CN106661030B - 用于药物制剂中的PI3K δ选择性抑制剂的改良形式 - Google Patents

用于药物制剂中的PI3K δ选择性抑制剂的改良形式 Download PDF

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Publication number
CN106661030B
CN106661030B CN201580034288.7A CN201580034288A CN106661030B CN 106661030 B CN106661030 B CN 106661030B CN 201580034288 A CN201580034288 A CN 201580034288A CN 106661030 B CN106661030 B CN 106661030B
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salt
disease
tgr
ptsa salt
disorder
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CN201580034288.7A
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CN106661030A (zh
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斯瓦鲁普·库马尔·文卡塔·萨蒂亚·瓦卡拉恩卡
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Rhizen Pharmaceuticals AG
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Rhizen Pharmaceuticals AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201580034288.7A 2014-05-27 2015-05-26 用于药物制剂中的PI3K δ选择性抑制剂的改良形式 Expired - Fee Related CN106661030B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010471226.5A CN111635406A (zh) 2014-05-27 2015-05-26 用于药物制剂中的PI3Kδ选择性抑制剂的改良形式

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN2596/CHE/2014 2014-05-27
IN2597/CHE/2014 2014-05-27
IN2597CH2014 2014-05-27
IN2596CH2014 2014-05-27
PCT/IB2015/053940 WO2015181728A1 (en) 2014-05-27 2015-05-26 Improved forms of a pi3k delta selective inhibitor for use in pharmaceutical formulations

Related Child Applications (1)

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CN202010471226.5A Division CN111635406A (zh) 2014-05-27 2015-05-26 用于药物制剂中的PI3Kδ选择性抑制剂的改良形式

Publications (2)

Publication Number Publication Date
CN106661030A CN106661030A (zh) 2017-05-10
CN106661030B true CN106661030B (zh) 2020-06-30

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CN201580034288.7A Expired - Fee Related CN106661030B (zh) 2014-05-27 2015-05-26 用于药物制剂中的PI3K δ选择性抑制剂的改良形式
CN202010471226.5A Pending CN111635406A (zh) 2014-05-27 2015-05-26 用于药物制剂中的PI3Kδ选择性抑制剂的改良形式

