CN106668190A - Chinese herbal compound external preparation for treating haemorrhoids - Google Patents

Chinese herbal compound external preparation for treating haemorrhoids Download PDF

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Publication number
CN106668190A
CN106668190A CN201611245919.2A CN201611245919A CN106668190A CN 106668190 A CN106668190 A CN 106668190A CN 201611245919 A CN201611245919 A CN 201611245919A CN 106668190 A CN106668190 A CN 106668190A
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parts
external preparation
chinese medicine
hemorrhoid
treatment
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吴义香
任磊
顾大业
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Hefei Anderson Pharma Co Ltd
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Hefei Anderson Pharma Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Life Sciences & Earth Sciences (AREA)
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Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a Chinese herbal compound external preparation for treating haemorrhoids. The Chinese herbal compound external preparation for treating the haemorrhoids is prepared from the following raw materials in parts by weight: 30-90 parts of radix rumicis japonici, 5-30 parts of honeysuckle flower, 1-30 parts of radix angelicae dahuricae and 5-40 parts of liquorice root. The composition provided by the invention can be prepared into needed external preparations such as ointment, aerosol and lotion by means of simple physical crushing or extraction and refining; the Chinese herbal compound external preparation is reasonable in medicine formula; the prepared preparation has the characteristics of being free from toxic and side effect, convenient to use, and the like, has the function of treating or improving hemorrhoidal bleeding, and is definite in clinical effect, remarkable in curative effect and quick in response.

Description

A kind of Chinese medicine compound prescription external preparation for treating hemorrhoid
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine compound prescription external preparation for treating hemorrhoid.
Background technology
Anal and bowel pile is commonly called as hemorrhoid, is a kind of common disease, frequently-occurring disease.Mainly under rectum end mucous membrane, anal tube and anus There is the venous group that expansion, varicose form softness in the subcutaneous veniplex of door edge；Or anus edge pleat chafing, hypertrophy, knot Form hyperblastosis；Or anal veins rupture, the stagnant formation thrombus of the blood stasis of blood.
In recent years due to the change of dietary structure and eating habit, hyperpyrexia, pungent, heavy wool become quite a few state of China The diet taste of the people, the incidence of disease for making hemorrhoid substantially rises.Hemorrhoid are a kind of common diseases being detrimental to health, multiple Disease, shows according to relevant information, and the incidence of disease of anorectal disease is 59.1%, and hemorrhoid account for the 87.25% of all recial diseases, account for institute Have the 52.19% of anal and intestinal disease.Men and women can fall ill, and women is more than the male sex, and any age all can fall ill, wherein 20~40 years old People is more common, and gradually increases with the growth at age more, and this disease is most commonly seen with bleeding, pain, the big symptom of constipation three.According to The difference of disease locus, can be divided into internal piles, external piles and mixed hemorrhoid three types.At present, treatment of the modern medicine to this disease, generally Using oral medicinal herb, outward control and the treatment method such as acupuncture, operation, treatment method of taking medicine is divided into medicine for oral administration and externally applied drug treatment, Surgical intervention curative effect is not very good, and treatment time is long, affects work, this treatment method both to cause economical negative to patient Load, causes body and mind pain again.
Have many using Chinese medicines that are oral or applying outward or Western medicine in prior art, but the curative effect that these medicines have not substantially, Easily recurrence, treatment cycle are long.
The content of the invention
The purpose of the present invention is the not enough effect treatment hemorrhoid short there is provided a kind of effective in cure good, treatment cycle for more than Chinese medicine compound prescription external preparation.
To realize object above, the present invention is achieved by the following technical programs：
A kind of Chinese medicine compound prescription external preparation for treating hemorrhoid, is made up of the raw material of following heavy number：30~90 parts of Rumex madaio, 5~30 parts of honeysuckle, 1~30 part of the root of Dahurain angelica, 5~40 parts of Radix Glycyrrhizae.
Preferably, the Chinese medicine compound prescription external preparation of the treatment hemorrhoid is made up of the raw material of following heavy number：Rumex madaio 45 ~80 parts, 6~25 parts of honeysuckle, 5~15 parts of the root of Dahurain angelica, 6~25 parts of Radix Glycyrrhizae.
Preferably, the Chinese medicine compound prescription external preparation of the treatment hemorrhoid is made up of the raw material of following heavy number：Rumex madaio 60 Part, 18 parts of honeysuckle, 6 parts of the root of Dahurain angelica, 18 parts of Radix Glycyrrhizae.
The Chinese medicine compound prescription external preparation of the treatment hemorrhoid in the present invention can be prepared by following methods:
(1) weigh each bulk drug by formula ratio, in input extractor, add the mixture of water or water and ethanol as molten Agent, decocts 1h, collects filtrate, and so repeatedly 2~3 times, merging filtrate is filtered, and obtains extract；By the extract in 70~80 The thick paste that relative density is 1.12~1.20 is condensed at DEG C, activity extract is obtained final product, it is standby；
(2) step (1) gained activity extract is made clinically according to common process and pharmaceutically acceptable carrier Acceptable external preparation.
Wherein, the clinically acceptable external preparation includes but is not limited to ointment, lotion, aerosol.
The preparation method of ointment is：The various matrix of ointment are added in above-mentioned steps (1) gained activity extract, Externally-applied soft ointment is made with common process.
Lotion, production of aerosol are：Customary adjuvant is added in above-mentioned steps (1) gained activity extract, with normal Rule technique makes lotion, aerosol.
The Chinese medicine compound prescription external preparation of the treatment hemorrhoid in the present invention can also be prepared by following methods:
(1) each bulk drug is weighed by formula ratio, each bulk drug is ground to form into impalpable powder by conventional method, obtain Chinese medicine superfine Powder, it is standby；
(2) the various matrix of ointment are added in step (1) gained Chinese medicine impalpable powder, ointment is made with common process Agent.
The preferred ointment of external preparation of the present invention.Ointment according to decentralized system can be divided into solution-type, suspension type and Ointment.Some additives such as preservative, penetrating agent, surfactant, penetrating agent, nitrogen can also be added in ointment bases Ketone, propane diols, glycerine, polyethylene glycol, the preferred DMSO of penetrating agent.The preferred non-ionic surfactant of surfactant, such as aliphatic acid Sorb is smooth, polysorbate, polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, the preferred ethyl-para-hydroxybenzoate of preservative.
Lotion of the present invention is, by the concentration of active ingredient of Chinese herbs extract, to add appropriate preservative, and is added certain The thickener of amount, is well mixed prepared.The preferred suspension aerosol of aerosol of the present invention, active ingredient of Chinese herbs is extracted Thing is dried, and then carries out nanosizing process, adds a certain amount of supensoid agent and propellant, bottling to obtain final product.
Matrix of the present invention includes：
1st, conventional oleaginous base such as globefish oil, vegetable oil, sesame oil, cottonseed oil, peanut oil, hydrogenated vegetable oil；
2nd, hydro carbons such as vaseline, ceresine, atoleine；
3rd, lipoid such as lanolin, lanonol, beeswax, cera alba, spermaceti, cholesterol；
