CN106687474A - 新型胰淀素和降钙素受体激动剂 - Google Patents

新型胰淀素和降钙素受体激动剂 Download PDF

Info

Publication number
CN106687474A
CN106687474A CN201580046850.8A CN201580046850A CN106687474A CN 106687474 A CN106687474 A CN 106687474A CN 201580046850 A CN201580046850 A CN 201580046850A CN 106687474 A CN106687474 A CN 106687474A
Authority
CN
China
Prior art keywords
mimylin
peptide
preceding aspects
seq
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580046850.8A
Other languages
English (en)
Chinese (zh)
Inventor
T.克鲁塞
L.舍夫弗
K.达尔
C.波森
K.劳恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CN106687474A publication Critical patent/CN106687474A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201580046850.8A 2014-09-04 2015-09-02 新型胰淀素和降钙素受体激动剂 Pending CN106687474A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14183551 2014-09-04
EP14183551.2 2014-09-04
PCT/EP2015/069996 WO2016034604A1 (en) 2014-09-04 2015-09-02 Novel amylin and calcitonin receptor agonist

Publications (1)

Publication Number Publication Date
CN106687474A true CN106687474A (zh) 2017-05-17

Family

ID=51483301

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580046850.8A Pending CN106687474A (zh) 2014-09-04 2015-09-02 新型胰淀素和降钙素受体激动剂

Country Status (8)

Country Link
US (2) US9593149B2 (https=)
EP (1) EP3189071B1 (https=)
JP (3) JP6728141B2 (https=)
CN (1) CN106687474A (https=)
AR (1) AR101742A1 (https=)
ES (1) ES2887370T3 (https=)
TW (1) TW201625671A (https=)
WO (1) WO2016034604A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109248323A (zh) * 2017-07-14 2019-01-22 杭州先为达生物科技有限公司 酰化的glp-1衍生物
CN110467666A (zh) * 2019-09-17 2019-11-19 湖北强耀生物科技有限公司 一种新型胰岛淀粉样多肽的合成方法
WO2025195008A1 (zh) * 2024-03-19 2025-09-25 深圳湾实验室 多肽或其类似物及其应用

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017019378A2 (pt) 2015-03-18 2019-02-19 Zealand Pharma A/S análogos de amilina
US10071140B2 (en) 2016-09-09 2018-09-11 Zealand Pharma A/S Amylin analogues
ES2828526T3 (es) 2016-11-07 2021-05-26 Novo Nordisk As Esteres activos DCHBS de compuestos PEG y sus usos
US11274158B2 (en) 2018-01-30 2022-03-15 Flagship Pioneering Innovations V, Inc. Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators
AR116632A1 (es) 2018-10-11 2021-05-26 Intarcia Therapeutics Inc Polipéptidos análogos de la amilina humana y sus métodos de uso
WO2020180534A1 (en) 2019-03-01 2020-09-10 President And Fellows Of Harvard College Methods and compositions for protein delivery
TWI850611B (zh) * 2020-12-18 2024-08-01 丹麥商諾佛 儂迪克股份有限公司 Glp-1及澱粉素受體之共促效劑
AR124295A1 (es) 2020-12-18 2023-03-15 Lilly Co Eli Agonistas duales del receptor de amilina y calcitonina y usos de los mismos
WO2022248419A2 (en) 2021-05-22 2022-12-01 Adocia Compositions comprising short-acting hormones for treating or preventing obesity and pumps comprising said composition
EP4144362A1 (en) 2021-09-06 2023-03-08 Adocia Compositions comprising short-acting hormones for treating or preventing obesity and pumps comprising said composition
EP4129324A1 (en) 2021-08-02 2023-02-08 Adocia Compositions comprising at least an amylin receptor agonist and a glp-1 receptor agonist
AU2022386166A1 (en) 2021-11-10 2024-06-20 I2O Therapeutics, Inc. Ionic liquid compositions
CN116621944A (zh) * 2022-02-10 2023-08-22 成都奥达生物科技有限公司 一种长效肝炎病毒进入抑制剂
JP2025530743A (ja) 2022-08-29 2025-09-17 イーライ リリー アンド カンパニー 経口投与のための組成物
US12116388B2 (en) 2022-12-22 2024-10-15 Novo Nordisk A/S Amylin receptor agonists
TW202540155A (zh) 2023-11-30 2025-10-16 丹麥商諾佛 儂迪克股份有限公司 Glp-1、gip及澱粉素受體之三重促效劑
WO2025240893A1 (en) 2024-05-17 2025-11-20 Eli Lilly And Company 4-phenyl-1h-pyrazolo[3,4-b]pyridine-5-carboxamide derivatives as amylin and/or calcitonin receptor agonists for the treatment of type 2 diabetes, obesity or overweight

