CN106632401B - 用于稠合氨基二氢噻嗪衍生物的合成的方法和化合物 - Google Patents
用于稠合氨基二氢噻嗪衍生物的合成的方法和化合物 Download PDFInfo
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- CN106632401B CN106632401B CN201610875412.9A CN201610875412A CN106632401B CN 106632401 B CN106632401 B CN 106632401B CN 201610875412 A CN201610875412 A CN 201610875412A CN 106632401 B CN106632401 B CN 106632401B
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- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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| GB0912777D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydropyrimidone derivatives |
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| UY34278A (es) | 2011-08-25 | 2013-04-05 | Novartis Ag | Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades |
| GB201212816D0 (en) * | 2012-07-19 | 2012-09-05 | Eisai Ltd | Novel compounds |
| TWI639607B (zh) | 2013-06-18 | 2018-11-01 | 美國禮來大藥廠 | Ｂａｃｅ抑制劑 |
| CN107106568B (zh) * | 2014-10-10 | 2023-09-26 | 卫材R&D管理有限公司 | 稠合氨基二氢噻嗪衍生物的药物组合物 |
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- 2012-01-20 CN CN201280004193.7A patent/CN103502231A/zh active Pending
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- 2012-01-20 EP EP12702690.4A patent/EP2665716B1/en active Active
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| WO2011005738A1 (en) * | 2009-07-09 | 2011-01-13 | Eli Lilly And Company | Bace inhibitors |
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| CN106632401A (zh) | 2017-05-10 |
| US20130197244A1 (en) | 2013-08-01 |
| IL226405A0 (en) | 2013-07-31 |
| US20140309429A1 (en) | 2014-10-16 |
| SG191710A1 (en) | 2013-08-30 |
| SG10201601516QA (en) | 2016-03-30 |
| CN103502231A (zh) | 2014-01-08 |
| MX2013005115A (es) | 2013-06-03 |
| US8962858B2 (en) | 2015-02-24 |
| RU2013138226A (ru) | 2015-02-27 |
| JP5993875B2 (ja) | 2016-09-14 |
| EP2665716B1 (en) | 2017-03-08 |
| US8802871B2 (en) | 2014-08-12 |
| WO2012100179A1 (en) | 2012-07-26 |
| CA2814014A1 (en) | 2012-07-26 |
| BR112013016241A2 (pt) | 2016-07-12 |
| JP2016121177A (ja) | 2016-07-07 |
| US8426584B2 (en) | 2013-04-23 |
| US20120190848A1 (en) | 2012-07-26 |
| JP6087005B2 (ja) | 2017-03-01 |
| ES2624288T3 (es) | 2017-07-13 |
| EP2665716A1 (en) | 2013-11-27 |
| JP2014503001A (ja) | 2014-02-06 |
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