CN106574891A - 使用流式细胞仪评价多峰事件 - Google Patents

使用流式细胞仪评价多峰事件 Download PDF

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Publication number
CN106574891A
CN106574891A CN201580042309.XA CN201580042309A CN106574891A CN 106574891 A CN106574891 A CN 106574891A CN 201580042309 A CN201580042309 A CN 201580042309A CN 106574891 A CN106574891 A CN 106574891A
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CN
China
Prior art keywords
waveform
multimodal
light
light beam
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580042309.XA
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English (en)
Chinese (zh)
Inventor
杰弗里·W·德格拉
托马斯·L·思拉舍
卡利·罗斯
布鲁斯·G·贝利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Publication of CN106574891A publication Critical patent/CN106574891A/zh
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
    • G01P3/00—Measuring linear or angular speed; Measuring differences of linear or angular speeds
    • G01P3/36—Devices characterised by the use of optical means, e.g. using infrared, visible, or ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N2015/1461—Coincidence detecting; Circuits therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Electromagnetism (AREA)
  • Power Engineering (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201580042309.XA 2014-08-06 2015-07-20 使用流式细胞仪评价多峰事件 Pending CN106574891A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462034002P 2014-08-06 2014-08-06
US62/034,002 2014-08-06
PCT/US2015/041069 WO2016022276A1 (en) 2014-08-06 2015-07-20 Evaluation of multi-peak events using a flow cytometer

Publications (1)

Publication Number Publication Date
CN106574891A true CN106574891A (zh) 2017-04-19

Family

ID=53773550

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580042309.XA Pending CN106574891A (zh) 2014-08-06 2015-07-20 使用流式细胞仪评价多峰事件

Country Status (5)

Country Link
US (1) US20170227447A1 (https=)
EP (1) EP3177908B1 (https=)
JP (1) JP2017526914A (https=)
CN (1) CN106574891A (https=)
WO (1) WO2016022276A1 (https=)

Cited By (4)

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CN109283121A (zh) * 2018-10-11 2019-01-29 迈克医疗电子有限公司 脉冲识别方法和装置、分析仪器、存储介质
CN111504869A (zh) * 2020-05-15 2020-08-07 中国计量科学研究院 流式聚集体杂质分析仪
CN112154317A (zh) * 2018-04-26 2020-12-29 贝克顿·迪金森公司 颗粒分析仪的表征和分选
CN113316715A (zh) * 2019-01-31 2021-08-27 快速定量微生物学股份有限公司 一种包括用于流体样品的通道的盒、包括盒的组件以及将光学装置与盒的通道对齐的方法

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EP3244191B8 (en) 2016-05-06 2025-03-19 Deutsches Rheuma-Forschungszentrum Berlin Method and system for characterizing particles using a flow cytometer
JP2019178978A (ja) * 2018-03-30 2019-10-17 ソニーセミコンダクタソリューションズ株式会社 光学測定器、およびフローサイトメータ
US11131618B2 (en) 2018-08-10 2021-09-28 Cytek Biosciences, Inc. Smart flow cytometers with self monitoring and self validation
DE102018219891A1 (de) * 2018-11-20 2020-05-20 Robert Bosch Gmbh Verfahren zum Betreiben eines Partikelsensors
WO2021101692A1 (en) * 2019-11-20 2021-05-27 Becton, Dickinson And Company A light detection module with adjustable sensitivity
EP4111169A4 (en) * 2020-02-27 2023-08-09 Becton, Dickinson and Company METHODS FOR IDENTIFYING SATURATED DATA SIGNALS IN CELL SORTING AND RELATED SYSTEMS
EP3933376A1 (en) 2020-07-02 2022-01-05 Deutsches Rheuma-Forschungszentrum Berlin Method and system for characterizing particles using an angular detection in a flow cytometer
CN112730202B (zh) * 2020-12-29 2023-06-16 深圳市科曼医疗设备有限公司 血球分析仪的阻抗法检测系统和识别阻抗通道堵孔的方法
WO2024238175A1 (en) * 2023-05-12 2024-11-21 Beckman Coulter, Inc. Particles characterization in flow cytometry
US12584902B2 (en) 2023-12-10 2026-03-24 Instrumentation Laboratory Company Acoustic separation of a test sample

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CN103460018A (zh) * 2011-02-04 2013-12-18 塞通诺米/St有限责任公司 颗粒分选设备和方法

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JPS6358235A (ja) * 1986-08-29 1988-03-14 Toa Medical Electronics Co Ltd 信号処理方法および装置
JP2001281133A (ja) * 2000-03-30 2001-10-10 Sysmex Corp フローサイトメータ
JP2001281132A (ja) * 2000-03-30 2001-10-10 Sysmex Corp フローサイトメータ
US20020028434A1 (en) * 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
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Publication number Priority date Publication date Assignee Title
CN112154317A (zh) * 2018-04-26 2020-12-29 贝克顿·迪金森公司 颗粒分析仪的表征和分选
CN109283121A (zh) * 2018-10-11 2019-01-29 迈克医疗电子有限公司 脉冲识别方法和装置、分析仪器、存储介质
CN109283121B (zh) * 2018-10-11 2021-04-09 迈克医疗电子有限公司 脉冲识别方法和装置、分析仪器、存储介质
CN113316715A (zh) * 2019-01-31 2021-08-27 快速定量微生物学股份有限公司 一种包括用于流体样品的通道的盒、包括盒的组件以及将光学装置与盒的通道对齐的方法
CN113316715B (zh) * 2019-01-31 2024-03-15 快速定量微生物学股份有限公司 一种布置光学装置的盒、组件以及方法
CN111504869A (zh) * 2020-05-15 2020-08-07 中国计量科学研究院 流式聚集体杂质分析仪
CN111504869B (zh) * 2020-05-15 2021-06-08 中国计量科学研究院 流式聚集体杂质分析仪

Also Published As

Publication number Publication date
EP3177908A1 (en) 2017-06-14
US20170227447A1 (en) 2017-08-10
JP2017526914A (ja) 2017-09-14
WO2016022276A1 (en) 2016-02-11
EP3177908B1 (en) 2019-04-17

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