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622386A (en) * 1985-03-28 1986-11-11 Armour Pharmaceutical Company [1,7-di-alanine]calcitonin
WO1996040220A1 (en) * 1995-06-07 1996-12-19 Amylin Pharmaceuticals, Inc. Treatment of type ii diabetes mellitus with amylin agonists
CN102076353A (zh) * 2008-06-25 2011-05-25 诺沃-诺迪斯克有限公司 胰岛淀粉样多肽和鲑鱼降钙素的衍生杂合肽
CN103826655A (zh) * 2011-05-25 2014-05-28 安米林药品有限责任公司 胰岛淀粉样多肽及其衍生物和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414149A (en) 1983-03-04 1983-11-08 Armour Pharmaceutical Company Glycine8 -D-arginine24 calcitonin
US4495097A (en) 1983-04-04 1985-01-22 Armour Pharmaceutical Company Des-serine2 -glycine8 calcitonin
US4659804A (en) 1984-11-01 1987-04-21 Armour Pharmaceutical Company (Bis-1,7-S-acetamidomethyl-L-cysteine)salmon calcitonin
EP0297159A1 (en) * 1987-07-01 1989-01-04 Armour Pharmaceutical Company [N-Acyl, 1,7-Di-Aline] calcitonins, method for their preparation, pharmaceutical compositions and use
US5153308A (en) 1988-06-16 1992-10-06 Teijin Limited S-sulfonated calcitonin derivatives
CN1064051C (zh) 1997-04-30 2001-04-04 中国人民解放军军事医学科学院毒物药物研究所 不含二硫键的鲑鱼和鳗鱼降钙素类似物及其制备方法
US6087334A (en) * 1998-08-21 2000-07-11 Amylin Pharmaceuticals, Inc. Anti-diabetic peptides
US8076288B2 (en) * 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
WO2007014051A2 (en) 2005-07-22 2007-02-01 Amylin Pharmaceuticals, Inc. Use of amylin and amylin agonists as cardioprotective or myoprotective agents
ES2622877T3 (es) 2009-01-22 2017-07-07 Keybioscience Ag Tratamiento para la obesidad
CA2755068C (en) 2009-03-12 2018-11-06 Keybioscience Ag Treatment of diabetes and metabolic syndrome
PT2621515T (pt) * 2010-09-28 2017-07-12 Aegerion Pharmaceuticals Inc Polipéptido quimérico de leptina de foca-ser humano com solubilidade aumentada
JP6121992B2 (ja) * 2011-06-10 2017-04-26 ノヴォ ノルディスク アー／エス ポリペプチド

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622386A (en) * 1985-03-28 1986-11-11 Armour Pharmaceutical Company [1,7-di-alanine]calcitonin
WO1996040220A1 (en) * 1995-06-07 1996-12-19 Amylin Pharmaceuticals, Inc. Treatment of type ii diabetes mellitus with amylin agonists
CN102076353A (zh) * 2008-06-25 2011-05-25 诺沃-诺迪斯克有限公司 胰岛淀粉样多肽和鲑鱼降钙素的衍生杂合肽
CN103826655A (zh) * 2011-05-25 2014-05-28 安米林药品有限责任公司 胰岛淀粉样多肽及其衍生物和用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
H.E. LEBOVITZ: "New treatments of diabetes: The β-amylin agonists", 《ANNALES D ENDOCRINOLOGIE》 *
严国文等: "抗糖尿病肽类药物研究进展", 《药物生物技术》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109248323A (zh) * 2017-07-14 2019-01-22 杭州先为达生物科技有限公司 酰化的glp-1衍生物
CN109248323B (zh) * 2017-07-14 2023-09-08 杭州先为达生物科技有限公司 酰化的glp-1衍生物
CN110467666A (zh) * 2019-09-17 2019-11-19 湖北强耀生物科技有限公司 一种新型胰岛淀粉样多肽的合成方法
WO2025195008A1 (zh) * 2024-03-19 2025-09-25 深圳湾实验室 多肽或其类似物及其应用

Also Published As

Publication number Publication date
JP2022130522A (ja) 2022-09-06
WO2016034604A1 (en) 2016-03-10
ES2887370T3 (es) 2021-12-22
US20170145059A1 (en) 2017-05-25
JP2020169197A (ja) 2020-10-15
TW201625671A (zh) 2016-07-16
JP2017530108A (ja) 2017-10-12
JP7095027B2 (ja) 2022-07-04
US9593149B2 (en) 2017-03-14
EP3189071A1 (en) 2017-07-12
EP3189071B1 (en) 2021-07-28
US20160272683A1 (en) 2016-09-22
US10174082B2 (en) 2019-01-08
AR101742A1 (es) 2017-01-11
JP6728141B2 (ja) 2020-07-22

Similar Documents

Publication Publication Date Title
JP7095027B2 (ja) 新規のアミリン及びカルシトニン受容体アゴニスト
TWI810606B (zh) Gip/glp1共促效劑化合物
CN103649115B (zh) 多肽
CN112074531B (zh) Gip衍生物及其用途
TWI694082B (zh) 選擇性ｐｙｙ化合物及其用途
EP3068421B1 (en) Selective pyy compounds and uses thereof
TWI795698B (zh) 腸促胰島素(incretin)類似物及其用途
CN102197049B (zh) 胰岛淀粉样多肽衍生物
CN102933598A (zh) 新型胰高血糖素类似物
EP3204408B1 (en) Stable glp-1 based glp-1/glucagon receptor co-agonists
JP2013505221A (ja) 長時間作用性ｙ２受容体アゴニスト
CN102918055A (zh) 新的胰高血糖素类似物
CN104395338A (zh) 人胰岛淀粉样多肽类似物
CN106536547A (zh) 用于医疗用途的glp‑1/胰高血糖素受体共激动剂
WO2021110845A1 (en) Optimized gip peptide analogues

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination