CN106661028B - 用于稳定化发光底物的组合物和方法 - Google Patents

用于稳定化发光底物的组合物和方法 Download PDF

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CN106661028B
CN106661028B CN201580026864.3A CN201580026864A CN106661028B CN 106661028 B CN106661028 B CN 106661028B CN 201580026864 A CN201580026864 A CN 201580026864A CN 106661028 B CN106661028 B CN 106661028B
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tak
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furimazine
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compound
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CN106661028A (zh
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T·柯克兰
K·V·伍德
M·哈尔
M·施温
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Promega Corp
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    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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  • General Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Urology & Nephrology (AREA)
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  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Electroluminescent Light Sources (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201580026864.3A 2014-05-23 2015-05-26 用于稳定化发光底物的组合物和方法 Active CN106661028B (zh)

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US201462002363P 2014-05-23 2014-05-23
US62/002,363 2014-05-23
PCT/US2015/032439 WO2015179864A1 (en) 2014-05-23 2015-05-26 Compositions and methods for stabilizing luminogenic substrates

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CN106661028B true CN106661028B (zh) 2021-08-06

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EP (1) EP3146066B1 (enExample)
JP (1) JP6641297B2 (enExample)
KR (1) KR102456212B1 (enExample)
CN (1) CN106661028B (enExample)
AU (1) AU2015263901B2 (enExample)
BR (1) BR112016027504B1 (enExample)
CA (1) CA2949447C (enExample)
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EP3661932B1 (en) 2017-08-04 2021-10-06 Promega Corporation Compositions and methods for stabilizing benzothiazole luciferin analogs
IL318819A (en) 2018-10-03 2025-04-01 Promega Corp Compounds and methods for stabilizing cholinetyrazine and its derivatives
CN111116594B (zh) * 2019-12-03 2021-05-28 山东大学 一种C-6位改造NanoLuc类型类似物及其制备方法与应用
CN121399275A (zh) * 2024-05-21 2026-01-23 深圳琅技生命科技有限公司 用于稳定腔肠素及其类似物的组合物及方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080020384A1 (en) * 2006-07-24 2008-01-24 National Institute Of Advanced Industrial Science And Technology Stabilizing composition and stabilizing method of coelenterazine solution for high-throughput measurement of luciferase activity
CN103370319A (zh) * 2010-11-02 2013-10-23 普罗美加公司 新型腔肠素底物及其使用方法

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DE2000622A1 (de) * 1970-01-08 1971-07-22 Agfa Gevaert Ag Verfahren zur Stabilisierung von Silberbildern
JP4639904B2 (ja) * 2005-03-30 2011-02-23 チッソ株式会社 蛍光活性を有するルシフェラーゼの活性増強方法
JP4761150B2 (ja) * 2006-07-24 2011-08-31 独立行政法人産業技術総合研究所 ハイスループット発光活性測定のためのセレンテラジン（ウミシイタケルシフェリン）溶液の安定化組成物および安定化法
EP2626703B1 (en) * 2008-03-27 2017-05-03 Promega Corporation Protein labeling with cyanobenzothiazole conjugates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080020384A1 (en) * 2006-07-24 2008-01-24 National Institute Of Advanced Industrial Science And Technology Stabilizing composition and stabilizing method of coelenterazine solution for high-throughput measurement of luciferase activity
CN103370319A (zh) * 2010-11-02 2013-10-23 普罗美加公司 新型腔肠素底物及其使用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Antioxidant e.ect of triazinone derivatives in thermal oxidation of polyisoprene;L.S. Pustoshnaya，等;《Polymer Degradation and Stability》;20001231;第70卷(第1期);第39-41页 *

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WO2015179864A1 (en) 2015-11-26
BR112016027504A2 (enExample) 2017-08-15
SG11201609382WA (en) 2016-12-29
AU2015263901A1 (en) 2016-11-24
JP2017519977A (ja) 2017-07-20
KR102456212B1 (ko) 2022-10-20
US20150337198A1 (en) 2015-11-26
BR112016027504B1 (pt) 2023-04-18
US9676997B2 (en) 2017-06-13
CA2949447A1 (en) 2015-11-26
EP3146066A1 (en) 2017-03-29
AU2015263901B2 (en) 2021-03-11
JP6641297B2 (ja) 2020-02-05
CA2949447C (en) 2022-10-04
CN106661028A (zh) 2017-05-10
KR20170012271A (ko) 2017-02-02

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