CN106706526B - 离子液体萃取–紫外可见分光光度法测定盐酸美西律的方法 - Google Patents
离子液体萃取–紫外可见分光光度法测定盐酸美西律的方法 Download PDFInfo
- Publication number
- CN106706526B CN106706526B CN201610888860.2A CN201610888860A CN106706526B CN 106706526 B CN106706526 B CN 106706526B CN 201610888860 A CN201610888860 A CN 201610888860A CN 106706526 B CN106706526 B CN 106706526B
- Authority
- CN
- China
- Prior art keywords
- mexiletine hydrochloride
- liquid
- mexiletine
- ultraviolet
- bpy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VLPIATFUUWWMKC-UHFFFAOYSA-N mexiletine Chemical compound CC(N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-UHFFFAOYSA-N 0.000 title claims abstract description 101
- 229960001070 mexiletine hydrochloride Drugs 0.000 title claims abstract description 101
- 239000007788 liquid Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims abstract description 27
- 238000005259 measurement Methods 0.000 title claims abstract description 25
- 238000000870 ultraviolet spectroscopy Methods 0.000 title claims abstract description 15
- 239000002608 ionic liquid Substances 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 238000000605 extraction Methods 0.000 claims abstract description 31
- 239000007853 buffer solution Substances 0.000 claims abstract description 24
- 238000002835 absorbance Methods 0.000 claims abstract description 19
- 239000012071 phase Substances 0.000 claims abstract description 17
- 239000012153 distilled water Substances 0.000 claims abstract description 15
- 239000012074 organic phase Substances 0.000 claims abstract description 12
- 239000000243 solution Substances 0.000 claims abstract description 11
- 239000008236 heating water Substances 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 150000002500 ions Chemical class 0.000 claims description 19
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 11
- 238000002798 spectrophotometry method Methods 0.000 claims description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 7
- -1 hexafluorophosphoric acid-N- butyl-pyridinium Chemical compound 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 5
- 230000008020 evaporation Effects 0.000 claims description 5
- HZNVUJQVZSTENZ-UHFFFAOYSA-N 2,3-dichloro-5,6-dicyano-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(C#N)=C(C#N)C1=O HZNVUJQVZSTENZ-UHFFFAOYSA-N 0.000 claims description 4
- 230000031709 bromination Effects 0.000 claims description 4
- 238000005893 bromination reaction Methods 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 claims description 4
- 239000013067 intermediate product Substances 0.000 claims description 4
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000007974 sodium acetate buffer Substances 0.000 claims description 2
- 239000000052 vinegar Substances 0.000 claims description 2
- 235000021419 vinegar Nutrition 0.000 claims description 2
- 239000000284 extract Substances 0.000 abstract description 3
- 238000004090 dissolution Methods 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- VLPIATFUUWWMKC-SNVBAGLBSA-N (2r)-1-(2,6-dimethylphenoxy)propan-2-amine Chemical compound C[C@@H](N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-SNVBAGLBSA-N 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 229960003404 mexiletine Drugs 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004737 colorimetric analysis Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- UZVUSORDFOESJG-UHFFFAOYSA-N 2-bromo-3-methyl-6-propan-2-ylphenol Chemical compound CC(C)C1=CC=C(C)C(Br)=C1O UZVUSORDFOESJG-UHFFFAOYSA-N 0.000 description 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000005486 organic electrolyte Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 238000005220 pharmaceutical analysis Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4055—Concentrating samples by solubility techniques
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4055—Concentrating samples by solubility techniques
- G01N2001/4061—Solvent extraction
Landscapes