4th, emulsion-type matrix such as stearic acid, cetanol, stearyl alcohol, lauryl sodium sulfate；Sodium stearyl sulfate, glycerine Monostearate, polyglycerol stearate, tween, polyoxyethylene (40) stearate, double calcium stearates, double stearic acid aluminium, department Disk；
5th, water-soluble base such as glycerin gelatine, glycerinum amyli, sodium alginate, polyethylene glycol, methylcellulose, carboxymethyl is fine The plain sodium of dimension.
The mixture of the preferred vaseline of ointment bases, lanolin and vaseline and lanolin in the present invention.When soft When cream base matter is the mixture of vaseline and lanolin, the part by weight preferably 1 of vaseline and lanolin：1.
The bulk drug property of medicine used in the present invention is as follows：
Rumex madaio：Cool, pungent, hardship, with the heat-clearing row stasis of blood, desinsection, removing toxic substances work(, for treat hemoptysis, lung carbuncle, rib inflammation, Constipation, carbuncle swells poison, eczema, mange etc..Return through lung spleen, large intestine channel.Modern pharmacological research shows that Rumex madaio has antibacterial, stops Blood, it is antitumor, anti-oxidant, etc. pharmacological action.
Honeysuckle：Sweet, slight bitter, it is pungent, tremble with fear.Return lung, stomach, the heart, large intestine channel.Honeysuckle containing inositol, flavonoids, inositol, The various pathogens such as staphylococcus aureus, shigella dysenteriae, with broad-spectrum antibacterial action, are had stronger suppression to make by tannin etc. With also having inhibitory action to multiple pathogenic microorganisms such as Leptospira, influenza virus and pathogenic moulds.
The root of Dahurain angelica：It is pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and clearing away cold, sensible pain relieving, apocenosis of invigorating blood circulation, myogenic pain relieving, eliminating dampness stops band.With In headache, toothache, nasosinusitis, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, pruitus.Modern pharmacological research proves that the root of Dahurain angelica also has There are anti-inflammatory, antipyretic-antalgic etc. to act on.
Radix Glycyrrhizae：It is sweet, flat, the thoughts of returning home, lung, spleen, stomach.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain reconciles all Medicine.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, abirritant It is thing toxicity, strong；Its active ingredient is glycyrrhizin, enoxolone, 4',7-Dihydroxyflavanone, licorice polysaccharide are clinically conventional medium-height grass One of medicine.
Beneficial effects of the present invention are：
The present invention adopts pure plant for raw material, or the active component in Chinese medicine material is extracted, using the modern times Preparation technique, is made into the pharmaceutically acceptable preparation such as ointment, lotion or aerosol, this pharmaceutical composition Jing science It is compatibility, reasonably combined, be conducive to treating thrombosed external hemorrhoid, inflammatory external hemorrhoid, with curative effect it is high, can thoroughly effect a radical cure, no longer recurrence, nothing Any side effect, treatment no pain, the low feature of medical expense, and work is not affected in therapeutic process.
Specific embodiment
The technical solution of the present invention is further illustrated with reference to specific embodiment, embodiment is not to be construed as right The restriction of technical solution.
Embodiment 1：Ointment
Chinese medicine preparation：60 parts of Rumex madaio, 18 parts of honeysuckle, 6 parts of the root of Dahurain angelica, 18 parts of Radix Glycyrrhizae.
Preparation method：By in the medicinal material input extractor of above-mentioned formula ratio, the decocting for adding 10 times of amounts boils 1h, collects filter Liquid, so repeatedly 3 times, after filtration, merges all of filtrate, filters, and discards residue, extract is obtained, by the extract in 70 The thick paste that relative density is 1.20 is condensed at DEG C, dry cream is sprayed into, fine powder is then comminuted into, the dusting cover crossed more than 150 mesh, institute Obtain fine powder to be added in 80 DEG C of vaseline, stir, to into paste, cooling, obtain final product the ointment for the treatment of hemorrhoid.
Embodiment 2：Lotion
Chinese medicine preparation：30 parts of rheum officinale, 30 parts of honeysuckle, 15 parts of the root of Dahurain angelica, 40 parts of Radix Glycyrrhizae.
Preparation method：By in the medicinal material input extractor of above-mentioned formula ratio, the decocting for adding 10 times of amounts boils 1h, collects filter Liquid, so repeatedly 3 times, merges all of filtrate, filters, and discards residue, obtains extract, and the extract is concentrated at 80 DEG C It is standby into the thick paste that relative density is 1.12；It is subsequently adding sodium carboxymethyl starch and Sodium Benzoate is well mixed, is configured to afterwards Solution, obtains final product the lotion for the treatment of hemorrhoid.
Embodiment 3：Aerosol
Chinese medicine preparation：80 parts of rheum officinale, 6 parts of honeysuckle, 30 parts of the root of Dahurain angelica, 5 parts of Radix Glycyrrhizae.
Preparation method：By in the medicinal material input extractor of above-mentioned formula ratio, the decocting for adding 10 times of amounts boils 1h, collects filter Liquid, so repeatedly 2 times, merges all filtrates, discards residue, obtains extract, and the extract is condensed into relatively at 70 DEG C Density is 1.20 thick paste, and nanosizing process is carried out after dried process, be eventually adding appropriate F-11, appropriate two Dichlorodifluoromethane and appropriate three oleic acid sorbitol ester, load tracheae bottle, obtain final product the aerosol for the treatment of hemorrhoid.
Embodiment 4：Ointment
Chinese medicine preparation：90 parts of rheum officinale, 5 parts of honeysuckle, 1 part of the root of Dahurain angelica, 25 parts of Radix Glycyrrhizae.
Preparation method：The medicinal material of above-mentioned formula ratio is ground to form into impalpable powder, gained impalpable powder is added to 80 DEG C of vaseline In, stir, to into paste, cooling, obtain final product the ointment for the treatment of hemorrhoid.
Embodiment 5：Ointment
Chinese medicine preparation：45 parts of rheum officinale, 25 parts of honeysuckle, 5 parts of the root of Dahurain angelica, 6 parts of Radix Glycyrrhizae.
Preparation method：By in the medicinal material input extractor of above-mentioned formula ratio, the decocting for adding 10 times of amounts boils 1h, collects filter Liquid, so repeatedly 2 times, after filtration, merges all of filtrate, filters, and discards residue, extract is obtained, by the extract in 70 The thick paste that relative density is 1.15 is concentrated at DEG C, qs glycerin is added, is well mixed, and be incubated at 80 DEG C, obtain mixture one, It is standby；
