CN106632008A - 一种氯羟吡啶生产工艺 - Google Patents

一种氯羟吡啶生产工艺 Download PDF

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Publication number
CN106632008A
CN106632008A CN201510879926.7A CN201510879926A CN106632008A CN 106632008 A CN106632008 A CN 106632008A CN 201510879926 A CN201510879926 A CN 201510879926A CN 106632008 A CN106632008 A CN 106632008A
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CN
China
Prior art keywords
clopidol
production process
product
dissolving
serving
Prior art date
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Pending
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CN201510879926.7A
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English (en)
Inventor
胡江海
张晓磊
于飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ningxia Jihua Environmental Safety Technology Co Ltd
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Ningxia Jihua Environmental Safety Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ningxia Jihua Environmental Safety Technology Co Ltd filed Critical Ningxia Jihua Environmental Safety Technology Co Ltd
Priority to CN201510879926.7A priority Critical patent/CN106632008A/zh
Publication of CN106632008A publication Critical patent/CN106632008A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Abstract

氯羟吡啶是一种重要的化工原料，氯羟吡啶的生产工艺为：在溶解釜内加入氯羟吡啶原料药粗品，用计量泵加入甲醇，同时升温至40℃左右，氯羟吡啶原料药混合溶解约5h，待完全溶解后用夹套冷冻水降温，降至5℃左右，产品结晶析出，完成后放入过滤器进行离心过滤，得到晶体去烘干。母液送至精馏塔回收套用。烘干后的晶体经过粉碎、过筛、混合后，包装得到成品。

Description

一种氯羟吡啶生产工艺
分子式：C7H7NOCl2
分子量：192.04
结构式
产品性状：本品为白色或类白色粉末，无臭。本品在甲醇或乙醇中微溶，在水、丙酮、乙醚、苯中不溶；在氢氧化钠中溶解。
主要用途：氯羟吡啶是我国使用最广泛的抗球虫药，其抗虫谱较广，对鸡的柔嫩、
毒害、布氏、巨型、堆型、和缓和早熟艾美耳球虫均有良效。
3、工艺说明
在溶解釜内加入氯羟吡啶原料药粗品，用计量泵加入甲醇，同时升温至40℃左右，氯羟吡啶原料药混合溶解约5h，待完全溶解后用夹套冷冻水降温，降至5℃左右，产品结晶析出，完成后放入过滤器进行离心过滤，得到晶体去烘干。母液送至精馏塔回收套用。烘干后的晶体经过粉碎、过筛、混合后，包装得到成品。
附图说明：
图1是物料平衡图。

Claims (2)

1.一种氯羟吡啶生产工艺。
2.本发明涉及生产原料成分及配比。
CN201510879926.7A 2015-12-06 2015-12-06 一种氯羟吡啶生产工艺 Pending CN106632008A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510879926.7A CN106632008A (zh) 2015-12-06 2015-12-06 一种氯羟吡啶生产工艺

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510879926.7A CN106632008A (zh) 2015-12-06 2015-12-06 一种氯羟吡啶生产工艺

Publications (1)

Publication Number Publication Date
CN106632008A true CN106632008A (zh) 2017-05-10

Family

ID=58851205

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510879926.7A Pending CN106632008A (zh) 2015-12-06 2015-12-06 一种氯羟吡啶生产工艺

Country Status (1)

Country Link
CN (1) CN106632008A (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3246001A (en) * 1963-09-25 1966-04-12 Dow Chemical Co 3, 5-dichloro-2, 6-dimethyl-4-pyridinol
CN1044462A (zh) * 1989-01-26 1990-08-08 程丽波 常压法制备3，5-二氯-2，6-二甲基吡啶酚

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3246001A (en) * 1963-09-25 1966-04-12 Dow Chemical Co 3, 5-dichloro-2, 6-dimethyl-4-pyridinol
CN1044462A (zh) * 1989-01-26 1990-08-08 程丽波 常压法制备3，5-二氯-2，6-二甲基吡啶酚

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
龚锐，等: "氯吡醇合成方法的研究", 《化学世界》 *

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Application publication date: 20170510