CN106574891A - 使用流式细胞仪评价多峰事件 - Google Patents

使用流式细胞仪评价多峰事件 Download PDF

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Publication number
CN106574891A
CN106574891A CN201580042309.XA CN201580042309A CN106574891A CN 106574891 A CN106574891 A CN 106574891A CN 201580042309 A CN201580042309 A CN 201580042309A CN 106574891 A CN106574891 A CN 106574891A
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CN
China
Prior art keywords
waveform
multimodal
light
light beam
granule
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Pending
Application number
CN201580042309.XA
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English (en)
Chinese (zh)
Inventor
杰弗里·W·德格拉
托马斯·L·思拉舍
卡利·罗斯
布鲁斯·G·贝利
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Beckman Coulter Inc
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Beckman Instruments Inc
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Publication date
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Publication of CN106574891A publication Critical patent/CN106574891A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
    • G01P3/00—Measuring linear or angular speed; Measuring differences of linear or angular speeds
    • G01P3/36—Devices characterised by the use of optical means, e.g. using infrared, visible, or ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N2015/1461—Coincidence detecting; Circuits therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Electromagnetism (AREA)
  • Power Engineering (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201580042309.XA 2014-08-06 2015-07-20 使用流式细胞仪评价多峰事件 Pending CN106574891A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462034002P 2014-08-06 2014-08-06
US62/034,002 2014-08-06
PCT/US2015/041069 WO2016022276A1 (en) 2014-08-06 2015-07-20 Evaluation of multi-peak events using a flow cytometer

Publications (1)

Publication Number Publication Date
CN106574891A true CN106574891A (zh) 2017-04-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580042309.XA Pending CN106574891A (zh) 2014-08-06 2015-07-20 使用流式细胞仪评价多峰事件

Country Status (5)

Country Link
US (1) US20170227447A1 (enExample)
EP (1) EP3177908B1 (enExample)
JP (1) JP2017526914A (enExample)
CN (1) CN106574891A (enExample)
WO (1) WO2016022276A1 (enExample)

Cited By (4)

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CN109283121A (zh) * 2018-10-11 2019-01-29 迈克医疗电子有限公司 脉冲识别方法和装置、分析仪器、存储介质
CN111504869A (zh) * 2020-05-15 2020-08-07 中国计量科学研究院 流式聚集体杂质分析仪
CN112154317A (zh) * 2018-04-26 2020-12-29 贝克顿·迪金森公司 颗粒分析仪的表征和分选
CN113316715A (zh) * 2019-01-31 2021-08-27 快速定量微生物学股份有限公司 一种包括用于流体样品的通道的盒、包括盒的组件以及将光学装置与盒的通道对齐的方法

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EP3244191B8 (en) 2016-05-06 2025-03-19 Deutsches Rheuma-Forschungszentrum Berlin Method and system for characterizing particles using a flow cytometer
US10337975B2 (en) 2016-05-06 2019-07-02 Deutsches Rheuma-Forschungszentrum Berlin Method and system for characterizing particles using a flow cytometer
JP2019178978A (ja) * 2018-03-30 2019-10-17 ソニーセミコンダクタソリューションズ株式会社 光学測定器、およびフローサイトメータ
US11131618B2 (en) 2018-08-10 2021-09-28 Cytek Biosciences, Inc. Smart flow cytometers with self monitoring and self validation
DE102018219891A1 (de) * 2018-11-20 2020-05-20 Robert Bosch Gmbh Verfahren zum Betreiben eines Partikelsensors
WO2021101692A1 (en) * 2019-11-20 2021-05-27 Becton, Dickinson And Company A light detection module with adjustable sensitivity
EP4111169A4 (en) * 2020-02-27 2023-08-09 Becton, Dickinson and Company METHODS FOR IDENTIFYING SATURATED DATA SIGNALS IN CELL SORTING AND RELATED SYSTEMS
EP3933376A1 (en) 2020-07-02 2022-01-05 Deutsches Rheuma-Forschungszentrum Berlin Method and system for characterizing particles using an angular detection in a flow cytometer
CN112730202B (zh) * 2020-12-29 2023-06-16 深圳市科曼医疗设备有限公司 血球分析仪的阻抗法检测系统和识别阻抗通道堵孔的方法
EP4533066A1 (en) * 2023-05-12 2025-04-09 Beckman Coulter, Inc. Particles characterization in flow cytometry

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JP2001281132A (ja) * 2000-03-30 2001-10-10 Sysmex Corp フローサイトメータ
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US20020028434A1 (en) * 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
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US20120236291A1 (en) * 2006-09-29 2012-09-20 Emd Millipore Corporation Differentiation of flow cytometry pulses and applications
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CN103460018A (zh) * 2011-02-04 2013-12-18 塞通诺米/St有限责任公司 颗粒分选设备和方法

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112154317A (zh) * 2018-04-26 2020-12-29 贝克顿·迪金森公司 颗粒分析仪的表征和分选
CN109283121A (zh) * 2018-10-11 2019-01-29 迈克医疗电子有限公司 脉冲识别方法和装置、分析仪器、存储介质
CN109283121B (zh) * 2018-10-11 2021-04-09 迈克医疗电子有限公司 脉冲识别方法和装置、分析仪器、存储介质
CN113316715A (zh) * 2019-01-31 2021-08-27 快速定量微生物学股份有限公司 一种包括用于流体样品的通道的盒、包括盒的组件以及将光学装置与盒的通道对齐的方法
CN113316715B (zh) * 2019-01-31 2024-03-15 快速定量微生物学股份有限公司 一种布置光学装置的盒、组件以及方法
CN111504869A (zh) * 2020-05-15 2020-08-07 中国计量科学研究院 流式聚集体杂质分析仪
CN111504869B (zh) * 2020-05-15 2021-06-08 中国计量科学研究院 流式聚集体杂质分析仪

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Publication number Publication date
EP3177908B1 (en) 2019-04-17
WO2016022276A1 (en) 2016-02-11
US20170227447A1 (en) 2017-08-10
JP2017526914A (ja) 2017-09-14
EP3177908A1 (en) 2017-06-14

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