JP6728141B2 - 新規のアミリン及びカルシトニン受容体アゴニスト - Google Patents

新規のアミリン及びカルシトニン受容体アゴニスト Download PDF

Info

Publication number
JP6728141B2
JP6728141B2 JP2017512822A JP2017512822A JP6728141B2 JP 6728141 B2 JP6728141 B2 JP 6728141B2 JP 2017512822 A JP2017512822 A JP 2017512822A JP 2017512822 A JP2017512822 A JP 2017512822A JP 6728141 B2 JP6728141 B2 JP 6728141B2
Authority
JP
Japan
Prior art keywords
place
peptide
mimiline
mimirin
preceding embodiments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017512822A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017530108A (ja
JP2017530108A5 (https=
Inventor
トーマス・クルーゼ
ラウゲ・シェーファー
キルステン・ダール
クリスティアン・ポールセン
キルステン・ラウン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of JP2017530108A publication Critical patent/JP2017530108A/ja
Publication of JP2017530108A5 publication Critical patent/JP2017530108A5/ja
Application granted granted Critical
Publication of JP6728141B2 publication Critical patent/JP6728141B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2017512822A 2014-09-04 2015-09-02 新規のアミリン及びカルシトニン受容体アゴニスト Active JP6728141B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14183551 2014-09-04
EP14183551.2 2014-09-04
PCT/EP2015/069996 WO2016034604A1 (en) 2014-09-04 2015-09-02 Novel amylin and calcitonin receptor agonist

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020114038A Division JP7095027B2 (ja) 2014-09-04 2020-07-01 新規のアミリン及びカルシトニン受容体アゴニスト

Publications (3)

Publication Number Publication Date
JP2017530108A JP2017530108A (ja) 2017-10-12
JP2017530108A5 JP2017530108A5 (https=) 2018-10-11
JP6728141B2 true JP6728141B2 (ja) 2020-07-22

Family

ID=51483301

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017512822A Active JP6728141B2 (ja) 2014-09-04 2015-09-02 新規のアミリン及びカルシトニン受容体アゴニスト
JP2020114038A Active JP7095027B2 (ja) 2014-09-04 2020-07-01 新規のアミリン及びカルシトニン受容体アゴニスト
JP2022100480A Pending JP2022130522A (ja) 2014-09-04 2022-06-22 新規のアミリン及びカルシトニン受容体アゴニスト

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020114038A Active JP7095027B2 (ja) 2014-09-04 2020-07-01 新規のアミリン及びカルシトニン受容体アゴニスト
JP2022100480A Pending JP2022130522A (ja) 2014-09-04 2022-06-22 新規のアミリン及びカルシトニン受容体アゴニスト

Country Status (8)

Country Link
US (2) US9593149B2 (https=)
EP (1) EP3189071B1 (https=)
JP (3) JP6728141B2 (https=)
CN (1) CN106687474A (https=)
AR (1) AR101742A1 (https=)
ES (1) ES2887370T3 (https=)
TW (1) TW201625671A (https=)
WO (1) WO2016034604A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017019378A2 (pt) 2015-03-18 2019-02-19 Zealand Pharma A/S análogos de amilina
US10071140B2 (en) 2016-09-09 2018-09-11 Zealand Pharma A/S Amylin analogues
ES2828526T3 (es) 2016-11-07 2021-05-26 Novo Nordisk As Esteres activos DCHBS de compuestos PEG y sus usos
CN109248323B (zh) * 2017-07-14 2023-09-08 杭州先为达生物科技有限公司 酰化的glp-1衍生物
US11274158B2 (en) 2018-01-30 2022-03-15 Flagship Pioneering Innovations V, Inc. Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators
AR116632A1 (es) 2018-10-11 2021-05-26 Intarcia Therapeutics Inc Polipéptidos análogos de la amilina humana y sus métodos de uso
WO2020180534A1 (en) 2019-03-01 2020-09-10 President And Fellows Of Harvard College Methods and compositions for protein delivery
CN110467666A (zh) * 2019-09-17 2019-11-19 湖北强耀生物科技有限公司 一种新型胰岛淀粉样多肽的合成方法
TWI850611B (zh) * 2020-12-18 2024-08-01 丹麥商諾佛 儂迪克股份有限公司 Glp-1及澱粉素受體之共促效劑
AR124295A1 (es) 2020-12-18 2023-03-15 Lilly Co Eli Agonistas duales del receptor de amilina y calcitonina y usos de los mismos
WO2022248419A2 (en) 2021-05-22 2022-12-01 Adocia Compositions comprising short-acting hormones for treating or preventing obesity and pumps comprising said composition
EP4144362A1 (en) 2021-09-06 2023-03-08 Adocia Compositions comprising short-acting hormones for treating or preventing obesity and pumps comprising said composition
EP4129324A1 (en) 2021-08-02 2023-02-08 Adocia Compositions comprising at least an amylin receptor agonist and a glp-1 receptor agonist
AU2022386166A1 (en) 2021-11-10 2024-06-20 I2O Therapeutics, Inc. Ionic liquid compositions
CN116621944A (zh) * 2022-02-10 2023-08-22 成都奥达生物科技有限公司 一种长效肝炎病毒进入抑制剂
JP2025530743A (ja) 2022-08-29 2025-09-17 イーライ リリー アンド カンパニー 経口投与のための組成物
US12116388B2 (en) 2022-12-22 2024-10-15 Novo Nordisk A/S Amylin receptor agonists
TW202540155A (zh) 2023-11-30 2025-10-16 丹麥商諾佛 儂迪克股份有限公司 Glp-1、gip及澱粉素受體之三重促效劑
CN120040558A (zh) * 2024-03-19 2025-05-27 深圳湾实验室 多肽或其类似物及其应用
WO2025240893A1 (en) 2024-05-17 2025-11-20 Eli Lilly And Company 4-phenyl-1h-pyrazolo[3,4-b]pyridine-5-carboxamide derivatives as amylin and/or calcitonin receptor agonists for the treatment of type 2 diabetes, obesity or overweight