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610888860.2A CN106706526B (zh) | 2016-10-12 | 2016-10-12 | 离子液体萃取–紫外可见分光光度法测定盐酸美西律的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610888860.2A CN106706526B (zh) | 2016-10-12 | 2016-10-12 | 离子液体萃取–紫外可见分光光度法测定盐酸美西律的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106706526A CN106706526A (zh) | 2017-05-24 |
CN106706526B true CN106706526B (zh) | 2019-08-20 |
Family
ID=58940379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610888860.2A Active CN106706526B (zh) | 2016-10-12 | 2016-10-12 | 离子液体萃取–紫外可见分光光度法测定盐酸美西律的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106706526B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109752356B (zh) * | 2018-11-27 | 2021-02-26 | 河南师范大学 | 一种快速可视化筛选离子液体催化剂的方法 |
CN110514609B (zh) * | 2019-09-26 | 2022-08-02 | 武汉海关技术中心 | 固体食品样品中铅金属元素的分析检测方法 |
CN114018844A (zh) * | 2021-10-19 | 2022-02-08 | 福建立标低碳研究院有限公司 | 吡啶类离子液体对赤芍药中芍药苷的萃取测定方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006044795A1 (de) * | 2006-09-13 | 2008-03-27 | Schweigert, Florian, Prof. Dr.med.vet. | Bestimmung von Inhaltsstoffen aus biologischen Materialien |
CN106153750A (zh) * | 2015-04-10 | 2016-11-23 | 浙江海洋学院 | 一种利用离子液体萃取/hplc检测昆明山海棠根茎中雷公藤次碱含量的方法 |
CN105866292B (zh) * | 2016-05-31 | 2019-04-12 | 中华人民共和国吉林出入境检验检疫局 | 一种离子液体均相液液萃取-高效液相色谱法测定甾体激素的方法 |
-
2016
- 2016-10-12 CN CN201610888860.2A patent/CN106706526B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN106706526A (zh) | 2017-05-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Xia et al. | Ionic liquids based single drop microextraction combined with electrothermal vaporization inductively coupled plasma mass spectrometry for determination of Co, Hg and Pb in biological and environmental samples | |
Wang et al. | Determination of triazines in honey by dispersive liquid–liquid microextraction high-performance liquid chromatography | |
CN106706526B (zh) | 离子液体萃取–紫外可见分光光度法测定盐酸美西律的方法 | |
CN104357044B (zh) | 一种荧光探针及其制备方法和应用 | |
Xiao et al. | Application of derivative and derivative ratio spectrophotometry to simultaneous trace determination of rhodamine B and rhodamine 6G after dispersive liquid–liquid microextraction | |
CN103149309A (zh) | 变压器油中糠醛含量测定方法 | |
CN108181396A (zh) | 一种灵芝中17种三萜化合物含量的检测方法 | |
CN103592248A (zh) | 土壤含水率的比色测定方法 | |
Wu et al. | Ionic liquid sensitized fluorescence determination of four isoquinoline alkaloids | |
CN107941980A (zh) | 水产品中利福平残留的超高效液相色谱串联质谱快速测定方法 | |
CN105842235A (zh) | 高灵敏度、可裸眼检测易挥发性有机胺的荧光试纸及制备 | |
CN106706826A (zh) | 一种毫克级植物中植物激素的分析方法 | |
CN103308641A (zh) | 烟草及烟草制品中三种酰胺类除草剂的高效液相色谱-串联质谱测定方法 | |
CN106634968A (zh) | 一种线粒体靶向的粘度荧光探针及其制备方法和应用 | |
CN102384907B (zh) | 香草醛-硫酸比色法测定光甘草定含量的方法 | |
CN101865887B (zh) | 高效液相色谱串联质谱测蜂王浆中硝基咪唑类残留的方法 | |
CN103497189B (zh) | 1-羟基-3,4:9,10-苝四羧酸二酰亚胺、其合成方法及在氟含量测定中的应用 | |
CN106018608B (zh) | 加速溶剂萃取-液相色谱串联质谱法测定烟用接装纸中高氯酸根的方法 | |
CN104650105A (zh) | 含8-氨基喹啉基团的罗丹明B衍生物、制备方法、应用及对Cr3+及Cu2+进行荧光分析的方法 | |
CN110161151A (zh) | 一种通过检测肌酐和1-甲基海因含量推断水中尸体浸没时间的方法 | |
CN106596442A (zh) | 一种快速定量检测甲拌磷残留的方法 | |
CN106198811A (zh) | 快速测定水和水产品中孔雀石绿和结晶紫的试剂盒及方法 | |
CN106243093B (zh) | 双香豆素衍生物及其制备方法 | |
CN106706824B (zh) | 一种色质联用的昆虫体内保幼激素jh ii的检测方法 | |
Heydari et al. | Simultaneous determination of Tropaeolin O and brilliant blue in food samples after cloud point extraction |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190724 Address after: Room 616, 13 Block Huayuan, Jindi, 87 Quanxiu Road, Fengze District, Quanzhou City, Fujian Province, 362000 Applicant after: Pan Zhongwei Address before: Room 401, 74 Xin'an Road, Fengcheng Town, Anxi County, Quanzhou City, Fujian Province Applicant before: Lin Shengzhuo |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20201105 Address after: 362000 2nd floor, building 32, Xinmen jieyuanhe 1916 Creative Industry Park, Licheng District, Quanzhou City, Fujian Province Patentee after: QUANZHOU GREEN LOW CARBON Research Institute Address before: Room 616, 13 Block Huayuan, Jindi, 87 Quanxiu Road, Fengze District, Quanzhou City, Fujian Province, 362000 Patentee before: Pan Zhongwei |