Separately take stearic acid, hexadecanol, glycerin monostearate, atoleine and be heated to 80~85 DEG C, make fusing, and mix Uniformly, mixture two is obtained, then mixture two is slowly added in mixture one, and emulsify 5~6min, take out cooling, i.e., The ointment of hemorrhoid must be treated.
Clinical data:
1st, general data
To verify therapeutic effect of the Chinese medicine preparation of embodiment of the present invention preparation to hemorrhoid, hemorrhoid patients 130 are randomly choosed Example carries out clinical observation.It is wherein male 78, female 52,20~65 years old age.130 patients are randomly divided into into test group and control Group.
2nd, diagnostic criteria
Internal piles：Have difficulty in passing one's motions, there is a falling inflation sense, having a rest property of defecation time band blood, bleed or spray blood, haemorrhoids is deviate from.
External piles：Red and swollen heat pain, oedema, hyperemia substantially, there is tenderness, and pain increases during defecation, and has a small amount of secretion, has Can be with general malaise and heating.
Mixed hemorrhoid：Have the symptom of inside and outside hemorrhoid concurrently.
All persons that has above-mentioned symptom, are diagnosed as hemorrhoid patients, can be chosen as clinical observation.
3rd, treatment method
Test group：First anus cleaned up during treatment, the ointment for then being prepared with embodiment 1 is applied to affected part, by affected part All cover, Internal hemorrhoid hemorrhage can use 10 parts of ointment, injected in anus by noting anus device, it is daily sooner or later each 1 time, it is a treatment within 10th Journey.
Control group：First anus cleaned up during treatment, is then taken jiuhua plaster and is applied to affected part in right amount, affected part is all covered Lid, Internal hemorrhoid hemorrhage can use 10 parts of ointment and be injected in anus by note anus device, and the daily morning and evening is each once, be within 10th 1 course for the treatment of.
Two groups with treat 10 days as a course for the treatment of, statistics after 2 courses for the treatment of.
4th, efficacy assessment standard
Curative effect judging standard：With reference to《New Chinese medicine treats the guideline of clinical investigations of hemorrhoid》Voluntarily draft.
Recovery from illness：Haemorrhoids atrophy, clinical symptoms are eliminated, always without recurrence after treatment.
It is effective：Symptom is substantially achieved alleviation.
Take a turn for the better：Symptom makes moderate progress, and pain has mitigated, and needs the further treatment of medicine.
It is invalid：Symptom has pain without improvement, or even has the trend for increasing.
5th, treatment results
After by clinical observation, 1 is the results are shown in Table.
The clinical treatment outcome of table 1
Group Case load Recovery from illness It is effective Effectively It is invalid Total effective rate (%)
Test group 65 33 16 12 4 93.8
Control group 65 12 14 14 15 76.9
6th, discuss
Chinese medicine preparation of the present invention has clearing heat and detoxicating, and promoting blood circulation and removing blood stasis, swelling and pain relieving liter carries admittedly de- work(, such that it is able to reach Hemorrhoid are prevented or cure a disease the purpose removed.Clinical effectiveness shows, in test group in 65 61 effectively, total effective rate is up to 93.8% and cure rate Height, therefore it is considered a kind of safely and effectively medicine.Ointment convenient drug administration, effect is significant, cure rate is high, and clinic is promoted and made With.
7th, model case
Case 1
Lee, man, 50 years old, more than 2 years, sometimes pain must be difficult to stand anus, have blood in stool sometimes, at 1.5cm in anus for illness There is old anal, and form an alliance and form tissue external piles, be diagnosed as old anal.
Treatment：Treated using the ointment in the embodiment of the present invention 1, it is daily sooner or later each 1 time, it is applied in affected part.Make With 1 week, pain and swelling disappeared substantially, stable disease.It is continuing with 10, fully recovers, items checks normal, and follow-up 2 years is not multiple Send out.
Case 2
Certain is thanked, man, 42 years old, hemorrhoid 4 years, haemorrhoids is bigger, and quality is harder, surface micro-strip canescence, haemorrhoids abjection when just Outside anus, or even walking, cough, sneeze or can also deviate from when standing, it is impossible to voluntarily Hui Na, must be returned with hand push, or prostration, hot compress After can Hui Na, few or no longer bleeding of having blood in stool.
Treatment：Treated using the ointment in the embodiment of the present invention 1, it is daily sooner or later each 1 time, affected part is applied in, make With 3 days, symptom slightly alleviation, following the service was used 7, and symptom difference is light, and stable, is continuing with, and using more than 1 month, haemorrhoids was certainly Row add-back is received, no longer bleeding, recovery from illness, and items check normal, and follow-up 3 years is not recurred.
Case 3
Zhang, female 33 years old, suffered from hemorrhoid and anal fissure before 3 years, i.e. bleeding of defecating.
Treatment：Treated using the ointment in the embodiment of the present invention 4, it is daily sooner or later each 1 time, affected part is applied in, make With 24h, anal fissure, having blood in stool significantly improves, and using this paste 2 weeks, anal fissure and having blood in stool was clearly better following the service.Paste of the present invention is used again More than January, anal fissure and stool disappear to the greatest extent, fully recover, follow-up so far there are no recurrence.
Case 4
27 years old, there is lump abjection in anus from period of gestation in Liu, women, and with bleeding during stool, does not come in time Hospital therapy, the state of an illness constantly increases.Lump developed into by one it is multiple, two weeks defecate every time occur spray mass formed by blood stasis shape, go out It is existing dizzy, the symptom such as weak.
Treatment：Treated using the ointment in the embodiment of the present invention 5, it is daily sooner or later each 1 time, affected part is applied in, make With 24h, the withered atrophy of haemorrhoids comes off, stopped bleeding.After 1 week, normal diet and defecation.Smooth without obvious scar at anus after several months , without bleeding, stool is normal, pays a return visit without exception after 1 year for trace.

