott Laboratories Primer and probe sequences for detecting chlamydia trachomatis
CN101868542A (zh) * 2007-06-22 2010-10-20 凯津公司 具有改进的经修饰的寡核苷酸的定向核苷酸交换
CN103687961A (zh) * 2011-05-06 2014-03-26 赛卢拉有限公司 用于等温全基因组扩增的方法和组合物
CN103635575A (zh) * 2011-06-15 2014-03-12 盖立复治疗公司 用于测定人免疫缺陷病毒（hiv）的方法、组合物和试剂盒

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Evaluation of multiplex Polymerase chain reaction utilising multiple targets in Mycobacterium tuberculosis direct test negative but culture positive cases：A potential method for enhancing the diagnosis of tuberculosis;Sharma K等;《Indian journal of medical microbiology》;20130926;第31卷(第4期);第371页左栏第7行-第372页左栏倒数第14行 *
结核/非结核分枝杆菌核酸快速检测方法临床应用价值;康丽军等;《中国防痨杂志》;20110510;第33卷(第5期);第263-266页 *

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EP3191607A2 (en) 2017-07-19
JP2017521086A (ja) 2017-08-03
EP3835430A1 (en) 2021-06-16
US20190048400A1 (en) 2019-02-14
RU2017102991A3 (enExample) 2019-01-23
US20200347438A9 (en) 2020-11-05
US20210198721A1 (en) 2021-07-01
EP4282961A3 (en) 2024-02-28
EP3191607B1 (en) 2019-08-21
JP6840207B2 (ja) 2021-03-10
EP4282961A2 (en) 2023-11-29
ES2752761T3 (es) 2020-04-06
ES2962636T3 (es) 2024-03-20
US10072306B2 (en) 2018-09-11
CA2955771C (en) 2022-08-30
EP3835430B1 (en) 2023-08-16
WO2016014240A2 (en) 2016-01-28
CN113652492A (zh) 2021-11-16
US20160024561A1 (en) 2016-01-28
CA2955771A1 (en) 2016-01-28
US11932911B2 (en) 2024-03-19
JP6596066B2 (ja) 2019-10-23
WO2016014240A9 (en) 2016-05-06
ES2864855T3 (es) 2021-10-14
CN106715718A (zh) 2017-05-24
EP3578668B1 (en) 2020-12-30
JP2020010714A (ja) 2020-01-23
AP2017009731A0 (en) 2017-02-28
US10975446B2 (en) 2021-04-13
EP3578668A1 (en) 2019-12-11
MX377788B (es) 2025-03-10
RU2017102991A (ru) 2018-08-27
MX2017001134A (es) 2017-10-11
BR112017001500A2 (pt) 2018-02-20
EP3191607A4 (en) 2017-12-20
RU2697502C2 (ru) 2019-08-14
EP4282961B1 (en) 2025-08-20
WO2016014240A3 (en) 2016-03-17

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