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414149A (en) 1983-03-04 1983-11-08 Armour Pharmaceutical Company Glycine8 -D-arginine24 calcitonin
US4495097A (en) 1983-04-04 1985-01-22 Armour Pharmaceutical Company Des-serine2 -glycine8 calcitonin
US4659804A (en) 1984-11-01 1987-04-21 Armour Pharmaceutical Company (Bis-1,7-S-acetamidomethyl-L-cysteine)salmon calcitonin
US4622386A (en) * 1985-03-28 1986-11-11 Armour Pharmaceutical Company [1,7-di-alanine]calcitonin
EP0297159A1 (en) * 1987-07-01 1989-01-04 Armour Pharmaceutical Company [N-Acyl, 1,7-Di-Aline] calcitonins, method for their preparation, pharmaceutical compositions and use
US5153308A (en) 1988-06-16 1992-10-06 Teijin Limited S-sulfonated calcitonin derivatives
US6143718A (en) * 1995-06-07 2000-11-07 Amylin Pharmaceuticals, Inc. Treatment of Type II diabetes mellutis with amylin agonists
CN1064051C (zh) 1997-04-30 2001-04-04 中国人民解放军军事医学科学院毒物药物研究所 不含二硫键的鲑鱼和鳗鱼降钙素类似物及其制备方法
US6087334A (en) * 1998-08-21 2000-07-11 Amylin Pharmaceuticals, Inc. Anti-diabetic peptides
US8076288B2 (en) * 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
WO2007014051A2 (en) 2005-07-22 2007-02-01 Amylin Pharmaceuticals, Inc. Use of amylin and amylin agonists as cardioprotective or myoprotective agents
CN102076353A (zh) * 2008-06-25 2011-05-25 诺沃-诺迪斯克有限公司 胰岛淀粉样多肽和鲑鱼降钙素的衍生杂合肽
ES2622877T3 (es) 2009-01-22 2017-07-07 Keybioscience Ag Tratamiento para la obesidad
CA2755068C (en) 2009-03-12 2018-11-06 Keybioscience Ag Treatment of diabetes and metabolic syndrome
PT2621515T (pt) * 2010-09-28 2017-07-12 Aegerion Pharmaceuticals Inc Polipéptido quimérico de leptina de foca-ser humano com solubilidade aumentada
KR20140045433A (ko) * 2011-05-25 2014-04-16 아밀린 파마슈티칼스, 엘엘씨. 아밀린 펩티드 및 그의 유도체 및 용도
JP6121992B2 (ja) * 2011-06-10 2017-04-26 ノヴォ ノルディスク アー／エス ポリペプチド

Also Published As

Publication number Publication date
JP2022130522A (ja) 2022-09-06
WO2016034604A1 (en) 2016-03-10
ES2887370T3 (es) 2021-12-22
US20170145059A1 (en) 2017-05-25
JP2020169197A (ja) 2020-10-15
CN106687474A (zh) 2017-05-17
TW201625671A (zh) 2016-07-16
JP2017530108A (ja) 2017-10-12
JP7095027B2 (ja) 2022-07-04
US9593149B2 (en) 2017-03-14
EP3189071A1 (en) 2017-07-12
EP3189071B1 (en) 2021-07-28
US20160272683A1 (en) 2016-09-22
US10174082B2 (en) 2019-01-08
AR101742A1 (es) 2017-01-11

Similar Documents

Publication Publication Date Title
JP7095027B2 (ja) 新規のアミリン及びカルシトニン受容体アゴニスト
CN103649115B (zh) 多肽
CN112074531B (zh) Gip衍生物及其用途
JP6594856B2 (ja) 医療用の安定な遷延性ｇｌｐ−１／グルカゴン受容体コアゴニスト
TWI814219B (zh) 升糖素受體選擇性多肽和彼之使用方法
CN104395338A (zh) 人胰岛淀粉样多肽类似物
JP2017525656A (ja) 医療用のｇｌｐ−１／グルカゴン受容体コアゴニスト
EP3204408B1 (en) Stable glp-1 based glp-1/glucagon receptor co-agonists
CN102933598A (zh) 新型胰高血糖素类似物
JP2014510739A (ja) 新規のグルカゴン類似体
CN107205949A (zh) 包含片芯和立即释放包衣的用于口服glp‑1给药的药物组合物
JP2019167361A (ja) 医療用の安定な遷延性ｇｌｐ−１／グルカゴン受容体コアゴニスト

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180830

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180830

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190624

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190913

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200601

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200701

R150 Certificate of patent or registration of utility model

Ref document number: 6728141

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250