Claims (7)

1. a kind of Chinese medicine compound prescription external preparation for treating hemorrhoid, it is characterised in that be made up of the raw material of following heavy number：Rumex madaio 30~90 parts, 5~30 parts of honeysuckle, 1~30 part of the root of Dahurain angelica, 5~40 parts of Radix Glycyrrhizae.
2. it is according to claim 1 treatment hemorrhoid Chinese medicine compound prescription external preparation, it is characterised in that by following heavy number Raw material is made：45~80 parts of Rumex madaio, 6~25 parts of honeysuckle, 5~15 parts of the root of Dahurain angelica, 6~25 parts of Radix Glycyrrhizae.
3. it is according to claim 2 treatment hemorrhoid Chinese medicine compound prescription external preparation, it is characterised in that by following heavy number Raw material is made：60 parts of Rumex madaio, 18 parts of honeysuckle, 6 parts of the root of Dahurain angelica, 18 parts of Radix Glycyrrhizae.
4. the Chinese medicine compound prescription external preparation of the treatment hemorrhoid according to any one of claim 1-3, it is characterised in that by following Method is prepared：
(1) each bulk drug is weighed by recipe quantity, in input extractor, adds the mixture of water or water and ethanol as solvent, decocted Boil 1h, collect filtrate, so repeatedly 2~3 times, merging filtrate is filtered, and obtains extract；By the extract at 70~80 DEG C The thick paste that relative density is 1.12~1.20 is condensed into, activity extract is obtained final product, it is standby；
(2) making step (1) gained activity extract according to common process and pharmaceutically acceptable carrier clinically can connect The external preparation received.
5. the Chinese medicine compound prescription external preparation for the treatment of hemorrhoid according to claim 4, it is characterised in that the external preparation is Ointment, lotion or aerosol.
6. the Chinese medicine compound prescription external preparation for the treatment of hemorrhoid according to claim 4, it is characterised in that the external preparation is Ointment.
7. the Chinese medicine compound prescription external preparation of the treatment hemorrhoid according to any one of claim 1-3, it is characterised in that by following Method is prepared：
(1) each bulk drug is weighed by recipe quantity, each bulk drug is ground to form into impalpable powder by conventional method, obtain Chinese medicine impalpable powder, It is standby；
(2) the various matrix of ointment are added in step (1) gained Chinese medicine impalpable powder, ointment is made with common process.
CN201611245919.2A 2016-12-29 2016-12-29 Chinese herbal compound external preparation for treating haemorrhoids Pending CN106668190A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105267316A (en) * 2014-07-25 2016-01-27 高晓燕 Hemorrhoid treating formula

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105267316A (en) * 2014-07-25 2016-01-27 高晓燕 Hemorrhoid treating formula

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
白苏子等: "《中华实用奇方全书》", 30 September 2013, 黑龙江科学技术出版社 *

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Application publication date: 20170517