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US (4) US9969740B2 (https=)
EP (2) EP3149000B1 (https=)
JP (3) JP6987501B2 (https=)
KR (1) KR20170007480A (https=)
CN (2) CN106661030B (https=)
AU (1) AU2015265542B2 (https=)
BR (1) BR112016027674A2 (https=)
CA (1) CA2949932C (https=)
CY (1) CY1124316T1 (https=)
DK (1) DK3149000T3 (https=)
EA (1) EA032506B1 (https=)
ES (1) ES2880999T3 (https=)
HR (1) HRP20211151T1 (https=)
HU (1) HUE054916T2 (https=)
IL (1) IL249058B2 (https=)
LT (1) LT3149000T (https=)
PL (1) PL3149000T3 (https=)
PT (1) PT3149000T (https=)
RS (1) RS62136B1 (https=)
SI (1) SI3149000T1 (https=)
SM (1) SMT202100532T1 (https=)
WO (1) WO2015181728A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015265542B2 (en) * 2014-05-27 2019-05-09 Rhizen Pharmaceuticals Sa Improved forms of a PI3K delta selective inhibitor for use in pharmaceutical formulations
EP3463318A4 (en) 2016-05-27 2020-01-01 TG Therapeutics Inc. COMBINATION OF ANTI-CD20-ANTIBODIES, P13-KINASE-DELTA-SELECTIVE INHIBITOR AND BTK-INHIBITOR FOR THE TREATMENT OF PROLIFERATIVE B-CELL DISORDERS
WO2018049263A1 (en) 2016-09-09 2018-03-15 Tg Therapeutics, Inc. Combination of an anti-cd20 antibody, pi3 kinase-delta inhibitor, and anti-pd-1 or anti-pd-l1 antibody for treating hematological cancers
KR20220035169A (ko) * 2019-07-15 2022-03-21 존슨 맛쎄이 퍼블릭 리미티드 컴파니 비정질 움브랄리십 모노토실레이트
US20220143026A1 (en) 2020-11-12 2022-05-12 Tg Therapeutics, Inc. Triple combination to treat b-cell malignancies
US11965032B1 (en) 2022-06-01 2024-04-23 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11814439B1 (en) 2022-06-01 2023-11-14 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11884740B1 (en) 2022-06-01 2024-01-30 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11807689B1 (en) 2022-06-01 2023-11-07 Tg Therapeutics, Inc. Anti-CD20 antibody compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1440408A (zh) * 2000-04-25 2003-09-03 艾科斯有限公司 人磷脂酰肌醇3－激酶δ的抑制剂
WO2014006572A1 (en) * 2012-07-04 2014-01-09 Rhizen Pharmaceuticals Sa Selective pi3k delta inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI335821B (en) 2002-12-16 2011-01-11 Genentech Inc Immunoglobulin variants and uses thereof
WO2005016348A1 (en) 2003-08-14 2005-02-24 Icos Corporation Method of inhibiting immune responses stimulated by an endogenous factor
KR20160091440A (ko) 2008-11-13 2016-08-02 길리아드 칼리스토가 엘엘씨 혈액 종양에 대한 요법
BRPI1012333A2 (pt) 2009-03-24 2016-03-29 Gilead Calistoga Llc atropisômeros de derivados de 2-purinil-3-tolil-quinazolinonas e métodos de uso
AP2011005956A0 (en) 2009-04-20 2011-10-31 Gilead Calistoga Llc Methods of treatment for solid tumors.
AU2015265542B2 (en) * 2014-05-27 2019-05-09 Rhizen Pharmaceuticals Sa Improved forms of a PI3K delta selective inhibitor for use in pharmaceutical formulations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1440408A (zh) * 2000-04-25 2003-09-03 艾科斯有限公司 人磷脂酰肌醇3－激酶δ的抑制剂
WO2014006572A1 (en) * 2012-07-04 2014-01-09 Rhizen Pharmaceuticals Sa Selective pi3k delta inhibitors

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Publication number Publication date
JP2022082680A (ja) 2022-06-02
CA2949932C (en) 2021-08-10
US20210269446A1 (en) 2021-09-02
EA201692255A1 (ru) 2017-04-28
EP3149000B1 (en) 2021-06-30
SI3149000T1 (sl) 2021-09-30
IL249058B2 (en) 2023-03-01
CY1124316T1 (el) 2022-07-22
ES2880999T3 (es) 2021-11-26
RS62136B1 (sr) 2021-08-31
IL249058B (en) 2022-11-01
DK3149000T3 (da) 2021-08-30
US20170121336A1 (en) 2017-05-04
US20190016725A1 (en) 2019-01-17
CN111635406A (zh) 2020-09-08
KR20170007480A (ko) 2017-01-18
US9969740B2 (en) 2018-05-15
CA2949932A1 (en) 2015-12-03
HUE054916T2 (hu) 2021-10-28
AU2015265542B2 (en) 2019-05-09
AU2015265542A1 (en) 2016-12-08
CN106661030A (zh) 2017-05-10
JP2020122022A (ja) 2020-08-13
EA032506B1 (ru) 2019-06-28
IL249058A0 (en) 2017-01-31
JP2017516785A (ja) 2017-06-22
EP3971188A1 (en) 2022-03-23
US10947244B2 (en) 2021-03-16
WO2015181728A1 (en) 2015-12-03
PL3149000T3 (pl) 2021-11-02
EP3149000A1 (en) 2017-04-05
SMT202100532T1 (it) 2021-11-12
PT3149000T (pt) 2021-07-27
JP6987501B2 (ja) 2022-01-05
BR112016027674A2 (pt) 2017-08-15
LT3149000T (lt) 2021-09-10
US10414773B2 (en) 2019-09-17
US20190382411A1 (en) 2019-12-19
HRP20211151T1 (hr) 2021-10-15

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